scholarly journals The role of inhibin B in the regulation of spermatogenesis and its clinical significance in male infertility

2019 ◽  
Vol 9 (1) ◽  
pp. 39-45
Author(s):  
Nikolaj P. Lihonosov ◽  
Abdul H. Ajub ◽  
Alina Ju. Babenko ◽  
Sergey Yu. Borovets
Keyword(s):  
Male Infertility ◽  
Clinical Significance ◽  
Independent Predictor ◽  
Scientific Evidence ◽  
Inhibin B ◽  
Male Factor Infertility ◽  
Male Factor ◽  
Important Indicator ◽  
Spermatogenic Epithelium

The article contains a review of domestic and foreign literature on the assessment of the clinical significance of inhibin B in the male factor infertility. Modern scientific evidence is given that inhibin B plays an important role in the regulation of spermatogenesis and can be an independent predictor of early violations of spermatogenesis, damage to the spermatogenic epithelium, as well as an important indicator in the identification of disorders of spermatogenesis.

scholarly journals Recent advances in understanding and managing male infertility

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 670 ◽  
Author(s):  
Jonathan Fainberg ◽  
James A. Kashanian
Keyword(s):  
Male Infertility ◽  
Paternal Age ◽  
World Health ◽  
Testicular Sperm Extraction ◽  
Male Factor Infertility ◽  
Male Factor ◽  
Lifestyle Choices ◽  
Health Organization ◽  
Shed Light

Infertility is a prevalent condition affecting an estimated 70 million people globally. The World Health Organization estimates that 9% of couples worldwide struggle with fertility issues and that male factor contributes to 50% of the issues. Male infertility has a variety of causes, ranging from genetic mutations to lifestyle choices to medical illnesses or medications. Recent studies examining DNA fragmentation, capacitation, and advanced paternal age have shed light on previously unknown topics. The role of conventional male reproductive surgeries aimed at improving or addressing male factor infertility, such as varicocelectomy and testicular sperm extraction, have recently been studied in an attempt to expand their narrow indications. Despite advances in the understanding of male infertility, idiopathic sperm abnormalities still account for about 30% of male infertility. With current and future efforts examining the molecular and genetic factors responsible for spermatogenesis and fertilization, we may be better able to understand etiologies of male factor infertility and thus improve outcomes for our patients.

Infertility and the Military Male

2019 ◽  
Vol 37 (01) ◽  
pp. 005-011
Author(s):  
Amanda B. Reed-Maldonado ◽  
Kristin C. Madden
Keyword(s):  
Male Infertility ◽  
Military Service ◽  
Clinical Investigation ◽  
Male Factor Infertility ◽  
Military Population ◽  
Male Factor ◽  
Scientific Publications ◽  
Military Service Members ◽  
Infertile Couples ◽  
The Military

AbstractMale infertility is a condition that affects approximately 50% of infertile couples and about 30% of those couples have only male factor infertility identified. There has been speculation that male military service members may have an even greater lifetime prevalence of infertility as compared to the general population, but very few scientific publications focus on male factor infertility in the military population specifically. This review will discuss many of the unique considerations regarding male infertility in the military and highlight future opportunities for research. The military/federal health system has the potential to serve as a leader in both the delivery of health care for male factor infertility and in the clinical investigation into the etiologies of and treatments for male factor infertility.

Gender, Family Norms, and Male-Factor Infertility in Japan: An Analysis of Internet Blogs

2018 ◽  
Vol 39 (14) ◽  
pp. 3713-3731
Author(s):  
Kimiko Tanaka ◽  
Nan E. Johnson ◽  
Deborah Lowry
Keyword(s):  
Cultural Studies ◽  
Literature Review ◽  
Male Infertility ◽  
Cross Cultural ◽  
Male Factor Infertility ◽  
Male Factor ◽  
Japanese Male ◽  
Family Norms ◽  
Cross Cultural Studies

This study analyzes blogs about male-factor infertility posted on a Japanese blogsite on a certain day in April 2014. It focuses on an understudied topic and is the first study of Japanese male infertility based on blogs. The blog format afforded anonymity to the bloggers, and our sample of 97 adults yields the largest number of individual respondents of all cross-cultural studies cited in our literature review. We extract three major themes from the analysis of the blogs, offer suggestions for a redirection of family and infertility policy in Japan, and suggest lines for further research.

scholarly journals Is there a place for nutritional supplements in the treatment of idiopathic male infertility?

2014 ◽  
Vol 86 (3) ◽  
pp. 164 ◽  
Author(s):  
Davide Arcaniolo ◽  
Vincenzo Favilla ◽  
Daniele Tiscione ◽  
Francesca Pisano ◽  
Giorgio Bozzini ◽  
...  
Keyword(s):  
Male Infertility ◽  
Sperm Count ◽  
Nutritional Supplements ◽  
Semen Parameters ◽  
Male Factor ◽  
Treatment Regimens ◽  
Idiopathic Male Infertility ◽  
Infertile Men ◽  
Wide Variability

Objective: Infertility affects 15% of couples in fertile age. Male factor is a cause of infertility in almost half of cases, mainly due to oligoasthenoteratozoospermia (OAT). The purpose of this study is to review the effects of nutritional supplements as medical treatment for idiopathic male infertility. Material and methods: A Pub Med and Medline review of the published studies utilizing nutritional supplements for the treatment of male infertility has been performed. Results: Clinical trials on Vitamin E, Vitamin A, Vitamin C. Arginine, Carnitine, N-Acetyl-Carnitine, Glutathione, Coenzyme Q10, Selenium and Zinc were reviewed. Although there is a wide variability in selected population, dose regimen and final outcomes, nutritional supplements both alone and in combination seems to be able to improve semen parameters (sperm count, sperm motility and morphology) and pregnancy rate in infertile men. Conclusions: There are rising evidences from published randomized trials and systematic review suggesting that nutritional supplementation may improve semen parameters and the likelihood of pregnancy in men affected by OAT. This improvement, however, is not consistent and there is a wide variation in the treatment regimens used. Well designed and adequately powered RCTs are needed to better clarify the role of nutritional supplements as treatment for male infertility.

