Prevalence of sub clinical hypothyroidism and pregnancy outcome: a prospective comparative study

Background: In pregnancy, subclinical hypothyroidism is more common than overt hypothyroidism, ranging from 15% to 28% in Iodine sufficient region. Evidence suggests that subclinical hypothyroidism is associated with adverse pregnancy outcome. The aim of this study was to find the prevalence of subclinical hypothyroidism in pregnant women and adverse pregnancy outcome.Methods: This hospital based prospective comparative study was conducted over a period of 6 months from 1st July 2018 to 31st December 2018 in department of obstetrics and gynecology SKIMS Soura Kashmir. All the subjects who fulfilled the inclusion criteria and who consented to participate were screened for subclinical hypothyroidism.Results: A total of 175 pregnant women participated in the study and subclinical hypothyroidism was diagnosed in 25 pregnant women (14.2%). Most of our patients were in age group 21 to 30 years (69.1%). Pregnant women with subclinical hypothyroidism had significant risk of preeclampsia (35%) and higher cesarean section rate (29.6%). Neonate of women with subclinical hypothyroidism had higher incidence poor Apgar score, NICU admission.Conclusions: The prevalence of subclinical hypothyroidism is high in pregnant women and the gravity of the complications like pre-eclampsia, neonate with low Apgar score, increased NICU admission, overweight the cost of screening. In this view, we propose screening of all pregnant women in the first trimester for diagnosis.

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567: Co-prescription of opioids and psychotropics among commercially insured US pregnant women and adverse pregnancy outcome

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2018.11.589 ◽

2019 ◽

Vol 220 (1) ◽

pp. S377-S378

Author(s):

Kartik K. Venkatesh ◽

Virginia Pate ◽

Kim Boggess ◽

Michele Funk ◽

Marcela Smid

Keyword(s):

Pregnant Women ◽

Pregnancy Outcome ◽

Adverse Pregnancy Outcome ◽

Adverse Pregnancy

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247 Adverse pregnancy outcome in DES-exposed pregnant women managed by a high risk obstetric protocol

American Journal of Obstetrics and Gynecology ◽

10.1016/0002-9378(91)90987-3 ◽

1991 ◽

Vol 164 (1) ◽

pp. 314

Keyword(s):

High Risk ◽

Pregnant Women ◽

Pregnancy Outcome ◽

Adverse Pregnancy Outcome ◽

Adverse Pregnancy

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Periodontal Disease and Bacterial Vaginosis Increase the Risk for Adverse Pregnancy Outcome

Infectious Diseases in Obstetrics and Gynecology ◽

10.1155/2005/642939 ◽

2005 ◽

Vol 13 (4) ◽

pp. 213-216 ◽

Cited By ~ 8

Author(s):

Juha Oittinen ◽

Tapio Kurki ◽

Minnamaija Kekki ◽

Minna Kuusisto ◽

Pirkko Pussinen ◽

...

Keyword(s):

Multivariate Analysis ◽

Confidence Interval ◽

Periodontal Disease ◽

Bacterial Vaginosis ◽

Pregnant Women ◽

Pregnancy Outcome ◽

Adverse Pregnancy Outcome ◽

Strong Association ◽

Adverse Pregnancy ◽

Rule Out

Objectives.To determine whether periodontal disease or bacterial vaginosis (BV) diagnosed before pregnancy increase the risk for adverse pregnancy outcome.Methods.We enrolled a total of 252 women who had discontinued contraception in order to become pregnant. The first 130 pregnant women were included in the analyses.Results.Multivariate analysis showed a strong association between periodontal disease and adverse pregnancy outcome (OR 5.5, 95% confidence interval 1.4–21.2;p= 0.014), and a borderline association between BV and adverse pregnancy outcome (OR 3.2, 95% confidence interval 0.9–10.7;p= 0.061).Conclusion.Our study suggests that pre-pregnancy counseling should include both oral and vaginal examinations to rule out periodontal disease and BV. This may ultimately have an impact on antenatal healthcare, and decrease the risk for adverse pregnancy outcome.

