scholarly journals Correlation of lipids and lipoprotein concentration with body mass index in obese, overweight and normal weight south Indian adults

2017 ◽  
Vol 5 (11) ◽  
pp. 4803
Author(s):  
Gayathri B. ◽  
Vinodhini V. M.
Keyword(s):  
Body Mass Index ◽  
Total Cholesterol ◽  
Body Mass ◽  
Density Lipoprotein ◽  
Public Health Problem ◽  
Cardiac Risk ◽  
Normal Weight ◽  
Research Centre ◽  
College Hospital ◽  
South Indian

Background: Obesity a chronic disorder is gradually becoming a serious public health problem in many countries. The aim of the study was designed to measure serum lipids and lipoproteins as marker for cardiovascular disease among obese and overweight South Indian adults.Methods: The study was done between June 2016 to December 2016, in SRM medical college hospital and research centre, Kattankulathur which comprised of 270 participants of both gender in the age of 18- 55 years. 90 individuals with body mass index (BMI ≥25kg/m2), 90 individuals with BMI in the range of 23.0 to 24.99kg/m2 and 90 age and sex matched controls (BMI = 18 to 22.99kg/m2) were selected for the study. Serum levels of total cholesterol, Triacylglycerol, high density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C) were analyzed by using auto analyzer Beckman Coulter AU480. The cardiac risk ratio 1 (cholesterol/HDL-C ratio) and 2 (LDL-C/HDL-C) ratio were calculated.Results: The difference between the mean values of total cholesterol, triglycerides and LDL-C, were found to be statistically significant across the three groups. Positive correlation was observed between BMI and cardiac risk ratios one and two in both obese and overweight groups.Conclusions: Cardiac risk is increased in South Indian overweight and obese individuals which is evident from the elevated levels of total cholesterol, triglycerides, LDL-C and cardiac rick ratio one (cholesterol/HDL-C ratio) and two (LDL-C/HDL-C).

scholarly journals Hubungan indeks massa tubuh dengan profil lipid pada pasien diabetes melitus tipe 2

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Pradika H. Koampa ◽  
Karel Pandelaki ◽  
Marthen C.P. Wongkar
Keyword(s):  
Body Mass Index ◽  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
Body Mass ◽  
Pearson Correlation ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Diabetes Melitus

Abstract: Body Mass Index (BMI) is a measurement of nutritional status by calculating the ratio of height and weight. Type 2 Diabetes Mellitus (T2DM) is more common in a person with a BMI of more than normal. In patients with T2DM, there is lipid metabolism disorder, dyslipidaemia. Changes in lipid profiles consist of increased levels of total cholesterol, Low Density Lipoprotein (LDL), and triglycerides, and decreased levels of High Density Lipoprotein (HDL). This study aimed to obtain the correlation between body mass index and lipid profile in T2DM patients in Prof. Dr. R. D. Kandou Hospital Manado. This was a descriptive analytical study using patients’ medical record in Endocrine Clinic Prof. Dr. R. D. Kandou Hospital Manado from September to November 2015. The Pearson correlation test showed correlations between BMI and total cholesterol levels with r=0.037and p=0.763; between BMI and HDL levels with r=-0.249 and p=0.039; between BMI and LDL levels with r=0.091 and p=0,455; and between BMI and triglyceride levels with r=0.179 and p=0.142. Conclusion: Among T2DM patients, there were no significant correlations between body mass index and total cholesterol, LDL cholesterol, as wello as triglyceride levels. However, there was a significant correlation between body mass index and HDL levels. Keywords: body mass index, total cholesterol, HDL, LDL, triglycerides, T2DM Abstrak: Indeks Massa Tubuh (IMT) merupakan salah satu pengukuran status gizi dengan menghitung perbandingan tinggi badan dan berat badan. Diabetes Melitus Tipe 2 (DMT2) lebih sering terjadi pada individu dengan IMT lebih dari normal. Pada pasien DMT2 terjadi gangguan metabolisme lipid yaitu dislipidemia. Perubahan profil lipid yang terjadi yaitu peningkatan kadar Kolesterol Total, Low Density Lipoprotein (LDL), dan trigliserida, serta penurunan kadar High Density Lipoprotein (HDL). Penelitian ini bertujuan untuk mengetahui hubungan antara IMT dengan profil lipid pada pasien DMT2di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ini deskriptif analitik dengan menggunakan data rekam medik pasien di Poliklinik Endokrin Bagian/SMF Ilmu Penyakit Dalam RSUP. Prof. Dr. R. D. Kandou Manado periode September – November 2015. Hasil uji korelasi Pearson memperlihatkan nilai hubungan antara IMT dan kadar kolesterol total r = 0,037 dan p = 0,763 ; nilai hubungan antara IMT dan kadar HDL r = -0,249 dan p = 0,039 ; nilai hubungan antara IMT dan kadar LDL r = 0,091 dan p = 0,455; serta nilai hubungan antara IMT dan kadar trigliserida r = 0,179 dan p = 0,142. Simpulan: Pada pasien DMT2 tidak dijumpai hubungan bermakna antara IMT dengan kadar kolesterol total, kadar LDL, dan kadar trigliserida, namun terdapat hubungan bermakna antara IMT dengan kadar HDL.Kata kunci: IMT, kolesterol total, HDL, LDL, trigliserida, DMT2

