Brucellosis with Bone Marrow Granulomas- Two Case Reports

The increasing use of radiological examination, especially magnetic resonance imaging (MRI), will probably increase the risk of unintended discovery of bone marrow abnormalities in patients where a hematologic disease would not be expected. In this paper we present four patients with different hematologic malignancies of nonplasma cell types. In all patients the MRI bone marrow abnormalities represent an initial presentation of the disease. These case reports illustrate the importance of a careful diagnostic follow-up without delay of patients with MRI bone marrow abnormalities, because such abnormalities can represent the first sign of both acute promyelocytic leukemia as well as other variants of acute leukemia.

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Lessons learned from bone marrow failure in systemic lupus erythematosus: Case reports and review of the literature

Seminars in Arthritis and Rheumatism ◽

10.1016/j.semarthrit.2017.12.004 ◽

2018 ◽

Vol 48 (1) ◽

pp. 90-104 ◽

Cited By ~ 2

Author(s):

Erik Anderson ◽

Bhakti Shah ◽

Anne Davidson ◽

Richard Furie

Keyword(s):

Systemic Lupus Erythematosus ◽

Bone Marrow ◽

Lupus Erythematosus ◽

Case Reports ◽

Bone Marrow Failure ◽

Lessons Learned ◽

Review Of The Literature ◽

Systemic Lupus ◽

Systemic Lupus Erythematosus Case

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Bone Marrow Necrosis

Journal of Intensive Care Medicine ◽

10.1177/088506669501000403 ◽

1995 ◽

Vol 10 (4) ◽

pp. 171-178 ◽

Cited By ~ 3

Author(s):

Marcel E. Conrad

Keyword(s):

Bone Marrow ◽

Cancer Chemotherapy ◽

Case Reports ◽

Blood Stasis ◽

Pathological Finding ◽

Vascular Occlusion ◽

High Dose ◽

Bone Marrow Necrosis ◽

Clinical Illness ◽

Lost To Follow Up

Bone marrow necrosis is regarded as an uncommon entity that is associated with a poor prognosis. However, organized studies using either bone marrow biopsy specimens or autopsy material showed that bone marrow necrosis can be demonstrated in approximately one third of specimens. It is found in a large number of both malignant and nonmalignant disorders, in addition to occurring following large exposures to radiation or high dose cancer chemotherapy. In the absence of radiation or cancer chemotherapy, it probably eventuates from either vascular occlusion or blood stasis in small blood vessels. When bone marrow necrosis is prolonged, it may be associated with the development of bone marrow fibrosis, and it may serve as a predisposing etiology for idiopathic myelofibrosis. Most patients discovered with bone marrow necrosis have few symptoms, and they are eventually lost to follow-up without evident progression or development of a clinical illness. In acute disorders and in those who undergo effective therapy, recovery appears to occur without complications. This frequently overlooked finding is the subject of many case reports in the medical literature, but it has only been rarely systematically investigated. The latter is probably warranted because of the potential role of bone marrow necrosis in the pathophysiology of a number of disorders and the paucity of information for treatment of this pathological finding.

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Bone marrow elements in cerebrospinal fluid: Review of literature with a case study

CytoJournal ◽

10.4103/1742-6413.119009 ◽

2013 ◽

Vol 10 ◽

pp. 20 ◽

Cited By ~ 1

Author(s):

Anitha Ann Thomas ◽

Felicia Tze Yee Goh

Keyword(s):

Central Nervous System ◽

Bone Marrow ◽

Cerebrospinal Fluid ◽

Nervous System ◽

Young Children ◽

Case Reports ◽

Central Nervous System Infection ◽

The Elderly ◽

Review Of Literature

Presence of bone marrow elements in cerebrospinal fluid is rare. Journal publications on this topic are few and majority of them were written over a decade ago mostly as case reports in young children or the elderly. The increased cellularity and presence of myeloid precursors can be a pitfall and may be misdiagnosed as leukemia or lymphoma or central nervous system infection, when the specimen is actually not representative. With the intention to create awareness of potential pitfalls and avoid erroneous diagnoses, as well as adding on to the current photo archive of bone marrow elements in CSF, we present a recent case of bone marrow contaminants in the CSF of a 16-year-old girl.

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Multiple Myeloma Associated GI Polyposis

Blood ◽

10.1182/blood.v120.21.5009.5009 ◽

2012 ◽

Vol 120 (21) ◽

pp. 5009-5009

Author(s):

Nassim Nabbout ◽

Mohamad El Hawari ◽

Thomas K. Schulz

Keyword(s):

Multiple Myeloma ◽

Bone Marrow ◽

Plasma Cells ◽

Conflicts Of Interest ◽

Case Reports ◽

Bone Marrow Failure ◽

Bone Lesions ◽

Rare Manifestation ◽

History Of ◽

Central Ulceration

Abstract Abstract 5009 Multiple myeloma is a neoplastic proliferation of monoclonal plasma cells that can result in osteolytic bone lesions, hypercalcemia, renal impairment, bone marrow failure, and the production of monoclonal gammopathy. The gastrointestinal tract is rarely involved in myeloma. GI polyposis is a rare manifestation of extra-medullary disease in multiple myeloma. Such cases usually present as gastrointestinal hemorrhage or intestinal obstruction. A 53-year-old African American male recently diagnosed with multiple myeloma presented with three-day history of rectal bleed and fatigue. EGD showed multiple raised, polypoid, rounded lesions with a superficial central ulceration in the stomach. Colonoscopy showed similar lesions in the ascending and transverse areas of the colon that ranged in size from 5 to 16 mm in diameter. Biopsies showed that these polyps were made of plasma cells. A bone marrow biopsy showed diffuse involvement (greater than 90%) of bone marrow with multiple myeloma with anaplastic features. The patient was started on bortezomib at diagnosis, however, he passed away a few weeks later. This type of metastatic disease has been described in isolated case reports in the literature, while solitary GI plasmacytoma has been reported more frequently. In rare cases, multiple myeloma can involve the GI tract which may lead to bleed or obstruction. This involvement is likely a marker of aggressivity. This example of extra-medullary disease in myeloma is an uncommon variant with features of poor prognosis and dedifferentiation. Disclosures: No relevant conflicts of interest to declare.

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