Hypovitaminosis D in pregnancy and its correlation with preeclampsia and gestational diabetes mellitus

Background: Hypovitaminosis D has been associated with a number of adverse pregnancy outcomes, and has been recognised as a public health concern. The objective of this study was to determine the impact of Vitamin D deficiency on maternal complications like gestational diabetes mellitus (GDM) and preeclampsia (PE) among pregnant women.Methods: This was a case control study undertaken at antenatal clinics and indoor of BRD Medical College, Gorakhpur, Uttar Pradesh, India. Two maternal blood samples, one at <20 weeks and other at term along with cord blood at delivery were taken. Patients were classified into preeclampsia (n=60), gestational diabetes mellitus (n=35) and control group (n=180) after abstracting past medical records at delivery. Vitamin D was estimated by 25- Hydroxyvitamin D125 RIA kit and categorized according to ACOG criteria. Statistical analysis was done by using chi square test, binary logistic regression and Pearson’s correlation coefficient to compare between two variables. P<0.05 was considered statistically significant.Results: Out of 275 women included in the study, 78% of women were Vitamin D deficient. Mean serum vitamin D was significantly lower among preeclamptic women 11.53±6.22 ng/ml and GDM women 12.62±6.69 ng/ml as compared to controls 24.25±14.44 ng/ml (median=18.2 ng/ml) (P<0.05). Vitamin D deficiency was significantly higher in pregnant women GDM (94.28% vs 68.3%) and preeclampsia (96.67% vs 68.3%) when compared to uncomplicated group.Conclusions: Maternal vitamin D deficiency is highly prevalent in early pregnancy and is significantly associated with elevated risk for GDM and preeclampsia.

Download Full-text

Estimation of maternal serum vitamin D levels and its correlation with gestational diabetes mellitus

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20183343 ◽

2018 ◽

Vol 7 (8) ◽

pp. 3348

Author(s):

Anupriya Narain ◽

Alka Goel ◽

Parul Goyal

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Hypovitaminosis D ◽

P Value ◽

Serum Vitamin D ◽

Vitamin D Levels

Background: Several studies in the past two decades have proved beyond doubt that there is a high prevalence of hypovitaminosis D worldwide including India which has almost taken the shape of a pandemic. The study aims to determine the prevalence of hypovitaminosis D in the pregnant population of Delhi and its correlation with gestational diabetes mellitus.Methods: This prospective cross sectional observational study was conducted at the Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research (PGIMER), Dr R.M.L Hospital, New Delhi over a period of 1 year and 4 months. Four hundred term patients were enrolled randomly from amongst the patients admitted in labor room or antenatal ward at PGIMER, Dr. Ram Manohar Lohia Hospital who fulfilled the inclusion and exclusion criteria. 3-4ml of fasting blood samples were collected of all the enrolled women and were analysed for total serum calcium levels and serum vitamin D levels. History of presence of gestational diabetes mellitus was noted along with any treatment history. The 25(OH)D levels for each subject was recorded and correlation of vitamin D levels with gestational diabetes mellitus was analysed. Statistical analysis was done using ANOVA/ Kruska Wallis test and Chi-Square test/ Fisher’s exact test. A p value of <0.05 was considered statistically significant.Results: The overall prevalence of vitamin D deficiency in the present study was 86.25%. The overall mean serum vitamin D level was 14.06±9.43 ng/ml. Thirty five out of 37 GDM patients had hypovitaminosis D i.e. 94.59%. The prevalence of hypovitaminosis D among non-GDM population was 85.40%. The association between GDM and Vitamin D deficiency was statistically non- significant in the present study with p value=0.186.Conclusions: There is a very high prevalence of hypovitaminosis D in pregnant females attending present institute i.e. 86.25%. Although 94.59 % of Gestational Diabetes Mellitus patients had vitamin D deficiency, there is no statistically significant association between Gestational diabetes mellitus and serum vitamin D levels.

Download Full-text

Serum vitamin D deficiency and risk of gestational diabetes mellitus: a meta-analysis

Archives of Medical Science ◽

10.5114/aoms.2020.94433 ◽

2020 ◽

Vol 16 (4) ◽

pp. 742-751

Author(s):

Lanling Wang ◽

Chunlei Zhang ◽

Yuhuan Song ◽

Zhennan Zhang

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Vitamin D Deficiency ◽

Meta Analysis ◽

Serum Vitamin ◽

Serum Vitamin D

Download Full-text

Hypovitaminosis D in Gestational Diabetes Mellitus: The Impact of Vitamin D Status on Insulin Resistance, Parathyroid Hormone, and Perinatal Outcome

Journal of Medical Science And clinical Research ◽

10.18535/jmscr/v6i1.112 ◽

2018 ◽

Vol 6 (1) ◽

Author(s):

