Normobaric interval hypoxytherapy in the correction of neuroimmunoendocrine disorders in children and adolescents with autoimmune thyroiditis

2021 ◽  
Author(s):  
Z.Kh. Abazova ◽  
A.B. Ivanov ◽  
I.Kh. Borukaeva ◽  
K.Yu. Shkhagumov
Keyword(s):  
Children And Adolescents ◽  
Key Words ◽  
Thyroid Function ◽  
Autoimmune Thyroiditis ◽  
Neurological Status ◽  
Training Method ◽  
Autoimmune Process ◽  
Mental Performance ◽  
Cd8 Cells ◽  
Hypoxic Training

130 children and adolescents aged 6 to 16 years with a diagnosis of autoimmune thy-roiditis (AIT) at the stage of hypothyroidism underwent a course of hypoxytherapy. The high ef-ficiency of the normobaric interval hypoxic training method in the treatment of hypothyroidism on the background of AIT is shown. An increase in the function and number of CD8+ cells after a course of hypoxytherapy prevents the progression of the autoimmune process and promotes the restoration of thyroid function, which in turn leads to positive dynamics in the neurological status of patients: improved indicators of mental performance and fine coordination of move-ments. Key words: autoimmune thyroiditis, hypothyroidism, hypoxytherapy, interval hypoxic training, neuroimmunoendocrine disorders.

scholarly journals HYPOXIC THERAPY IN THE CORRECTION OF NEUROIMMUNOENDOCRINE DISORDERS IN AUTOIMMUNE THYROIDITIS

2019 ◽  
Vol 19 (1S) ◽  
pp. 49-51
Author(s):  
Z Kh Abazova ◽  
I Kh Borukaeva
Keyword(s):  
Children And Adolescents ◽  
Autoimmune Thyroiditis ◽  
Motor Coordination ◽  
Neurological Status ◽  
Fine Motor ◽  
Compensatory Mechanisms ◽  
Cd8 Cells ◽  
Humoral Immune ◽  
Hypoxic Training ◽  
Cell Immunity

Efficiency of interval hypoxic training in treatment of hypothyroidism with autoimmune genesis in children and adolescents was shown. The therapeutic effect of hypoxic therapy realized not only through amplification of compensatory mechanisms for the oxygen delivery to the tissues, but also through inhibition of humoral immune responses and the stimulation of T-cell immunity in patients with autoimmune thyroiditis. Increase of function and quantity of CD8+-cells after a course of hypoxic therapy prevents the progression of the autoimmune process and helps to restore the function of the thyroid gland, which in turn leads to positive changes in the neurological status of patients: improved mental performance indicators and fine motor coordination. Complications of therapy or deterioration of the patients were not observed. Follow-up monitoring of patients conducted after 6-8 months after treatment showed that the positive effect of hypoxic therapy maintained throughout this period. Positive hormonal and immunological and neurological dynamics in children and adolescents with autoimmune thyroiditis after the interval hypoxic training suggests its inclusion in the scheme of pathogenetic treatment of patients with this pathology.

scholarly journals Hypoxic training as a way of the human brain protection from the damaging effects of oxygen deficiency

2018 ◽  
Vol 9 (4) ◽  
pp. 33-41
Author(s):  
A. Yu. Eroshenko ◽  
N. V. Kochubejnik ◽  
D. V. Shatov ◽  
S. M. Groshilin ◽  
V. N. Sklyarov ◽  
...  
Keyword(s):  
Human Brain ◽  
Alpha Rhythm ◽  
Oxygen Deficiency ◽  
Effective Means ◽  
Brain Protection ◽  
Mental Performance ◽  
Hypoxic Training ◽  
The Brain ◽  
Integral Indicator ◽  
Damaging Effects

