scholarly journals Indicators of lipid peroxidation and the activity of antioxidant system enzymes as predictors of the development of metabolic disorders in primary obesity

2021 ◽  
Vol 102 (5) ◽  
pp. 765-772
Author(s):  
T V Nikishova ◽  
I A Kurnikova
Keyword(s):  
Insulin Resistance ◽  
Lipid Peroxidation ◽  
Body Fat ◽  
Metabolic Disorders ◽  
Whole Body ◽  
Immunoreactive Insulin ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Enzyme Systems ◽  
The Relationship

Aim. To assess the effectiveness of indicators of lipid peroxidation and the activity of antioxidant system enzymes in the early diagnosis of metabolic disorders. Methods. The study included 269 women of fertile age with primary obesity. The control group consisted of 35 women. The clinical examination included identification of the type of obesity, whole-body fat percentage, the level of glycemia and the index of insulin resistance, biochemical markers of lipids, hormones (leptin and insulin), malondialdehyde and enzyme activity (peroxidase and catalase). The statistical significance of the differences was determined by using the inversion test. Spearman's rank correlation coefficient was used to assess the degree of relationship between quantitative characteristics, and scatter diagrams were used to compare two variables (Statistica software version 10.0). Results. A statistically significant increase in basal and stimulated immunoreactive insulin was found in obese patients compared with the controls (p 0.01). Stimulated immunoreactive insulin levels, insulin resistance score (HOMA-IR) and the level of leptin in the group of patients with android obesity was higher than in the group with gynoid obesity (p 0.01). The relationship between the concentration of serum malondialdehyde and whole-body fat percentage was found to be more significant (r=0.412; p 0.001) than the relationship with the type of obesity (r=0.257; p 0.01). Positive correlations were found between serum malondialdehyde and insulin (r=0.35; p 0.001) and leptin (r=0.32; p 0.001) levels. The relationship between the concentration of serum malondialdehyde and the activity of enzyme systems was also noted. The activity of lipid peroxidation was higher in the group of patients with android obesity (malondialdehyde 3.3 mol/L) compared with the group of patients with gynoid obesity. In the same group, a higher activity of enzyme systems was noted. Conclusion. An increase in the concentration of serum malondialdehyde and the activity of enzyme systems should be considered as indicators of a high risk of developing metabolic syndrome.

scholarly journals Body mass index and waist circumference are better predictors of insulin resistance than total body fat percentage in middle-aged and elderly Taiwanese

Medicine ◽  
2017 ◽  
Vol 96 (39) ◽  
pp. e8126 ◽  
Author(s):  
Yiu-Hua Cheng ◽  
Yu-Chung Tsao ◽  
I-Shiang Tzeng ◽  
Hai-Hua Chuang ◽  
Wen-Cheng Li ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Waist Circumference ◽  
Body Mass ◽  
Body Fat ◽  
Body Fat Percentage ◽  
Middle Aged ◽  
Fat Percentage ◽  
Total Body Fat ◽  
Total Body

scholarly journals Accelerometer-determined peak cadence and weight status in children from São Caetano do Sul, Brazil

2017 ◽  
Vol 22 (11) ◽  
pp. 3689-3698
Author(s):  
Gerson Luis de Moraes Ferrari ◽  
Timóteo Araújo ◽  
Luis Carlos Oliveira ◽  
Victor Keihan Rodrigues Matsudo ◽  
Emily Mire ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Fat ◽  
Weight Status ◽  
Bioelectrical Impedance ◽  
Normal Weight ◽  
Body Fat Percentage ◽  
Obese Children ◽  
Fat Percentage ◽  
The Relationship ◽  
Brazilian Children

Abstract The purpose of this study was to determine the relationship between peak cadence indicators and body mass index (BMI) and body fat percentage (BF%)-defined weight status in children. The sample comprised 485 Brazilian children. Minute-by-minute step data from accelerometry were rank ordered for each day to identify the peak 1-minute, 30-minute and 60-minute cadence values. Data were described by BMI–defined and bioelectrical impedance-determined BF% weight status. BMI-defined normal weight children had higher peak 1-minute (115.5 versus 110.6 and 106.6 steps/min), 30-minute (81.0 versus 77.5 and 74.0 steps/min) and 60-minute cadence (67.1 versus 63.4 and 60.7 steps/min) than overweight and obese children (p<.0001), respectively. Defined using %BF, normal weight children had higher peak 1-minute (114.5 versus 106.1 steps/min), 30-minute (80.4 versus 73.1 steps/min) and 60-minute cadence (66.5 versus 59.9 steps/min) than obese children (p<.0001). Similar relationships were observed in boys; however, only peak 1- minute cadence differed significantly across BMI and %BF-defined weight status categories in girls. Peak cadence indicators were negatively associated with BMI and BF% in these schoolchildren and significantly higher among normal weight compared to overweight or obese children.

