scholarly journals Plasmapheresis and hyperbaric oxygenation in the treatment of psoriasis complicated by polyarthritis

2001 ◽  
Vol 82 (4) ◽  
pp. 301-302
Author(s):  
V. N. Korobkov ◽  
G. G. Slepukha ◽  
I. G. Yapparov ◽  
A. K. Saetgaraev
Keyword(s):  
Metabolic Disorders ◽  
Hyperbaric Oxygenation ◽  
Immune Status ◽  
Systemic Disease ◽  
Free Radical Oxidation ◽  
Skin Inflammation ◽  
Practical Medicine ◽  
Radical Oxidation ◽  
Skin Cells ◽  
Oxidative Processes

Treatment of psoriasis (Ps) is still one of the most difficult tasks of practical medicine. The disease often affects young and able-bodied people, and the process itself has a persistent and progressive nature, not amenable to treatment by traditional methods. PS as a systemic disease is based on the phenomena of chronic nonspecific skin inflammation with intracellular edema, infiltration, microcirculatory and metabolic disorders. PS is also characterized by disorders of oxidative processes in skin cells and in the system of free-radical oxidation of lipids. The study of immune status in PS patients revealed disorders of circulating immune complexes (CIC), in particular immunoglobulins A, M, G, against the background of suppressed cellular immunity and phagocytic activity of neutrophils.

LOCAL IMMUNE STATUS AND FREE RADICAL OXIDATION IN RHINOSURGIСAL PATIENTS IN EARLY POST-SURGICAL PERIOD

2018 ◽  
Vol 95 (4) ◽  
pp. 26-32
Author(s):  
O. A. Gizinger ◽  
◽  
A. M. Korkmazov ◽  
M. Yu. Korkmazov ◽  
◽  
...  
Keyword(s):  
Free Radical ◽  
Immune Status ◽  
Free Radical Oxidation ◽  
Radical Oxidation

Features of the clinical course, diagnosis and treatment of paranasal sinusitis in patients with type 2 diabetes mellitus

2021 ◽  
Vol 20 (6) ◽  
pp. 93-101
Author(s):  
T. A. Mashkova ◽  
◽  
A. B. Mal’tsev ◽  
A. N. Pavlov ◽  
A. V. Suslenko ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Paranasal Sinuses ◽  
Immune Status ◽  
Prolonged Exposure ◽  
Inflammatory Diseases ◽  
Rapid Development ◽  
Free Radical Oxidation ◽  
The Body ◽  
Radical Oxidation ◽  
Paranasal Sinusitis

The issue of treating paranasal sinusitis, improving the methods of their treatment and prevention remains relevant to the present. Particular attention shall be paid to patients with concomitant somatic pathology, which contributes to the chronicity of inflammatory processes in the paranasal sinuses and increases the frequency of their recurrence. Among the pathology of ENT organs, acute sinusitis is most common (5–10%). Inflammatory diseases of the nose and paranasal sinuses are fraught with various complications. Thus, the percentage of orbital rhinogenic complications ranges from 6.6 to 12.4%. Patients with a history of diabetes mellitus are more exposed to various diseases, including ENT organs, with their rapid development and subsequent complications. The clinic of purulent sinusitis in them is characterized by a prolonged course with periodic exacerbations and the involvement of nearby anatomical structures in the pathological process with atypical data of radiation studies and frequent complications. The disease proceeds against the background of pronounced changes in the immune status, which affect all links of immunity, including a significant decrease in phagocytosis indicators and an increase in the content of circulating immune complexes of small size. Prolonged exposure of the body to products of free radical oxidation, especially in excess volume, leads to metabolic disorders at all levels and also disrupts the immune status, which leads to a complicated course of diseases. The presence of a pronounced imbalance towards the production of free radicals and a weakening of antioxidant protection leads to the development of oxidative stress and destructive changes at different levels. Treatment of this category of patients is a difficult task, in the solution of which the state of immunity and antioxidant system plays an important role.

scholarly journals Metabolic disorders in liver in late period of cranial-skeletal trauma and their correction by Thiocetam

2015 ◽  
Vol 17 (2) ◽  
Author(s):  
I. A. Mykhaylyuk ◽  
A. A. Hudyma
Keyword(s):  
Superoxide Dismutase ◽  
Free Radical ◽  
Metabolic Disorders ◽  
Free Radical Oxidation ◽  
Antioxidant Protection ◽  
Late Period ◽  
Skeletal Trauma ◽  
Radical Oxidation ◽  
Antioxidant Mechanisms