scholarly journals Factors associated with serum lipids of adolescents from the Brazilian South

2014 ◽  
Vol 27 (1) ◽  
pp. 35-43 ◽  
Author(s):  
Carmem Cristina Beck ◽  
Adair da Silva Lopes ◽  
José Cazuza de Farias Júnior
Keyword(s):  
Body Mass Index ◽  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
Body Mass ◽  
High Density Lipoprotein Cholesterol ◽  
Serum Lipids ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Factors Associated ◽  
Independent Variables

OBJECTIVE: This study analyzes factors associated with serum lipids in adolescents from southern Brazil. METHODS: This is a school-based cross-sectional study with a probabilistic sample composed of 660 adolescents aged 14 to 19 years from the city of Três de Maio, Rio Grande do Sul state, Brazil. The following independent variables were analyzed: body mass index; waist-to-height ratio; moderate to vigorous level of physical activity; sedentary behaviour; lipid, total saturated fatty acid, cholesterol, sodium, and fiber intakes; smoking; and alcohol abuse. Linear regression analysis tested the association between the independent variables and total cholesterol and high density lipoprotein-cholesterol. RESULTS: Body mass index was directly associated with total cholesterol (β=0.96, p=0.001) and reversely associated with high density lipoprotein-cholesterol (β=-0.45, p<0.001). CONCLUSION: High body mass index may have a negative impact on the lipid profile of adolescents. Thus, monitoring nutritional status is important to prevent and control dyslipidemia in adolescents. We suggest multidisciplinary and intersectoral actions that encourage teenagers to acquire a healthy lifestyle, with emphasis on the adoption of an active lifestyle and balanced diet.

scholarly journals CLOCK 3111TT Genotype Is Associated with Increased Total Cholesterol and Low-Density Lipoprotein Levels in Menopausal Women with a Body Mass Index of at Least 25 kg/m2

2020 ◽  
Vol 28 (1) ◽  
pp. 1-9
Author(s):  
Natalya Semenova ◽  
Irina Madaeva ◽  
Sergey Kolesnikov ◽  
Lyubov Rychkova ◽  
Tatjana Bairova ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Gene Polymorphism ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Body Mass ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Minor Allele ◽  
Low Density ◽  
Menopausal Women

Lipid profile comparative analysis was performed to reveal the interdependence of lipids with Circadian locomoter output cycles protein kaput (CLOCK) 3111T/C gene polymorphism in menopausal women with/without a body mass index (BMI) of ≥25 kg/m2. Methods: A total of 193 female volunteers aged 45 to 60 years were divided into two groups: Those with BMI < 25 kg/m2 (control) and those with BMI ≥ 25 kg/m2. Each group was then divided into two subgroups: Those with the CLOCK TT-genotype and those with the CLOCK TC-, CC-genotypes. Lipid metabolism parameters were determined by the enzymatic method. Single-nucleotide polymorphisms (SNPs) were detected via polymerase chain reaction–restriction fragment length polymorphism technology. Results: There were no differences in CLOCK 3111T/C genotypes or allele frequency between the control and main groups. In addition, there were no differences in lipid profile parameters between women of the control group and different CLOCK 3111T/C genotypes. The total cholesterol (p = 0.041) and low-density lipoprotein cholesterol (p = 0.036) levels were higher in the subgroup of women with a BMI ≥ 25 kg/m2 and CLOCK TT-genotype as compared to the subgroup with a BMI ≥ 25 kg/m2 and minor allele 3111C. Conclusions: SNP 3111T/C of the CLOCK gene is not associated with BMI however, data suggest that the minor allele of the CLOCK 3111T/C gene polymorphism may have a protective role in atherogenic lipid levels in women with a BMI greater than or equal to 25 kg/m2.

