HYPOXIC THERAPY IN THE CORRECTION OF NEUROIMMUNOENDOCRINE DISORDERS IN AUTOIMMUNE THYROIDITIS

Efficiency of interval hypoxic training in treatment of hypothyroidism with autoimmune genesis in children and adolescents was shown. The therapeutic effect of hypoxic therapy realized not only through amplification of compensatory mechanisms for the oxygen delivery to the tissues, but also through inhibition of humoral immune responses and the stimulation of T-cell immunity in patients with autoimmune thyroiditis. Increase of function and quantity of CD8+-cells after a course of hypoxic therapy prevents the progression of the autoimmune process and helps to restore the function of the thyroid gland, which in turn leads to positive changes in the neurological status of patients: improved mental performance indicators and fine motor coordination. Complications of therapy or deterioration of the patients were not observed. Follow-up monitoring of patients conducted after 6-8 months after treatment showed that the positive effect of hypoxic therapy maintained throughout this period. Positive hormonal and immunological and neurological dynamics in children and adolescents with autoimmune thyroiditis after the interval hypoxic training suggests its inclusion in the scheme of pathogenetic treatment of patients with this pathology.

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Normobaric interval hypoxytherapy in the correction of neuroimmunoendocrine disorders in children and adolescents with autoimmune thyroiditis

10.34014/mpphe.2021-3-6 ◽

2021 ◽

Author(s):

Z.Kh. Abazova ◽

A.B. Ivanov ◽

I.Kh. Borukaeva ◽

K.Yu. Shkhagumov

Keyword(s):

Children And Adolescents ◽

Key Words ◽

Thyroid Function ◽

Autoimmune Thyroiditis ◽

Neurological Status ◽

Training Method ◽

Autoimmune Process ◽

Mental Performance ◽

Cd8 Cells ◽

Hypoxic Training

130 children and adolescents aged 6 to 16 years with a diagnosis of autoimmune thy-roiditis (AIT) at the stage of hypothyroidism underwent a course of hypoxytherapy. The high ef-ficiency of the normobaric interval hypoxic training method in the treatment of hypothyroidism on the background of AIT is shown. An increase in the function and number of CD8+ cells after a course of hypoxytherapy prevents the progression of the autoimmune process and promotes the restoration of thyroid function, which in turn leads to positive dynamics in the neurological status of patients: improved indicators of mental performance and fine coordination of move-ments. Key words: autoimmune thyroiditis, hypothyroidism, hypoxytherapy, interval hypoxic training, neuroimmunoendocrine disorders.

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A Translatable Subunit Nanovaccine for COVID-19

10.26434/chemrxiv.12301157.v1 ◽

2020 ◽

Author(s):

Lixin Liu ◽

Zhijia Liu ◽

Haolin Chen ◽

Hong Liu ◽

Qiang Gao ◽

...

Keyword(s):

Lipid A ◽

Vero Cells ◽

Toll Like Receptor ◽

Toll Like Receptor 4 ◽

Cd8 Cells ◽

Humoral Immune ◽

Monophosphoryl Lipid A ◽

Monophosphoryl Lipid ◽

Cell Immunity ◽

Iga Antibody

In order to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in the world, we formulate S1 subunit of the virus with two types of adjuvants, amphiphilic adjuvant monophosphoryl lipid A (MPLA) for Toll-like receptor 4 (TLR4) and CpG ODN for TLR9, into cationic multifunctional liposomes to produce a potent, safer, and translatable nanovaccine. The results show that the nanovaccine can efficiently elicit humoral immune response in mice. The sera from the vaccinated mice significantly inhibit SARS-CoV-2 to infect Vero cells. Moreover, relatively to the free S1 with traditional Alum adjuvant, the nanovaccine can elicit strong T cell immunity by activating both CD4+ and CD8+ cells, which may play critical roles in eliminating viral load in patients. Most importantly, the nanovaccine can elicit strong IgA antibody, providing potential mucosal protection to host. Altogether, this study offers a translatable design for a potent subunit SARS-CoV-2 nanovaccine.

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A Translatable Subunit Nanovaccine for COVID-19

10.26434/chemrxiv.12301157 ◽

2020 ◽

Author(s):

Lixin Liu ◽

Zhijia Liu ◽

Haolin Chen ◽

Hong Liu ◽

Qiang Gao ◽

...

