scholarly journals Predictive significance of first trimester serum uric acid as risk factor for the gestational diabetes mellitus.

2021 ◽  
Vol 28 (7) ◽  
pp. 967-972
Author(s):  
Anjum Rehman ◽  
◽  
Sadia Saeed ◽  
Syeda Fariha Hasny ◽  
Nathumal Maheshwari ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Serum Uric Acid ◽  
Fasting Blood Glucose ◽  
First Trimester ◽  
Gynecology And Obstetrics ◽  
Diagnostic Threshold

Objective: Determining the predictive significance of first trimester serum uric acid for the development of gestational diabetes mellitus (GDM) in pregnant women. Study Design: Case Control study. Setting: Department Gynecology and Obstetrics, Shaheed Muhtrama Benazir Bhutto Medical College Layari General Hospital Karachi. Period: March 2017 to December 2018. Material & Methods: Sample of 172 pregnant women in first trimester (<14 weeks gestation) were divided into; 72 controls and 72 cases through purposive sampling. Pregnant women with fasting blood glucose (FBG) ≥100 mg/dl were defined as GDM. FBG was estimated by hexokinase and uric acid by enzymatic method (uricase) using commercial colorimetric assay (Nikken Seal Co., Ltd, Japan). Data was analyzed on SPSS software 21.0 (IBM, Inc USA) at 95% CI. Results: Maternal age of control and cases was noted 30.23±1.47 and 30.14±1.41 years. Gestational age in controls was 9.80±2.23 weeks compared to 10.37±2.34 weeks in cases. Serum Uric acid in control was 3.19±0.49 mg/dl compared to 3.73±0.43 mg/dl in cases (P=0.0001). Logistic regression analysis model generated ROC curve shows excellent area under the curve (AUC) of 0.92 [95% CI (0.87-0.97)] with a diagnostic threshold of 3.91 mg/dl for uric acid. At this Uric acid threshold, the specificity and sensitivity was 96.4% and 69.7% respectively (P=0.0001). Conclusion: It is concluded first trimester serum uric acid may be used for predicting the future development of gestational diabetes mellitus.

scholarly journals Correlation between first trimester uric acid level and subsequent development of gestational diabetes mellitus

2017 ◽  
Vol 6 (2) ◽  
pp. 606
Author(s):  
Amudha P. ◽  
Nithya D. ◽  
Pradeeba S. ◽  
Manochithra B.
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Subsequent Development ◽  
First Trimester

Background: The aim of the study was to correlate between first trimester uric acid level and its association with subsequent development of gestational diabetes mellitus.Methods: This is a prospective study conducted at Govt. Raja Mirasudar Hospital attached to Thanjavur Medical College, Thanjavur over a period of one year from September 2015. A total of one hundred and eighty seven ante natal women less than 14 weeks of gestational age who attended the outpatient antenatal department were included in this study. Serum uric acid estimation was done in women with <14 weeks of gestation and they were subsequently screened for GDM between 24 to 28 weeks by oral glucose tolerance test (OGTT) with 75 gms glucose according to IADPSG criteria.Results: In our study, among 178 antenatal pregnant women 13 with uric acid >3.6 mg/dl and 2 with serum uric acid <3.6 mg/dl developed GDM. This shows development of GDM increases with increase in uric acid concentration.Conclusions: Though our study results suggest that serum uric acid level estimation in first trimester can be used as a marker to predict GDM in pregnant women, large scale studies are required before it can be recommended as a routine first trimester screening test for prediction of gestational diabetes mellitus.

scholarly journals First trimester uric acid level: a reliable marker for gestational diabetes mellitus

2019 ◽  
Vol 8 (6) ◽  
pp. 2358
Author(s):  
Suvarna Jyothi Ganta ◽  
Sunanda R. Kulkarni
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Serum Uric Acid ◽  
First Trimester ◽  
Family History Of Diabetes ◽  
Increased Risk ◽  
In Pregnancy

