Features of the clinical course, diagnosis and treatment of paranasal sinusitis in patients with type 2 diabetes mellitus

2021 ◽  
Vol 20 (6) ◽  
pp. 93-101
Author(s):  
T. A. Mashkova ◽  
◽  
A. B. Mal’tsev ◽  
A. N. Pavlov ◽  
A. V. Suslenko ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Paranasal Sinuses ◽  
Immune Status ◽  
Prolonged Exposure ◽  
Inflammatory Diseases ◽  
Rapid Development ◽  
Free Radical Oxidation ◽  
The Body ◽  
Radical Oxidation ◽  
Paranasal Sinusitis

The issue of treating paranasal sinusitis, improving the methods of their treatment and prevention remains relevant to the present. Particular attention shall be paid to patients with concomitant somatic pathology, which contributes to the chronicity of inflammatory processes in the paranasal sinuses and increases the frequency of their recurrence. Among the pathology of ENT organs, acute sinusitis is most common (5–10%). Inflammatory diseases of the nose and paranasal sinuses are fraught with various complications. Thus, the percentage of orbital rhinogenic complications ranges from 6.6 to 12.4%. Patients with a history of diabetes mellitus are more exposed to various diseases, including ENT organs, with their rapid development and subsequent complications. The clinic of purulent sinusitis in them is characterized by a prolonged course with periodic exacerbations and the involvement of nearby anatomical structures in the pathological process with atypical data of radiation studies and frequent complications. The disease proceeds against the background of pronounced changes in the immune status, which affect all links of immunity, including a significant decrease in phagocytosis indicators and an increase in the content of circulating immune complexes of small size. Prolonged exposure of the body to products of free radical oxidation, especially in excess volume, leads to metabolic disorders at all levels and also disrupts the immune status, which leads to a complicated course of diseases. The presence of a pronounced imbalance towards the production of free radicals and a weakening of antioxidant protection leads to the development of oxidative stress and destructive changes at different levels. Treatment of this category of patients is a difficult task, in the solution of which the state of immunity and antioxidant system plays an important role.

Gender differences in biochemical measurement reflecting the state of free-radical oxidation and antioxidant protection among workers in metallurgical production

2019 ◽  
Vol 1 (10) ◽  
pp. 877-881
Author(s):  
I. A. Umnyagina ◽  
L. A. Strakhova ◽  
T. V. Blinova
Keyword(s):  
Oxidative Stress ◽  
Gender Differences ◽  
Free Radical ◽  
Biochemical Parameters ◽  
Free Radical Oxidation ◽  
The Body ◽  
Antioxidant Protection ◽  
Radical Oxidation ◽  
Metallurgical Production ◽  
Production Factors

Introduction. To date, age and sex differences have been established for many biochemical parameters. Gender differences in indicators for systems such as antioxidant, thiol-disulfide, oxidative stress and inflammation systems are absent or under study.The aim of the study was to identify gender differences in biochemical parameters reflecting the functioning of antioxidant systems of the body and free radical oxidation in workers of metallurgical production, in contact with harmful production factors.Materials and methods. The blood of men and women working at the metallurgical enterprise of the Nizhny Novgorod region (n=80) under the influence of a complex of physical and chemical production factors was studied. Total oxidative stress, total antioxidant capacity of serum, glutathione levels were studied by photometric biochemical methods. Levels of C-reactive protein and 8-hydroxy–2-deoxyguanosine were studied by ELISA.Results. The average amount of peroxides in the serum of women exceeded 1.6 times this figure in men. In the group of men, the content of 8-Ondg was higher by 26% (p=0.012), the level of GS-by 12% (p=0.019), the activity of SOD — by 1.5–2 times (p=0.0001), the level of CRP — by 2 times (p=0.008) compared to similar indicators in women.Conclusions. Studies of gender differences in workers under the influence of harmful production factors will allow more effective approach to the etiology, treatment and prognosis of production-related diseases. Indicators of oxidative stress and antioxidant protection can be indicators of the health of workers under the influence of harmful industrial factors and be important in the prevention of diseases associated with oxidative stress.

