scholarly journals Effectiveness of physical exercise as a treatment for lymphedema in cancer patients

2021 ◽  
Vol 8 (2) ◽  
pp. 89-113
Author(s):  
Javier Eliecer Pereira-Rodríguez ◽  
Juan Sebastián De Marcos-Sánchez ◽  
Alejandra Patricia Viloria-Madrid ◽  
Rolando José Hernández-Romero ◽  
William Alberto Delgadillo-Espinosa ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Cancer Patients

scholarly journals POSITIVE study: physical exercise program in non-operable lung cancer patients undergoing palliative treatment

BMC Cancer ◽  
2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Joachim Wiskemann ◽  
Simone Hummler ◽  
Christina Diepold ◽  
Melanie Keil ◽  
Ulrich Abel ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Physical Exercise ◽  
Cancer Patients ◽  
Palliative Treatment ◽  
Exercise Program ◽  
Lung Cancer Patients ◽  
Positive Study

Are palliative cancer patients willing and able to participate in a physical exercise program?

2005 ◽  
Vol 3 (4) ◽  
pp. 281-287 ◽  
Author(s):  
LINE M. OLDERVOLL ◽  
JON H. LOGE ◽  
HANNE PALTIEL ◽  
MAY B. ASP ◽  
UNNI VIDVEI ◽  
...  
Keyword(s):  
Palliative Care ◽  
Physical Exercise ◽  
Training Program ◽  
Cancer Patients ◽  
Physical Training ◽  
Exercise Program ◽  
Group Exercise ◽  
Medical Problems ◽  
Incurable Cancer ◽  
The Individual

Objective: The primary aim of the present article was to identify palliative care patient populations who are willing to participate in and able to complete a group exercise/physical training program designed specifically for the individual patient.Method: We conducted a prospective phase II intervention study examining the willingness and ability of palliative care cancer patients to participate in a group exercise physical training program. Patients who were diagnosed with incurable cancer and had a life expectancy of less than 1 year at two outpatient clinics were invited to participate in an exercise program in the hospitals. The groups met twice a week over a 6-week period.Results: One hundred one consecutive patients were asked for inclusion. Sixty-three patients agreed to participate. Sixteen (25%) of the 63 patients dropped out after consent was given, but before the program started due to medical problems, social reasons, or death. Thus, 47 patients started the exercise program. Thirteen patients withdrew during the program due to sudden death, medical problems, or social reasons. The most frequent reasons for withdrawal were increased pain or other symptoms. Thirty-four patients completed the exercise program.Significance of results: A high proportion of incurable cancer patients were willing to participate (63%) in a structured exercise program. The attrition rate was high, but despite being severely ill, 54% of the patients completed the exercise period. This shows that a physical exercise program tailored to the individual patient is feasible in this population.

scholarly journals Feasibility and efficacy of a supervised home-based physical exercise program for metastatic cancer patients receiving oral targeted therapy: study protocol for the phase II/III - UNICANCER SdS 01 QUALIOR trial

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Florence Joly ◽  
Claudia Lefeuvre-Plesse ◽  
Claire Garnier-Tixidre ◽  
Carole Helissey ◽  
Nathalie Menneveau ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Targeted Therapy ◽  
Physical Exercise ◽  
Cancer Patients ◽  
Phase Ii ◽  
Metastatic Cancer ◽  
Activity Program ◽  
Home Based