Mohamed A Youssry MD ◽

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Vitamin D ◽

Parathyroid Hormone ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Perinatal Outcome ◽

Hypovitaminosis D ◽

Vitamin D Status ◽

The Impact

Download Full-text

Serum Vitamine D3 Level in Women with Gestational Diabetes Mellitus

Journal of Advances in Medicine and Medical Research ◽

10.9734/jammr/2021/v33i730880 ◽

2021 ◽

pp. 90-98

Author(s):

Riham M. Enab ◽

Amal A. El Sokary ◽

Heba A. Mourad ◽

Amal E. Mahfouz

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Vitamin D3 ◽

Serum Vitamin ◽

Control Group ◽

Study Group ◽

Significant Difference

Background: Vitamin D3 is synthesized in skin and sequentially metabolized in liver and kidney in humans. It is well known for its function in maintaining calcium and phosphorus homeostasis and promoting bone mineralization. The primary objective of this study was to evaluate vitamin D3 level in pregnant women who were suffering from gestational diabetes mellitus and comparing it with the control groups. Materials and Methods: This case control study was conducted on 100 pregnant women who were attending the inpatient and outpatient clinics of Obstetrics department, Tanta University Hospital, who were divided into two equal groups.Group A (control group): Fifty apparently healthy pregnant women at 24th-28th weeks of gestation. Group B (study group): Fifty pregnant women had gestational diabetes. Results: There is significant increase between the two studied groups according to HbA1c, also there is decrease between the two groups as regards VIT D. Mean HbA1c % was statistically significant higher in the study group versus control group. There was statistical significant difference noted between mean serum level of vitamin D among the two studied groups. A statistically significant negative correlation was observed between serum 25 OH vitamin D and HbA1c among our cases (r=- 0.745) (p ≤ 0.001). Mean serum vitamin D was significantly lower in cases with complications than those with normal outcome. Conclusion: Vitamin D deficiency may have a positive relationship with gestational diabetes mellitus.

Download Full-text

Hypovitaminosis D Is Associated with Some Metabolic Indices in Gestational Diabetes Mellitus

Biomedicine Hub ◽

10.1159/000508207 ◽

2020 ◽

Vol 5 (2) ◽

pp. 1-14

Author(s):

Ayobola Abimbola Sonuga ◽

Oyebola Oluwagbemiga Sonuga

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Glucose Intolerance ◽

Serum Insulin ◽

Hypovitaminosis D ◽

Control Group ◽

The Relationship

Background: Gestational diabetes mellitus (GDM), a pregnancy complication, is defined as any degree of glucose intolerance with onset or first recognition during pregnancy. Vitamin D deficiency and insufficiency has recently been recognized as a contributing factor to the pathogenesis of GDM, and this link might be associated with hyperglycemia, insulin resistance, and inflammation, which are implicated in GDM. Objectives: This study aims at investigating the relationship between vitamin D, fasting plasma glucose (FPG), insulin, zinc, ferritin, and high-sensitivity C-reactive protein (CRP) in GDM. Method: A case-control study in which 80 women attending the antenatal clinic of University College Hospital (UCH), Ibadan, Nigeria, were recruited; the women were grouped into controls (40 nondiabetic pregnant women) and cases (40 pregnant women with GDM). Blood samples were taken at the second trimester, and metabolites were quantified by standard laboratory methods. Student’s t test and Pearson correlation were used to compare variables and determine the relationship between variables, respectively. Results: Results showed significant (p < 0.05) low levels of serum vitamin D and zinc, and significant (p < 0.05) higher levels of FPG and serum insulin, ferritin, and CRP in the GDM group compared to the control group. In the GDM group, a positive weak relationship was observed between vitamin D and zinc (r = 0.18, p < 0.05), while vitamin D was inversely correlated with FPG, serum insulin, ferritin, and CRP (r = –0.23, –0.21, –0.20, –0.46, respectively, p < 0.05). Conclusion: This study suggests that hypovitaminosis D might be associated with glucose intolerance, insulin insensitivity, and inflammation, which are factors implicated in the development and progression of GDM.

Download Full-text

Serum vitamin D receptor levels in gestational diabetes mellitus

LaboratoriumsMedizin ◽

10.1515/labmed-2017-0149 ◽

2018 ◽

Vol 42 (4) ◽

pp. 149-154

Author(s):

Seçkin Özgür Tekeli ◽

Feyza Yağmur Tekeli ◽

Onur Erol ◽

Hamit Yaşar Ellidag ◽

Esin Eren ◽

...

