To the pathogenesis and clinic of nephrosis

1937 ◽  
Vol 33 (2) ◽  
pp. 126-132
Author(s):  
A. G. Teregulov
Keyword(s):  
Uric Acid ◽  
Lipid Metabolism ◽  
Blood Plasma ◽  
Osmotic Pressure ◽  
Protein Metabolism ◽  
Protein Fraction ◽  
Plasma Proteins ◽  
The Body ◽  
Blood Plasma Proteins ◽  
In Blood Plasma

Clinically, with nephrosis, we observe edema, albuminuria, lipoiduria, which, as follows from the data of modern clinics, along with changes in the kidneys, largely depend on the general suffering of the body disorders of protein and lipid metabolism. Indeed, studies have established that with nephrosis there are deep biochemical shifts - a decrease in blood plasma proteins, a change in the ratio of the protein fraction of the blood towards globulins, an increase in the content of fibrinogen, uric acid, a decrease in osmotic pressure and, finally, in parallel with a change in protein metabolism and changes in fat-lipoid metabolism - hypercholesterolemia.

The influence of alkylation on the photophysical properties of BODIPYs and their labeling in blood plasma proteins

2020 ◽  
Vol 304 ◽  
pp. 112717 ◽  
Author(s):  
Lyubov A. Antina ◽  
Alexander A. Ksenofontov ◽  
Alexander A. Kalyagin ◽  
Pavel S. Bocharov ◽  
Nadezhda V. Kharitonova ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Plasma Proteins ◽  
Photophysical Properties ◽  
Blood Plasma Proteins ◽  
In Blood Plasma

scholarly journals Protective action of carnosine and organic lithium salts in case of ethanol-induced oxidative damage of proteins and lipids of blood plasma in healthy persons and alcoholic patients

2019 ◽  
Vol 65 (1) ◽  
pp. 28-32 ◽  
Author(s):  
V.D. Prokopieva ◽  
E.V. Plotnikov ◽  
E.G. Yarygina ◽  
N.A. Bokhan
Keyword(s):  
Blood Plasma ◽  
Plasma Proteins ◽  
Protective Action ◽  
Lithium Carbonate ◽  
Lithium Salts ◽  
Oxidized Proteins ◽  
Blood Plasma Proteins ◽  
Healthy Persons ◽  
In Blood Plasma

Organic lithium salts containing anionic components (succinate, fumarate, pyruvate and antioxidant ascorbate) were tested for protection of blood plasma proteins and lipids against ethanol-induced oxidation in vitro. We used normothymic lithium carbonate and well-known antioxidant dipeptide carnosine (b-alanyl-L-histidine) as the reference drugs. The oxidized proteins and lipids were determined by the level of carbonylated proteins (CP) and TBA-reactive products (TBA-RP), respectively. In alcoholic patients the level of oxidized proteins and lipids was higher than in healthy persons. Incubation of blood with ethanol resulted in an increase in oxidized proteins and lipids in blood plasma of healthy persons but had no influence on the level of CP and TBA-RP in blood plasma of alcoholic patients. Lithium carbonate, lithium ascorbate, and lithium succinate exhibited protective action against ethanol-induced oxidation of biomolecules of blood plasma of healthy people. These effects were comparable with carnosine action. The studied compounds had no effect on the level of CP and TBA-RP of blood plasma of alcoholic patients.

Post-Translational Oxidation Modifications of Blood Plasma Proteins of Cosmonauts after a Long-term Flight: Part I

2020 ◽  
Vol 46 (5) ◽  
pp. 531-539
Author(s):  
I. M. Larina ◽  
A. G. Brzhzovsky ◽  
A. M. Nosovsky ◽  
A. S. Kononikhin ◽  
O. I. Orlov
Keyword(s):  
Blood Plasma ◽  
Plasma Proteins ◽  
Blood Plasma Proteins

scholarly journals BIOPHYSICAL STUDIES OF BLOOD PLASMA PROTEINS

1946 ◽  
Vol 165 (1) ◽  
pp. 21-35 ◽  
Author(s):  
H.F. Deutsch ◽  
R.A. Alberty ◽  
L.J. Gosting
Keyword(s):  
Blood Plasma ◽  
Plasma Proteins ◽  
Biophysical Studies ◽  
Blood Plasma Proteins

scholarly journals Plasma radio-metabolite analysis of PET tracers for dynamic PET imaging: TLC and autoradiography