Background: The prevalence of diabetes mellitus (DM) is increasing worldwide and more in developing countries like India. The diabetic epidemic experienced in India can be due to strong genetic factors coupled with increasing urbanization, sedentary lifestyle, changes in the dietary patterns and increasing obesity. Indians are at an 11-fold increased risk of developing gestational glucose intolerance and hence universal screening is essential. Uric acid is a known marker of oxidative stress. Hyperuricemia in early pregnancy may be an indicator of the existing metabolic disturbance which can hinder the maternal physiological adaptations generally seen in pregnancy thus making the pregnant women more vulnerable to the development of gestational diabetes mellitus. The objective of this study was to investigate the association between elevated uric acid levels in the first trimester of pregnancy with gestational diabetes.Methods: This prospective observational study was conducted in Chinmaya mission hospital, Bangalore from June 2016 to March 2017 (10 months). Three hundred and twelve (312) pregnant women of gestational age less than 12 weeks who attended the OBG outpatient department within this time of period for regular antenatal check-up were enrolled in the study. Along with the other antenatal investigations serum uric acid levels were estimated before 12 weeks and also between 24-28 weeks. At 24-28 weeks screening for GDM was done by OGCT using 75 gms of glucose (IADPISG criteria). Other parameters like age, parity, BMI, family history of diabetes was noted and compared.Results: In our study, among the 312 pregnant women, 88 (28%) developed GDM. Of these 74 Women (84%) with GDM had uric acid levels above 3.5 mg/dl and 14 women (15.9%) with GDM had uric acid levels below 3.5 mg/dl. Women with higher BMI showed high uric acid levels.Conclusions: Elevated serum uric acid in the first trimester has a significant correlation with development of GDM. In present study; the cut-off level of maternal serum uric acid of 3.5 mg/dl in the first trimester appears to have a good sensitivity and specificity in identifying those patients who are most likely to develop GDM later in pregnancy.

scholarly journals Increased first trimester serum uric acid as a predictor of Gestational diabetes mellitus

2021 ◽  
Vol 8 (3) ◽  
pp. 292-295
Author(s):  
Ushadevi Gopalan ◽  
Irkm Sivasarupa ◽  
Sivankumar Kumarapillai
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Serum Uric Acid ◽  
First Trimester ◽  
The Body ◽  
The Mean ◽  
In Pregnancy

Women with raised uric acid in pregnancy are interlinked with more incidence of unfavourable outcomes in pregnancy such as gestational diabetes mellitus. The study aims at testing the hypothesis that elevated uric acid in first trimester of pregnancy is associated with subsequent development of gestational diabetes.: All pregnant women less than 12 weeks were included in this study after informed consent. Blood samples were collected for serum uric acid analysis and all these patients were followed up with oral glucose tolerance test at twenty-four to twenty-eight weeks of gestation.The mean age of pregnant women was 29.84 ± 4.94 years. The mean height and weight was 151.52 ± 7.49 cms and 50.60 ± 6.88 kg respectively. The body mass index of patients was 22.13 ± 3.31 kg/m.The mean gestational age of pregnant women was 11.14 ± 1.30 weeks. The mean uric acid level was 3.81 ± 1.24 mg/dl. In this study the p value was 0.018 using chi-square test which was significant. Hyperuricemia in first trimester is a reliable marker for the prediction of gestational diabetes mellitus in later pregnancy.

scholarly journals The joint prediction model of pBMI and eFBG in predicting gestational diabetes mellitus

2019 ◽  
Vol 48 (4) ◽  
pp. 030006051988919
Author(s):  
Ying Pan ◽  
Ji Hu ◽  
Shao Zhong
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Roc Curve ◽  
Predictive Value ◽  
Fasting Blood Glucose ◽  
First Trimester ◽  
Credibility Interval ◽  
Roc Curve Analysis

