Maternal serum CA-125 repeated measurement during pregnancy and how to use as a prognostic factor of first trimester pregnancy outcome

Background: The aim of this study was to estimate the prognostic efficacy of repeated measurement of maternal serum CA125 in first trimester threatened miscarriage.Methods: Prospective case control study was conducted in the outpatient clinic. 100 pregnant women were divided into 50 women with normal course of pregnancy, and the other 50 were subdivided into 25 pregnant women with lower abdominal pain without vaginal bleeding and 25 presented with minimal vaginal bleeding. Repeated measuring of serum CA125 was done for each case on the 5th, 10th weeks of gestation.Results: Findings of this study suggested the possibility of using serum CA-125 for determining the prognosis of first trimester threatened miscarriage with cut-off value of CA125 38.25 U/ml on the 5th week of gestation and 53 U/ml on the 10th week of gestation in patients presented with pain only but in patients presented with minimal vaginal bleeding the cut-off value of CA125 on the 5th week of gestation become 45.6 U/ml and 68 U/ml on the 10th week of gestation.Conclusions: CA125, on its own, can discriminate between continued and non-continued pregnancy.

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Maternal and perinatal outcomes in women with first trimester vaginal bleeding

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20194850 ◽

2019 ◽

Vol 8 (11) ◽

pp. 4320

Author(s):

K. Suganya ◽

Latha Maheswari Subbarayan

Keyword(s):

Pregnant Women ◽

Vaginal Bleeding ◽

Case Control Study ◽

Preterm Labour ◽

Perinatal Outcomes ◽

First Trimester ◽

Case Control ◽

Second Trimester ◽

Trimester Abortion ◽

Control Study

Background: First trimester bleeding is one of the common complications during pregnancy which affects almost 16-25% of all pregnancies. To evaluate and ascertain the adverse maternal and perinatal outcomes in pregnant women presenting with first trimester vaginal bleeding.Methods: Prospective case-control study. A case control study involving 60 pregnant women with vaginal bleeding in the first 13 weeks + 6 days of gestational age with 60 matched controls. The study period was from March 2015 to March 2016 and conducted at PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu.Results: The complications seen in the study group were: first trimester abortion (16.7%), second trimester abortion (6.7%), preterm labour (25%), abruption (6.7%), neonatal intensive care admission (25%), ectopic (6.7%), IUGR (10%), IUD (1.7%) and PROM (8.3%). When compared with the parity matched controls there was statistically significant increase in first and second trimester abortions, preterm labour, abruption, NICU admission and ectopic pregnancy whereas there was no significant difference between the two groups with regard to intrauterine growth restriction (IUGR) and intrauterine death (IUD).Conclusions: Women with first trimester vaginal bleeding had several adverse outcomes in both the mother and the fetus, and it is very important to explain about the possibility of these outcomes and ensure proper follow up with close antenatal surveillance.

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Prognostic value of repeated serum CA 125 measurements in first trimester pregnancy

European Journal of Obstetrics & Gynecology and Reproductive Biology ◽

10.1016/s0301-2115(00)00533-9 ◽

2001 ◽

Vol 97 (2) ◽

pp. 168-173 ◽

Cited By ~ 26

Author(s):

Torsten Schmidt ◽

Daniel T. Rein ◽

Dolores Foth ◽

Hans-Walter Eibach ◽

Christian M. Kurbacher ◽

...

Keyword(s):

Prognostic Value ◽

First Trimester ◽

Ca 125 ◽

First Trimester Pregnancy ◽

Trimester Pregnancy

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The Effect of Down Syndrome Biochemical Markers on Predicting Severity of Preeclampsia

10.21203/rs.3.rs-132123/v1 ◽

2020 ◽

Author(s):

AYSE OZBAN

Keyword(s):

Down Syndrome ◽

Pregnant Women ◽

Biochemical Markers ◽

First Trimester ◽

Maternal Serum ◽

Screening Tests ◽

Second Trimester ◽

Study Results ◽

Second Trimester Screening ◽

Trimester Screening

Abstract Objective: This study aims to determine whether it is possible to predict preeclampsia by comparing postpartum results and test results of the pregnant women diagnosed with preeclampsia, whose first and/or second trimester screening tests were accessible, and to demonstrate the predictability of severity and week of onset.Background: 204 patients underwent renal transplantation in our center and 84 of them were female. Five of our patients (one of them had two births) gave birth to a total of 6 pregnancies.Method: 135 patients were diagnosed with preeclampsia and their first and/or second trimester screening tests were accessible, and 366 control participants gave birth to a healthy baby between 37-41 weeks after standard follow-up period for pregnancy and their screening tests were also accessible.Results: The study results show that the first trimester maternal serum PAPP-A level is significantly low in preeclamptic pregnant women, and that the second trimester maternal serum AFP and hCG levels are significantly high and uE3 levels are significantly low The results also suggest that the first and second trimester Down syndrome biochemical markers can be used in preeclampsia screening.Conclusion: Among these markers, uE3 is the parameter which affects the possibility of preeclampsia the most. However, the first and second trimester Down syndrome biochemical markers are not effective in predicting the severity and onset week of preeclampsia.

