scholarly journals Association of recurrent pregnancy loss and anticardiolipin antibodies: prevalence and prognosis of subsequent pregnancy in women with recurrent pregnancy loss

2017 ◽  
Vol 7 (1) ◽  
pp. 74
Author(s):  
Malathi Verabelly ◽  
Swapnarani Seedipally
Keyword(s):  
Pregnant Women ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Systemic Disease ◽  
Anticardiolipin Antibodies ◽  
Obstetric Complications ◽  
Control Group ◽  
Study Group ◽  
Study Objective ◽  
History Of

Background: Anticardiolipin antibodies (ACA) are found with increased prevalence in women with unexplained recurrent pregnancy loss but their impact on future pregnancy is not clearly known. Therefore, present study objective was to compare the prevalence of ACA in patients with recurrent pregnancy loss and normal healthy pregnant women.Methods: This prospective observational study from 100 pregnant women attending the outpatient department of Obstetrics and Gynaecology were studied. Study included 50 pregnant women with a history of three or more consecutive unexplained pregnancy loss as a study group and 50 pregnant women with two or more live children with no history of any previous pregnancy loss as a control group. Exclusion criteria included cases with any uterine anomaly, uterine structural abnormalities, induced abortions, infections, systemic disease, Rh-ve pregnancy, coagulation disorders and personal or family history of thrombosis.Results: Overall, 9 patients tested positive for ACA, of which one (2%) patient was from the control group and remaining 8 (16%) were from study group. Overall, 42 (84%) patients had negative test for ACA in the study group and 49 (98%) patients in the control group. The live birth rate among study group was only 34 (68%) whereas all 50 (100%) pregnant women in the control group.Conclusions: The findings described here in demonstrate that, ACA -positive patients are also the primary predictor of adverse pregnancy outcome and obstetric complications. Therefore, the role of early detection of ACA in all pregnant women is very important to prevent foetal outcomes and obstetric complications. 

scholarly journals Thyroid Autoimmunity is a Risk Factor for Recurrent Pregnancy Loss

2018 ◽  
Vol 30 (1) ◽  
pp. 49-55
Author(s):  
Sharmin Sultana ◽  
Mosammat Nargis Shamima ◽  
Sahela Jesmin ◽  
Nargis Zahan ◽  
Md Abu Zahid ◽  
...  
Keyword(s):  
Risk Factor ◽  
Pregnant Women ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Recurrent Miscarriage ◽  
Control Group ◽  
Genital Organ ◽  
Thyroid Antibodies ◽  
History Of ◽  
The Mean

This was a hospital based case control study. The study included patients attending in outdoor and indoor Department of Obstetrics and Gynaecology of Rajshahi Medical College, Hospital since July 2014 to June 2016. The aim of this study was to determine thyroid antibodies is a risk factor for recurrent pregnancy loss. Sixty seven pregnant or non pregnant women with history of recurrent miscarriage during 1st trimester were selected as case group and another sixty seven pregnant women who reached their 12 weeks uneventfully with no history of recurrent miscarriage were selected as control group. Patients with other cause of recurrent miscarriage such as metabolic or endocrinologic disorders, genital organ anomaly, uterine fibroid were excluded from the study. Thyroid function test and thyroid antibodies (FT4, TSH and TPO-Ab) were measured for the two groups. The result of this study showed that the percentage of positive TPO-Ab in target and control group is 67.16% and 5.95% respectively. The study observed that the mean serum concentrations of FT4 in the control subject was significantly higher than the mean of the target group (p-value <0.05). The TSH concentration was increased in miscarriage women with positive antibodies compared with the concentration of TSH in the control group with positive antibodies. The conclusions are that there is a deficiency in thyroid hormones or thyroid’s functional capacity is unable to meet the extra demands of pregnancy which may be one of the causes of recurrent miscarriage. Moreover positive thyroid antibodies pregnant women can reach term and have babies when the concentration of TSH is low during the first trimester, so the risk of miscarriage could be high in positive thyroid antibodies.TAJ 2017; 30(1): 49-55

scholarly journals Does recurrent pregnancy loss have an inflammatory background?