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Fiona Li ◽  
Justin W. Hicks ◽  
Lihai Yu ◽  
Lise Desjardin ◽  
Laura Morrison ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Blood Plasma ◽  
Kinetic Parameters ◽  
High Performance ◽  
The Body ◽  
Accurate Estimation ◽  
Dynamic Pet ◽  
Arterial Concentration ◽  
In Blood Plasma

Abstract Background In molecular imaging with dynamic PET, the binding and dissociation of a targeted tracer is characterized by kinetics modeling which requires the arterial concentration of the tracer to be measured accurately. Once in the body the radiolabeled parent tracer may be subjected to hydrolysis, demethylation/dealkylation and other biochemical processes, resulting in the production and accumulation of different metabolites in blood which can be labeled with the same PET radionuclide as the parent. Since these radio-metabolites cannot be distinguished by PET scanning from the parent tracer, their contribution to the arterial concentration curve has to be removed for the accurate estimation of kinetic parameters from kinetic analysis of dynamic PET. High-performance liquid chromatography has been used to separate and measure radio-metabolites in blood plasma; however, the method is labor intensive and remains a challenge to implement for each individual patient. The purpose of this study is to develop an alternate technique based on thin layer chromatography (TLC) and a sensitive commercial autoradiography system (Beaver, Ai4R, Nantes, France) to measure radio-metabolites in blood plasma of two targeted tracers—[18F]FAZA and [18F]FEPPA, for imaging hypoxia and inflammation, respectively. Results Radioactivity as low as 17 Bq in 2 µL of pig’s plasma can be detected on the TLC plate using autoradiography. Peaks corresponding to the parent tracer and radio-metabolites could be distinguished in the line profile through each sample (n = 8) in the autoradiographic image. Significant intersubject and intra-subject variability in radio-metabolites production could be observed with both tracers. For [18F]FEPPA, 50% of plasma activity was from radio-metabolites as early as 5-min post injection, while for [18F]FAZA, significant metabolites did not appear until 50-min post. Simulation study investigating the effect of radio-metabolite in the estimation of kinetic parameters indicated that 32–400% parameter error can result without radio-metabolites correction. Conclusion TLC coupled with autoradiography is a good alternative to high-performance liquid chromatography for radio-metabolite correction. The advantages of requiring only small blood samples (~ 100 μL) and of analyzing multiple samples simultaneously, make the method suitable for individual dynamic PET studies.

Oxidative and Nitrative Modifications of Blood Plasma Proteins in Patients with Myasthenia Gravis

2016 ◽  
Vol 100 ◽  
pp. S166
Author(s):  
Izabela Sadowska-Bartosz ◽  
Sabina Galiniak ◽  
Grzegorz Bartosz ◽  
Izabela Rozmiłowska ◽  
Damian Czyżewski ◽  
...  
Keyword(s):  
Myasthenia Gravis ◽  
Blood Plasma ◽  
Plasma Proteins ◽  
Blood Plasma Proteins

Feracryl, a new hemostatic polymer, and its interaction with blood plasma proteins

1980 ◽  
Vol 14 (7) ◽  
pp. 431-433 ◽  
Author(s):  
V. Z. Annenkova ◽  
N. G. Dianova ◽  
V. M. Annenkova ◽  
G. S. Ugryumova ◽  
M. G. Voronkov
Keyword(s):  
Blood Plasma ◽  
Plasma Proteins ◽  
Blood Plasma Proteins

Quantitative target proteomics of chromosome 13 human blood plasma proteins

2017 ◽  
Vol 476 (1) ◽  
pp. 326-328 ◽  
Author(s):  
A. T. Kopylov ◽  
E. V. Ilgisonis ◽  
O. V. Tikhonova ◽  
T. E. Farafonova ◽  
S. E. Novikova ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Human Blood ◽  
Plasma Proteins ◽  
Human Blood Plasma ◽  
Chromosome 13 ◽  
Blood Plasma Proteins
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