Abstract 39: Added Sugar Intake and Lipids Profile Among US Adolescents: NHANES 2005-2010

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Zefeng Zhang ◽  
Cathleen Gillespie ◽  
Frank Hu ◽  
Quanhe Yang
Keyword(s):  
Body Mass Index ◽  
Measurement Error ◽  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
Body Mass ◽  
Density Lipoprotein ◽  
High Density ◽  
Added Sugar ◽  
Race Ethnicity ◽  
Lipids Profile

Background: Studies suggest that higher consumption of added sugar is associated with cardiovascular risk factors in adolescents. However, these studies were subject to measurement error due to the lack of adjustment for day-to-day variability. Hypothesis: We hypothesized that higher usual percent of calories from added sugar is associated with dyslipidemia. Methods: We analyzed data on 3322 adolescents aged 12-19 years who were not on low fat/low cholesterol diet or on sugar free/low sugar diet from the 2005-2010 National Health and Nutrition Examination Surveys. We estimated the usual percent of calories from added sugar from the diet accounting for measurement error. Multivariable linear regression was used to examine the associations between the percent of calories from added sugar with lipids profile. Results: The average usual percent of calories from added sugar was 17.5%. Ninety-one percent and 11% adolescents had usual percent ≥10% and ≥25%, respectively. After adjustment for potential confounders (age, sex, race/ethnicity, body mass index, parental educational attainment, smoking status, physical activity, 2010 Health Eating Index score except sugar component, and total calorie intake), usual percent of calories from added sugar was inversely associated with high-density lipoprotein and positively associated with triglycerides and the ratio of total cholesterol to high-density lipoprotein. Among the lowest and the highest quintiles of intake, high-density lipoprotein were 52.4 mg/dL (95% CI: 50.9 to 53.9) and 49.0 (95% CI: 47.9 to 50.2) (P trend = 0.003), triglycerides were 80.2 mg/dL (95% CI: 70.5 to 90.0) and 100.4 mg/dL (95% CI: 86.7 to 114.2) (P trend = 0.028), and the ratio of total cholesterol to high-density lipoprotein were 3.16 (95% CI: 2.8 to 3.6) and 3.49 (95% CI: 3.0 to 4.0) (P trend =0.006), respectively. The patterns of association were largely consistent across gender, race/ethnicity, and body mass index (normal vs. overweight/obese) subgroups, except in non-Hispanic black and Mexican American, in which the magnitude of the association tended to be smaller. Sensitivity analysis showed that, when intake data from the 1 st 24-hour dietary recall was used, the association remained significant but attenuated substantially. No association was found for total cholesterol and low-density lipoprotein. Conclusions: Overwhelming majority of US adolescents consumed more added sugar than recommended for heart health. Increased intake of added sugar is associated with several measures of dyslipidemia, and reduction of added sugar consumption among adolescents might reduce the risk of developing cardiovascular disease in adults.

scholarly journals ASSOCIATION OF LIPID PROFILE WITH BODY MASS INDEX IN GALL STONE DISEASE

2019 ◽  
Vol 3 (7) ◽  
Author(s):  
Dr. Pravin Shirke ◽  
Dr. Suryakant Nagtilak
Keyword(s):  
Body Mass Index ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Body Mass ◽  
Gall Stone ◽  
Density Lipoprotein ◽  
College Teaching ◽  
Stone Disease ◽  
Gall Stones ◽  
Gall Stone Disease