2021 ◽  
Vol 38 (4) ◽  
pp. 420-424
Author(s):  
Huri GÜVEY ◽  
Samettin ÇELİK ◽  
Canan SOYER ÇALIŞKAN ◽  
Burak YAŞAR ◽  
Bahadır YAZICIOĞLU ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Recurrent Miscarriage ◽  
Control Group ◽  
Study Group ◽  
Reactive Protein ◽  
Randomized Controlled Studies ◽  
Significant Difference ◽  
Living Children

Although several pathophysiological mechanisms are defined in etiology recurrent pregnancy loss, still causes of half of the cases haven’t revealed yet. It is reported that inflammatory processes take place in the etiology of the disease. In our study, we aimed to reveal the relationship between recurrent pregnancy loss with white blood cell count (WBC), C-reactive protein (CRP) and ferritin levels. We included our study 90 pregnant women having recurrent miscarriage history and 101 pregnant women without recurrent miscarriages, 191 patients in total. Maternal and gestational age, height, weight, body mass index (BMI), gravidity, parity, abortion and living children count and WBC, CRP and ferritin levels of these pregnant were evaluated retrospectively. According to outcomes, while the age (p = 0.01; p<0.05), gravidity (p = 0.00; p<0.01) and abortion counts (p = 0.004; p<0.01) of the study group were found significantly to be higher than that of the control group, weight measurement of them was significantly lower than that of the control group (p = 0.04; p <0.05). Height and BMI measurements, parity and living children counts of the groups showed no statistically significant difference (p>0.05). While WBC levels of the study group was found to be lower (p=0.045, p<0,05) than that of control group, there was no significant difference regarding ferritin and CRP levels (p> 0.05). In our study, WBC, CRP and ferritin parameters did not indicate the inflammatory background in recurrent pregnancy loss. We think that further prospective randomized controlled studies are required regarding these parameters.

scholarly journals Evaluation of factor VIII value in normal women and whom encountered recurrent pregnancy loss: is there any significant difference?

2020 ◽  
Vol 9 (3) ◽  
pp. 1034
Author(s):  
Douaa Al Rez ◽  
Hasan Naser Eldine ◽  
Marwan Alhalabi
Keyword(s):  
Factor Viii ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Fetal Loss ◽  
Control Group ◽  
Increased Risk ◽  
Significant Difference ◽  
History Of ◽  
Normal Women ◽  
High Level

Background: Recurrent pregnancy loss (RPL) is a serious problem on the women, it defined as two or more consecutive pregnancy losses before the fetus has reached birth. The aim of this study is to evaluate the association between the elevation in the factor VIII and RPL. Because women who have thrombophilia have increased risk of fetal loss in most studies.Methods: A total 72 women were recruited in this case control study. They divided into two groups: the RPL group included 41 women with a history of recurrent pregnancy loss and the control group included 31 healthy women, who had at least one successful pregnancy and none of them had a history of fetal loss or complicated pregnancy.Results: A majority of the patients of this study didn't have a high level of factor VIII, 9 of 41 (22%) patients of RPL group in comparison with 21 of 32 (65,6%) of control group, that suffer from the increase rate of FVIII, this means that factor VIII doesn't effect on RPL.Conclusions: The present study showed that the serum elevation in the factor VIII is not significantly associated with RPL.

The Association Between Sperm DNA Fragmentation and Idiopathic Early Recurrent Pregnancy Loss

KnE Medicine ◽  
2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Binarwan Halim
Keyword(s):  
Dna Fragmentation ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Control Group ◽  
Case Group ◽  
Sperm Dna Fragmentation ◽  
Male Factor ◽  
Sperm Dna ◽  
History Of ◽  
Group 5

