scholarly journals Comparative study of oral mifepristone and endocervical prostaglandin-E2 gel as pre-induction cervical ripening agents in parturition

2020 ◽  
Vol 9 (9) ◽  
pp. 3825
Author(s):  
Prabhkiran Dhillon ◽  
Manash Biswas ◽  
Priyanka Tripathi ◽  
Vinod G. Nair
Keyword(s):  
Oral Administration ◽  
Comparative Study ◽  
Prostaglandin E2 ◽  
Caesarean Delivery ◽  
Cervical Ripening ◽  
P Value ◽  
Term Pregnancy ◽  
Exclusion Criteria ◽  
Pg E2 ◽  
Vertex Presentation

Background: Intracervical instillation of prostaglandin E2 is a well-known and widely practiced method of pre-induction cervical ripening. Mifepristone, due to its anti-progesterone action has been found to be a potential cervical ripening agent. This study was conducted to compare the safety, efficacy and outcome of these two drugs in pre-induction cervical ripening.Methods: One hundred antenatal women were recruited for the study; 50 in mifepristone arm and 50 in PG-E2 gel arm. Any singleton term pregnancy in vertex presentation with intact membranes and bishop’s score of <4 was included in the study. Any contraindication for vaginal delivery and any contraindication for mifepristone or PG-E2 were considered as exclusion criteria. Participants in the mifepristone arm were given tablet mifepristone 200 mg orally and those in PG-E2 gel group received endocervical instillation of PGE2 gel 0.5 mg, two doses 6 hours apart (if necessary). Induction of labour was considered successful if the parturient delivered within 48 hours of administration of mifepristone or first dose of PG-E2 gel, with or without labour augmentation with oxytocin. Delivery after 48 hours and caesarean delivery were considered unsuccessful induction.Results: There was a significant improvement in bishop’s score in mifepristone group 5.0±1.55 as compared to PG-E2 gel group 3.64±2.14; p value 0.001.Conclusions: Oral administration of 200 mg mifepristone is a safe, effective and convenient alternative to intracervical instillation of prostaglandin-E2 gel for pre-induction cervical ripening.

scholarly journals Efficacy and safety of oral mifepristone for cervical priming and induction of labor in term pregnancy

2018 ◽  
Vol 7 (7) ◽  
pp. 2766 ◽  
Author(s):  
Abhilasha Gupta ◽  
Aruna Verma ◽  
Iti Madan ◽  
Monika Kashyap
Keyword(s):  
Controlled Trial ◽  
Group Versus ◽  
Perinatal Outcomes ◽  
Active Phase ◽  
Cervical Ripening ◽  
Control Group ◽  
P Value ◽  
Study Group ◽  
Bishop Score ◽  
Term Pregnancy

Background: The objectives of the study was to assess the efficacy of mifepristone in priming the cervix/inducing labor over next 96 hrs in term pregnancy.Methods: In this single blind randomized controlled trial 200 women with term pregnancy beyond 39 weeks and Bishop’ score <6 were randomly allocated into two groups. Tab Mifepristone 400 mg orally was given to women in study group (n=100) and no intervention in control group (n=100). On follow up one case was lost in control group. All women were observed for change in the bishop’s score or onset of labor in next 96 hrs. If Bishop’s score was <6, the choice of induction was left on the clinician/patient.Results: Mean induction to delivery interval, duration of active phase and improved Bishop score were 79.35±53.43 hr, 2.47±1.23 hr, 6.68±1.69 for study group versus 148±65.66 hr, 3.09±1.45 hr, 5.8±2.15  for control group (p value is <0.001) respectively.  Seventy one (71%) women in study group and 39 (39.3%) women in control group delivered vaginally within 96 hrs without any need of augmentation. There were 9 (9%) caesareans in study group and 24 (24.2%) caesareans in control group but no instrumental delivery in both groups. There was no statistically difference in perinatal outcomes between two groups.Conclusions: Mifepristone is an effective drug for cervical ripening and initiation of labor when given in term pregnancy beyond 39 weeks with poor Bishop’s score (<6) and appearing to reduce need for other agent for augmentation of labor.

scholarly journals EFEKTIVITAS PEMBERIAN PREBIOTIK TERHADAP DURASI DIARE PADA ANAK PRA SEKOLAH DI RUANG DURIAN RUMAH SAKIT UMUM DAERAH KLUNGKUNG

2020 ◽  
Vol 4 (2) ◽  
pp. 32
Author(s):  
A.A. Ngurah Nara Kusuma ◽  
Ni Ketut Sri Wahyuni
Keyword(s):  
Comparative Study ◽  
General Hospital ◽  
School Children ◽  
Acute Diarrhea ◽  
Standard Therapy ◽  
Pediatric Patients ◽  
Observational Research ◽  
P Value ◽  
Exclusion Criteria ◽  
The World