<p>In the conditions of cranial-skeletal trauma throughout the period of late signs of traumatic disease (14–28 days),<br />the processes of lipidic peroxidation don’t calm down, the activity of antioxidant protection ferments remains reduced,<br />the pro-oxidant mechanisms dominate. The use of thiocetam in 250 mg/kg dosage intraperatoneal throughout 14<br />days after striking of cranial-skeletal trauma essentially lowers the manifestations of free radical oxidation of the<br />lipids, the activity of superoxide dismutase and catalase increases, the antioxidant mechanisms predominate. By<br />the 28th day the normalization of the most of the indices occurs.</p>

THE INFLUENCE OF ANTHROPOGENIC POLLUTION ON SOME INDICATORS OF CONGENITAL IMMUNITY AND OXIDIZING PROCESSES IN BREAM ABRAMIS BRAMA INHABITING LAKE NERO AND THE RYBINSK RESERVOIR

2017 ◽  
pp. 43-47
Author(s):  
N. I. Silkina ◽  
V. R. Mikryakov
Keyword(s):  
Rybinsk Reservoir ◽  
Immune Status ◽  
Fractional Composition ◽  
Free Radical Oxidation ◽  
Anthropogenic Pollution ◽  
Abramis Brama ◽  
Radical Oxidation ◽  
Bream Abramis Brama ◽  
Biochemical Indices ◽  
The Rybinsk Reservoir

The results of a comparative analysis of some blood serum immune-biochemical indices of bream that inhabits lake Nero and the Rybinsk Reservoir are reported. The following indices were investigated: anti-microbial properties: proportion of immune-deficient animals, common lipids level and their fractional composition, content of malondialdehyde and antioxidant activity. Unlike fishes from relatively clean waters, fishes from ecologically unfavorable areas show low immune status, alterations in lipid metabolism and increased free radical oxidation.

scholarly journals Іntensity of oxygen consumption by bull sperm due to the action of L-carnitine

Biologija ◽  
2018 ◽  
Vol 63 (4) ◽  
Author(s):  
Viktoriia Koberska ◽  
Oleh Yermishev
Keyword(s):  
Oxygen Consumption ◽  
Aerobic Glycolysis ◽  
Free Radical Oxidation ◽  
Metabolic Activation ◽  
Mitochondrial Oxygen Consumption ◽  
Radical Oxidation ◽  
Activity Of Enzymes ◽  
Oxidative Processes ◽  
Bull Sperm ◽  
Research Show

The research is devoted to the study of peculiarities of oxygen consumption intensity and the activity of enzymes of antioxidant protection of bull sperm due to the action of L-carnitine. We used bull sperm that was mixed with sperm dilution for the “Bioexel” to the ratio 1:1. Diluted semen was divided into two parts – one control and three experimental. L-carnitine was added to the diluent in the amount of 10 mg/100 ml in part 2, 30 mg/100 ml in part 3, and 60 mg/100 ml in part 4; the sperm was dissolved in this liquid to the ratio of 3:1. The intensity of oxygen consumption, the activity of enzymes superoxidedismutase, catalase, glutathioneperoxidase and survival of spermatozoa were thoroughly investigated in the diluted semen. L-carnitine, which was added to the diluent of semen 10 and 30 mg/100 ml, stimulates aerobic glycolysis by 5.9 and 11.9%, and decreases oxidative processes by 5.6% and 11.4%, respectively. It is not related to the synthesis of ATP. It increases the survival of bull spermatozoa. The results of current research show that carnitine promotes a rise in the activity of CAT and GPO, and the activity of SOD decreases. We established that L-carnitine impacts the reduction of the overall consumption of oxygen by increasing the share of mitochondrial oxygen consumption and aerobic glycolysis, along with the decrease in free radical oxidation. It is probably related to the metabolic activation between the semen and the environment. We found that the optimal concentration of L-carnitine in the bull diluted sperm is 30 mg/100 ml.

