scholarly journals First trimester uric acid level: a reliable marker for gestational diabetes mellitus

2019 ◽  
Vol 8 (6) ◽  
pp. 2358
Author(s):  
Suvarna Jyothi Ganta ◽  
Sunanda R. Kulkarni
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Serum Uric Acid ◽  
First Trimester ◽  
Family History Of Diabetes ◽  
Increased Risk ◽  
In Pregnancy

Background: The prevalence of diabetes mellitus (DM) is increasing worldwide and more in developing countries like India. The diabetic epidemic experienced in India can be due to strong genetic factors coupled with increasing urbanization, sedentary lifestyle, changes in the dietary patterns and increasing obesity. Indians are at an 11-fold increased risk of developing gestational glucose intolerance and hence universal screening is essential. Uric acid is a known marker of oxidative stress. Hyperuricemia in early pregnancy may be an indicator of the existing metabolic disturbance which can hinder the maternal physiological adaptations generally seen in pregnancy thus making the pregnant women more vulnerable to the development of gestational diabetes mellitus. The objective of this study was to investigate the association between elevated uric acid levels in the first trimester of pregnancy with gestational diabetes.Methods: This prospective observational study was conducted in Chinmaya mission hospital, Bangalore from June 2016 to March 2017 (10 months). Three hundred and twelve (312) pregnant women of gestational age less than 12 weeks who attended the OBG outpatient department within this time of period for regular antenatal check-up were enrolled in the study. Along with the other antenatal investigations serum uric acid levels were estimated before 12 weeks and also between 24-28 weeks. At 24-28 weeks screening for GDM was done by OGCT using 75 gms of glucose (IADPISG criteria). Other parameters like age, parity, BMI, family history of diabetes was noted and compared.Results: In our study, among the 312 pregnant women, 88 (28%) developed GDM. Of these 74 Women (84%) with GDM had uric acid levels above 3.5 mg/dl and 14 women (15.9%) with GDM had uric acid levels below 3.5 mg/dl. Women with higher BMI showed high uric acid levels.Conclusions: Elevated serum uric acid in the first trimester has a significant correlation with development of GDM. In present study; the cut-off level of maternal serum uric acid of 3.5 mg/dl in the first trimester appears to have a good sensitivity and specificity in identifying those patients who are most likely to develop GDM later in pregnancy.

scholarly journals Increased first trimester serum uric acid as a predictor of Gestational diabetes mellitus

2021 ◽  
Vol 8 (3) ◽  
pp. 292-295
Author(s):  
Ushadevi Gopalan ◽  
Irkm Sivasarupa ◽  
Sivankumar Kumarapillai
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Serum Uric Acid ◽  
First Trimester ◽  
The Body ◽  
The Mean ◽  
In Pregnancy

Women with raised uric acid in pregnancy are interlinked with more incidence of unfavourable outcomes in pregnancy such as gestational diabetes mellitus. The study aims at testing the hypothesis that elevated uric acid in first trimester of pregnancy is associated with subsequent development of gestational diabetes.: All pregnant women less than 12 weeks were included in this study after informed consent. Blood samples were collected for serum uric acid analysis and all these patients were followed up with oral glucose tolerance test at twenty-four to twenty-eight weeks of gestation.The mean age of pregnant women was 29.84 ± 4.94 years. The mean height and weight was 151.52 ± 7.49 cms and 50.60 ± 6.88 kg respectively. The body mass index of patients was 22.13 ± 3.31 kg/m.The mean gestational age of pregnant women was 11.14 ± 1.30 weeks. The mean uric acid level was 3.81 ± 1.24 mg/dl. In this study the p value was 0.018 using chi-square test which was significant. Hyperuricemia in first trimester is a reliable marker for the prediction of gestational diabetes mellitus in later pregnancy.

scholarly journals Correlation between first trimester uric acid level and subsequent development of gestational diabetes mellitus

2017 ◽  
Vol 6 (2) ◽  
pp. 606
Author(s):  
Amudha P. ◽  
Nithya D. ◽  
Pradeeba S. ◽  
Manochithra B.
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Subsequent Development ◽  
First Trimester

