Antifungal activity of dermadex-agents for the treatment of microsporia and trichophytia

2001 ◽  
Vol 82 (3) ◽  
pp. 214-214
Author(s):  
L. R. Zakieva ◽  
R. S. Garaev ◽  
M. T. Tremasov
Keyword(s):  
Antifungal Activity ◽  
Antifungal Agent ◽  
Medicinal Form ◽  
Toxicological Evaluation ◽  
Fungistatic Activity

The aim of our study was the toxicological evaluation of the drug Dermadex, which is a new medicinal form of the antifungal agent 2-mercantobenzothiazole, as well as the study of its fungicidal and fungistatic activity with the development of tactics for the treatment of microsporia and trichophytia.

scholarly journals Vepris macrophylla (Baker) I. Verd Essential Oil: An Antifungal Agent against Phytopathogenic Fungi

2020 ◽  
Vol 21 (8) ◽  
pp. 2776 ◽  
Author(s):  
Laura Giamperi ◽  
Anahi Elena Ada Bucchini ◽  
Donata Ricci ◽  
Bruno Tirillini ◽  
Marcello Nicoletti ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Essential Oil ◽  
Antifungal Agent ◽  
Alternaria Solani ◽  
Phytopathogenic Fungi ◽  
Dilution Method ◽  
Agar Dilution Method ◽  
Fungistatic Activity ◽  
Leaf Essential Oil ◽  
Main Components

Rutaceae are widely used in ethnomedicine to treat infectious diseases in humans and plants. In this study, the antifungal activity of the Vepris macrophylla leaf essential oil (VEO) and its main components, citral and citronellol, was evaluated against six phytopathogenic fungi. In addition, the possible action of VEO on the synthesis of mycotoxins was evaluated as well. To determine the antifungal activity of VEO we used the agar dilution method and VEO showed inhibitory activity against all the tested fungi. In particular, VEO resulted to be fungicidal against Phytophthora cryptogea and Fusarium avenaceum. For all other fungi VEO exhibited fungistatic activity and the weakest effect was observed on Alternaria solani. Citral was very effective against P. cryptogea, F. avenaceum, F. poae and F. graminearum. On the other hand, citronellol showed good activity towards P. cryptogea and F. avenaceum and weaker activity towards F. poae and F. graminearum. It can be concluded that VEO can be considered a promising antifungal agent, especially against P. cryptogea and F. avenaceum, suggesting a possible use in the formulation of new selective and natural fungicides.

scholarly journals Synthesis and Antifungal Activity of Butenafine Hydrochloride (KP-363), a New Benzylamine Antifungal Agent

1991 ◽  
Vol 111 (2) ◽  
pp. 126-137 ◽  
Author(s):  
Tetsuya MAEDA ◽  
Mitsuo TAKASE ◽  
Akihiko ISHIBASHI ◽  
Toshiyuki YAMAMOTO ◽  
Kazuya SASAKI ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Antifungal Agent

scholarly journals Antifungal activities of thiosemicarbazones and semicarbazones against mycotoxigenic fungi

2014 ◽  
Vol 38 (6) ◽  
pp. 531-537 ◽  
Author(s):  
Rojane de Oliveira Paiva ◽  
Lucimar Ferreira Kneipp ◽  
Carla Marins Goular ◽  
Mariana Almeida Albuquerque ◽  
Aurea Echevarria
Keyword(s):  
Antifungal Activity ◽  
Aspergillus Flavus ◽  
Fungicidal Activity ◽  
Fusarium Verticillioides ◽  
Animal Health ◽  
Fungistatic Activity ◽  
Mycotoxigenic Fungi ◽  
Quality Of Food ◽  
Chelating Effect

Mycotoxigenic fungi can compromise the quality of food, exposing human and animal health at risk. The antifungal activity of eight thiosemicarbazones (1-8) and nine semicarbazones (9-17) was evaluated against Aspergillus flavus, A. nomius, A. ochraceus, A. parasiticus and Fusarium verticillioides. Thiosemicarbazones had MIC values of 125-500 µg/ml. The thiosemicarbazones 1 and 2 exerted fungistatic activity against Aspergillus spp., and thiosemicarbazone 2 exerted fungicidal activity against F. verticillioides. Compound 2 showed an iron chelating effect of 63%. The ergosterol content of A. parasiticus had a decrease of 28 and 71% for the 31.2 and 62.5 µg/ml concentrations of thiosemicarbazone 2 compared to the control. The obtained results of antifungal activity revealed that thiosemicarbazone class was more active when compared to semicarbazone class and, the thiosemicarbazone 2 was the most active compound, specially, against Aspergillus spp.