The relationship between thyroid hormone and lipid metabolism/body fat content in euthyroid male patients with type 2 diabetes mellitus in China: A cross-sectional study

2020 ◽  
Author(s):  
Xia Sun ◽  
Liping Chen ◽  
Rongzhen Wu ◽  
Dan Zhang ◽  
Yinhui He
Keyword(s):  
Body Fat ◽  
Visceral Fat ◽  
Fat Content ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Body Fat Content ◽  
Male Patients ◽  
The Relationship ◽  
Visceral Fat Content

Abstract Background: This study compared the relationship between thyroid hormones and lipid metabolism/body fat content in euthyroid male patients with type 2 diabetes mellitus (T2DM) in China. Methods: A total of 64 male patients who were diagnosed as T2DM and 64 non-diabetic males who underwent health examination were matched according to age at a 1:1 ratio. Results: The 32 subjects in each sub-group showed differences in age, body mass index (BMI), mean arterial pressure, waist circumference, visceral fat content, body fat percentage, HbA1c, HOMA-IR, FT3, TSH, HDL-c, adiponectin, leptin, visfatin and TNF-α (all P < 0.05). In the overall population, FT3 was positively correlated with body fat percentage (r=0.21, P=0.02), and negatively correlated with HOMA-IR (r=-0.18, P=0.04) and visfatin (r=-0.47, P <0.01); TSH was positively correlated with body fat percentage (r=0.23, P=0.01). In the T2DM-OB group FT3 was positively correlated with BMI (r=0.45, P <0.05), visceral fat content (r=0.50, P <0.05), and body fat percentage (r=0.44, P <0.05); FT4 was positively correlated with visceral fat content (r=0.38, P <0.05); and TSH was positively correlated with HOMA-IR (r=0.39, P <0.05). Conclusion: TSH increased in obese people and FT3 was lower in patients with T2DM.

scholarly journals The Relationship between Vitamin D Metabolites and Androgens in Women with Polycystic Ovary Syndrome

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1219
Author(s):  
Jakub Mesinovic ◽  
Helena J. Teede ◽  
Soulmaz Shorakae ◽  
Gavin W. Lambert ◽  
Elisabeth A. Lambert ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Polycystic Ovary ◽  
Total Testosterone ◽  
Body Fat Percentage ◽  
Vitamin D Metabolites ◽  
Fat Percentage ◽  
Ovary Syndrome ◽  
Hs Crp ◽  
The Relationship

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age, with hyperandrogenism present in up to 90% of affected women. Some evidence suggests a link between vitamin D deficiency and PCOS features via insulin resistance and inflammation. Our aim was to explore the relationship between biochemical markers of vitamin D status and androgens in women with PCOS. This cross-sectional study used bio-banked samples from 46 pre-menopausal women with PCOS (mean ± SD: age 30 ± 6 years; BMI 29 ± 6 kg/m2). We measured 25-hydroxyvitamin D (25[OH]D), vitamin D-binding protein (DBP), total testosterone, sex hormone-binding globulin (SHBG), and calculated the free androgen index (FAI) and bioavailable and free 25(OH)D. Fasting glucose and insulin were used to calculate the homeostatic model assessment of insulin resistance (HOMA-IR) and body fat percentage was determined via dual energy x-ray absorptiometry. High-sensitivity C-reactive protein (hs-CRP) was measured as a marker of inflammation. DBP was positively associated with total 25(OH)D and expectedly, negatively associated with free 25(OH)D. There were no associations between vitamin D metabolites and total testosterone, SHBG or FAI, even after adjusting for age, body fat percentage, HOMA-IR and hs-CRP. We found no associations between vitamin D metabolites and androgens in women with PCOS. Studies that have identified a vitamin D–androgen link have largely relied on methodology with numerous pitfalls; future studies should exclusively use gold-standard measures to confirm these findings in this population.

scholarly journals Reduced Olfactory Bulb Volume in Obesity and Its Relation to Metabolic Health Status

2020 ◽  
Vol 14 ◽  
Author(s):  
Maria Poessel ◽  
Nora Breuer ◽  
Akshita Joshi ◽  
André Pampel ◽  
Arno Villringer ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Olfactory Bulb ◽  
Eating Behavior ◽  
Body Fat ◽  
Explanatory Models ◽  
Metabolic Health ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Height Ratio ◽  
Waist Height Ratio

