scholarly journals Effectiveness of Cabergoline therapy in hyperprolactinemic infertility

2019 ◽  
Vol 8 (6) ◽  
pp. 2389
Author(s):  
Devdatt Laxman Pitale
Keyword(s):  
Adverse Effects ◽  
Luteal Phase ◽  
Cost Effective ◽  
Serum Prolactin ◽  
Menstrual Irregularity ◽  
Exclusion Criteria ◽  
Endocrine Activity ◽  
Ovulatory Dysfunction ◽  
Irregular Menses ◽  
Luteal Phase Defect

Background: Hyperprolactinemia may be associated with ovulatory dysfunction and resultant subfertility. Hyperprolactinemia affects the pulsatile release of GnRH, which in turn impairs the secretion of FSH and LH. It may also affect the endocrine activity of ovarian follicles, resulting into luteal phase defect and ovulatory dysfunction. Hyperprolactinemia may be associated with infertility in up to one-third of women undergoing infertility workup. Women with hyperprolactinemia are generally treated with dopamine receptor agonists to reduce serum prolactin levels and regularisation of menses. The aim of this study was to study the effectiveness of cabergoline therapy in hyperprolactinaemic infertility.Methods: This prospective study was performed from June 2017 to July 2018 in women with Hyperprolactinemic infertility attending the infertility clinic at INHS Patanjali. In this study, 20 women with hyperprolactinemic infertility who satisfied the inclusion and exclusion criteria were started on four week cabergoline therapy. The effectiveness of therapy was evaluated on the basis of normalization of prolactin levels, regularization of menses, reduction in galactorrhea, successful conception and adverse effects if any.Results: The women on Cabergoline therapy showed marked improvement in menstrual irregularity, near normal prolactin levels and reduced galactorrhea. After the four week Cabergoline therapy the frequency of galactorrhea and irregular menses was reduced in 8 (80%) and 14 (93.3) per cent, of women respectively. Successful conception was achieved in 17 (85%) women after regularization of menses with no any major adverse effects.Conclusions: This study shows the effectiveness of cabergoline therapy both on lowering the serum prolactin levels and successful Conception with no any major adverse effects. Cabergoline therapy is a cost effective and safe option in hyperprolactinaemic infertility.

scholarly journals Management of Luteal Phase Defect in Adolescent Girls

2012 ◽  
Vol 4 (1) ◽  
pp. 10-11 ◽  
Author(s):  
Indranil Dutta ◽  
Dilip Kumar Dutta
Keyword(s):  
Menstrual Cycle ◽  
South Asian ◽  
Adolescent Girls ◽  
Study Design ◽  
Luteal Phase ◽  
Adolescent Girl ◽  
West Bengal ◽  
Endometrial Thickness ◽  
Menstrual Irregularity ◽  
Luteal Phase Defect

ABSTRACT Objective To find out the effect of dydrogesterone drug on menstral cycle of adolescent girl. Study design A total of 50 adolescent girl (16-19 years) who were suffering from irregular menstruation were recruited for this study from April 2008 to February 2009, at JNM Hospital, Kalyani, West Bengal, India. Results Menstrul cycle was found to be regular within 6 months of treatment along with the reduction of endometrial thickness. Conclusion Dydrogesterone was found to be safest drug to regularize menstrual cycle of adolescent girl suffering from menstrual irregularity due to luteal phase defect. How to cite this article Dutta DK, Dutta I. Management of Luteal Phase Defect in Adolescent Girls. J South Asian Feder Obst Gynae 2012;4(1):10-11.