Background: The aim of the study was to correlate between first trimester uric acid level and its association with subsequent development of gestational diabetes mellitus.Methods: This is a prospective study conducted at Govt. Raja Mirasudar Hospital attached to Thanjavur Medical College, Thanjavur over a period of one year from September 2015. A total of one hundred and eighty seven ante natal women less than 14 weeks of gestational age who attended the outpatient antenatal department were included in this study. Serum uric acid estimation was done in women with <14 weeks of gestation and they were subsequently screened for GDM between 24 to 28 weeks by oral glucose tolerance test (OGTT) with 75 gms glucose according to IADPSG criteria.Results: In our study, among 178 antenatal pregnant women 13 with uric acid >3.6 mg/dl and 2 with serum uric acid <3.6 mg/dl developed GDM. This shows development of GDM increases with increase in uric acid concentration.Conclusions: Though our study results suggest that serum uric acid level estimation in first trimester can be used as a marker to predict GDM in pregnant women, large scale studies are required before it can be recommended as a routine first trimester screening test for prediction of gestational diabetes mellitus.

scholarly journals Predictive significance of first trimester serum uric acid as risk factor for the gestational diabetes mellitus.

2021 ◽  
Vol 28 (7) ◽  
pp. 967-972
Author(s):  
Anjum Rehman ◽  
◽  
Sadia Saeed ◽  
Syeda Fariha Hasny ◽  
Nathumal Maheshwari ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Serum Uric Acid ◽  
Fasting Blood Glucose ◽  
First Trimester ◽  
Gynecology And Obstetrics ◽  
Diagnostic Threshold

Objective: Determining the predictive significance of first trimester serum uric acid for the development of gestational diabetes mellitus (GDM) in pregnant women. Study Design: Case Control study. Setting: Department Gynecology and Obstetrics, Shaheed Muhtrama Benazir Bhutto Medical College Layari General Hospital Karachi. Period: March 2017 to December 2018. Material & Methods: Sample of 172 pregnant women in first trimester (<14 weeks gestation) were divided into; 72 controls and 72 cases through purposive sampling. Pregnant women with fasting blood glucose (FBG) ≥100 mg/dl were defined as GDM. FBG was estimated by hexokinase and uric acid by enzymatic method (uricase) using commercial colorimetric assay (Nikken Seal Co., Ltd, Japan). Data was analyzed on SPSS software 21.0 (IBM, Inc USA) at 95% CI. Results: Maternal age of control and cases was noted 30.23±1.47 and 30.14±1.41 years. Gestational age in controls was 9.80±2.23 weeks compared to 10.37±2.34 weeks in cases. Serum Uric acid in control was 3.19±0.49 mg/dl compared to 3.73±0.43 mg/dl in cases (P=0.0001). Logistic regression analysis model generated ROC curve shows excellent area under the curve (AUC) of 0.92 [95% CI (0.87-0.97)] with a diagnostic threshold of 3.91 mg/dl for uric acid. At this Uric acid threshold, the specificity and sensitivity was 96.4% and 69.7% respectively (P=0.0001). Conclusion: It is concluded first trimester serum uric acid may be used for predicting the future development of gestational diabetes mellitus.

scholarly journals Diabetes in Pregnancy and Risk of Antepartum Depression: A Systematic Review and Meta-Analysis of Cohort Studies

2020 ◽  
Vol 17 (11) ◽  
pp. 3767 ◽  
Author(s):  
Kai Wei Lee ◽  
Siew Mooi Ching ◽  
Navin Kumar Devaraj ◽  
Seng Choi Chong ◽  
Sook Yee Lim ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Cohort Studies ◽  
Pregnant Women ◽  
Meta Analysis ◽  
Diabetes In Pregnancy ◽  
Antepartum Depression ◽  
Increased Risk ◽  
In Pregnancy