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Does the average drug exposure in pregnant women affect pregnancy outcome? A comparison of two approaches to estimate the baseline risks of adverse pregnancy outcome

Pharmacoepidemiology and Drug Safety ◽

10.1002/pds.3744 ◽

2015 ◽

Vol 24 (4) ◽

pp. 353-360 ◽

Cited By ~ 11

Author(s):

Evelin Wacker ◽

Ana Navarro ◽

Reinhard Meister ◽

Stephanie Padberg ◽

Corinna Weber-Schoendorfer ◽

...

Keyword(s):

Pregnant Women ◽

Pregnancy Outcome ◽

Drug Exposure ◽

Adverse Pregnancy Outcome ◽

Adverse Pregnancy

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Pregnancy outcome in women treated for subclinical hypothyroidism detected in early gestation

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20180194 ◽

2018 ◽

Vol 7 (2) ◽

pp. 685

Author(s):

Raja Rajeswari C. ◽

Suman Paul ◽

Madhusmita Nayak

Keyword(s):

Pregnancy Outcome ◽

Subclinical Hypothyroidism ◽

Adverse Pregnancy Outcome ◽

Treated Group ◽

Endocrine Disorders ◽

Free T4 ◽

Early Gestation ◽

Significant Difference ◽

Gestational Age At Delivery ◽

Adverse Pregnancy

Background: Thyroid disorders are among the most common endocrine disorders in pregnancy. Objective of present study were to investigate the outcome of pregnancy in those women detected to have subclinical hypothyroidism in early gestation and to evaluate whether treatment of subclinical hypothyroidism reduces the adverse pregnancy outcome.Methods: Pregnant women detected to have Subclinical hypothyroidism (TSH >2.5- 6 mU/L and N Free T4) in the 1st trimester were selected and randomly divided into 2 groups. One group received treatment with Thyroxine. They were followed up till delivery and outcome noted.Results: The mean maternal age of both the group was 26 yrs. The gestational age at delivery and the newborn birth weight did not show any statistically significant difference. Antenatal complications like Gestational Diabetes, hypertension, small for gestation, and preterm were almost the same in both groups. There was significant increase in the primary caesarean rate in the treated group. No significant difference in the number of term vaginal delivery in both groups.Conclusions: Treatment of women with SCH (TSH <6 mU/L) does not reduce the risk of adverse pregnancy outcome. Benefits of treatment need to be weighed against any potential risks.

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Treatment and pregnancy outcomes of pregnant women exposed to second-line anti-tuberculosis drugs in South Africa

BMC Pregnancy and Childbirth ◽

10.1186/s12884-021-03956-6 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Idah Mokhele ◽

Nelly Jinga ◽

Rebecca Berhanu ◽

Thandi Dlamini ◽

Lawrence Long ◽

...

Keyword(s):