Assessment of the Biochemical Status of Workers Manufacturing Ethylbenzene and Styrene

2020 ◽  
pp. 40-43
Author(s):  
RR Galimova ◽  
ET Valeeva ◽  
GV Timasheva ◽  
AB Bakirov
Keyword(s):  
Catalase Activity ◽  
Free Radical Oxidation ◽  
The Body ◽  
Atherogenic Index ◽  
Radical Oxidation ◽  
Professional Groups ◽  
Biochemical Status ◽  
The Central Nervous System ◽  
Hepatic Protein Synthesis ◽  
Increased Activity

Introduction: Production of ethylbenzene and styrene (EBS) is one of the most important stages in organic synthesis. The products have general toxic, hepatotoxic, irritating and narcotic effects on the human body. Severe exposures to EВS can induce pronounced disorders of the central nervous system such as styrene sickness and encephalopathy and of peripheral blood such as leukopenia and lymphocytosis. Materials and methods: We studied homeostasis indices in 376 workers of the main professional groups engaged in the production of EBS including equipment operators, repairmen, and instrumentation and automation fitters. Results: We established an increase in lipid peroxidation by the level of malondialdehyde amid an increase in catalase activity and a decrease in blood retinol and α-tocopherol levels. We also noted an increased activity of indicator enzymes including ALT, AST, GGT, and alkaline phosphatase. Significant changes in lipid metabolism in the form of cholesterolemia, triglyceridemia, a higher atherogenic index, and lower cholesterol of non-atherogenic blood serum lipids demonstrating atherogenic changes in the body were revealed. Conclusions: The earliest prenosological disorders in the body of the examined workers included an impaired hepatic protein synthesis, the development of cytolysis processes and a change in the integrity and functional activity of the liver cell in individuals, an imbalance in the oxidant-antioxidant system, one of the reasons of which was the adverse occupational exposure to hazardous chemicals. An increase in catalase activity is a protective compensatory reaction during the activation of free radical oxidation processes.

Analysis of the content of zinc ions in the ejaculate of men with inflammatory diseases of the genitourinary system with indicators of sperm motility

2021 ◽  
pp. 28-32
Author(s):  
O.A. Gizinger
Keyword(s):  
Superoxide Dismutase ◽  
Plasma Membrane ◽  
Free Radical ◽  
Seminal Plasma ◽  
Inflammatory Diseases ◽  
Free Radical Oxidation ◽  
Zinc Ions ◽  
Radical Oxidation ◽  
Genitourinary System ◽  
Sperm Dna

The results of previous studies have shown that the content of zinc ions in the semen significantly correlated with the number of sperm and influenced the volume of ejaculate. After ejaculation, the zinc contained in the seminal plasma binds to the plasma membrane and stabilizes the sperm DNA. Due to its cyto- and immunoprotective properties: induction of zinc-dependent superoxide dismutase, protection of DNA and transcriptional proteins from free radical oxidation, inhibition of proteinases, zinc is an indispensable trace element in the processes of DNA synthesis and repair, embryogenesis and reproduction.

scholarly journals Features of free oxidation in liver homogenates of rats in combined action of copper and subtoxic level of stearate potassium and sodium

2016 ◽  
Author(s):  
O. V. Lototska
Keyword(s):  
Free Radical ◽  
Liver Homogenate ◽  
Sodium Stearate ◽  
Free Radical Oxidation ◽  
The Body ◽  
Antioxidant Systems ◽  
Radical Oxidation ◽  
Combined Action ◽  
Liver Homogenates ◽  
Free Oxidation

Toxic effects of heavy metals on animals and humans is aggravating the presence of surfactants. The aim of our research was to identify the peculiarities of free radical oxidation and antioxidant protection in the use of drinking water with subtoxic doses of potassium and sodium stearates in combination with copper on the body of warmblooded animals, such as the liver of experimental rats. Analysis of indicators allows asserting that in experimental rats liver homogenate observed activation of free radical oxidation, the intensity of which depended on the concentration of stearates in water. More pronounced changes were in animals that consumed water with potassium stearate.The action of potassium stearate observed inhibition of antioxidant systems while under the influence of sodium stearate – its activation. Changes in performance were more pronounced in combination stearates with copper.

scholarly journals Plasmapheresis and hyperbaric oxygenation in the treatment of psoriasis complicated by polyarthritis

2001 ◽  
Vol 82 (4) ◽  
pp. 301-302
Author(s):  
V. N. Korobkov ◽  
G. G. Slepukha ◽  
I. G. Yapparov ◽  
A. K. Saetgaraev
Keyword(s):  
Metabolic Disorders ◽  
Hyperbaric Oxygenation ◽  
Immune Status ◽  
Systemic Disease ◽  
Free Radical Oxidation ◽  
Skin Inflammation ◽  
Practical Medicine ◽  
Radical Oxidation ◽  
Skin Cells ◽  
Oxidative Processes

Treatment of psoriasis (Ps) is still one of the most difficult tasks of practical medicine. The disease often affects young and able-bodied people, and the process itself has a persistent and progressive nature, not amenable to treatment by traditional methods. PS as a systemic disease is based on the phenomena of chronic nonspecific skin inflammation with intracellular edema, infiltration, microcirculatory and metabolic disorders. PS is also characterized by disorders of oxidative processes in skin cells and in the system of free-radical oxidation of lipids. The study of immune status in PS patients revealed disorders of circulating immune complexes (CIC), in particular immunoglobulins A, M, G, against the background of suppressed cellular immunity and phagocytic activity of neutrophils.