Smell perception plays an important role in eating behavior and might be involved in body weight gain. Since a body of literature implies that olfactory perception and function is hampered in obesity, we here investigate neuroanatomical correlates of this phenomenon. We assessed olfactory bulb (OB) volume with magnetic resonance imaging in 67 healthy participants with a body mass index (BMI) from 18.9 to 45.4 kg/m2 (mean = 28.58 ± 6.64). Moreover, we obtained psychophysiological data on olfactory ability (Sniffin’ Sticks, Food associated odor test) and self-report measurements on eating behavior. Additionally, we collected parameters associated with metabolic health in obesity (waist-hip ratio, waist-height ratio, leptin levels, body fat percentage, fat mass index, insulin resistance) to investigate recently proposed mechanistic explanatory models of why olfaction may be altered in obesity. We showed that OB volume was significantly lower in participants with obesity when compared to those of normal weight. Moreover, we found weak to moderate negative correlations between OB volume and BMI and related measures of metabolic health, especially leptin, body fat percentage, waist-height ratio and insulin resistance. However, neither OB volume nor BMI were related to olfactory function in our young and healthy sample. Nevertheless, our results provide first indications that obesity is associated with brain anatomical changes in the OBs.

Relationship between body fat percentage and insulin resistance in adults with Bmi values below 25 Kg/M2 in a private clinic

2019 ◽  
Vol 13 (5) ◽  
pp. 2855-2859 ◽  
Author(s):  
Paolo A. Zegarra-Lizana ◽  
Elizabeth J. Ramos-Orosco ◽  
Mirella Guarnizo-Poma ◽  
Betzi Pantoja-Torres ◽  
Socorro Paico-Palacios ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Fat ◽  
Private Clinic ◽  
Body Fat Percentage ◽  
Fat Percentage

scholarly journals Associations between folate intake, body composition, and liver status in healthy adults

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Monika Młodzik-Czyżewska ◽  
Anna Malinowska ◽  
Agata Chmurzynska
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Fatty Liver ◽  
Body Mass ◽  
Body Fat ◽  
Liver Steatosis ◽  
Folate Intake ◽  
Whole Body ◽  
Body Fat Percentage ◽  
Fat Percentage

AbstractA link has recently been underlined between one-carbon metabolism and body weight and body composition, suggesting that folate may account for body mass determination and lipid metabolism. The aim of this study was thus to analyze whether folate intake is associated with body weight, body mass index (BMI), body fat percentage, and liver status.409 subjects aged 20–40 were enrolled in Poznań, Poland from 2016 to 2018. Food intake was assessed using three-day food records. Folate intake was calculated based on food composition tables using the Diet 5.0 program (National Food and Nutrition Institute, Poland). Weight to 0.1 kg and height to 0.01 m were measured using an electronic scale and a stadiometer, respectively. BMI was calculated as body weight in kilograms divided by height in meters squared. Fat mass and lean body mass were determined using whole-body air-displacement plethysmography (BodPod, Cosmed, Italy). Genotyping of rs1801133 (MTHFR) was performed with TaqMan probes. The following biomarkers of liver steatosis were calculated: NAFLD liver fat score (NAFLD-LFS), fatty liver index (FLI), and hepatic steatosis index (HSI). To analyze the associations between folate intake and the measured parameters, we used multiple regression with adjustments for age, sex, and energy intake.The mean body weight was 78.57 ± 18.14 kg, BMI 25.96 ± 5.28 kg/m2, and fat percentage 29.20% ± 10.78%. The median folate intake was 299.3 μg/day. Dietary folate intake was negatively associated with body weight, BMI, and body fat percentage (p < 0.05 for all associations). Folate intake was also associated with fatty liver indices—namely HSI (p < 0.05) and FLI (p < 0.05). There was no association between folate intake and NAFLD-LFS. MTHFR rs1801133 polymorphism was not associated with any of the measured parameters.Our findings suggest that folate intake may affect body weight and composition, as well as liver status. Higher folate intake could have a protective effect against obesity, but further studies are necessary to investigate the mechanism.The authors declare that they have no conflict of interests.This work was supported by the Polish National Science Centre(grants 2014/15/B/NZ9/02134 and 2016/21/N/NZ9/01195).

The Relationship Between Body Mass Index and Body Fat Percentage is Moderated by Race and Age in Women

2008 ◽  
Vol 40 (Supplement) ◽  
pp. S272-S273
Author(s):  
Joshua C. Neuman ◽  
Sigurbjörn Á. Arngrímsson ◽  
Daina M. Mallard ◽  
Gunnhildur Hinriksdóttir ◽  
Annie L. Parrett ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Body Fat ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
The Relationship
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