Effects of Vitamin D Deficiency on Incidence Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-analysis

Aims: To date, it is largely unknown how body mass index (BMI), gestational weight (GW), and stored vitamin D (25(OH)D) levels change in the vitamin D-supplemented gestational diabetes mellitus (GDM) patients, irrespective of their pre-pregnancy BMI. Therefore, to study this association, a prospective systematic review and meta-analysis protocol is proposed here. Methods: Primarily, different databases (PubMed, Embase and Scopus) will be searched (without any limitation to date or language) for randomised parallel-arm trials comparing GW, BMI and stored vitamin D level in the body among GDM patients who were supplemented and not supplemented with vitamin D, besides their conventional GDM care. The study selection process and the consecutive risk of bias assessment will adhere to the PRISMA 2009 flow chart and the Cochrane collaboration’s guideline, respectively. These interventions’ effect on the respective outcomes will be compared by meta-analysis (along with an assessment of the statistical heterogeneity) when comparable data will be available from at least 4 studies. Subgroup analysis and Egger’s meta-regression will follow if an adequate number of trials are available. Narrative reporting will be considered when a quantitative comparison is not feasible for any of the outcomes. Conclusion: The proposed review aims to compare the BMI, GW, and 25(OH)D levels in the blood between the vitamin D supplemented and not supplemented GDM patients.

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Association between Gene Polymorphisms of Vitamin D Receptor and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18010205 ◽

2020 ◽

Vol 18 (1) ◽

pp. 205

Author(s):

Qian Zhou ◽

Shiwu Wen ◽

Miao Liu ◽

Sulei Zhang ◽

Xin Jin ◽

...

Keyword(s):

Diabetes Mellitus ◽

Systematic Review ◽

Vitamin D ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Vitamin D Receptor ◽

Odds Ratio ◽

Meta Analysis ◽

Receptor Gene ◽

Vitamin D Receptor Gene

(1) Background: Studies on the association between Vitamin D receptor gene polymorphism and gestational diabetes mellitus have been inconsistent. The aim of this study was to summarize available evidence on the association between polymorphisms of Vitamin D receptor genes and susceptibility to gestational diabetes mellitus. (2) Methods: We searched databases of PubMed, Web of Science, Embase, China national knowledge infrastructure (CNKI), China science and technology journal database (VIP), and Wanfang Data for relevant articles. A systematic review and a meta-analysis were done to compare the distribution of Vitamin D receptor gene polymorphisms in gestational diabetes mellitus patients with those in controls using allelic, codominant, dominant, and recessive models. (3) Results: A total of eight eligible articles were included in the systematic review and of them, six articles were included in the meta-analysis. The vitamin D receptor gene rs7975232 polymorphism was associated with gestational diabetes mellitus under the allelic model (odds ratio = 1.28, 95% confidence interval 1.06–1.56), codominant model (CC vs. AA odds ratio = 1.97, 95% confidence interval 1.28–3.05), and recessive model (odds ratio = 1.83, 95% confidence interval 1.27–2.64) in the case of low heterogeneity. High heterogeneity existed in studies on the association of vitamin D receptor genes rs1544410, rs2228570, and rs731236 with gestational diabetes mellitus, and the most common sources of heterogeneity were the year of publication and matching. (4) Conclusion: Polymorphism of the vitamin D receptor gene rs7975232 may be associated with risk of developing gestational diabetes mellitus. Future studies should be designed to include standardized data collection and matching for important confounding factors such as body mass index, age, and race.

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Maternal vitamin D status and risk of gestational diabetes mellitus: A systematic review and meta-analysis of prospective cohort studies

Clinical Nutrition ◽

10.1016/j.clnu.2021.03.037 ◽

2021 ◽

Vol 40 (5) ◽

pp. 2576-2586

Author(s):

Alireza Milajerdi ◽

Fatemeh Abbasi ◽

Seyed Mohammad Mousavi ◽

Ahmad Esmaillzadeh

Keyword(s):

Diabetes Mellitus ◽

Systematic Review ◽

Vitamin D ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Meta Analysis ◽

Vitamin D Status ◽

Maternal Vitamin ◽

Prospective Cohort Studies ◽

Maternal Vitamin D Status

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A comparison of the risk of cesarean section in gestational diabetes mellitus patients supplemented antenatally with vitamin D containing supplements versus placebo: A systematic review and meta-analysis of double-blinded randomized controlled trials

Journal of the Turkish-German Gynecological Association ◽

10.4274/jtgga.galenos.2020.2019.0164 ◽

2020 ◽

Vol 21 (3) ◽

pp. 201-212

Author(s):

Sumanta Saha ◽

Sujata Saha

Keyword(s):

Diabetes Mellitus ◽

Systematic Review ◽

Vitamin D ◽

Gestational Diabetes ◽

Cesarean Section ◽

Gestational Diabetes Mellitus ◽

Meta Analysis ◽

Controlled Trials ◽

Randomized Controlled ◽

Double Blinded

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A systematic review and meta-analysis of the association between vitamin D deficiency and gestational diabetes mellitus

Biomedical Research and Therapy ◽

10.15419/bmrat.v5i3.422 ◽

2018 ◽

Vol 5 (3) ◽

pp. 2078-2095

Author(s):

Shahin Nargesi ◽

Ayub Ghorbani ◽

Ehsan Shirzadpour ◽

Mahmoud Mohamadpour ◽

Seyedeh Fatemeh Mousavi ◽

...

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Vitamin D Deficiency ◽

Meta Analysis ◽

Final Analysis ◽

Vitamin D Insufficiency ◽

Cochrane Library ◽

Pubmed Database

Introduction: Vitamin D deficiency has become quite prevalent and is known to cause a great many diseases. Numerous studies have investigated the association between vitamin D deficiency and gestational diabetes, and the results are somewhat contradictory. The present study deals with the relationship between the vitamin D deficiency and gestational diabetes. Methods: Two researchers made use of MeSH, Scopus, PubMed database, Science Direct, the Cochrane Library, the Web of Science, CINAHL, and Google Scholar search engines to identify qualified studies and articles carried out and published before August 2017 and reported the risk of gestational diabetes developing as a result of vitamin D deficiency. The association between the two conditions was measured using odds ratios (ORs) with 95% confidence intervals (CIs). Funnel plots, Egger’s, and Begg’s tests were also used to assess publication bias. All analysis was done by STATA (version 11.2). Results: Twenty-nine eligible studies with a total of 14,497 participants were included in the final analysis. Overall, maternal vitamin D insufficiency was significantly associated with a greater risk of gestational diabetes (OR = 1.15; 95% CI, 1.00-1.30; p<0.001). Serum 25OHD was significantly lower in participants with gestational diabetes mellitus than in those with natural glucose tolerance (−29.7 nmol/L, 95% CI, −36.6 to −22.8; p=0.000). Conclusion: According to the current meta-analysis results, vitamin D deficiency is correlated with the risk of gestational diabetes development.

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