scholarly journals Maternal and perinatal outcomes in women with first trimester vaginal bleeding

2019 ◽  
Vol 8 (11) ◽  
pp. 4320
Author(s):  
K. Suganya ◽  
Latha Maheswari Subbarayan
Keyword(s):  
Pregnant Women ◽  
Vaginal Bleeding ◽  
Case Control Study ◽  
Preterm Labour ◽  
Perinatal Outcomes ◽  
First Trimester ◽  
Case Control ◽  
Second Trimester ◽  
Trimester Abortion ◽  
Control Study

Background: First trimester bleeding is one of the common complications during pregnancy which affects almost 16-25% of all pregnancies. To evaluate and ascertain the adverse maternal and perinatal outcomes in pregnant women presenting with first trimester vaginal bleeding.Methods: Prospective case-control study. A case control study involving 60 pregnant women with vaginal bleeding in the first 13 weeks + 6 days of gestational age with 60 matched controls. The study period was from March 2015 to March 2016 and conducted at PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu.Results: The complications seen in the study group were: first trimester abortion (16.7%), second trimester abortion (6.7%), preterm labour (25%), abruption (6.7%), neonatal intensive care admission (25%), ectopic (6.7%), IUGR (10%), IUD (1.7%) and PROM (8.3%). When compared with the parity matched controls there was statistically significant increase in first and second trimester abortions, preterm labour, abruption, NICU admission and ectopic pregnancy whereas there was no significant difference between the two groups with regard to intrauterine growth restriction (IUGR) and intrauterine death (IUD).Conclusions: Women with first trimester vaginal bleeding had several adverse outcomes in both the mother and the fetus, and it is very important to explain about the possibility of these outcomes and ensure proper follow up with close antenatal surveillance.

scholarly journals Determinants of Anemia Among Pregnant Women Attending Antenatal Care in Bale-Robe Town Health Facilities, Bale zone, Southeast Ethiopia: A Case-Control Study

2021 ◽  
Author(s):  
Mohammed Hasen Badeso ◽  
Falaho Sani Kalili ◽  
Mohammed Seid Abdulle
Keyword(s):  
Antenatal Care ◽  
Dietary Intake ◽  
Pregnant Women ◽  
Case Control Study ◽  
Case Control ◽  
Health Facilities ◽  
Menstrual Bleeding ◽  
Second Trimester ◽  
Southeast Ethiopia ◽  
Control Study

Abstract IntroductionIn Ethiopia, the prevalence of anemia in pregnant women differs geographically and ranged from 15.8–56.8%. The objective of this study is to identify the determinants of anemia among pregnant women attending antenatal care in health facilities of Bale-Robe Town, Southeast Ethiopia.MethodsA facility-based case-control study was conducted in Bale-Robe hospital and Baha-biftu health center in Bale-Robe, Southeast Ethiopia. A total of 282 pregnant women participated in the study (141 cases and 141 controls). Cases were pregnant women with altitude-adjusted hemoglobin value < 11.0 g/dl at the first and third trimesters, and < 10.5 g/dl at the second trimester. Controls were pregnant women with hemoglobin value ≥ 11.0 g/dl at first and third trimesters and ≥ 10.5 g/dl at the second trimester. A structured and pretested questionnaire was used to collect data. A multivariable logistic regression analysis was applied to assess the determinants of anemia. Determinants were categorized as sociodemographic and economic, obstetric and medical, and dietary intake and behavioral.ResultsHousewife occupation (AOR=2.1, 95% CI=1.12-3.92), prolonged menstrual bleeding (AOR=2.33, 95% CI=1.38-3.92) and undernutrition (AOR=4.03, 95% CI=1.38-11.83) were factors significantly associated with anemia in pregnant women.ConclusionHousewife occupation, prolonged menstrual bleeding, and malnutrition were the determinants of anemia in pregnant women. Hence, anemia prevention and control strategy in pregnant women should include adequate dietary intake, and strengthening nutritional counseling for pregnant women during antenatal care is also required by the health care provider.

First-trimester placental function in levothyroxine-using pregnant women: a case-control study

2019 ◽  
Vol 36 (3) ◽  
pp. 233-237
Author(s):  
Gökhan Tosun ◽  
Semir Kose ◽  
Banu İşbilen Başok ◽  
Sabahattin Altunyurt
Keyword(s):  
Pregnant Women ◽  
Case Control Study ◽  
First Trimester ◽  
Case Control ◽  
Placental Function ◽  
Control Study

scholarly journals FGF21 Serum Levels in the Early Second Trimester Are Positively Correlated With the Risk of Subsequent Gestational Diabetes Mellitus: A Propensity-Matched Nested Case-Control Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Zhiheng Wang ◽  
Min Yuan ◽  
Chengjie Xu ◽  
Yang Zhang ◽  
Chunmei Ying ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Case Control Study ◽  
Case Control ◽  
Fibroblast Growth Factor 21 ◽  
Second Trimester ◽  
Nested Case Control ◽  
Control Study