Previous literature has reported that patients with diabetes in pregnancy (DIP) are at risk of developing antepartum depression but the results have been inconsistent in cohort studies. We conducted a systematic review and performed a meta-analysis to quantify the association between DIP and risk of antepartum depression in cohort studies. Medline, Cinahl, and PubMed databases were searched for studies investigating DIP involving pregnant women with pre-existing diabetes and gestational diabetes mellitus and their risk of antepartum depression that were published in journals from inception to 27 December 2019. We derived the summary estimates using a random-effects model and reported the findings as pooled relative risks (RR) and confidence interval (CI). Publication bias was assessed using a funnel plot and was quantified by Egger and Begg’s tests. Ten studies, involving 71,036 pregnant women were included in this meta-analysis. The pooled RR to develop antepartum depression was (RR = 1.430, 95% CI: 1.251–1.636) among women with gestational diabetes mellitus. Combining pregnant women with pre-existing diabetes mellitus and gestational diabetes mellitus, they had a significant increased risk of developing antepartum depression (RR = 1.431, 95% CI: 1.205–1.699) compared with those without it. In comparison, we found no association between pre-existing diabetes mellitus in pregnancy (RR = 1.300, 95% CI: 0.736–2.297) and the risk of developing antepartum depression. This study has a few limitations: first, different questionnaire and cut-off points were used in evaluation of depression across the studies. Second, there was a lack of data on history of depression prior to pregnancy, which lead to confounding bias that could not be solved by this meta-analysis. Third, data were dominated by studies in Western countries; this is due to the studies from Eastern countries failing to meet our inclusion criteria for statistical analysis. Women with gestational diabetes mellitus have an increased risk of developing antepartum depression compared to those without the disease. Therefore, more attention on the mental health status should be given on pregnant women diagnosed with pre-existing diabetes mellitus and gestational diabetes mellitus.

scholarly journals Association of first trimester serum uric acid levels gestational diabetes mellitus development

2016 ◽  
Vol 13 (2) ◽  
pp. 71-74 ◽  
Author(s):  
Seda Şahin Aker ◽  
Tuncay Yüce ◽  
Erkan Kalafat ◽  
Murat Seval ◽  
Feride Söylemez
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Serum Uric Acid ◽  
First Trimester

scholarly journals Vitamin D status and association with gestational diabetes mellitus in a pregnant cohort in Iceland

2021 ◽  
Author(s):  
Kristin S. Magnusdottir ◽  
Ellen A. Tryggvadottir ◽  
Ola K. Magnusdottir ◽  
Laufey Hrolfsdottir ◽  
Thorhallur I. Halldorsson ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
First Trimester ◽  
Vitamin D Status ◽  
Increased Risk ◽  
Vitamin D Levels ◽  
25Ohd Concentration

Background: Vitamin D deficiency has been associated with an increased risk of gestational diabetes mellitus (GDM), one of the most common pregnancy complications. The vitamin D status has never previously been studied in pregnant women in Iceland. Objective: The aim of this research study was to evaluate the vitamin D status of an Icelandic cohort of pregnant women and the association between the vitamin D status and the GDM incidence. Design: Subjects included pregnant women (n = 938) who attended their first ultrasound appointment, during gestational weeks 11–14, between October 2017 and March 2018. The use of supplements containing vitamin D over the previous 3 months, height, pre-pregnancy weight, and social status were assessed using a questionnaire, and blood samples were drawn for analyzing the serum 25‑hydroxyvitamin D (25OHD) concentration. Information regarding the incidence of GDM later in pregnancy was collected from medical records. Results: The mean ± standard deviation of the serum 25OHD (S-25OHD) concentration in this cohort was 63±24 nmol/L. The proportion of women with an S-25OHD concentration of ≥ 50 nmol/L (which is considered adequate) was 70%, whereas 25% had concentrations between 30 and 49.9 nmol/L (insufficient) and 5% had concentrations < 30 nmol/L (deficient). The majority of women (n = 766, 82%) used supplements containing vitamin D on a daily basis. A gradual decrease in the proportion of women diagnosed with GDM was reported with increasing S-25OHD concentrations, going from 17.8% in the group with S-25OHD concentrations < 30 nmol/L to 12.8% in the group with S-25OHD concentrations ≥75 nmol/L; however, the association was not significant (P for trend = 0.11). Conclusion: Approximately one-third of this cohort had S-25OHD concentrations below adequate levels (< 50 nmol/L) during the first trimester of pregnancy, which may suggest that necessary action must be taken to increase their vitamin D levels. No clear association was observed between the vitamin D status and GDM in this study.