Objective:to evaluate the possibilities of normobaric hypoxic training (NHT) in the human brain protection from the damaging effects of oxygen defciency.Materials and methods:the study involved 18 men, aged 19-23 years, who underwent NHT: 15 treatments daily 2-hour stay in a hypoxic gas medium (HGM) having an oxygen content 15.0 ± 0.5% (HGM-15). Beforestarting the NHT (I phase), and afer 1-2 days afer its closure (II stage) were carried hypoxic samples (staying in HGM-15) before and during which the subjects were recorded the electroencephalogram (EEG) and mental performance were evaluated (the «Route» test).Results:when the frst hypoxic test was carried out, the subjects had a decrease in the alpha-rhythm index (on average by 10-15 %, p = 0.013) and its amplitude (by 10-12 %, p = 0.044) compared to the usual environmental conditions. At the same time, the share of low-amplitude slow waves increased (p = 0.019). Te integral indicator of the «Route» test during staying of the subjects in the HGM-15 decreased on average by 18% compared to the usual conditions (p <0.001). Te obtained data testifed about negative influence of staying in HGM -15 on the functioning of the higher parts of the brain. Afer carrying out NHT, all subjects showed a signifcant reduction in the negative reactions of spontaneous EEG to hypoxia: when the sample was repeated, the alpha-rhythm index and its amplitude did not change signifcantly (in comparison with air breathing), signs of excessive slow wave activity were absent. Reduction of the integral indicator of mental performance when staying in HGM-15 amounted to an average of only 6%.Conclusions:NHT in the developed regime is an effective means of the brain protection from the damaging effect of oxygen defciency and can be used in the system of physiological training of specialists to perform tasks of activity in conditions of reduced partial pressure of oxygen.

scholarly journals Abnormal Thyroid Function and Recurrent Pregnancy Loss

2014 ◽  
Vol 9 (1) ◽  
pp. 29-32
Author(s):  
A Shrestha ◽  
CD Chawla
Keyword(s):  
Longitudinal Study ◽  
Thyroid Function ◽  
Autoimmune Thyroiditis ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Disorder ◽  
Positive Message ◽  
Effect Of Treatment ◽  
Tsh Levels

Aims: The aim of our study was to observe the benefit of screening for thyroid function amongst women with recurrent pregnancy loss and effect of treatment for thyroid disorder on pregnancy outcome. Methods: This was a longitudinal study conducted from June 2012 to December 2013. One hundred and three patients with recurrent pregnancy loss without features of thyroid disorder were included. They were investigated for thyroid stimulating hormone (TSH), free tri iodothyronin (FT3), free thyroxine (FT4) levels and for auto-antibodies against thyroperoxidase (anti TPO). The patients with abnormal TSH levels were treated with thyroxine depending on the level of TSH. Results: TSH, FT3, FT4 and anti TPO levels were measured. Amongst 103 ladies, thirty-eight (36.89%) had high levels of TSH. Thirty-five (33.98%) of them underwent test for anti TPO, of which two (5.71%) had autoimmune thyroiditis. Nine (8.73%) out of 103 had high FT4 levels. Ladies with diagnosis of hypothyroidism underwent treatment and 17 (44.73%) out of 38 had conceived. Conclusions: Of 103 women with recurrent pregnancy loss, abnormal thyroid function was detected in 47. Seventeen (44.73%) of them with increased TSH level conceived after treatment with thyroxine, which gives a positive message that hypothyroidism is a treatable cause for recurrent pregnancy loss. DOI: http://dx.doi.org/10.3126/njog.v9i1.11184 NJOG 2014 Jan-Jun; 2(1):29-32

Depletion of CD4+and CD8+Cells Eliminates Immunologic Memory of Thyroiditogenicity in Murine Experimental Autoimmune Thyroiditis

Autoimmunity ◽  
1994 ◽  
Vol 19 (3) ◽  
pp. 161-168 ◽  
Author(s):  
Brian E. Fuller ◽  
Alvaro A. Giraldo ◽  
Herman Waldmann ◽  
Stephen P. Cobbold ◽  
Yi-Chi M. Kong
Keyword(s):  
Autoimmune Thyroiditis ◽  
Immunologic Memory ◽  
Experimental Autoimmune Thyroiditis ◽  
Cd8 Cells ◽  
Experimental Autoimmune