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Determinants of Antenatal Care Service Utilization during the First Trimester among Pregnant Women in Boke Woreda, Ethiopia: A Facility Based Unmutched Case Control Study

Current Trends in Biomedical Engineering & Biosciences ◽

10.19080/ctbeb.2018.15.555904 ◽

2018 ◽

Vol 15 (1) ◽

Author(s):

Teklemariam Ergat Yarinbab

Keyword(s):

Antenatal Care ◽

Pregnant Women ◽

Service Utilization ◽

Case Control Study ◽

Care Service ◽

First Trimester ◽

Case Control ◽

Control Study

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Role of Maternal Serum Glycodelin as Predictor of Ectopic Pregnancy in First Trimester

International Journal of Women s Health and Reproduction Sciences ◽

10.15296/ijwhr.2019.77 ◽

2018 ◽

Vol 7 (4) ◽

pp. 467-470

Author(s):

Wasan Wajdi Ibrahim ◽

Afraa Mahjoob Al-Naddawi ◽

Hayder A. Fawzi

Keyword(s):

Ectopic Pregnancy ◽

Predictive Value ◽

First Trimester ◽

Maternal Serum ◽

Intrauterine Pregnancy ◽

Receiver Operator Curve Analysis ◽

Medical City ◽

First Trimester Of Pregnancy ◽

Control Study

Objectives: Assessment of glycodelin (GD) as a marker for unruptured ectopic pregnancy (EP) in the first trimester of pregnancy. Materials and Methods: This case-control study was conducted during June 2016 to May 2017 in the Obstetrics and Gynecological Department of Baghdad University at Baghdad teaching hospital/medical city complex. In this study, 100 pregnant women in their first trimester of pregnancy were included after clinical and ultrasonic findings. Results: Based on the results, GD levels in EP were significantly lower than those with normal intrauterine pregnancy (1.58 ± 1.18 vs. 30.1 ± 11.9). In addition, using receiver operator curve analysis, the cut-off GD level of 9.5 and less had acceptable validity results (100% sensitivity, 100% specificity, 95% positive predictive value, 100% negative predictive value, and accuracy 100%) to predict EP. Conclusions: In general, serum GD is considered as an excellent predictor of unruptured EP.

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Apelin 13 and Blood Pressure, Is there any Association in Pre-eclampsia? - A Case-control Study

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2021/46243.14403 ◽

2021 ◽

Author(s):

Rajeev Gandham ◽

CD Dayanand ◽

SR Sheela

Keyword(s):