Introduction: Gall stone disease is common in northern regions of India including Uttarakhand. It is traditionally seen in fat, fertile, female of fourty. Apart from this, age, obesity, hyperlipidemia, smoking & diabetes are other risk factors. Gall stones show more association with elevated levels of triglyceride and low high density lipoprotein (HDL-C) where less association with total cholesterol and low density lipoprotein (LDL-C). Increased prevalence of gall stone reported in overweight. This present study conducted with an aim to find out the co-relation of lipid profile, BMI (body mass index) and gall stones in Uttarakhand population attending Shridev Suman Subharti Medical College Teaching Hospital, Dehradun. Material & Methods: Total 120 patients (10 M, 110 F) were included in the study following confirmation of diagnosis of gall stones on ultrasound. Age, sex, dietary habits, occupation, medical history and drug history of each patient were recorded in predesigned, tested proforma. The BMI calculated as weight in Kg/height in meter square. BMI of 18 to 24.9 were regarded as normal, whereas, 25 to 29.9 as overweight, 30 to 39.9 as obese and above 40 as morbid obese. The serum cholesterol, LDL, HDL and Triglyceride were estimated on a fasting sample by keeping patient nil orally for 12hrs after their normal meal. Results: Out of total 120 patients, 110(91.67%) were female & 10(8.33%) were male, with female to male ratio 9:1. The age-group of 21 to 40 years was the most common, with 64(53.33%) patients belonging to this group. Triglyceride was raised in 35(29.17%) patients, total cholesterol was raised in 7(5.83%) patients and LDL was raised in 5(4.17%) patients. The cholesterol was lowered in 13(10.83%) patients, HDL was lowered in 8(6.66%) patients and triglyceride was lowered in 3(2.5%) patients. Triglyceride & LDL were raised in 4(3.3%) patients, cholesterol and triglyceride were raised in 3(2.5%) patients and cholesterol and HDL were lowered in 4 (3.33%) patients. Patients with BMI of 18.0-24.9 were 72(60.00%), BMI of 25-29.9 were 36(30.00%) and BMI of 30-39.9 were 9(7.50%) respectively. Conclusion: The present study on presence of Gall stones which are more commonly found in females aged 21 to 40 years. Raised levels of Triglyceride and lower levels of cholesterol are associated with gall stones. There is no association between Increased BMI & presence of gall stones. BMI is associated with higher level of   Triglyceride. Key Words: Gall stone, BMI, Triglyceride, Cholesterol, and HDL-C.

scholarly journals Assessment of Lipid and Atherogenic Profile of Scavengers at Refuse Dumpsites in Port Harcourt, Rivers State, Nigeria

2020 ◽  
pp. 52-58
Author(s):  
Happiness I. Nti ◽  
Holy Brown ◽  
Ebirien-Agana S. Bartimaeus
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
Body Mass ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Port Harcourt ◽  
Significant Difference

Aim: Scavengers are individuals who gather waste and recyclable materials from refuse dumpsites, and thus are exposed to varieties of deleterious substances that have the potential to modulate and affect human health. This study was designed to assess the lipid and atherogenic profile of scavengers utilising refuse dumpsites in Port Harcourt, Nigeria.  Methodology: Fifty (50) exposed (scavengers) aged 31.32±9.49 years and 50 non-exposed (control) aged 32.92 ±10.63 years (age-matched) male subjects were sampled. The blood pressure was measured and body mass index calculated from the height and weight of the subjects. Total cholesterol, high density lipoprotein, low density lipoprotein and triglycerides levels of the subjects were determined from fasting serum samples using standard spectrophotometric methods. Atheogenic ratios were also computed using established formulae. The data was analyzed using Statistical Package for Social Sciences (SPSS) version 21 and expressed as mean and standard deviations. Variations between parameters was considered significant at p<0.05. Results: The result obtained revealed that the mean ± SD of total cholesterol, triglycerides and low density lipoprotein showed no significant difference (p > 0.05) while the level of high density lipoprotein showed significant difference (p < 0.05) between exposed (scavengers) and non-exposed (control) individuals. Body mass index and blood pressure did not also vary significantly (p>0.05) between the two group of subjects. Conclusion: Cardiovascular disease risk exist among the study subjects as revealed by atherogenic profiling of the subjects indicating the need for life style changes and socio economic intervention among the subjects.

scholarly journals Association between Aerobic Exercise and High-Density Lipoprotein Cholesterol Levels across Various Ranges of Body Mass Index and Waist-Hip Ratio and the Modulating Role of the Hepatic Lipase rs1800588 Variant