Diarrhea is the second leading cause of death in children in the world, as well as in Indonesia. To reduce mortality due to diarrhea, it needs fast and appropriate management. Probiotics have been widely used in cases of acute diarrhea in children but have not been recommended at the Klungkung Regional General Hospital. This study aims to determine the effectiveness of prebiotic administration on the duration of diarrhea in pre-school children.This type of quantitative observational research uses a comparative study design. This study involved 40 respondents who were selected based on inclusion and exclusion criteria with purposive sampling technique.The results showed that the duration of diarrhea in pre-school children given prebiotics averaged 23.74 or 24 hours 14 minutes, while the duration of diarrhea in pre-school children given standard therapy was on average 47 hours 49 minutes. The results of the Independent T Test obtained p value = 0.001 <0.05, which means that prebiotic administration is more effective than giving standard therapy to the duration of diarrhea in pre-treated children. Suggested to the Hospital so that prebiotics can be used as standard therapy for pediatric patients who suffer from diarrhea. Keywords: Prebiotics, Duration of Diarrhea, Pre-school Children 

scholarly journals A Comparative Study of 25 mcg vs 50 mcg of Vaginal Misoprostol for Induction of Labor

2013 ◽  
Vol 5 (3) ◽  
pp. 111-115
Author(s):  
Anjanappa Bharathi ◽  
K Ashok Kumar ◽  
A Pavana Ganga
Keyword(s):  
Comparative Study ◽  
Antenatal Clinic ◽  
Induction Of Labor ◽  
P Value ◽  
Study Group ◽  
Maternal Complications ◽  
Singleton Pregnancy ◽  
Vaginal Misoprostol ◽  
Vertex Presentation ◽  
Heart Rate Pattern

ABSTRACT Objectives To compare the efficacy and safety of 25 mcg intravaginal misoprostol vs 50 mcg misoprostol for induction of labor. Material and methods This study group consisted of 100 cases of low-risk singleton pregnancies attending the antenatal clinic of SAH and RC, or admitted to the antenatal ward. Study group included singleton pregnancy, Over 37 weeks of gestation with Vertex presentation, with unfavorable cervix (bishop score <4) and patients not in labor with reactive fetal heart rate pattern with intact membranes. Women were randomized to either 25 mcg (n = 50) or 50 mcg (n = 50) of intravaginal misoprostol. The dose was repeated every 4 hours (maximum number of doses limited to 3 doses). The main outcome was induction vaginal delivery interval. Results Induction delivery interval was significantly less with 50 mcg misoprostol —9.45 hours in comparison to 25 mcg 14.2 hours (p-value <0.001), most cases delivered vaginally with 25 mcg misoprostol p value < 0.013, cesarean section rates were high in 50 mcg misoprostol group p-value <0.007, the proportion of women delivering vaginally with single dose of vaginal misoprostol was high in 50 mcg group, i.e. 64%, incidence of maternal complications like tachysystole and hyperstimulation was more with 50 mcg group. Conclusion In the present study, it is concluded that 25 mcg of misoprostol is safe and effective for labor induction. How to cite this article Bharathi A, Kumar KA, Ganga AP. A Comparative Study of 25 mcg vs 50 mcg of vaginal Misoprostol for Induction of Labor. J South Asian Feder Obst Gynae 2013;5(3):111-115.

A STUDY OF ENDOMETRIAL THICKNESS IN TRANS VAGINAL SONOGRAPHY IN RELATION WITH HISTOPATHOLOGY REPORT IN DILATION & CURRATAGE IN AUB WOMEN

2019 ◽  
pp. 1-2
Keyword(s):  
Comparative Study ◽  
Endometrial Thickness ◽  
P Value ◽  
First Line ◽  
Non Invasive ◽  
Dilation And Curettage ◽  
Study Results ◽  
Vaginal Sonography ◽  
In Trans

A study of of endometrial thickness on TVS in relation with histopathology report on dilation and curettage. AIM AND OBJECTIVE-To set a cut off limit of endometrial thickness on TVS for differtiating between normal and abnormal endometrium. MATERIAL AND METHOD-hospital based comparative study. RESULTS-TVS is non invasive ,simple first line procedure in AUB women. Mean endometrial thickness in normal endometrial group was 8.00±2.44 mm and in abnormal endometrial group was 15.16±33 mm.The difference was found highly significant (p value<.001)

Sign in / Sign up

Export Citation Format

Share Document