Blood Pressure ◽

Pregnant Women ◽

Gestational Age ◽

Case Control Study ◽

Case Control ◽

Maternal Serum ◽

Research Centre ◽

Categorical Variables ◽

Enzyme Linked Immunosorbent Assay ◽

Control Study

Introduction: Pre-eclampsia is a pregnancy specific disorder, characterised by the onset of hypertension and proteinuria. Pre-eclampsia is the leading cause of maternal, perinatal morbidity and mortality. The exact cause of pre-eclampsia is not known clearly and needs to be explored. Aim: To evaluate the maternal serum apelin 13 levels among pre-eclampsia and healthy pregnant women and also, to find the association between apelin 13 and blood pressure. Materials and Methods: A case-control study was conducted between Department of Biochemistry and Department of Obstetrics and Gynaecology, RL Jalappa Hospital and Research Centre, Kolar, Karnataka, India. After approval from the Institutional Ethics Committee and written informed consent from study subjects, a total of 270 pregnant women were recruited for this study. Among them, 135 pre-eclamptic women were considered as cases and 135 normotensive healthy pregnant women served as controls. According to the pre-eclampsia severity, cases were grouped into mild (n=47) and severe pre-eclampsia (n=88). Blood samples were collected from all the study subjects and was analysed for apelin 13 by Enzyme Linked Immunosorbent Assay (ELISA) method. Maternal and foetal adverse outcomes were recorded. Results were expressed as mean±Standard Deviation (SD). Categorical variables were expressed in percentages. Spearman’s correlation was applied and p<0.05 was considered significant. Results: The mean gestational age was 36.66±3.69 weeks which was, significantly low in pre-eclamptic women compared with healthy pregnant women. BMI (26.94±3.81 kg/m2), systolic (157.82±15.14 mmHg), diastolic (101.68±11.02 mmHg) and Mean Arterial Pressure (MAP) (120.20±11.12 mmHg), pulse rate (88.14±5.82 bpm), Aspartate Transaminase (AST) (25.25±12.49 IU/L) and Alanine Transaminase (ALT) (19.01±10.95 IU/L) were significantly increased in pre-eclamptic women when compared with control group. Mean maternal serum apelin 13 (341.44±218.63 pg/mL) concentrations were significantly lower in pre-eclampsia compared with healthy pregnant women. Maternal serum apelin 13 concentrations were negatively correlated with Systolic Blood Pressure (SBP) (r = -0.196), Diastolic Blood Pressure (DBP) (r = -0.172) and MAP (r =-0.204). Adverse maternal outcomes such as epigastric pain 75 (55.55%), oedema 62 (45.92%) and persistent headache 35 (25.92%) were higher in pre-eclamptic group. Additionally, adverse foetal outcomes were more in pre-eclamptic cases including significantly decreased birth weight (2.40±0.65), babies requiring Neonatal Intensive Care Unit (NICU) admission were 54 (40%), preterm birth (≤37 wks) in 50 (37.03%), Respiratory Distress Syndrome (RDS) 31 (22.96%), Small for Gestational Age (SGA) in 4 (2.96%) and Intra Uterine Death (IUD) in 11 (8.14%) babies. Conclusion: It was concluded from the present study that there was low maternal serum apelin 13 concentrations in pre-eclampsia and had negative correlation with blood pressure, suggesting its potential role in the pathophysiology of pre-eclampsia.

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Gestational diabetes mellitus and first trimester pregnancy-associated plasma protein A: A case-control study in a Chinese population

Journal of Diabetes Investigation ◽

10.1111/jdi.12672 ◽

2017 ◽

Vol 9 (1) ◽

pp. 204-210 ◽

Cited By ~ 7

Author(s):

Di Xiao ◽

Wang Chenhong ◽

Xu Yanbin ◽

Zhou Lu

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Chinese Population ◽

Case Control Study ◽

Protein A ◽

First Trimester ◽

Case Control ◽

First Trimester Pregnancy ◽

Trimester Pregnancy ◽

Control Study

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Leptin, resistin and visfatin as useful predictors of gestational diabetes mellitus

Lipids in Health and Disease ◽

10.1186/s12944-019-1169-2 ◽

2019 ◽

Vol 18 (1) ◽

Cited By ~ 6

Author(s):

Ahmed Tijani Bawah ◽

Mohammed Mustapha Seini ◽

Albert Abaka-Yawason ◽

Huseini Alidu ◽

Salifu Nanga

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Operating Characteristic ◽

Case Control Study ◽

First Trimester ◽

Anthropometric Parameters ◽

Receiver Operating Characteristic Curves ◽

Control Study

Abstract Background Lipids and adipokines including leptin, resistin and visfatin play various roles in the pathophysiology of Gestational Diabetes Mellitus (GDM). This study was aimed at determining whether serum leptin, resistin and visfatin are significantly altered during the first trimester of pregnancies that subsequently develop GDM and whether such changes are useful in predicting the disease. Methods This was a case-case control study which compared first trimester biochemical and anthropometric parameters in 70 pregnant women who subsequently developed GDM and 70 pregnant women without GDM at the Volta Regional Hospital, Ho, Ghana. Lipid profile and some selected adipokines were analyzed and first trimester body mass index (BMI) was determined. Results There were significant differences (p < 0.05) in leptin, resistin, and visfatin as well as significant dyslipidemia among those with GDM compared to those without GDM. Furthermore, the area under the Receiver Operating Characteristic Curves (AUCs) for leptin, resistin and visfatin were; 0.812, 0.836 and 0.799 respectively. Increased first trimester leptin (OR = 1.166; CI = 1.104–1.233; p < 0.0001), resistin (p < 0.0001) and visfatin (p < 0.0001) were associated with GDM. Conclusion Hyperleptinemia, hyperesistinemia and hypervisfatinemia precede GDM and can serve as good predictive indices for gestational diabetes mellitus.

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