Ketoconazole - an antifungal drug for oral use

1981 ◽  
Vol 19 (23) ◽  
pp. 91-92
Keyword(s):  
Antifungal Activity ◽  
Cell Membrane ◽  
Oral Administration ◽  
Antifungal Agent ◽  
Systemic Effect ◽  
Antifungal Drug ◽  
The Other ◽  
Membrane Synthesis ◽  
Fungal Cell

Ketoconazole (Nizoral - Janssen) is a new antifungal agent. Like the other imidazoles with antifungal activity such as miconazole,1 clotrimazole2 and econazole,3 it acts by inhibiting fungal cell-membrane synthesis.4 It is well absorbed and exerts a systemic effect; it is thus suitable for oral administration.

scholarly journals O-Methylation steps during strobilurin and bolineol biosynthesis

RSC Advances ◽  
2019 ◽  
Vol 9 (54) ◽  
pp. 31527-31531 ◽  
Author(s):  
Karen E. Lebe ◽  
Russell J. Cox
Keyword(s):  
Antifungal Activity ◽  
Antifungal Agent

Two methyltransferase genes involving in the biosynthesis of the antifungal agent strobilurin A were investigated. The antifungal activity of pathway intermediates increses with methylation.

scholarly journals Bis(4,6-dimethyl-2-pyridylseleno)zinc 3,3’-dicyanide, A Potent Antifungal Agent

2019 ◽  
pp. 1-4
Author(s):  
V. H. Shah ◽  
A. A. Zohri ◽  
P. K. Talpara ◽  
P. A. Sangala ◽  
M. A. Abdelazim
Keyword(s):  
Mass Spectrometry ◽  
Antifungal Activity ◽  
1H Nmr ◽  
13C Nmr ◽  
Antifungal Agent ◽  
Candida Glabrata ◽  
Biological Screening ◽  
Spectral Analyses ◽  
Reference Drug

A novel zinc chelate of 3-cyano-4,6-dimethyl-2(1H)-selenone pyridine was synthesized and its structure was confirmed on the basis IR, 1H NMR, 13C NMR spectral analyses and TOF mass spectrometry. Biological screening against Candida glabrata reveals a greater antifungal activity of the zinc chelate as compared to the fluconazole reference drug.

scholarly journals Antifungal Activity of Various Extracts of Seeds of the Plant Malva Parviflora (Linn)

2017 ◽  
Vol 14 (4) ◽  
pp. 1409-1412
Author(s):  
Jadhav Raina ◽  
Parihar Sangeeta
Keyword(s):  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Antifungal Agent ◽  
Antifungal Agents ◽  
Diffusion Method ◽  
Dilution Method ◽  
Significant Activity ◽  
Water As Solvent ◽  
Malva Parviflora ◽  
Agar Well Diffusion Method

ABSTRACT: Development of more effective and less toxic antifungal agents is required for the treatment of various fungal disease.Plants and their extraction preparation have beenused as medicine against infectious diseases.The present study was aimed to study, the antifungal activity of the seeds of various seed abstract of plant Malva Parviflora (Linn). The antifungal activity of seeds extract of plant was determine by using agar well diffusion method,MIC(minimum inhibitoryconcentration) and MFC (minimum fungicidal count)by using micro dilution method . The seeds extract of the plant were examined using Methanol, Ethyl acetate ,Petroleum ether and water as solvent and tested against different fungi pathogens. From the result it can be concluded that the all the seeds extract shows the significant activity against the micro organism, hence these extract may be used as a source of antifungal agent obtained from herbal medicine and may be explore as new and effective antifungal agent. Various solvent extracts of the plant Malva parvifiora (Linn) have been found to possess enough antibacterial activity and may potentially be explored as human antifungal agent.

scholarly journals Evaluation of bisphenylthiazoles as a promising class for combating multidrug-resistant fungal infections

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0258465
Author(s):  
Mohamed Hagras ◽  
Nader S. Abutaleb ◽  
Ahmed M. Sayed ◽  
Ehab A. Salama ◽  
Mohamed N. Seleem ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Amphotericin B ◽  
Antifungal Agent ◽  
Fungal Infections ◽  
Multidrug Resistant ◽  
Candida Auris ◽  
Conformationally Restricted ◽  
Normal Human

To minimize the intrinsic toxicity of the antibacterial agent hydrazinyloxadiazole 1, the hydrazine moiety was replaced with ethylenediamine (compound 7). This replacement generated a potent antifungal agent with no antibacterial activity. Notably, use of a 1,2-diaminocyclohexane moiety, as a conformationally-restricted isostere for ethylenediamine, potentiated the antifungal activity in both the cis and trans forms of N-(5-(2-([1,1’-biphenyl]-4-yl)-4-methylthiazol-5-yl)-1,3,4-oxadiazol-2-yl)cyclohexane-1,2-diamine (compounds 16 and 17). Both compounds 16 and 17 were void of any antibacterial activity; nonetheless, they showed equipotent antifungal activity in vitro to that of the most potent approved antifungal agent, amphotericin B. The promising antifungal effects of compounds 16 and 17 were maintained when assessed against an additional panel of 26 yeast and mold clinical isolates, including the Candida auris and C. krusei. Furthermore, compound 17 showed superior activity to amphotericin B in vitro against Candida glabrata and Cryptococcus gattii. Additionally, neither compound inhibited the normal human microbiota, and both possessed excellent safety profiles and were 16 times more tolerable than amphotericin B.

Sign in / Sign up

Export Citation Format

Share Document