State of the enzyme link of antioxidant protection in boys with hypoandrogenism

2020 ◽  
Vol 40 (4) ◽  
pp. 32-36
Author(s):  
L. K. Parkhomenko ◽  
◽  
L. A. Strashok ◽  
S. I. Turchina ◽  
G. V. Kosovtsova ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Free Radical ◽  
Glutathione Peroxidase ◽  
Free Radical Oxidation ◽  
Conjugated Dienes ◽  
Delayed Puberty ◽  
Control Group ◽  
Antioxidant Protection ◽  
Radical Oxidation

Recently, interest in the problem of free radical oxidation in biological membranes, which is directly related to both the normal functioning of cells and the occurrence, course and outcome of many pathological conditions, has increased again in clinical medicine. The aim was to determine the role and impact of antioxidant defense in boys with hypoandrogenism. The study involved 75 adolescents with hypoandrogenism aged 13–18 years, who underwent a complex of clinical and laboratory examinations. All patients were conducted complex of anthropometric research and determination of the degree of delayed puberty, laboratory and instrumental examination. Free radical oxidation was determined by the levels of malondialdehyde, conjugated dienes, carbonated proteins, superoxide dismutase and catalase in the serum, and restored glutathione and glutathione peroxidase in whole blood. Based on their determination, the coefficient of oxidative stress was calculated. Statistical processing of results was performed using parametric and nonparametric methods. The study of indicators of the free radical oxidation process found that adolescents with hypoandrogenism have multidirectional changes in the oxidation of proteins and lipids, namely: the level of conjugated dienes increases, the concentration of malondialdehyde remains at the level of the control group, and the level of carbonated proteins tends to decrease. As for the activity of antioxidant protection enzymes, a significant decrease in the level of glutathione peroxidase was detected, while the level of superoxide dismutase and catalase remained at the level of normative indicators. Oxidative stress accompanies and is one of the pathogenetic links in the formation or maintenance of the state of hypoandrogenism in boys. This requires the use of antioxidants, the complex of which must be selected individually.

Adaptogenic correction of free radical brain damage in subchronic exposure to sodium fl uoride

2020 ◽  
pp. 381-386
Author(s):  
A. G. Zhukova ◽  
L. G. Gorokhova ◽  
A. S. Kazitskaya ◽  
T. K. Yadykina ◽  
N. N. Mikhailova ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Free Radical ◽  
Brain Tissue ◽  
Free Radical Oxidation ◽  
Radical Oxidation ◽  
Free Radical Processes ◽  
Subchronic Exposure ◽  
Antioxidant Defense Enzymes ◽  
Radical Processes ◽  
Complex Drug

Introduction. Fluorine compounds in small doses, but with prolonged exposure, cause various disorders in organs at the cellular and molecular levels. Activation of free-radical processes plays an important role in the damaging eff ect of fl uorides. Th erefore, one of the most eff ective ways to limit fl uorine-induced damage is to directly aff ect free-radical processes using herbal preparations with antioxidant properties.The aim of the study is to study the eff ect of a dihydroquercetin-based drug on the activity of free radical processes in brain tissue under subchronic exposure to sodium fl uoride (NaF).Materials and methods. Th e work was performed on white male laboratory rats weighing 200-250 g. Th e rats were divided into 3 groups: 1 — control; 2 — rats with chronic exposure to sodium fl uoride (NaF) for 9 weeks; 3 — rats receiving a NAF solution with simultaneous administration of a complex drug based on dihydroquercetin at a dose of 3 mg/kg in 1% starch gel for 3, 6 and 9 weeks. The activity of free radical oxidation and antioxidant defense enzymes — superoxide dismutase (SOD) and catalase-was determined in the cerebral cortex. Th e level of expression of hypoxia-induced transcription factor HIF — 1A and inducible forms of proteins HSP72 and HSP32 were determined in the cytosolic fraction of brain tissue.Results. In the early stages of subchronic fl uoride exposure (1-3 weeks), the expression of protective proteins HIF-1α, HSP72, HSP32 and catalase was shown in the rat cortex, as a result of which the activity of free-radical processes was maintained at the control level. An increase in the timing of fl uoride intake to 9 weeks led to a decrease in antioxidant protection and signifi cant activation of free radical oxidation in brain tissue. Daily administration of a complex drug with dihydroquercetin for 3, 6 and 9 weeks to rats with subchronic fl uoride exposure led to a decrease in the severity of pro- and antioxidant balance disorders in the cerebral cortex. At the same time, the greatest protective eff ect of dihydroquercetin with fl uoride exposure was manifested by the 9th week of its administration.Conclusions. When subchronic intake of fl uorides in the body, the drug based on dihydroquercetin has a neuroprotective eff ect, which is manifested by an increase in the activity of antioxidant enzymes of fr ee radical oxidation and catalase and the resistance of the cortex to induced fr ee radical oxidation.

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