Abstract Background Currently, oral targeted therapies are known to be effective and are frequently used to treat metastatic cancer patients, but fatigue is a frequently reported early side effect of these treatments. This fatigue may impact the patient’s treatment adherence and result in a negative impact on quality of life. Physical exercise significantly improved the general well-being and quality of life of advanced cancer patients. However, there is no specific physical activity program adapted for patients with advanced disease. Methods QUALIOR is a two-part, randomized, open-label, and multicenter with two arms phase II/III trial. Patients (phase II: n = 120; phase III: n = 312) with metastatic cancer (breast cancer, kidney cancer, lung cancer, and other cancers [including but not limited to colon cancer, melanoma, sarcoma, or hepatocarcinoma]) treated with a first- or second-line oral targeted therapy without chemotherapy will be included. Patients will be randomized (2:1) to a 3-month supervised home-based standardized physical activity program or to a recommended adapted physical activity (via a booklet). The primary objective of the phase II is to evaluate the feasibility of the supervised program. The primary objective of the phase III is the evaluation of the benefit of the supervised home-based program compare to the recommended program in terms of fatigue and quality of life at 3 months. The secondary objectives aim to evaluate the impact of the supervised program on fatigue over time, pain, physical capacities, psychosocial and cognitive functions, general quality of life, frequency of dose reduction and patients’ adherence to the targeted therapy, overall survival, and progression-free survival. This study will also evaluate the medico-economic impact of supervised program compared to the recommended adapted physical activity program. Discussion The aim of this study is to evaluate home-based physical exercise program for metastatic cancer patients treated with oral targeted therapies to help patients to cope with fatigue and improve quality of life. Trial registration This trial was registered in ClinicalTrials.gov since May 2017 (NCT03169075).

A phase II-III, multicenter, randomized, open study evaluating the feasibility and efficacy of a supervised home-based standard physical exercise program for metastatic cancer patients receiving oral targeted therapy: The UNICANCER SdS 01 QUALIOR study (ID-RCB: 2015-A01922-47).

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. TPS10126-TPS10126
Author(s):  
Florence Joly Lobbedez ◽  
Laurence Vanlemmens ◽  
Jean-Marc Descotes ◽  
Sophie Abadie-Lacourtoisie ◽  
Claude Boiron ◽  
...  
Keyword(s):  
Physical Activity ◽  
Physical Exercise ◽  
Cancer Patients ◽  
Phase Ii ◽  
Metastatic Cancer ◽  
Exercise Program ◽  
Well Being ◽  
Phase Iii ◽  
Ethic Committee Approval ◽  
Home Based

TPS10126 Background: Fatigue is a frequent side effect with oral targeted therapies (OTT). Physical activity has been reported to improve fatigue and quality of life (QoL). However, few studies focused on metastatic cancer patients and mainly among patients treated with chemotherapy. Furthermore, recent guidelines recommend evaluation and optimization of standardized exercise programs. The aim of our study is to evaluate home-based standard physical exercise program (SPEP) for metastatic cancer patients treated with OTT. Methods: This phase II-III study will randomize (2:1) patients starting first-line OTT for metastatic cancer between an individualized SPEP supervised by a personal coach, and recommended physical exercises via a booklet. Eligible patients will have received ≤2 lines of metastatic chemotherapy, ECOG PS ≤2, controlled pain (VAS < 3/10), and life expectancy ≥3 months. The phase II part (120 patients) will evaluate the feasibility of a 3-month SPEP using the rate of patients performing ≥50% of SPEP (2-stage Fleming: one-sided α = 5%; β = 85%). An interim analysis is planned after the phase II. The phase III will compare the efficacy of an SPEP as opposed to recommendations to reduce fatigue and/or improve physical well-being (PWB) dimensions of QoL (evaluated with FACT-G and FACT-F questionnaires). To show a difference of ≥5 points in PWB and 2.5 for fatigue (α = 2.5%; β = 80%), 312 patients are required in the phase III trial. . Secondary objectives include: PFS, OS, other dimensions of QoL, tolerability and observance of OTT, change in body composition, physical benefits, and a medico-economic study. The SPEP was developed by specialized coaches involved in physical activity and cancer. The study has Ethic committee approval and accrual is planned in 18 French centers in April 2017, for 30 months. This is the first randomized trial dedicated to patients with metastatic cancer treated with OTT evaluating the feasibility and the efficacy of a well design home based SPEP on fatigue and physical well-being.

Sign in / Sign up

Export Citation Format

Share Document