Gelatin is a heterogeneous mixture of single or multi-stranded polymers made of amino acids. Its film formability, air permeability, biocompatibility, and hemostatic activity render it appropriate for wound dressing. In this study, we used a syringe to drop gelatin solution into oligomeric proanthocyanidins solution to prepare the composite microspheres. Physical properties of the composite microsphere, such as swelling, stability in water, contact angle, and Fourier transform infrared spectroscopy were examined. We aimed at investigating its potential use in promoting wound healing along with wound dressings. The greatest swelling (1480 %) of the gelatin/OPC composite microsphere was achieved in 10 min. The composite microspheres dissolved 90% in the first 60 min during water stability test. Therefore, the developed composite microsphere has great hydrophilic and can be used in biomedical applications.
PRODUCTION and CHARACTERIZATION of GELATIN FUNCTIONALIZED HYDROXYAPATITE COMPOSITE MICROSPHERES for BIOMEDICAL APPLICATIONS