scholarly journals Evaluation of cerebral venous thrombosis by computed tomography/MRI and magnetic resonance venography in pregnant and postpartum women: a prospective study

2018 ◽  
Vol 6 (10) ◽  
pp. 3381
Author(s):  
Neelam Singh ◽  
Dinesh Udainiya ◽  
Sonal Kulshreshtha ◽  
Jyoti Bindal
Keyword(s):  
Venous Thrombosis ◽  
Temporal Lobe ◽  
Cerebral Venous Thrombosis ◽  
Post Partum ◽  
Transverse Sinus ◽  
Venous System ◽  
Postpartum Women ◽  
Hemorrhagic Infarction ◽  
Sagittal Sinus ◽  
A Prospective Study

Background: Diagnosis of Cerebral venous thrombosis (CVT) is challenging as it is an uncommon cause of stroke with varied clinical presentations, predisposing factors, imaging findings, and outcomes. Prompt and accurate diagnosis is important for timely intervention in order to reverse and significantly reduce the acute and long-term sequel. Aims and objectives was to study cerebral venous thrombosis in pregnant and post-partum women.Methods: Hundred pregnant and postpartum women having CVT were studied at Kamla Raja Hospital and JA Group of Hospital at GR Medical College, Gwalior Madhya Pradesh for study period of 2016 to 2017. All the women had undergone CT/MRI and MRV.Results: Age of CVT patients ranged from 18-35 years with a maximum incidence (84%) in the 2nd decade (20-30 years). Sixty two percent women had infarction; out of that 53% had hemorrhagic infarction. Frontal lobe (10%) and temporal lobe (10%) were more affected. Superior sagittal sinus (SSS) was most commonly involved (71%) followed by transverse sinus (66%) and sigmoid sinus (45%). Superficial venous system was involved in 32 patients while deep venous system was involved in 20 patients. Majority of (82%) patients had combination of sinuses and venous involvement.Conclusions: CVT was more prevalent in young pregnant and postpartum women. Hemorrhagic infarction were common and affecting frontal and temporal lobe. SSS were mostly affected in CVT. MRV should be the first line diagnostic tool for diagnosis of CVT in pregnant and postpartum women.

scholarly journals Role of diffusion-weighted imaging in the diagnosis of cerebral venous thrombosis

2020 ◽  
Vol 48 (6) ◽  
pp. 030006052093344
Author(s):  
Bin Lv ◽  
Cheng-lin Tian ◽  
Xiang-yu Cao ◽  
Xin-feng Liu ◽  
Jun Wang ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Diffusion Weighted Imaging ◽  
Disease Onset ◽  
Transverse Sinus ◽  
Control Group ◽  
Lower Sensitivity ◽  
Sagittal Sinus ◽  
Diffusion Weighted ◽  
Hyperintense Signal

Objective To evaluate the hyperintense signal (HIS) performance on diffusion-weighted imaging (DWI) in diagnosing cerebral venous thrombosis (CVT). Methods Seventy-eight patients with CVT hospitalized from January 2004 to January 2015 were retrospectively studied alongside 78 controls without intracranial organic diseases. Diagnostic accuracy indices of HIS on DWI or T2-weighted imaging (T2WI) to diagnose CVT at different sites and states were analyzed. Results The overall sensitivity of HIS on DWI for the diagnosis of CVT was significantly lower than that of HIS on T2WI (34.6% vs. 79.5%). HIS on T2WI was more sensitive than HIS on DWI in detecting thrombosis, especially in the superior sagittal sinus and transverse sinus. HIS on DWI was inversely related to the time between disease onset and imaging. Compared with HIS on T2WI, combining HIS on DWI and T2WI did not increase the sensitivity for detecting CVT. HIS on DWI was not detected in the control group, but HIS on T2WI was detected in 26.3% of control individuals. The specificity of HIS on DWI for CVT was higher than that of HIS on T2WI (97.4% vs. 76.9%). Conclusion HIS on DWI has a lower sensitivity, but a higher specificity, than HIS on T2WI for diagnosing CVT.

scholarly journals Cerebral venous thrombosis secondary to hyperthyroidism: A case report

2018 ◽  
Vol 15 (1) ◽  
pp. 29-31
Author(s):  
Basant Pant ◽  
Malika Bajracharya ◽  
Avinash Chandra ◽  
Ramita Bati ◽  
Reema Rajbhadari ◽  
...  
Keyword(s):  
Case Report ◽  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Thrombus Formation ◽  
Thyroid Function Test ◽  
Transverse Sinus ◽  
Severe Headache ◽  
Cerebral Veins ◽  
First Case ◽  
Red Flag

Cerebral Venous Thrombosis (CVT) is a rare form of Stroke characterized by thrombus formation in the cerebral veins. CVT is a result of various reasons among which the hyperthyroidism is not so frequently encountered. This is probably the first case report published from Nepal. The aim of this case report is to give the message that persistent severe headache in patient with hyperthyroidism can be the red flag and needs to be investigated further. We present a case of a 35 years old female who presented with complaints of severe headache and persistent in nature associated with vomiting since 5 days. She was a diagnosed subacute thryroiditis and under medicine from 1 month before presenting to us. Her Magnetic Resonance Venography (MRV) brain showed venous thrombosis within superior saggital sinus, left transverse sinus and sigmoid sinus. Her thyroid function test showed pretreatment T3 of 2.98 ng/ml T4 of 1.02 mg/ ml and TSH of 0.12 μIU/L. She was kept on anticoagulants and other supportive measures. The patient showed improving status with the conservative management.Nepal Journal of Neuroscience 15:29-31, 2018

scholarly journals A young woman with headache and seizures

2013 ◽  
pp. 25-29
Author(s):  
A.M. Pizzini ◽  
M. Silingardi ◽  
I. Iori
Keyword(s):  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Mr Angiography ◽  
Sinus Thrombosis ◽  
Factor V Leiden ◽  
Transverse Sinus ◽  
Acute Onset ◽  
Factor V ◽  
Neuroimaging Techniques

