scholarly journals Features of formation of biliary dysfunctions in children consuming drinking water with high nitrate content

2019 ◽  
Vol 36 (5) ◽  
pp. 65-70
Author(s):  
Olga G. Tolmacheva ◽  
Olga Yu. Ustinova ◽  
Olga A. Maklakova ◽  
Yulia A. Ivashova ◽  
Alexsandra Yu. Vandisheva
Keyword(s):  
Drinking Water ◽  
Total Bilirubin ◽  
Comparison Group ◽  
School Age Children ◽  
Nitrate Content ◽  
School Age ◽  
Observation Group ◽  
Nitrate Level ◽  
Second Child ◽  
Increased Activity

Introduction. In recent years, there is more and more information about the global distribution of nitrates in soil, water, food. Purpose. To study the features of the formation of biliary dysfunction in children with drinking water with high nitrate content. Materials. 124 school-age children consuming drinking water with high nitrate content (1.3 MPC) were examined. The comparison group included 52 children living in areas where the nitrate level in drinking water was 4.7 times lower. Results. In children of the observation group, the concentration of N-nitrosodimethylamine in the blood was 3.3 times higher than in the comparison group, and the concentration of nitrates in urine was 1.8 times higher. Every second child with a pathology of the gastrointestinal tract consuming drinking water with a high content of nitrates was diagnosed with biliary dysfunction manifested by hepatocellular dysfunction (increased activity of AST) and a violation of motor-tonic function of the gallbladder by hyperkinetic type against the background of hemolysis of erythrocytes (increased total bilirubin) with a stable level of hemoglobin.

scholarly journals СHANGES OF IMMUNOREGULATORY INDEXES IN CHILDREN EXPOSED TO STRONTIUM

2018 ◽  
Vol 20 (6) ◽  
pp. 899-904
Author(s):  
E. A. Otavina ◽  
O. V. Dolgikh ◽  
K. G. Starkova ◽  
O. A. Kazakova ◽  
A. A. Mazunina
Keyword(s):  
Drinking Water ◽  
Immune Regulation ◽  
Comparison Group ◽  
Fold Increase ◽  
Immune Defense ◽  
Phagocytic Index ◽  
Control Group ◽  
Observation Group ◽  
Strontium Content ◽  
Humoral Factors

Evaluation of the immune system parameters can be used in order to assess capacity to adapt under conditions of increased external chemical load, including exposure to metals, which can exert either activating and inhibitory effects upon immune regulation parameters. The aim of this work was the analysis of immunoregulatory markers in a children’s population who consumed water with high strontium content (a sample from the Perm region). We carried out immunological evaluation of the children aged 7 to 12 years, living at a territory with a high strontium content in the drinking water. The comparison group included children from the conventionally clean region. We studied differential changes in cellular immunity (phagocytosis rates), humoral factors of immune defense (serum immunoglobulins), development of specific sensitization for strontium, as well as the processes of apoptosis triggering and regulation. A 3.68-fold increase in strontium levels was shown in fresh water within observation area, and the average  blood strontium content in the children of appropriate observation group was 1.55-fold higher than in children of the comparison group. At the same time, 1.2-fold increase in phagocytic activity determined as phagocytic number and phagocytic index was found, as compared to the control group. In 80% of the subjects, a reduction in serum IgG level was observed when compared to physiological norm, as well as a significant decrease in IgG and enhance in IgM production against the levels found in the comparison group. Wehave also shown an enhanced total sensitization in 55.0% of the observation group as shown by the total IgE test compared with normal age ranges, as well as excessive specific sensitization to strontium by 2.49 times, according to the IgG criterion. Disturbance in apoptosis triggering was associated with decreased number of CD95+ lymphocytes and TNFR1+ cells (2.8-fold compared to reference values), shifted balance in apoptogenic proteins, an average of 2.6-fold decrease in Bcl-2 expression, a 2.8-fold reduction of the p53 transcription factor expression relative to the reference interval. Thus, we have shown an ability of strontium excess in drinking water to influence the most important indices of immune regulation in pediatric population. These changes may serve as indices of populational health status under of external strontium exposure.

scholarly journals Intellectual Impairment in School-Age Children Exposed to Manganese from Drinking Water

2011 ◽  
Vol 119 (1) ◽  
pp. 138-143 ◽  
Author(s):  
Maryse F. Bouchard ◽  
Sébastien Sauvé ◽  
Benoit Barbeau ◽  
Melissa Legrand ◽  
Marie-Ève Brodeur ◽  
...  
Keyword(s):  
Drinking Water ◽  
School Age Children ◽  
School Age ◽  
Intellectual Impairment

Does Perchlorate in Drinking Water Affect Thyroid Function in Newborns or School-Age Children?