LOCAL IMMUNE STATUS AND FREE RADICAL OXIDATION IN RHINOSURGIСAL PATIENTS IN EARLY POST-SURGICAL PERIOD

2018 ◽  
Vol 95 (4) ◽  
pp. 26-32
Author(s):  
O. A. Gizinger ◽  
◽  
A. M. Korkmazov ◽  
M. Yu. Korkmazov ◽  
◽  
...  
Keyword(s):  
Free Radical ◽  
Immune Status ◽  
Free Radical Oxidation ◽  
Radical Oxidation

scholarly journals Association between Malondialdehyde and Glutathione (L-gamma-Glutamyl-Cysteinyl-Glycine/GSH) Levels on Workers Exposed to Benzene in Indonesia

2019 ◽  
Vol 7 (7) ◽  
pp. 1198-1202 ◽  
Author(s):  
Abdul Rohim Tualeka ◽  
Tri Martiana ◽  
Ahsan Ahsan ◽  
Syamsiar S. Russeng ◽  
Wulan Meidikayanti
Keyword(s):  
Free Radicals ◽  
Free Radical Oxidation ◽  
Thiobarbituric Acid ◽  
The Body ◽  
Radical Oxidation ◽  
Benzene Concentration ◽  
Flame Ionisation Detector ◽  
Glutathione Enzymes ◽  
The Impact ◽  
Detoxification Process

BACKGROUND: Chemicals that enter the body, especially benzene, will undergo a detoxification process. Unfortunately, at the detoxification process, sometimes benzene can produce free radicals. Free radical oxidation of lipids produces MDA compounds (malondialdehyde). To overcome these free radicals, the body will adapt to produce Glutathione (GSH) enzymes. AIM: The purpose of this study was to analyse the relationship between benzene concentration, MDA levels and glutathione enzymes in Shoe-Maker Home Industry workers exposed to benzene for more than 10 years. METHODS: Measurement of benzene concentration using a gas chromatography-flame ionisation detector (GC-FID). MDA levels used a modified spectrophotometric and GSH method of thiobarbituric acid (TBA) test. RESULT: The results showed that the majority of respondents had benzene concentrations still below the TLV value, mean of MDA levels were 6.94 mg/ml, while GSH was 4.54 mg/ml. Benzene concentration did not have a significant correlation with MDA and glutathione levels, whereas MDA levels had a strong correlation with glutathione levels (p = 0.000; r = -0.947). CONCLUSION: Workers should always use PPE and always eat foods that contain lots of glutathione enzymes such as spinach or broccoli to reduce the impact of free radicals from benzene inhalation.

scholarly journals ACETAMINOPHEN EFFECT ON FREE RADICAL OXIDATION INDICES IN RATS WITH TYPE 2 DIABETES MELLITUS

2017 ◽  
Author(s):  
O. B. Furka ◽  
I. B. Ivanusa ◽  
M. M. Mykhalkiv ◽  
I. M. Klishch
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Free Radical ◽  
Liver Homogenate ◽  
Free Radical Oxidation ◽  
Maximum Increase ◽  
Radical Oxidation ◽  
Age Related

Background. Acetaminophen is a drug used to relieve pain syndrome. It is used both independently and in composition of combined drugs. Type 2 diabetes is an age-related disease that is associated with a violation of insulin synthesis by pancreas.Objective. The aim of the research was to study the effect of acetaminophen on major free radical oxidation indices of rats with type 2 diabetes mellitus in time dynamics.Methods. We conducted two series of experiments. The first series comprised rats with type 2 diabetes mellitus and acute acetaminophen toxic lesions. The second series involved rats with type 2 diabetes mellitus and acetaminophen administration at a dose of 55 mg/kg for the period of 7 days.Results. Administration of acetaminophen for rats with type 2 diabetes mellitus caused the increase in the content of malondialdehyde, diene and triene conjugates and Schiff bases in blood plasma and malondialdehyde, diene and triene conjugates in liver homogenate. The maximum increase in these indices was observed on the first day of the experiment. Gradually these indices decreased on the 3rd, 5th and 7th days of the experiment.Conclusions. Free radical oxidation increased in both series of the experiment. This process developed in rats with type 2 diabetes mellitus and acute acetaminophen toxic lesions more intensively, than in rats with type 2 diabetes mellitus and administration of acetaminophen at the highest therapeutic dose during 7 days.

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