CASE REPORT We describe a 31 year-old woman with headache and acute onset of seizures. Medical history and physical examination were unremarkable. She has been on therapy with oral contraceptives for many years for dysmenorrhea. A CT scan was negative, but MRI and MR-angiography showed left transverse sinus thrombosis. Screening for thrombophilia revealed hyperhomocysteinemia and Factor V Leiden heterozigousity. The patient received unfractionated heparin, followed by long-term anticoagulation with warfarin (INR 2-3). CONCLUSIONS Cerebral venous thrombosis is a rare cerebrovascular disorder, frequently in young adult (about 75% are women). The diagnosis might be difficult with consequent high long-term morbidity and mortality rate. New neuroimaging techniques (MRI and MR-angiography) and more effective treatment (anticoagulation and endovascular thrombolysis) have improved the prognosis and the natural history. The risk factors, the clinical presentation, the diagnostic evaluation and the management of cerebral venous thrombosis are reviewed.

scholarly journals Specific Polymorphism 4G/5G Gene for PAI-1 as a Possible Cause of Cerebral Venous Thrombosis: A Case Report

2017 ◽  
Vol 18 (2) ◽  
pp. 169-173
Author(s):  
Tatjana Boskovic Matic ◽  
Aleksandar Gavrilovic ◽  
Snezana Simovic ◽  
Dejan Aleksic ◽  
Katarina Vesic ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Plasminogen Activator ◽  
Cerebral Venous Thrombosis ◽  
Sinus Thrombosis ◽  
Plasminogen Activator Inhibitor ◽  
Plasminogen Activator Inhibitor 1 ◽  
Sagittal Sinus ◽  
Clinical Center ◽  
The Impact ◽  
Activator Inhibitor

AbstractThrombosis of veins and venous sinus (CVT) is the rare cerebral vascular disorder which makes less than 1% of all strokes. Thrombosis of veins and venous sinuses is picturesquely called “мајоr neurological forger” since it is characterized by very varied clinical picture. Among the various causes of CVT, which can be of infective or non-infective nature, the congenital hyper coagulations especially stand out, diagnosis is based on highly sophisticated diagnostic tests.We present the case of a female patient, 36 years old, who was hospitalized at the Clinic for Neurology in Clinical Center because of the diffuse headache she had for the last few days, with milder right-sided hemiparesis and one generalized tonic-clonic epileptic seizure. With nuclear magnetic resonance (MR/2D venography) the thrombosis of the upper and lower sagittal sinuses is confirmed. By appropriate laboratory tests, as well as by confirmatory immunological and genetic analyses, the impact of the most of the factors is excluded which can contribute to the occurrence of venous thrombosis. The only pathological findings which indicated the possible congenital thrombophilia as the cause of the sagittal sinus thrombosis was the determination of the specific polymorphism of the 4G/5G gene for plasminogen activator inhibitor 1.According to our knowledge, this is the first decribed case of the possible impact of the specific polymorphism of the 4G/5G gene for plasminogen activator inhibitor of 1 on the development of cerebral venous thrombosis.

scholarly journals Dulaglutide-induced cerebral venous thrombosis in a patient with type 2 diabetes mellitus

2018 ◽  
pp. bcr-2018-226346 ◽  
Author(s):  
Rajesh Rajput ◽  
Vaibhav Pathak ◽  
Pawan Kumar Yadav ◽  
Sanat Mishra
Keyword(s):  
Diabetes Mellitus ◽  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Sinus Thrombosis ◽  
Transverse Sinus ◽  
Nausea And Vomiting ◽  
Acute Infarct ◽  
Patients With Diabetes ◽  
The Right

Though patients with diabetes mellitus are at a high risk of atherothrombotic events, every such event should not be attributed to the disease itself. We present a case of a patient with diabetes with headache and blurring of vision for 3 days. Brain imaging revealed right transverse sinus thrombosis and acute infarct of the right posterior parieto-occipital region, predominantly in the posterior cortical watershed zone. The patient was on subcutaneous dulaglutide for 3 weeks and was having nausea and vomiting. Various causes of cerebral venous thrombosis were ruled out with appropriate laboratory investigations. Finally, cerebral venous thrombosis was attributed to dulaglutide-induced nausea and vomiting which led to severe dehydration.

scholarly journals Cerebral venous thrombosis complicated by hemorrhagic infarction in pregrancy: case report

2011 ◽  
Vol 17 (1) ◽  
pp. 29-31
Author(s):  
Metin Balduz ◽  
Oktay Kapan ◽  
Hasan Huseyin Ozdemir ◽  
Iklimya Dagli ◽  
Caner Demir
Keyword(s):  
Case Report ◽  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Hemorrhagic Infarction
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