Luteal Phase Defect

2014 ◽  
pp. 155-155
Author(s):  
Sankalp Singh ◽  
Swati Singh ◽  
CM Ashraf
Keyword(s):  
Luteal Phase ◽  
Luteal Phase Defect

Pleural Effusions: Pathophysiology and Management

1994 ◽  
Vol 28 (7-8) ◽  
pp. 894-903 ◽  
Author(s):  
Carlota O. Andrews ◽  
Mary Lea Gora
Keyword(s):  
Adverse Effects ◽  
English Language ◽  
Treatment Options ◽  
Cost Effective ◽  
Underlying Disease ◽  
Pleural Space ◽  
Pleural Effusions ◽  
Medline Search ◽  
Sclerosing Agents ◽  
Study Selection

OBJECTIVE: To review the pathophysiology and management of pleural effusions, including available agents for pleural sclerosis. DATA SOURCES: A MEDLINE search (1966 to present) was performed that included clinical studies in the English language involving the pathophysiology and management of pleural effusions; references used in those articles were screened for additional published information. STUDY SELECTION: All clinical trials were considered for potential inclusion in the review. DATA SYNTHESIS: Pleural effusion is an accumulation of fluid in the pleural space that results when homeostatic forces that control the flow into and out of the area are disrupted. The management of transudative pleural effusions is primarily directed at treatment of the underlying disease. There are several treatment options for pleural effusions, including chemical pleurodesis. Many of the trials that examine the use of talc, bleomycin, and doxycycline have poorly described study designs and end points, with inconsistent evaluation of patients. Each agent is considered to be generally effective and safe, with fever and pain as the most frequently reported adverse effects. The use of talc requires sterilization, and many clinicians use general anesthesia with instillation, which increases the risk associated with the procedure. Bleomycin is generally safe; however, it should not be used in doses exceeding 40 mg/m2. Only uncontrolled trials support the use of doxycycline; however, it provides an effective, safe, and relatively inexpensive alternative. CONCLUSIONS: Pleural effusions are defined as an accumulation of fluid in the pleural space. Treatment is generally palliative. Intrapleural administration of talc, bleomycin, and doxycycline are effective sclerosing agents for treatment of recurrent, symptomatic pleural effusions. Although the most cost-effective agent has not been determined, doxycycline is an inexpensive alternative to bleomycin, and may have fewer adverse effects than talc.

Effects of ascorbic acid supplementation on serum progesterone levels in patients with a luteal phase defect

2003 ◽  
Vol 80 (2) ◽  
pp. 459-461 ◽  
Author(s):  
Hirofumi Henmi ◽  
Toshiaki Endo ◽  
Yoshimitsu Kitajima ◽  
Kengo Manase ◽  
Hiroshi Hata ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Luteal Phase ◽  
Serum Progesterone ◽  
Acid Supplementation ◽  
Luteal Phase Defect ◽  
Ascorbic Acid Supplementation

scholarly journals Management of erythema and skin preservation; advice for patients receiving radical radiotherapy to the breast: a systematic literature review

2011 ◽  
Vol 11 (1) ◽  
pp. 44-54 ◽  
Author(s):  
K. Butcher ◽  
K. Williamson
Keyword(s):  
Relevant Literature ◽  
Cost Effective ◽  
Radical Radiotherapy ◽  
Exclusion Criteria ◽  
Hand Search ◽  
Radiation Induced ◽  
Randomised Controlled ◽  
Double Blinded ◽  
Larger Sample ◽  
Review Criteria

AbstractObjective: To systematically review and critically appraise all evidence on skin care advice and products tailored for patients receiving radical radiotherapy for breast cancer and to determine an evidence-based conclusion regarding the most effective products.Data Resources and Review Methods: Major healthcare databases were searched with additional efforts made to hand-search current journals. All relevant literature fulfilling the inclusion and exclusion criteria was subjected to quality assurance checks. Those that passed underwent a more rigorous appraisal and were included in the review.Results: Ten studies were identified as fulfilling the review criteria with regards to aims and quality. All were randomised controlled trials; three were double-blinded, three were single-blinded, the remaining were not blinded. Two addressed washing regimes, two addressed deodorant use, whilst the six remaining studies investigated creams, gels or dressings.Conclusions: The results suggest that there is a place for creams in the management and delay of radiation-induced skin toxicities; however, research fails to highlight one product which has a demonstrable benefit over others whilst still being cost effective and free from adverse effects. Patients should not be discouraged from washing with water or mild soaps and results suggest that the restriction of aluminium-free deodorant during treatment is unnecessary; however, more research in this area is needed with larger sample sizes.

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