<p><strong>Introduction</strong></p><p>Various etiologies of recurrent pregnancy loss (RPL) have been extensively studied, but more than half of them still remain unknown. Male factor may play a role in incidence of idiopathic early recurrent pregnancy loss. Sperm DNA fragmentation as one of sperm test for male factor can be measured and expressed by a DNA Fragmentation Index (DFI). The aim of the study is to evaluate the association between sperm DNA fragmentation and the incidence of idiopathic early recurrent pregnancy loss.</p><p><strong>Material &amp; Methods</strong></p><p>A prospective study was done by recruiting 40 cases of  male couple from patients with a history of idiopathic early recurrent pregnancy loss and 40 cases of control from normal fertile population from May 2010 to September 2011 in Halim Fertility Center. Sperm DNA fragmentation was detected by halosperm kit.</p><p><strong>Results</strong><br />Both of groups were comparable in terms of the age of male patients, body mass index, duration of infertility, history of miscarriage and sperm parameters. Sperm DFI in the case group was 34.12%. and in the control group was 16.02%. There was significantly higher sperm DFI in the case group than in the control group. Sperm DFI &lt;30 was increased in control group (95%) compared with case group (40%). Sperm DFI ≥30 was increased in case group (60%) compared with control group (5%). There was a significant association between sperm DFI ≥30 and idiopathic early recurrent pregnancy loss (p&lt;0,05).</p><p><strong>Conclusion</strong></p><p>There is an association between higher sperm DNA fragmentation and incidence of idiopathic early recurrent pregnancy loss.</p>

Pregnancy outcomes among patients with recurrent pregnancy loss and chromosomal aberration (CA) without PGD

2018 ◽  
Vol 46 (7) ◽  
pp. 764-770 ◽  
Author(s):  
Maor Kabessa ◽  
Avi Harlev ◽  
Michael Friger ◽  
Ruslan Sergienko ◽  
Baila Litwak ◽  
...  
Keyword(s):  
Live Birth ◽  
Pregnancy Outcomes ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Control Group ◽  
Study Group ◽  
Birth Rates ◽  
Live Birth Rates ◽  
Index Pregnancy ◽  
Significant Difference

Abstract Background: Recurrent pregnancy loss (RPL) is defined by two or more failed clinical pregnancies. Three to four percent of the couples with RPL have chromosomal aberrations (CA) in at least one partner. The parent’s structural chromosomal abnormalities may cause an unbalanced karyotype in the conceptus which could lead to implantation failure, early or late pregnancy loss, or delivery of a child with severe physical and/or mental disabilities. Objective: To compare live birth rates of couples with CA to couples with normal karyotypes and to investigate medical and obstetric characteristics and pregnancy outcomes of couples with CA and RPL who attend an RPL clinic at a tertiary hospital. Methods: A retrospective cohort study, including 349 patients with two or more consecutive pregnancy losses. The study group consisted of 52 patients with CA, and the control group consisted of 297 couples with normal karyotype. All patients were evaluated and treated in the RPL clinic at Soroka University Medical Center and had at least one subsequent spontaneous pregnancy. Results: The demographic and clinical characteristics were not found to be statistically different between the two groups. The group of carriers of CA had 28/52 (53.8%) live births in their index pregnancy vs. the normal 202/297 (68%) (P=0.067, CI 95%) in the control group. No statistically significant etiology was found between the study group and the control group. A statistically significant difference in live birth rates was found when comparing the total amount of pregnancies [index pregnancy (IP)+post index pregnancy (PIP)] between the study group and the control group (54.16% vs. 67.82%, respectively, P=0.0328). Conclusion: Patients with RPL and CA who have spontaneous pregnancies, have a good prognosis (63.4%) of a successful pregnancy with at least one of the pregnancies (index or post index) resulting in a live birth.

scholarly journals Association of increased platelet distribution width and red cell distribution width with recurrent pregnancy loss

2017 ◽  
Vol 6 (3) ◽  
pp. 1083
Author(s):  
Rajani Meena ◽  
Mohan Lal Meena ◽  
Priyanka Meena ◽  
Renu Meena
Keyword(s):  
Pregnant Women ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Platelet Distribution Width ◽  
Distribution Width ◽  
History Of ◽  
Mean Corpuscular Haemoglobin

Background: Recurrent pregnancy loss is defined as three or more consecutive pregnancy losses at or less than 20 weeks of gestation or with a fetal weight less than 500 grams. The aim was to compare platelet distribution width and red cell distribution width between pregnant women with a history of recurrent pregnancy loss and pregnant women without a history of pregnancy loss.Methods: This was a prospective study to the evaluation of 70 pregnant women with a history of recurrent pregnancy loss and 70 pregnant women without a history of pregnancy loss in the first trimester.Results: When compared pregnant women with a history of recurrent pregnancy loss and 70 pregnant women without a history of pregnancy loss, the pregnant women with a history of recurrent pregnancy loss had significantly higher platelet distribution width and red cell distribution width (p≤0.001 for both). There was no statistically significant difference between the two groups in terms of age, BMI, Hemoglobin, TLC, hematocrit, platelecrit, mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration (p>0.05).Conclusions: An increased platelet distribution width and red cell distribution width with recurrent pregnancy loss.