Objective To explore the predictive value of prepregnancy body mass index (pBMI) and early gestational fasting blood glucose (eFBG) in gestational diabetes mellitus (GDM). Methods This case–control study enrolled pregnant women at 6 to 16 weeks of gestation. The pBMI, eFBG and glycosylated haemoglobin (HbA1c) was recorded in the first trimester of pregnancy. Receiver-operating characteristic (ROC) curve analysis was used to measure the efficacy of factors that predict GDM. Results A total of 2119 pregnant women were enrolled in this study. Of these, 386 were diagnosed with GDM and 1733 did not have GDM. The age (odds ratio [OR] 1.16; 95% confidence interval [CI] 1.13, 1.20), pBMI (OR 1.12; 95% CI 1.07, 1.17) and eFBG (OR 5.37; 95% CI 3.93, 7.34) were independent risk factors for GDM occurrence. The areas under the ROC curve of eFBG, pBMI and eFBG + pBMI were 0.68 (95% credibility interval 0.65, 0.71), 0.66 (95% credibility interval 0.63, 0.69) and 0.71 (95% credibility interval 0.69, 0.74), respectively. The area under the curve of eFBG + pBMI was significantly higher than that of eFBG or pBMI alone. Conclusion The combination of eFBG and pBMI had a high predictive value for GDM.

scholarly journals Association of first trimester serum uric acid levels gestational diabetes mellitus development

2016 ◽  
Vol 13 (2) ◽  
pp. 71-74 ◽  
Author(s):  
Seda Şahin Aker ◽  
Tuncay Yüce ◽  
Erkan Kalafat ◽  
Murat Seval ◽  
Feride Söylemez
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Serum Uric Acid ◽  
First Trimester

86-LB: Elevated First-Trimester Neutrophil Count Is Associated with the Development of Gestational Diabetes Mellitus in Pregnant Women

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 86-LB
Author(s):  
TIANGE SUN ◽  
FANHUA MENG ◽  
RUI ZHANG ◽  
ZHIYAN YU ◽  
SHUFEI ZANG ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Neutrophil Count ◽  
First Trimester

scholarly journals Leptin, resistin and visfatin as useful predictors of gestational diabetes mellitus

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Ahmed Tijani Bawah ◽  
Mohammed Mustapha Seini ◽  
Albert Abaka-Yawason ◽  
Huseini Alidu ◽  
Salifu Nanga
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Operating Characteristic ◽  
Case Control Study ◽  
First Trimester ◽  
Anthropometric Parameters ◽  
Receiver Operating Characteristic Curves ◽  
Control Study

Abstract Background Lipids and adipokines including leptin, resistin and visfatin play various roles in the pathophysiology of Gestational Diabetes Mellitus (GDM). This study was aimed at determining whether serum leptin, resistin and visfatin are significantly altered during the first trimester of pregnancies that subsequently develop GDM and whether such changes are useful in predicting the disease. Methods This was a case-case control study which compared first trimester biochemical and anthropometric parameters in 70 pregnant women who subsequently developed GDM and 70 pregnant women without GDM at the Volta Regional Hospital, Ho, Ghana. Lipid profile and some selected adipokines were analyzed and first trimester body mass index (BMI) was determined. Results There were significant differences (p < 0.05) in leptin, resistin, and visfatin as well as significant dyslipidemia among those with GDM compared to those without GDM. Furthermore, the area under the Receiver Operating Characteristic Curves (AUCs) for leptin, resistin and visfatin were; 0.812, 0.836 and 0.799 respectively. Increased first trimester leptin (OR = 1.166; CI = 1.104–1.233; p < 0.0001), resistin (p < 0.0001) and visfatin (p < 0.0001) were associated with GDM. Conclusion Hyperleptinemia, hyperesistinemia and hypervisfatinemia precede GDM and can serve as good predictive indices for gestational diabetes mellitus.

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