South Africa ◽

Pregnant Women ◽

Pregnancy Outcome ◽

Pregnancy Outcomes ◽

Adverse Pregnancy Outcome ◽

Adverse Pregnancy Outcomes ◽

Close Monitoring ◽

Second Line ◽

Tb Treatment ◽

Adverse Pregnancy

Abstract Background Multi-drug resistant and rifampicin-resistant tuberculosis (MDR/RR-TB) in pregnant women is a cause for concern globally; few data have described the safety of second-line anti-TB medications during pregnancy. We aim to describe TB treatment and pregnancy outcomes among pregnant women receiving second-line anti-tuberculosis treatment for MDR/RR-TB in Johannesburg, South Africa. Methods We conducted a retrospective record review of pregnant women (≥ 18 years) who received treatment for MDR/RR-TB between 01/2010–08/2016 at three outpatient treatment sites in Johannesburg, South Africa. Demographic, treatment and pregnancy outcome data were collected from available medical records. Preterm birth (< 37 weeks), and miscarriage were categorized as adverse pregnancy outcomes. Results Out of 720 women of child-bearing age who received MDR/RR-TB treatment at the three study sites, 35 (4.4%) pregnancies were identified. Overall, 68.7% (24/35) were HIV infected, 83.3% (20/24) were on antiretroviral therapy (ART). Most women, 88.6% (31/35), were pregnant at the time of MDR/RR-TB diagnosis and four women became pregnant during treatment. Pregnancy outcomes were available for 20/35 (57.1%) women, which included 15 live births (11 occurred prior to 37 weeks), 1 neonatal death, 1 miscarriage and 3 pregnancy terminations. Overall, 13/20 (65.0%) women with known pregnancy outcomes had an adverse pregnancy outcome. Of the 28 women with known TB treatment outcomes 17 (60.7%) completed treatment successfully (4 were cured and 13 completed treatment), 3 (10.7%) died and 8 (28.6%) were lost-to-follow-up. Conclusions Pregnant women with MDR/RR-TB suffer from high rates of adverse pregnancy outcomes and about 60% achieve a successful TB treatment outcome. These vulnerable patients require close monitoring and coordinated obstetric, HIV and TB care.

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Adverse Pregnancy Outcome among Different Maternal Age group - A Comparative Study

Scholars International Journal of Obstetrics and Gynecology ◽

10.36348/sijog.2020.v03i07.001 ◽

2020 ◽

Vol 3 (7) ◽

pp. 163-169

Author(s):

Dr. Serajoom Munira ◽

Professor Roksana Ivy ◽

Professor Fatema Ashraf ◽

Dr. Mohammad Ibrahim Khalil

Keyword(s):

Comparative Study ◽

Pregnancy Outcome ◽

Maternal Age ◽

Adverse Pregnancy Outcome ◽

Age Group ◽

Group A ◽

Adverse Pregnancy

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Association of Implementation of a Comprehensive Preconception-to-Pregnancy Management Plan With Pregnancy Outcomes Among Chinese Pregnant Women With Type 1 Diabetes: The CARNATION Study

10.2337/figshare.13623029.v1 ◽

2021 ◽

Author(s):

Xueying Zheng ◽

Daizhi Yang ◽

Sihui Luo ◽

Jinhua Yan ◽

Xiaohui Guo ◽

...

Keyword(s):

Pregnant Women ◽

Pregnancy Outcome ◽

Pregnancy Outcomes ◽

Prospective Cohort ◽

Retrospective Cohort ◽

Adverse Pregnancy Outcome ◽

Management Plan ◽

Comprehensive Management ◽

Adverse Pregnancy

Objective To investigate the effect on pregnancy outcome of integrating a comprehensive management plan for type 1 diabetic (T1D) patients into the WHO universal maternal care infrastructure. Research Design and Methods A comprehensive preconception-to-pregnancy management plan for women with T1D was implemented in 11 centers from eight Chinese cities during 2015–2017. Sequential eligible pregnant women (n=133 out of 137 initially enrolled) with T1D and singleton pregnancies attending these management centers formed the prospective cohort. The main outcome was severe adverse pregnancy outcome comprising maternal mortality, neonatal death, congenital malformation(s), miscarriage in the second trimester and stillbirth. We compared pregnancy outcomes in this prospective cohort with two control groups with the same inclusion and exclusion criteria: a retrospective cohort (n=153) of all eligible pregnant women with T1D attending the same management centers during 2012–2014 and a comparison cohort (n=116) of all eligible pregnant women with T1D receiving routine care during 2015–2017 in 11 different centers from seven cities. Results The rate of severe adverse pregnancy outcome was lower in the prospective cohort (6.02%) than in either the retrospective cohort (18.30%, adjusted odds ratio[aOR]=0.31, 95% CI 0.13–0.74) or the contemporaneous comparison cohort (25.00%, aOR=0.22, 95% CI 0.09–0.52). Conclusion The substantial improvements in the prospective cohort are evidence of a potentially clinically important effect of the comprehensive management plan on pregnancy outcomes among Chinese pregnant women with pregestational T1D. This supports the development of similar approaches in other countries.

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