scholarly journals Gestation in patients with a combination of antiphospholipid and torch syndromes

2021 ◽  
Vol 6 (2) ◽  
pp. 41-50
Author(s):  
E. N. Kravchenko ◽  
A. A. Goncharova
Keyword(s):  
Pregnant Women ◽  
Medical Records ◽  
Pregnancy Loss ◽  
Preconception Care ◽  
First Trimester ◽  
Placental Insufficiency ◽  
Control Group ◽  
Fetal Hypoxia ◽  
History Of ◽  
Threatened Abortion

Aim. To study the features of gestation in women with a combination of antiphospholipid and TORCH syndromes in relation to preconception care.Materials and Methods. We analyzed 137 medical records of women with a past medical history of pregnancy loss and antiphospholipid syndrome (APS), focusing on the presence or absence of plasmapheresis in the preconception period, and further ranking the patients into 2 subgroups (with and without TORCH syndrome). As a control group, we included 28 pregnant women without both syndromes.Results. Gestation in women with combined APS and TORCH syndromes was accompanied by a 10-fold higher risk of threatened abortion in the first trimester and 3-fold higher risk of placental insufficiency as compared to those without both syndromes. Notably, the combination of the syndromes doubled the risk of placental insufficiency in comparison with APS alone. The lack of plasmapheresis in patients with APS and TORCH syndrome was associated with > 2-fold higher risk of threatened abortion. Further, in patients with APS and TORCH syndrome, lack of plasmapheresis increased the likelihood of developing fetal hypoxia by a factor of 2 and 3 in comparison with those diagnosed with APS alone or control patients.Conclusions. TORCH syndrome is a major risk factor of adverse outcome in pregnant women with APS. Inclusion of plasmapheresis into the preconception care in women with APS and TORCH syndrome significantly reduced the development of pregnancy complications. 

scholarly journals Biochemical Markers for Prediction of Pregnancy Outcome in Cases of Recurrent Pregnancy Loss

2021 ◽  
Vol 5 (1) ◽  
Keyword(s):  
Pregnant Women ◽  
Pregnancy Outcome ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
First Trimester ◽  
Serum Progesterone ◽  
Study Results ◽  
Routine Basis ◽  
History Of ◽  
Β Hcg

Objective: To predict pregnancy outcome by studying the relation between serum βHCG, progesterone and CA125 and the occurrence of miscarriage in the first trimester, in cases with history of recurrent pregnancy loss. Methods: Serum βHCG, progesterone and CA125 levels in fifty pregnant women with history of recurrent pregnancy loss were compared to 50 pregnant women with no history of abortion, and to another group of women (No=50) who failed to complete the 1st trimester of pregnancy during the study. Results: Serum B-hCG showed a sensitivity of 100%, a specificity of 50%, a PPV of 50% and a NPV of 100%. Serum progesterone showed a sensitivity of 24%, a specificity of 73%, a PPV of 55.07% and a NPV of 85.18%, while serum CA125 showed a sensitivity of 15.6%, a specificity of 58.59%, a PPV of 16.32% and a NPV of 57.42%. Conclusion: The value of CA125 in recurrent abortions is still unclear and cannot recommended on routine basis. On the other hand, β-HCG is highly sensitive as a single serum measurement for the prediction of pregnancy outcome.

scholarly journals Study of bad obstetric history cases attending tertiary care centre, Tirupati

2021 ◽  
Vol 8 (4) ◽  
pp. 535-540
Author(s):  
Gowthami B ◽  
Sowjanya Kumari J ◽  
Lakshmi Narayanamma V
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Tertiary Care ◽  
Mode Of Delivery ◽  
Control Group ◽  
Chronic Hypertension ◽  
Age Group ◽  
Obstetric History

