First-trimester placental function in levothyroxine-using pregnant women: a case-control study

Background: First trimester bleeding is one of the common complications during pregnancy which affects almost 16-25% of all pregnancies. To evaluate and ascertain the adverse maternal and perinatal outcomes in pregnant women presenting with first trimester vaginal bleeding.Methods: Prospective case-control study. A case control study involving 60 pregnant women with vaginal bleeding in the first 13 weeks + 6 days of gestational age with 60 matched controls. The study period was from March 2015 to March 2016 and conducted at PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu.Results: The complications seen in the study group were: first trimester abortion (16.7%), second trimester abortion (6.7%), preterm labour (25%), abruption (6.7%), neonatal intensive care admission (25%), ectopic (6.7%), IUGR (10%), IUD (1.7%) and PROM (8.3%). When compared with the parity matched controls there was statistically significant increase in first and second trimester abortions, preterm labour, abruption, NICU admission and ectopic pregnancy whereas there was no significant difference between the two groups with regard to intrauterine growth restriction (IUGR) and intrauterine death (IUD).Conclusions: Women with first trimester vaginal bleeding had several adverse outcomes in both the mother and the fetus, and it is very important to explain about the possibility of these outcomes and ensure proper follow up with close antenatal surveillance.

Download Full-text

Investigation on the ability of first trimester glycodelin and angiopoietin-2 to predict small-for-gestational age pregnancies at delivery

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm-2015-0989 ◽

2016 ◽

Vol 0 (0) ◽

Author(s):

Young Bae Hansen ◽

Vibeke Myrhøj ◽

Finn Stener Jørgensen ◽

Steen Sørensen

Keyword(s):

Pregnant Women ◽

Gestational Age ◽

Small For Gestational Age ◽

False Positive ◽

Case Control Study ◽

First Trimester ◽

Case Control ◽

Detection Rates ◽

Angiopoietin 2 ◽

Control Study

AbstractThe aim was to investigate whether first trimester glycodelin and angiopoietin-2 can predict small-for-gestational age (SGA) at delivery, individually or in combination.In this case-control study we measured glycodelin and angiopoietin-2 on serum from 170 singleton pregnant women delivering SGA neonates and 985 singleton pregnant women delivering normal-weighted neonates. All values were converted to multiples of the medians (MoM).Pregnant women delivering SGA neonates had lower first trimester glycodelin and angiopoietin-2 MoM values [median (interquartile range)] compared with pregnant women delivering normal-weighted neonates for glycodelin: 0.86 (0.58–1.24) vs. 1.03 (0.74–1.45), p<0.001, and for angiopoietin-2: 0.89 (0.69–1.19) vs. 1.01 (0.78–1.31), p<0.001. The prediction performances of the biomarkers showed that the areas under the curve (AUC) were 0.59 (glycodelin), 0.58 (angiopoietin-2), and 0.60 (glycodelin and angiopoietin-2).We demonstrated that first trimester glycodelin and angiopoietin-2 were associated with SGA, but they were, individually and in combination, poor predictors of SGA at delivery. The AUCs were low which indicate low detection rates and high false positive rates.

Download Full-text

Maternal-Fetal Management in Trombophilia Related and Placenta-Mediated Pregnancy Complications

Revista de Chimie ◽

10.37358/rc.18.9.6541 ◽

2018 ◽

Vol 69 (9) ◽

pp. 2396-2401

Author(s):

Costin Berceanu ◽

Elena Loredana Ciurea ◽

Monica Mihaela Cirstoiu ◽

Sabina Berceanu ◽

Anca Maria Ofiteru ◽

...

Keyword(s):

Pregnant Women ◽

Pregnancy Complications ◽

Case Control Study ◽

Case Control ◽

Placental Insufficiency ◽

Management Options ◽

Specific Therapy ◽

Pregnancy Morbidity ◽

The Impact ◽

Control Study

It is widely accepted that thrombophilia in pregnancy greatly increases the risk of venous thromboembolism. Pregnancy complications arise, at least partly, from placental insufficiency. Any change in the functioning of the gestational transient biological system, such as inherited or acquired thrombophilia, might lead to placental insufficiency. In this research we included 64 pregnant women with trombophilia and 70 cases non-trombophilic pregnant women, with or without PMPC, over a two-year period. The purpose of this multicenter case-control study is to analyze the maternal-fetal management options in obstetric thrombophilia, the impact of this pathology on the placental structure and possible correlations with placenta-mediated pregnancy complications. Maternal-fetal management in obstetric thrombophilia means preconceptional or early diagnosis, prevention of pregnancy morbidity, specific therapy as quickly as possible and fetal systematic surveilance to identify the possible occurrence of placenta-mediated pregnancy complications.

Download Full-text

Risk Factors for Postpartum Hemorrhage in a Thai–Myanmar Border Community Hospital: A Nested Case-Control Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18094633 ◽

2021 ◽

Vol 18 (9) ◽

pp. 4633

Author(s):

Waraporn Thepampan ◽

Nuchsara Eungapithum ◽

Krittai Tanasombatkul ◽

Phichayut Phinyo

Keyword(s):