scholarly journals Diagnosis of Gestational Diabetes Mellitus in Urban Harare, Zimbabwe

2018 ◽  
Vol 11 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Godwell Nhidza ◽  
Kudzaishe Mutsaka ◽  
Garikai Malunga ◽  
Danai Tavonga Zhou
Keyword(s):  
Diabetes Mellitus ◽  
Family History ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Diagnostic Criteria ◽  
Blood Sugar ◽  
Family History Of Diabetes ◽  
Increased Risk ◽  
History Of

Introduction:According to the WHO, Gestational Diabetes Mellitus (GDM) means glucose intolerance with onset during pregnancy. Unfortunately, women affected by GDM could suffer from Type 2 diabetes (T2DM) later while babies born to mothers with GDM are at increased risk of being too large for gestational age. This cross-sectional study screened GDM in women attending Parirenyatwa Antenatal Clinic in urban Harare, Zimbabwe using 2006 WHO diagnostic criteria.Methodology:Urine samples were collected from all consenting pregnant women. If urinalysis indicated glycosuria and if a woman reported clinical symptoms of GDM, random blood sugar analysis was subsequently carried out. Those suspected of having GDM due to elevated glucose (n=17) were screened with glucose load challenge the following day, after collecting the sample for fasting blood sugar. Family history of diabetes was self-reported.Results:Women (N=150), between 24 – 28 weeks of gestation who consented were recruited. Participants had mean age 27.2(3.5) years and about half were gradiva 1. All participants reported no maternal history of T2DM, but reported other family history of T2DM. Out of the 150 recruited and 17 tested by OGTT, 10 (6.7%) tested positive for GDM.Conclusion:Prevalence of GDM is lower than two similar African studies but similar to one Indian study. Of note is the fact that variations in reported prevalence, in populations from different studies could be due to different diagnostic criteria used. Results need further enquiry on larger group of pregnant women using latest 2013 WHO criteria.

86-LB: Elevated First-Trimester Neutrophil Count Is Associated with the Development of Gestational Diabetes Mellitus in Pregnant Women

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 86-LB
Author(s):  
TIANGE SUN ◽  
FANHUA MENG ◽  
RUI ZHANG ◽  
ZHIYAN YU ◽  
SHUFEI ZANG ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Neutrophil Count ◽  
First Trimester

scholarly journals Childhood maltreatment and inflammation among pregnant women with gestational diabetes mellitus: A pilot study

2017 ◽  
Vol 10 (3) ◽  
pp. 120-124 ◽  
Author(s):  
Margaret Bublitz ◽  
Suzanne De La Monte ◽  
Susan Martin ◽  
Lucia Larson ◽  
Ghada Bourjeily
Keyword(s):  
Diabetes Mellitus ◽  
Pilot Study ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Birth Outcomes ◽  
Childhood Maltreatment ◽  
Secondary Data ◽  
Past Research ◽  
Increased Risk

Background Women with childhood maltreatment histories are at increased risk for adverse birth outcomes. Mechanisms explaining this link are poorly understood. Past research is limited by sampling pregnant women at low risk for adverse maternal and neonatal outcomes. Methods This pilot study was a secondary data analysis of 24 women with gestational diabetes mellitus; 17% of the sample also reported a maltreatment history. Women provided a blood sample to measure inflammatory cytokines and insulin resistance, and saliva samples to measure diurnal cortisol. Birth outcomes for past and current pregnancies were recorded. Results Histories of maltreatment were associated with elevated interleukin-15 and a marginally greater incidence of preterm delivery in current and past pregnancies. Conclusions This pilot study was the first to demonstrate an association between childhood maltreatment history and inflammatory cytokine levels in pregnant women diagnosed with gestational diabetes mellitus.

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