Keyword(s):

Lipid A ◽

Vero Cells ◽

Toll Like Receptor ◽

Toll Like Receptor 4 ◽

Cd8 Cells ◽

Humoral Immune ◽

Monophosphoryl Lipid A ◽

Monophosphoryl Lipid ◽

Cell Immunity ◽

Iga Antibody

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Motor coordination problems in children and adolescents with ADHD rated by parents and teachers: effects of age and gender

Journal of Neural Transmission ◽

10.1007/s00702-007-0827-0 ◽

2007 ◽

Vol 115 (2) ◽

pp. 211-220 ◽

Cited By ~ 112

Author(s):

E. Fliers ◽

N. Rommelse ◽

S. H. H. M. Vermeulen ◽

M. Altink ◽

C. J. M. Buschgens ◽

...

Keyword(s):

Children And Adolescents ◽

Motor Coordination ◽

Age And Gender ◽

Coordination Problems ◽

And Gender

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Psychosocial implications of poor motor coordination in children and adolescents

Human Movement Science ◽

10.1016/s0167-9457(01)00029-x ◽

2001 ◽

Vol 20 (1-2) ◽

pp. 73-94 ◽

Cited By ~ 349

Author(s):

Rosemary A Skinner ◽

Jan P Piek

Keyword(s):

Children And Adolescents ◽

Motor Coordination ◽

Psychosocial Implications

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Visuo-motor integration, vision perception and attention in mTBI patients. Preliminary findings

PLoS ONE ◽

10.1371/journal.pone.0250598 ◽

2021 ◽

Vol 16 (4) ◽

pp. e0250598

Author(s):

Mariagrazia Benassi ◽

Davide Frattini ◽

Sara Garofalo ◽

Roberto Bolzani ◽

Tony Pansell

Keyword(s):

Spatial Attention ◽

Motor Skills ◽

Motor Coordination ◽

Fine Motor ◽

Motor Deficits ◽

Motor Ability ◽

Critical Flicker Fusion ◽

Visuomotor Coordination ◽

Form Recognition ◽

Flicker Fusion

Patients with mild traumatic brain injuries (mTBI) often report difficulties in motor coordination and visuo-spatial attention. However, the consequences of mTBI on fine motor and visuo-motor coordination are still not well understood. We aimed to evaluate whether mTBI had a concomitant effect on fine motor ability and visuo-motor integration and whether this is related to visual perception and visuo-spatial attention impairments, including patients at different symptoms stage. Eleven mTBI patients (mean age 22.8 years) and ten healthy controls participated in the study. Visuo-motor integration of fine motor abilities and form recognition were measured with the Beery-Buktenica Developmental Test of Visual-Motor Integration test, motion perception was evaluated with motion coherence test, critical flicker fusion was measured with Pocket CFF tester. Visuo-spatial was assessed with the Ruff 2 & 7 Selection Attention Test. mTBI patients showed reduced visuo-motor integration, form recognition, and motor deficits as well as visuo-spatial attention impairment, while motion perception and critical flicker fusion were not impaired. These preliminary findings suggest that the temporary brain insults deriving from mTBI compromise fine motor skills, visuomotor integration, form recognition, and visuo-spatial attention. The impairment in visuo-motor coordination was associated with speed in visuo-attention and correlated with symptoms severity while motor ability was correlated with time since concussion. Given the strong correlation between visuomotor coordination and symptom severity, further investigation with a larger sample seems warranted. Since there appeared to be differences in motor skills with respect to symptom stage, further research is needed to investigate symptom profiles associated with visuomotor coordination and fine motor deficits in mTBI patients.

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Clinical-enabled aspects after Neurotoxoplasmosis in a patient with immunosuppression: a case report

10.5327/1516-3180.432 ◽

2021 ◽

Author(s):

Adrielle Galanti ◽

Verônia Corrêa César Rodrigues ◽

Daniela Maria Ribeiro Vaz ◽

Ana Paula Oliveira Borges

Keyword(s):