2000 ◽  
Vol 42 (6) ◽  
pp. 603-612 ◽  
Author(s):  
Casey Crump ◽  
Patricio Michaud ◽  
Rafael T??llez ◽  
Carlos Reyes ◽  
Gilberto Gonzalez ◽  
...  
Keyword(s):  
Drinking Water ◽  
Thyroid Function ◽  
School Age Children ◽  
School Age

Low level exposure to manganese from drinking water and cognition in school-age children

2018 ◽  
Vol 64 ◽  
pp. 110-117 ◽  
Author(s):  
Maryse F. Bouchard ◽  
Céline Surette ◽  
Pierre Cormier ◽  
Delphine Foucher
Keyword(s):  
Drinking Water ◽  
School Age Children ◽  
School Age ◽  
Low Level

Exposure to manganese from drinking water and IQ in school-age children

2016 ◽  
Vol 2016 (1) ◽  
Author(s):  
Maryse F. Bouchard* ◽  
Pierre Cormier ◽  
Delphine Foucher ◽  
Céline Surette
Keyword(s):  
Drinking Water ◽  
School Age Children ◽  
School Age

scholarly journals Neurobehavioral Function in School-Age Children Exposed to Manganese in Drinking Water

2014 ◽  
Vol 122 (12) ◽  
pp. 1343-1350 ◽  
Author(s):  
Youssef Oulhote ◽  
Donna Mergler ◽  
Benoit Barbeau ◽  
David C. Bellinger ◽  
Thérèse Bouffard ◽  
...  
Keyword(s):  
Drinking Water ◽  
School Age Children ◽  
School Age ◽  
Neurobehavioral Function

scholarly journals Osteopathy incidence in children and adolescents consuming drinking water with high content of natural strontium

2021 ◽  
Vol 100 (10) ◽  
pp. 1123-1127
Author(s):  
Irina E. Shtina ◽  
Olga A. Maklakova ◽  
Svetlana L. Valina ◽  
Olga Y. Ustinova
Keyword(s):  
Bone Mineral Density ◽  
Drinking Water ◽  
Children And Adolescents ◽  
Bone Mineral ◽  
Comparison Group ◽  
Ionized Calcium ◽  
Observation Group ◽  
Mineral Density ◽  
Strontium Content ◽  
Geochemical Province

Introduction. Excessive intake of heavy metals of natural origin with drinking water increases the risk of the formation of non-infectious diseases of systems and organs, depending on the tropism of the chemical compound. The aim is to study the incidence of disorders of bone density and structure (osteopathies) in children and adolescents who consume drinking water with an increased strontium content due to the geochemical characteristics of the territory. Materials and methods. The observation group consisted of 93 children living in a geochemical province with a stable strontium content of more than 2 MPC in the centralized drinking water supply system. The comparison group included 148 children living in an area where strontium concentration in drinking water does not exceed 1 MPC. The incidence evaluation was carried out according to the official data of statistical materials. The analysis of the average values of the concentration in the blood of strontium, ionized calcium, inorganic phosphorus and alkaline phosphatase activity and the frequency of deviations from the norm of the studied parameters was carried out in the studied groups. The value of bone mineral density (Z-index) was determined according to the results of ultrasonic densitometry. Results. The level of long-term incidence of osteopathies for the period 2010-2019 in children and adolescents, the observation area was 6.59 ± 1.32 and 11.26 ± 2.07 ‰, respectively, which was 1.8 and 2.0 times higher than the level of the comparison territory (p = 0.0003-0.0004 ). The concentration of strontium in the blood of children living in the territory of the geochemical province exceeded 2.1 times the permissible reference (p <0.001) and 2.9 times the index of the comparison group (p = 0.0001). In ¾ children of the observation group, increased content of strontium in the blood was recorded, which was 5.2 times more often than the comparison area (p <0.001). In 57% of cases, the children of the observation group had a reduced level of ionized calcium in the blood (p = 0.0001). Low bone mineral density (Z-index) in the observation group occurred 2.3 times more often (17.2 versus 7.4%, p = 0.019). Significant dependences were established by lowering the level of ionized calcium and the value of the Z-index with increasing strontium content in the blood. Conclusion. In children living in geochemical provinces with an elevated strontium content, an increase in the incidence of osteopathy was noted, manifested by a reduced level of ionized calcium in the blood and low bone mineral density, which must be taken into account for the timely diagnosis and prevention of these conditions.