BackgroundAs an important endocrine hormone regulating glucose metabolism, fibroblast growth factor 21 (FGF21) is increased in individuals with gestational diabetes mellitus (GDM) after 24 gestational weeks. However, it is unknown whether the increase in FGF21 precedes the diagnosis of GDM.MethodsIn this nested case-control study, 133 pregnant women with GDM and 133 pregnant women with normal glucose tolerance (NGT) were identified through propensity score matching, and serum FGF21 levels were measured at 14 to 21 gestational weeks, before GDM is routinely identified. The differences in FGF21 levels were compared. The association between FGF21 and the occurrence of GDM was evaluated using logistic regression models with adjustment for confounders.ResultsThe serum FGF21 levels of the GDM group at 14 to 21 gestational weeks were significantly higher than those of the NGT group overall (P &lt; 0.001), with similar results observed between the corresponding BMI subgroups (P &lt; 0.05). The 2nd (OR 1.224, 95% CI 0.603–2.485), 3rd (OR 2.478, 1.229–5.000), and 4th (OR 3.419, 95% CI 1.626–7.188) FGF21 quartiles were associated with greater odds of GDM occurrence than the 1st quartile after multivariable adjustments.ConclusionsThe serum FGF21 levels in GDM groups increased in the early second trimester, regardless of whether participants were stratified according to BMI. After adjusting for confounding factors, the FGF21 levels in the highest quartile were associated with more than three times higher probability of the diagnosis of GDM in the pregnancy as compared to levels in the first quartile.

Investigation on the ability of first trimester glycodelin and angiopoietin-2 to predict small-for-gestational age pregnancies at delivery

2016 ◽  
Vol 0 (0) ◽  
Author(s):  
Young Bae Hansen ◽  
Vibeke Myrhøj ◽  
Finn Stener Jørgensen ◽  
Steen Sørensen
Keyword(s):  
Pregnant Women ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
False Positive ◽  
Case Control Study ◽  
First Trimester ◽  
Case Control ◽  
Detection Rates ◽  
Angiopoietin 2 ◽  
Control Study

AbstractThe aim was to investigate whether first trimester glycodelin and angiopoietin-2 can predict small-for-gestational age (SGA) at delivery, individually or in combination.In this case-control study we measured glycodelin and angiopoietin-2 on serum from 170 singleton pregnant women delivering SGA neonates and 985 singleton pregnant women delivering normal-weighted neonates. All values were converted to multiples of the medians (MoM).Pregnant women delivering SGA neonates had lower first trimester glycodelin and angiopoietin-2 MoM values [median (interquartile range)] compared with pregnant women delivering normal-weighted neonates for glycodelin: 0.86 (0.58–1.24) vs. 1.03 (0.74–1.45), p<0.001, and for angiopoietin-2: 0.89 (0.69–1.19) vs. 1.01 (0.78–1.31), p<0.001. The prediction performances of the biomarkers showed that the areas under the curve (AUC) were 0.59 (glycodelin), 0.58 (angiopoietin-2), and 0.60 (glycodelin and angiopoietin-2).We demonstrated that first trimester glycodelin and angiopoietin-2 were associated with SGA, but they were, individually and in combination, poor predictors of SGA at delivery. The AUCs were low which indicate low detection rates and high false positive rates.

scholarly journals Serum Ferritin Level in Preterm Labour

1970 ◽  
Vol 24 (1) ◽  
pp. 14-17
Author(s):  
Ayesha Siddika ◽  
Begum Nasrin ◽  
Shayela Shamim ◽  
Nurjahan Begum ◽  
N Nahar ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Case Control Study ◽  
Preterm Labour ◽  
Ferritin Level ◽  
Case Control ◽  
The Difference ◽  
Term Labour ◽  
Control Study

Objective: The aim of this study was to investigate causal association of serum ferritin with pre-term labour. Materials and Methods: This is a case-control study done on one hundred and twenty women from July 2005 to June 2007 in the department of obstetrics and gynecology of Bangabandhu Sheikh Mujib Medical University (BSMMU) and Mother and Child Health Training Institute (MCHTI), Azimpur, Dhaka. Cases (n=60) were singleton pregnant women starting preterm labour within 28-36 weeks of pregnancy and control (n=60) were singleton pregnant women of >37 weeks of gestation who were in lalour. In this case-control study pre-term labour patients were compared with controls regarding their serum ferritin level. Result: Mean ±SD serum ferritin level of control and in pre-term labour group of women were 37.01±26.84 μg/L was 210.37±67.20 μg/L respectively. The difference between two groups was statistically highly significant (<0.001) Key words: Preterm lalour; serum ferritin DOI: 10.3329/bjog.v24i1.6321 Bangladesh J Obstet Gynaecol, 2009; Vol. 24(1) : 14-17

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