Case Report ◽

Motor Coordination ◽

Clinical Investigation ◽

Functional Independence ◽

Berg Balance Scale ◽

Fine Motor ◽

Cross Sectional ◽

Right Cerebral Hemisphere ◽

The Right ◽

Immunodeficiency Syndrome

Background: Neurotoxoplasmosis is an opportunistic infection caused by the protozoan Toxoplasma Gondii, frequent in patients with Acquired Immunodeficiency Syndrome who become immunosuppressed by the presence of the disease. It can be presented by one or more brain abscesses, encephalitis or ventriculitis. Objectives: case report of a volunteer after neurological sequelae of neurotoxoplasmosis in order to highlight the relevant findings for a neurofunctional rehabilitation. Design and setting: This is an observational, cross-sectional case report type study conducted at the Clínica Escola de Fisioterapia of the University of Franca (UNIFRAN), with CEP approval (CAAE 83164918.2.0000.5495). Methods: Female patient, 53 years old. In the physiotherapy sector, neurological evaluation of the components was performed: sensitivity, movement, tone, reflexes, motor coordination, balance and gait. Balance and gait were assessed using the Berg Balance Scale, the Standing and Walking Test and the Dynamic Walking Index. Results: After clinical investigation, neurological toxoplasmosis infection was found in the right cerebral hemisphere. The physiotherapeutic evaluation showed the presence of left hemiparesis, the presence of spastic hypertonia, patellar and achilles hyperreflexia, the absence of fine motor skills and the presence of a reaping gait. The BSE result was 32 points, the TUG was 10.3 seconds and IMD was 20 points. Conclusion: The compromises found have an impact on the functionality of the volunteer. This study emphasizes the valorization of neurofunctional physiotherapeutic semiology for a treatment proposal that promotes greater functional independence.

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Optimizing Motor Learning: Difficulty Manipulation Combined with Feedback- Frequency Enhance Under-Time-Pressure Fine-Motor-Coordination Skill Acquisition and Retention

Journal of Motor Behavior ◽

10.1080/00222895.2021.2016573 ◽

2021 ◽

pp. 1-13

Author(s):

Yousri Elghoul ◽

Fatma Bahri ◽

Khaled Trabelsi ◽

Hamdi Chtourou ◽

Mohamed Frikha ◽

...

Keyword(s):

Motor Learning ◽

Skill Acquisition ◽

Motor Coordination ◽

Time Pressure ◽

Fine Motor ◽

Learning Difficulty ◽

Fine Motor Coordination ◽

Feedback Frequency ◽

Coordination Skill

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Executive Function, Dexterity, and Discharge Disposition in Older Intensive Care Unit Survivors

American Journal of Critical Care ◽

10.4037/ajcc2020132 ◽

2020 ◽

Vol 29 (6) ◽

pp. 484-488

Author(s):

Maya N. Elías ◽

Cindy L. Munro ◽

Zhan Liang

Keyword(s):

Older Adults ◽

Intensive Care Unit ◽

Intensive Care ◽

Executive Function ◽

Cognitive Flexibility ◽

Motor Coordination ◽

Functional Decline ◽

Dimensional Change ◽

Fine Motor ◽

Discharge Disposition

Background Dexterity is a component of motor function. Executive function, a subdomain of cognition, may affect dexterity in older adults recovering from critical illness after discharge from an intensive care unit (ICU). Objectives To explore associations between executive function (attention and cognitive flexibility) and dexterity (fine motor coordination) in the early post-ICU period and examine dexterity by acuity of discharge disposition. Methods The study involved 30 older adults who were functionally independent before hospitalization, underwent mechanical ventilation in the ICU, and had been discharged from the ICU 24 to 48 hours previously. Dexterity was evaluated with the National Institutes of Health Toolbox (NIHTB) Motor Battery 9-Hole Pegboard Dexterity Test (PDT); attention, with the NIHTB Cognition Battery Flanker Inhibitory Control and Attention Test (FICAT); and cognitive flexibility, with the NIHTB Cognition Battery Dimensional Change Card Sort Test (DCCST). Exploratory regression was used to examine associations between executive function and dexterity (fully corrected T scores). Independent-samples t tests were used to compare dexterity between participants discharged home and those discharged to a facility. Results FICAT (β = 0.375, P = .03) and DCCST (β = 0.698, P = .001) scores were independently and positively associated with PDT scores. Further, PDT scores were worse among participants discharged to a facility than among those discharged home (mean [SD], 26.71 [6.14] vs 36.33 [10.30]; t24 = 3.003; P = .006). Conclusions Poor executive function is associated with worse dexterity; thus, dexterity may be a correlate of both post-ICU cognitive impairment and functional decline. Performance on dexterity tests could identify frail older ICU survivors at risk for worse discharge outcomes.

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