scholarly journals Essential Role of Sperm-Specific PLC-Zeta in Egg Activation and Male Factor Infertility: An Update

2020 ◽  
Vol 8 ◽  
Author(s):  
Alaaeldin Saleh ◽  
Junaid Kashir ◽  
Angelos Thanassoulas ◽  
Bared Safieh-Garabedian ◽  
F. Anthony Lai ◽  
...  
Keyword(s):  
Essential Role ◽  
Egg Activation ◽  
Male Factor Infertility ◽  
Male Factor

A modern view of male infertility

1994 ◽  
Vol 6 (1) ◽  
pp. 93 ◽  
Author(s):  
SJ Silber
Keyword(s):  
Male Infertility ◽  
Y Chromosome ◽  
Obstructive Azoospermia ◽  
Male Factor Infertility ◽  
Male Factor ◽  
Sperm Retrieval ◽  
Modern Approach ◽  
Vitro Fertilization ◽  
Defective Spermatogenesis

It is archaic to view male factor infertility today separately from in vitro fertilization (IVF) and treatment of the female partner. Oligoasthenozoospermia may be an inherited condition (most likely on the Y chromosome), and is refractory to any treatment of the male including hormones and varicocelectomy. IVF technology is the only justifiable approach for achieving a pregnancy in these couples. The reasons for this view and the suggested modern approach to couples with oligoasthenozoospermia are outlined in this review. However, obstructive azoospermia is different as it can be successfully corrected with microsurgery in over 90% of men. When it cannot be corrected, as in congenital absence of vas, microsurgical sperm retrieval combined with IVF can still be highly effective in producing pregnancy with sperm from the husband. The most important arena for research into male infertility in the next decade will be to map out the deletions on the Y chromosome that might result in defective spermatogenesis, and which probably cause most cases of non-obstructive male factor infertility.

The CFTR gene: male infertility and assisted conception

1999 ◽  
Vol 7 (2) ◽  
pp. 155-160 ◽  
Author(s):  
S Kulshrestha ◽  
A Makrigiannakis ◽  
P Patrizio
Keyword(s):  
Male Infertility ◽  
Vas Deferens ◽  
Cftr Gene ◽  
Obstructive Azoospermia ◽  
Male Factor Infertility ◽  
Assisted Conception ◽  
Male Factor ◽  
Fertility Treatments ◽  
Bilateral Absence ◽  
Testicular Failure

Approximately 30–40% of couples seeking fertility treatments have male factor infertility. Their dysfunctions include azoospermia, oligozoospermia, asthenozoospermia and teratozoospermia. Those with azoospermia represent about 25% of the total, and of these about 30% have an obstructive process while the remaining have either primary or secondary testicular failure. In the obstructive azoospermia group, 25% of males have congenital bilateral absence of the vas deferens (CBAVD).

scholarly journals Prevalence and Patterns of Male Infertility Based on Semen Analysis in Patients Visiting Massawa Hospital; Eritrea: Cross-Sectional Study; 2020

2021 ◽  
Author(s):  
Berhe Tesfai ◽  
Fitsum Kibreab ◽  
Hailemichael Gebremariam ◽  
Liwam Abraham
Keyword(s):  
Male Infertility ◽  
Sperm Motility ◽  
Sperm Count ◽  
Semen Analysis ◽  
Male Factor Infertility ◽  
Male Factor ◽  
Cross Sectional ◽  
Semen Volume ◽  
Primary Type ◽  
Study Participants

Abstract Background Semen analysis is the first step to identify male factor infertility. World Health Organization estimates that male factor accounts for 50% of couple sub-fertility. The objective of this study was to determine the prevalence and patterns of male factor infertility based on semen analysis in patients visiting Massawa Hospital with infertility complaints. Methods It was a retrospective, descriptive cross sectional hospital based type of study with a census sampling method. Patient’s medical records and hospital laboratory register were used to retrieve semen analysis results of patients from June 2018 to June 2020. Ethical approval was obtained from the Ministry of Health Research and Ethical Review Committee. Confidentiality of patients records kept was secured and consent was obtained from study participants to use their data. Results were presented in frequency, tables and p value < 0.05 was considered significant. Results A total of 112 patients data was analyzed in the study with 49.1% were aged between 20 to 30 years. The prevalence of male factor infertility in these patients was found to be 42% and 79.5% of them had primary type of infertility. Of the study participants; 63 (56.3%), 72 (64.3%) and 70 (62.5%) had sperm count < 15 million sperms/ml, sperm motility < 40 % and morphology of < 60% respectively. One tenth, 15 (13.4%) of the patients had a semen volume of < 1.5ml/ejaculate, out of which 13(86.7%) had primary type of infertility. Moreover; 72 (64.3%) patients had total sperm count/ejaculate of < 39 million and 59 (82%) of these had primary type of infertility. In addition; 50.8% and 50% of patients aged 20 to 30 years had a sperm count < 15 million/ml and sperm motility of < 40% respectively. Conclusion The prevalence of male factor infertility was slightly higher and was dominated with primary infertility. Most patients had lower sperm count, sperm motility but higher semen volume, and majority of the patients with abnormal sperm results were aged between 20 to 30 years. Further prospective researches to determine the risk factors for male infertility and introducing assisted type of fertility in Eritrea are highly recommended.

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