Barefoot Running Claims and Controversies

2011 ◽  
Vol 101 (3) ◽  
pp. 231-246 ◽  
Author(s):  
David W. Jenkins ◽  
David J. Cauthon
Keyword(s):  
Key Words ◽  
Training Method ◽  
Review Of The Literature ◽  
Barefoot Running ◽  
Running Shoes ◽  
Improved Performance ◽  
Anecdotal Information

Background: Barefoot running is slowly gaining a dedicated following. Proponents of barefoot running claim many benefits, such as improved performance and reduced injuries, whereas detractors warn of the imminent risks involved. Methods: Multiple publications were reviewed using key words. Results: A review of the literature uncovered many studies that have looked at the barefoot condition and found notable differences in gait and other parameters. These findings, along with much anecdotal information, can lead one to extrapolate that barefoot runners should have fewer injuries, better performance, or both. Several athletic shoe companies have designed running shoes that attempt to mimic the barefoot condition and, thus, garner the purported benefits of barefoot running. Conclusions: Although there is no evidence that either confirms or refutes improved performance and reduced injuries in barefoot runners, many of the claimed disadvantages to barefoot running are not supported by the literature. Nonetheless, it seems that barefoot running may be an acceptable training method for athletes and coaches who understand and can minimize the risks. (J Am Podiatr Med Assoc 101(3): 231–246, 2011)

scholarly journals Vitiligo in Children and Adolescents: a Lliterature Review / Vitiligo kod dece i omladine - pregled literature

2010 ◽  
Vol 2 (3) ◽  
pp. 95-104
Author(s):  
Sonja Prćić ◽  
Verica Đuran ◽  
Dragan Katanić
Keyword(s):  
Children And Adolescents ◽  
Autoimmune Thyroiditis ◽  
Thyroid Dysfunction ◽  
Social Acceptance ◽  
Pediatric Population ◽  
Age Groups ◽  
Autoimmune Disorders ◽  
Self Image ◽  
Annual Screening

Abstract Vitiligo is an acquired, often hereditary skin depigmentation disorder, characterized by discrete, well-circumscribed, chalk-white macules or patches. It affects all age groups, but in more than half of the patients it occurs before the age of twenty, when self-image is being formed and social acceptance is of great importance. Although similar to the disease in adults, vitiligo in children and adolescents does have differences in epidemiology, association with other endocrine and/or autoimmune disorders, and treatment. This is a review of vitiligo in the pediatric population, emphasizing key differences with vitiligo in adults. According to the literature reports, we suggest that children and adolescents with vitiligo, especially non-segmental type, should perform annual screening for thyroid dysfunction, particularly for parameters of autoimmune thyroiditis.

Different aetiologies in post-partum thyroiditis?

1983 ◽  
Vol 104 (2) ◽  
pp. 195-200 ◽  
Author(s):  
Per Anders Dahlberg ◽  
Rolf Jansson
Keyword(s):  
Thyroid Function ◽  
Autoimmune Thyroiditis ◽  
Thyroid Dysfunction ◽  
Post Partum ◽  
Lymphocytic Infiltration ◽  
Graves Disease ◽  
Thyroid Autoantibodies ◽  
Radioiodine Uptake ◽  
Thyroid Cytology

Abstract. During a 4 year period 19 women with post-partum onset of thyroid dysfunction have been seen in our clinic. Five women had high radioiodine uptake thyrotoxicosis (Graves' disease). Twelve women had hypothyroid symptoms starting within 3–6 months of delivery. All of these women had thyroid microsomal and/or cytoplasmic autoantibodies and thyroid lymphocytic infiltration suggesting aggravation of pre-existing subclinical autoimmune thyroiditis (Hashimoto's disease). At follow-up thyroid function gradually improved in all but signs of persistent thyroid hypofunction remained in seven. Thus women developing symptomatic postpartum hypothyroidism should be followed regularly and when thyroxine treatment is commenced in the post-partum period, it has to be continued indefinitely in many cases. Two women presented with transient low radioiodine uptake thyrotoxicosis and a small painless goitre. Thyroid cytology revealed thyroiditis but they had no thyroid autoantibodies. When followed after a succeeding delivery none of these women developed post-partum thyroid dysfunction in contrast to women in the autoimmune group. Probably the aetiology of thyroid dysfunction in these 2 women was different.

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