To assess the obstetric and medical risk factors in patients with bad obstetric history (BOH) and outcome of pregnancy in case of BOH. A prospective cross-sectional study was conducted in Government maternity hospital, Tirupati for a period of 1 year from December 2017 to November 2018. All pregnant women who were fulfilling inclusion criteria of BOH, as study group and all possible variable were compared with control group, who got selected randomly from the rest of deliveries. And analysed the results in terms of sociodemographic factors, risk factors, pregnancy complications, mode of delivery, maternal and foetal outcome. Of 102 pregnant women in BOH, 76.5% were in age group between 21-30yrs, and 14.7% in age group &#62;30yrs. Primary Recurrent pregnancy loss (RPL) was 51% and that of secondary recurrent pregnancy loss was 49%.History of hypertensive disorders including preeclampsia, eclampsia and chronic hypertension, noted in 11.8% cases, which was higher than previous studies, indicating changing trends in incidence.In foetal complications IUGR (0% vs 9.8%, p=0.026) and IUFD (0% Vs 7.8%, p=0.05) were more in BOH group and statistically significant also. Even though the maternal complications were more in BOH group, there was no statistical significance (P=0.075).Among the various causes of RPL found in the present study, endocrine causes were seen in 12.7%, Anatomical causes were found in 11.8% and in about 63.7% cases no definite cause was found and aetiology was unexplained. Present study, supporting the change in definition of recurrent pregnancy loss from 3 consecutive losses to 2. So early evaluation and with appropriate interventions in most of couples outcomes were fruitful.

Impacts of Covid-19 Pandemic on the Early Trimester Pregnancies

2021 ◽  
Vol 15 (8) ◽  
pp. 2508-2511
Author(s):  
Fatima Khosa ◽  
Masooda Naeem ◽  
Zahra Sultan ◽  
Aesha Sadaf Rizwan ◽  
Shazia Jang Sher ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Pregnancy Loss ◽  
Ethical Review ◽  
Control Group ◽  
Trimester Pregnancy ◽  
Ethical Approval ◽  
History Of ◽  
Global Health Care ◽  
Keywords Pregnancy ◽  
The Mean

Background and Aim: The COVID-19 pandemic caused by severe acute respiratory syndrome (SAR-CoV-2) had severe consequences and complications on the global health care system. Recent medical studies have been focused on the effect of COVID-19 pandemic on pregnancies outcomes especially early pregnancies. The present study aimed to investigate the impacts of the COVID-19 pandemic early-trimester pregnancies. Materials and Methods: This retrospective study was carried out on 76 women who visited Obstetrics and Gynecology department for the first and second-trimester viability scan at Government Hospital, Samnabad Lahore from 1st January 2021 to 30th June 2021. Individuals of age between 19 years and 40 years with a diagnosis of spontaneous miscarriage were enrolled in this study. Ethical approval was taken from the respective hospital's ethical review committee. Patients with recurrent pregnancy loss, induced miscarriage, and other co-morbidities were excluded. All the demographic details were taken from the hospital medical record. All the patients underwent routine baseline tests to confirm the COVID-19 history and its impacts on the early trimester of pregnancy. The outcomes of early trimester pregnancy were viable pregnancy, miscarriage, pregnancy loss, and ectopic pregnancy were calculated in terms of frequency and percentage. SPSS version 20 was used for data analysis. Results: The overall mean age study group patients was 28.72± 3.63 years. The control group comprised 57 pregnant women with a gestational age of 5 weeks to 11 weeks, and the mean maternal age was 34.83±4.91 years. Out of total pregnant women, 31 (40.7%) were of age 19-25 years old, 29 (38.2%) had age 25 to 30 years, and 31 to 40 years were 16 (21.1%). Of the total 76 pregnant women, about 41 (54%) had a miscarriage with positive COVID-19 tests and 24 (31.6%) had spouses who had COVID-19 positive tests. History of both spouse and personal positive COVID tests were eleven patients (14.4%). The incidence of miscarriage among control group was 10 (17.5%). Conclusion: Our study found that the COVID-19 pandemic significantly affects the rate of pregnancy loss during the early trimester (first and second pregnancy). The maternal viremia or vertical transmission caused early trimester pregnancy loss and maternal infection during COVID-19. Keywords: Pregnancy, Miscarriage, COVID-19 Pandemic

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