scholarly journals Association between Aerobic Exercise and High-Density Lipoprotein Cholesterol Levels across Various Ranges of Body Mass Index and Waist-Hip Ratio and the Modulating Role of the Hepatic Lipase rs1800588 Variant

Genes ◽  
2019 ◽  
Vol 10 (6) ◽  
pp. 440 ◽  
Author(s):  
Yasser Nassef ◽  
Oswald Ndi Nfor ◽  
Kuan-Jung Lee ◽  
Ming-Chih Chou ◽  
Yung-Po Liaw

Changes in concentrations of high-density lipoprotein cholesterol (HDL-C) are modified by several factors. We examined the relationship between aerobic exercise and HDL-C among different categories of body mass index (BMI) and waist-hip ratio (WHR) and the impact of rs1800588 variant in the hepatic lipase (LIPC) gene. We analyzed data from 6184 men and 8353 women aged 30–70 years. Participants were grouped into two WHR categories: Normal (0 < WHR < 0.9 for men and 0 < WHR < 0.8 for women) and abnormal (WHR ≥ 0.9 for men and WHR ≥ 0.8 for women). The BMI categories were: Underweight (BMI < 18.5 kg/m2), normal weight (18.5 ≤ BMI < 24 kg/m2), overweight (24 ≤ BMI < 27 kg/m2), and obese (BMI ≥ 27 kg/m2). Multivariate linear regression models were used to investigate associations between HDL-C and exercise. Aerobic exercise was significantly associated with higher HDL-C (β = 1.18325; p < 0.0001) when compared with no exercise. HDL-C was significantly lower in persons with abnormal compared to those with normal WHR (β = −3.06689; p < 0.0001). Compared with normal weight, overweight and obese categories were associated with lower HDL-C, with β values of −4.31095 and −6.44230, respectively (p < 0.0001). Unlike rs1800588 CT and TT genotypes, associations between aerobic exercise and HDL were not significant among CC carriers no matter their BMI or WHR.

2014 ◽  
Vol 27 (1) ◽  
pp. 35-43 ◽  
Author(s):  
Carmem Cristina Beck ◽  
Adair da Silva Lopes ◽  
José Cazuza de Farias Júnior

OBJECTIVE: This study analyzes factors associated with serum lipids in adolescents from southern Brazil. METHODS: This is a school-based cross-sectional study with a probabilistic sample composed of 660 adolescents aged 14 to 19 years from the city of Três de Maio, Rio Grande do Sul state, Brazil. The following independent variables were analyzed: body mass index; waist-to-height ratio; moderate to vigorous level of physical activity; sedentary behaviour; lipid, total saturated fatty acid, cholesterol, sodium, and fiber intakes; smoking; and alcohol abuse. Linear regression analysis tested the association between the independent variables and total cholesterol and high density lipoprotein-cholesterol. RESULTS: Body mass index was directly associated with total cholesterol (β=0.96, p=0.001) and reversely associated with high density lipoprotein-cholesterol (β=-0.45, p<0.001). CONCLUSION: High body mass index may have a negative impact on the lipid profile of adolescents. Thus, monitoring nutritional status is important to prevent and control dyslipidemia in adolescents. We suggest multidisciplinary and intersectoral actions that encourage teenagers to acquire a healthy lifestyle, with emphasis on the adoption of an active lifestyle and balanced diet.


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