Genes ◽  
2019 ◽  
Vol 10 (6) ◽  
pp. 440 ◽  
Author(s):  
Yasser Nassef ◽  
Oswald Ndi Nfor ◽  
Kuan-Jung Lee ◽  
Ming-Chih Chou ◽  
Yung-Po Liaw
Keyword(s):  
Body Mass Index ◽  
High Density Lipoprotein ◽  
Aerobic Exercise ◽  
Body Mass ◽  
High Density Lipoprotein Cholesterol ◽  
Hepatic Lipase ◽  
Density Lipoprotein ◽  
Normal Weight ◽  
Lipoprotein Cholesterol ◽  
Waist Hip Ratio

Changes in concentrations of high-density lipoprotein cholesterol (HDL-C) are modified by several factors. We examined the relationship between aerobic exercise and HDL-C among different categories of body mass index (BMI) and waist-hip ratio (WHR) and the impact of rs1800588 variant in the hepatic lipase (LIPC) gene. We analyzed data from 6184 men and 8353 women aged 30–70 years. Participants were grouped into two WHR categories: Normal (0 < WHR < 0.9 for men and 0 < WHR < 0.8 for women) and abnormal (WHR ≥ 0.9 for men and WHR ≥ 0.8 for women). The BMI categories were: Underweight (BMI < 18.5 kg/m2), normal weight (18.5 ≤ BMI < 24 kg/m2), overweight (24 ≤ BMI < 27 kg/m2), and obese (BMI ≥ 27 kg/m2). Multivariate linear regression models were used to investigate associations between HDL-C and exercise. Aerobic exercise was significantly associated with higher HDL-C (β = 1.18325; p < 0.0001) when compared with no exercise. HDL-C was significantly lower in persons with abnormal compared to those with normal WHR (β = −3.06689; p < 0.0001). Compared with normal weight, overweight and obese categories were associated with lower HDL-C, with β values of −4.31095 and −6.44230, respectively (p < 0.0001). Unlike rs1800588 CT and TT genotypes, associations between aerobic exercise and HDL were not significant among CC carriers no matter their BMI or WHR.

scholarly journals Study on Relationship of Serum Total Cholesterol Low Density Lipoprotein and Triglycerides With Body Mass Index

2013 ◽  
Vol 23 (2) ◽  
pp. 22-26
Author(s):  
Kamal Hossain ◽  
Mahmudul Hoque ◽  
Saifur Nahar Faiz ◽  
ASM Towhidul Alam
Keyword(s):  
Body Mass Index ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Body Mass ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Total Cholesterol ◽  
Renal Diseases ◽  
Low Density ◽  
Significant Difference

The present case control study was designed to determined the relationship between serum Total cholesterol, Low Density Lipoprotein (LDL), Triglycerides (TG) and Body Mass Index (BMI). The study was carried out in the Department of Biochemistry Chittagong Medical College during the period of January 2010- December 2010. Samples were collected from population of different area of Chittagong City Corporation of different occupations, age from 35- 60 years. The data were collected by a structured questionaries which includes age, sex, occupation, dietary habits, family history of hyperlipidemia and DM. BMI was calculated by standardized protocol. Population suffering from DM, renal diseases and other endocrine disease were excluded. A total of 105 subjects were included in this study. Among them 70 were considered as case ( whose BMI was 25 kg/m2) and 35 were considered as control ( whose BMI was < 25 Kg/ m2).Serum Total cholesterol, LDL-C, HDL-C and TG were measured in all samples in fasting state. Study showed that female were more obese than male,( 31.14 +2.23kg/m2 Vs 29.71 +2.69kg/mo), p= <0.05.Results showed that Serum TC(45%), LDL-C(65%), TG(70%) were significantly higher in cases than that of controls (p=<0.001).Serum HDL-C(35%) was significantly decreased in cases than that of controls (p=<0.001).Study showed that hypertriglyceridemia (70%) was the common lipid abnormality and then LDL-C (65%). Study revealed that there was no significant difference in lipid profile between male and female. Pearson's Correlation Coefficient showed that there were positive correlation between TC (r=0.234,p=<0.05), LDL-C (r=0.258,p=<0.01), TG (r=0.409,p=<0.001) and BMI, and was negative correlation between HDL-C(r= -0.403, p= <0.001) and BMI. So early detection and prevention of obesity and abnormal lipid profile can largely reduce morbidity and mortality and alleviate undue burden on our limited health budget. JCMCTA 2012 ; 23 (2): 22-26

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