scholarly journals DETERMINAN EKSES IODIUM PADA ANAK SEKOLAH DI WILAYAH DENGAN RIWAYAT EKSES IODIUM DI INDONESIA

2018 ◽  
Vol 17 (2) ◽  
pp. 75-84 ◽  
Author(s):  
Ina Kusrini ◽  
Muhamad Samsudin ◽  
Muhamad Arif Musoddaq ◽  
Sidiq Purwoko ◽  
Basuki Budiman
Keyword(s):  
Drinking Water ◽  
Iodine Content ◽  
Iodine Intake ◽  
School Age Children ◽  
Severe Illness ◽  
School Age ◽  
Food Frequency ◽  
Spectrophotometric Methods ◽  
Excess Iodine ◽  
The Status

ABSTRACT Iodine is the micronutrient needed for synthesis of thyroid hormones. Excess or lack of iodine will cause disruption of thyroid function. The results of previous studies indicate that there is an increased prevalence of excess iodine in school-age children. The purpose of this study was to determine the determinants of excess iodine in school-age children aged 6 to 12 years in Demak, Grobogan, and Dharmasraya Regencies. The number of sample of school-age children was 750 in three district, with the inclusion criteria for length of stay in the study area was >6 months, and the exclusion criteria was they did not have severe illness. The status of iodine was measured through iodine content in urine using spectrophotometric methods. To determine iodine intake, iodine levels were measured in salt and in water, and the interview used food frequency questionaire (FFQ). The results showed that the iodine status of respondents in Dharmasraya Regency was at the optimal category (EIU: 225 µg / l, whereas in Demak and Grobogan districts the iodine were at excess category (EIU: 446  /l and 453µg / l) with the intake source came from drinking water and noodles (more than 10 ppb). It can be concluded that the determinants of excess iodine in three locations were iodine levels in drinking water, and noodles with consumption >3 times per week. It is recommended that the iodized salt program in the three research locations needs to be reconsidered. Keywords: Determinant, iodine, excess   ABSTRAK Iodium adalah mikronutrien  yang diperlukan untuk sintesa hormon tiroid. Kelebihan maupun kekurangan  iodium akan menyebabkan gangguan fungsi tiroid. Hasil penelitian sebelumnya menunjukkan bahwa terdapat peningkatan prevalensi ekses iodium pada anak sekolah. Tujuan penelitian ini adalah untuk mengetahui determinan ekses iodium pada anak usia sekolah 6 sampai dengan 12 tahun di Kabupaten Demak, Grobogan dan Dharmasraya. Jumlah sampel anak sekolah sebanyak 750 anak usia sekolah di tiga kabupaten tersebut, dengan kriteria inklusi lama tinggal  di wilayah penelitian lebih atau sama dengan  6 bulan, dan kriteria ekslusi tidak memiliki sakit berat. Status iodium diukur melalui kadar iodium dalam urin  menggunakan metode spektrofotometri. Untuk mengetahui intake iodium, dilakukan pengukuran kadar iodium dalam garam dan dalam air dan wawancara menggunakann food frequency questionaire (FFQ). Hasil menunjukkan bahwa status iodium responden di Kabupaten Dharmasraya dalam kategori optimal (EIU: 225 µg/l, sedangkan di Kabupaten Demak  dan Grobogan dalam kategori ekses iodium (EIU: 446 µg/l dan 453 µg/l) dengan sumber intake berasal dari air minum dan mie (lebih dari 10 ppb). Dapat disimpulkan bahwa determinan ekses iodium di tiga lokasi  adalah kadar iodium dalam air minum dan mie dengan konsumsi lebih dari 3 kali per minggu. Disarankan pemberian garam beriodium di keitga lokasi penelitian perlu dipertimbangkan kembali. Kata kunci: Determinan, ekses, iodium

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