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Vitamin D Receptor ◽

Serum Vitamin ◽

Receptor Expression ◽

Control Group ◽

Significant Difference ◽

25 Oh Vitamin D

AbstractBackgroundVitamin D affects glucose metabolism by increasing insulin secretion and insulin receptor expression. Also, it exerts these effects by binding to its primary receptor, the vitamin D receptor (VDR). In this preliminary study, we aimed to examine serum 25-(OH) vitamin D3and serum VDR levels in gestational diabetes mellitus (GDM) patients.MethodsBlood samples were obtained during 24–28 weeks of pregnancy from patients with GDM (n=30) and age, body mass index (BMI), and gestational age-matched control subjects (n=33). Both groups were examined for changes in the levels of glucose, insulin, glycated hemoglobin (bA1c), 25-(OH) vitamin D3and VDR.ResultsThere were no significant differences in serum 25-(OH) vitamin D3and fasting insulin levels between the control and GDM groups (p=0.115, p=0.182). But serum VDR levels were significantly higher in the GDM group than in the control group (p=0.001).ConclusionsAlthough there was no significant difference between the two groups regarding 25-(OH) vitamin D3levels, it is notable that VDR levels were higher in GDM patients. To further define the role of vitamin D in the prophylaxis and treatment of GDM, it may be useful to conduct more extensive studies on VDR.

Download Full-text

Association of Vitamin D Deficiency in Newly Diagnosed Pulmonary Tuberculosis

10.53350/pjmhs2115102572 ◽

2021 ◽

Vol 15 (10) ◽

pp. 2572-2573

Author(s):

Khalil Ullah ◽

Sajid Ur Rehman ◽

Ramsha Nadeem ◽

Muhammad Abubakar ◽

Qasim Raza

Keyword(s):

Vitamin D ◽

Pulmonary Tuberculosis ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Sampling Technique ◽

Hypovitaminosis D ◽

Control Group ◽

Sputum Smear ◽

Study Group ◽

Serum Vitamin D

Aim: Relationship between Vitamin D deficiency and pulmonary tuberculosis. Methodology: Study duration: November 2020 to April 2021 Sampling technique: A case-control study Setting: Hayatabad Medical Complex, Peshawar It included 30 adult newly identified sputum-quality pulmonary tuberculosis patients and 30 age and sex matched healthy cases as controls. All cases had undergone a thorough medical examination and repeated laboratory tests, including vitamin D, calcium, and sputum for AFB and X-ray chest. Results: Majority were males (88%). In the Study group, BMI decreased significantly i.e. 19.0 vs 23.5. Serum vitamin D concentrations were significantly lower in the tuberculosis group i.e. 17.9ng/dl than in the control group 24.8ng/dl. Mean of serum albumin in the control group was 3.9 ng/dl whereas 2.9 ng/dl in the study group. Conclusion: Hypovitaminosis D was associated with more severe medical symptoms, increased sputum smear positivity and large lesions on chest radiographs in patients with pulmonary tuberculosis. Keywords: Vitamin D, Pulmonary Tuberculosis, Sputum

Download Full-text

Assessment of Polymorphism of the VDR Gene and Serum Vitamin D Values in Gestational Diabetes Mellitus

Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics ◽

10.1055/s-0039-1693678 ◽

2019 ◽

Vol 41 (07) ◽

pp. 425-431

Author(s):

Thais Walverde Siqueira ◽

Edward Araujo Júnior ◽

Rosiane Mattar ◽

Silvia Daher

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Serum Vitamin ◽

Vdr Gene ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Significant Difference

Objective To evaluate the relationship between vitamin D receptor (VDR) gene polymorphism (FokI [rs10735810]) and serum vitamin D concentration in gestational diabetes mellitus (GDM). Methods A prospective case-control study that recruited healthy pregnant women (control group) (n = 78) and women with GDM (GDM group) (n = 79), with no other comorbidities. Peripheral blood samples were collected in the 3rd trimester of gestation, and all of the pregnant women were followed-up until the end of the pregnancy and the postpartum period. Serum vitamin D concentrations were measured by high-performance liquid chromatography (HPLC). For genomic polymorphism analysis, the genomic DNA was extracted by the dodecyltrimethylammonium bromide/cetyltrimethylammonium bromide (DTAB/CTAB) method, and genotyping was performed by the polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP) technique, using the restriction enzyme FokI. The Student-t, Mann-Whitney, chi-squared, and Fischer exact tests were used for the analysis of the results. Results There was no significant difference between the pregnant women in the control and GDM groups regarding serum vitamin D levels (17.60 ± 8.89 ng/mL versus 23.60 ± 10.68 ng/mL; p = 0.1). Also, no significant difference was detected between the FokI genotypic frequency when the 2 groups were compared with each other (p = 0.41). Conclusion There was no association between the FokI polymorphism and the development of GDM, nor was there any change in serum vitamin D levels in patients with GDM.

Download Full-text