Risk Factors ◽

Pregnant Women ◽

Postpartum Hemorrhage ◽

Minority Groups ◽

Case Control Study ◽

Community Hospital ◽

Case Control ◽

Border Community ◽

Nested Case Control ◽

Control Study

Postpartum hemorrhage (PPH) is a common complication of pregnancy and a global public health concern. Even though PPH risk factors were extensively studied and reported in literature, almost all studies were conducted in non-Asian countries or tertiary care centers. Our study aimed to explore relevant risk factors for PPH among pregnant women who underwent transvaginal delivery at a Thai–Myanmar border community hospital in Northern Thailand. An exploratory nested case-control study was conducted to explore risk factors for PPH. Women who delivered transvaginal births at Maesai hospital from 2014 to 2018 were included. Two PPH definitions were used, which were ≥ 500 mL and 1000 mL of estimated blood loss within 24 h after delivery. Multivariable conditional logistic regression was used to identify significant risk factors for PPH and severe PPH. Of 4774 women with vaginal births, there were 265 (5.55%) PPH cases. Eight factors were identified as independent predictors for PPH and severe PPH: elderly pregnancy, minority groups, nulliparous, previous PPH history, BMI ≥ 35 kg/m2, requiring manual removal of placenta, labor augmentation, and fetal weight > 4000 gm. Apart from clinical factors, particular attention should be given to pregnant women who were minority groups as PPH risk significantly increased in this population.

Download Full-text

Dietary and serum vitamin D and preeclampsia risk in Chinese pregnant women: a matched case–control study

British Journal Of Nutrition ◽

10.1017/s0007114521002956 ◽

2021 ◽

pp. 1-26

Author(s):

Xue-min Huang ◽

Yan-hua Liu ◽

Han Zhang ◽

Yuan Cao ◽

Wei-feng Dou ◽

...

Keyword(s):

Vitamin D ◽

Dietary Intake ◽

Pregnant Women ◽

Case Control Study ◽

Serum Levels ◽

Case Control ◽

Serum Concentrations ◽

Matched Case ◽

Matched Case Control Study ◽

Control Study

Abstract The effect of vitamin D (VD) on the risk of preeclampsia (PE) is uncertain. Few of previous studies focused on the relationship between dietary VD intake and PE risk. Therefore, we conducted this 1:1 matched case-control study to explore the association of dietary VD intake and serum VD concentrations with PE risk in Chinese pregnant women. A total of 440 pairs of participants were recruited during March 2016 to June 2019. Dietary information was obtained using a 78-item semi-quantitative food frequency questionnaire. Serum concentrations of 25(OH)D2 and 25(OH)D3 were measured by liquid chromatography–tandem mass spectrometry. Multivariate conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines (RCS) were plotted to evaluate the dose-response relationship of dietary VD intake and serum VD concentrations with PE risk. Compared with the lowest quartile, the ORs of the highest quartile were 0.45 (95%CI: 0.29-0.71, Ptrend = 0.001) for VD dietary intake and 0.26 (95%CI: 0.11-0.60, Ptrend = 0.003) for serum levels after adjusting for confounders. In addition, the RCS analysis suggested a reverse J-shaped relationship between dietary VD intake and PE risk (P-nonlinearity = 0.02). A similar association was also found between serum concentrations of total 25(OH)D and PE risk (P-nonlinearity = 0.02). In conclusion, this study provides evidence that higher dietary intake and serum levels of VD are associated with the lower risk of PE in Chinese pregnant women.

Download Full-text

Associations between multiple serum metal exposures and low birth weight infants in Chinese pregnant women: A nested case-control study

Chemosphere ◽

10.1016/j.chemosphere.2019.05.103 ◽

2019 ◽

Vol 231 ◽

pp. 225-232 ◽

Cited By ~ 10

Author(s):

Qingzhi Hou ◽

Lulu Huang ◽

Xiaoting Ge ◽

Aimin Yang ◽

Xiaoyu Luo ◽

...

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Pregnant Women ◽

Case Control Study ◽

Case Control ◽

Low Birth Weight Infants ◽

Nested Case Control ◽

Control Study

Download Full-text

Association between Birth Plan Use and Maternal and Neonatal Outcomes in Southern Spain: A Case-Control Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18020456 ◽

2021 ◽

Vol 18 (2) ◽

pp. 456

Author(s):

Pedro Hidalgo-Lopezosa ◽

Ana María Cubero-Luna ◽

Andrea Jiménez-Ruz ◽

María Hidalgo-Maestre ◽

María Aurora Rodríguez-Borrego ◽

...

Keyword(s):

Pregnant Women ◽

Case Control Study ◽

Neonatal Resuscitation ◽

Case Control ◽

Neonatal Outcomes ◽

Southern Spain ◽

Retrospective Case ◽

Apgar Scores ◽

Primiparous Women ◽

Control Study

Background: Birth plans are used for pregnant women to express their wishes and expectations about childbirth. The aim of this study was to compare obstetric and neonatal outcomes between women with and without birth plans. Methods: A multicentre, retrospective case–control study at tertiary hospitals in southern Spain between 2009 and 2013 was conducted. A total of 457 pregnant women were included, 178 with and 279 without birth plans. Women with low-risk gestation, at full-term and having been in labour were included. Sociodemographic, obstetric and neonatal variables were analysed and comparisons were established. Results: Women with birth plans were older, more educated and more commonly primiparous. Caesarean sections were less common in primiparous women with birth plans (18% vs. 29%, p = 0.027); however, no significant differences were found in instrumented births, 3rd–4th-degree tears or episiotomy rates. Newborns of primiparous women with birth plans obtained better results on 1 min Apgar scores, umbilical cord pH and advanced neonatal resuscitation. No significant differences were found on 5 min Apgar scores or other variables for multiparous women. Conclusions: Birth plans were related to less intervention, a more natural process of birth and better outcomes for mothers and newborns. Birth plans can improve the welfare of the mother and newborn, leading to birth in a more natural way.

Download Full-text