scholarly journals Evaluation of the relationship of disease activity with neutrophile to lymphocyte ratio and platelet to lymphocyte ratio in patients with peptic ulcer and gastritis

2020 ◽  
Vol 8 (11) ◽  
pp. 3850
Author(s):  
Burcu Gulbagci ◽  
Fettah Sametoglu ◽  
Hasret Cengiz ◽  
Ceyhun Varim
Keyword(s):  
Peptic Ulcer ◽  
Evaluation Method ◽  
Demographic Data ◽  
Normal Subjects ◽  
Upper Gastrointestinal Endoscopy ◽  
Platelet To Lymphocyte Ratio ◽  
Ulcer Disease ◽  
Lymphocyte Ratio ◽  
Significant Difference ◽  
Internal Medicine Clinic

Background: Dyspepsia is a confusing complaint in terms of patient approach and management. Since the most important clinical diagnoses that occur with dyspeptic complaints are gastroduodenitis, peptic ulcer disease and gastric-esophageal cancers, endoscopic evaluation method is often preferred in the diagnosis. It has been shown that NLR (neutrophil to lymphocyte ratio) can be an important marker in many chronic systemic diseases, especially malignancies. Since upper gastrointestinal endoscopy is an invasive and costly procedure, NLR and PLR (Platelet to lymphocyte ratio) may be useful as a new marker to help in the diagnosis of gastritis and peptic ulcer. In our study, we aimed to investigate how NLR and PLR changes seen in patients with gastritis and peptic ulcer diseases.Methods: A total of 906 patients who applied to the internal medicine clinic of our hospital between January 2016 and September 2017 were included in the study. The demographic data, drugs, endoscopy and biopsy results and hemogram parameters of the patients were obtained from the outpatient clinic records. NLR and PLR values were calculated and statistically interpreted.Results: According to the endoscopy results, a total of 906 patients with 311 (34.3%) gastritis, 288 (31.8%) peptic ulcer and 307 (33.9%) normal findings were included in to the study. Male to female ratios were 55% to 45% in gastritis patients, 55,6% to 44,4% in peptic ulcer patients and 53,4% to 46,6% in normal subjects. The median age of the patients was 50 years (18-82 years). The median NLR and PLR ratios were 1.82 (0.54-8.35) and 107.8 (46.27-446.43) in the gastritis group, 1.9 (0.61-9.86) in the peptic ulcer group and 110.95 (44.03-340.65) and 1.71 (0.56-12.89) and 106.02 (40.41-397.62) in the normal group. While a significant difference was obtained between the groups in terms of NLR ((p=0.048), no significant difference was found for PLR (p=0.422).Conclusions: In our study, a statistical significant difference was found between patients with gastritis and peptic ulcer and normal subjects in terms of NLR, but this difference was not at a level that could be used in clinical practice.

scholarly journals Evaluation of Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and C-Reactive Protein in Tension-Type Headache Patients

2021 ◽  
Author(s):  
Hasan Hüseyin Özdemir ◽  
Ahmet Dönder
Keyword(s):  
Systemic Inflammation ◽  
Tension Type Headache ◽  
Neutrophil To Lymphocyte Ratio ◽  
Control Group ◽  
C Reactive Protein ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Reactive Protein ◽  
Significant Difference ◽  
Type Headache

Abstract Objectives A tension headache is the most common type of headache, and its causes are multifactorial. A relationship has been shown between migraine headaches and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and C-reactive protein (CRP). In this study, we investigated the NLR, PLR, and serum CRP levels in frequent episodic tension-type headache (FETTH) and chronic tension-type headache (CTTH) patients. Materials and Methods This retrospective study included 64 patients with FETTH, 80 patients with CTTH, and 60 healthy controls who were followed up in the neurology clinic. Hematological parameters were compared between the patient and control groups. Results In CTTH patients, platelets, NLR, PLR, and CRP values were statistically higher than in FETTH patients and patients in the control group. In FETTH patients, the PLR value was higher than in patients in the control group, but there was no statistically significant difference in NLR and CRP values between FETTH patients and patients in the control group. Also, there was no correlation between these values and age and gender. Conclusion Increase platelet count might have an effect on tension-type headache pathophysiology. Systemic inflammation parameters were shown to be significantly higher in CTTH patients. More comprehensive studies are needed to evaluate the effect of systemic inflammation on the chronicity of tension headaches.

scholarly journals Platelet-to-lymphocyte ratio (PLR) and Plateletcrit (PCT) in young patients with morbid obesity

2019 ◽  
Vol 65 (9) ◽  
pp. 1182-1187 ◽  
Author(s):  
Emrah Erdal ◽  
Mehmet İnanir
Keyword(s):  
Morbid Obesity ◽  
Healthy Subjects ◽  
Complete Blood Count ◽  
Young Patients ◽  
Obese Group ◽  
Platelet To Lymphocyte Ratio ◽  
Distribution Width ◽  
Lymphocyte Ratio ◽  
Platelet Counts ◽  
Significant Difference

SUMMARY OBJECTIVE To compare the complete blood counts, namely the plateletcrit (PCT) and Platelet-To-Lymphocyte Ratio (PLR) of healthy subjects and those with morbid obesity in the young population. METHODS We included 45 patients with morbid obesity (body mass index -BMI - greater than or equal to 45 kg/m2) and 45 healthy subjects (BMI less than or equal to 25 kg/m2) in our study. Blood samples were obtained from the participants following a 12-hour fasting period. Then we evaluated the levels of hemoglobin (Hb), hematocrit (HCT), red cell distribution width (RDW), mean platelet volume (MPV), white blood cell (WBC), PLR, platelet counts, and PCT in the complete blood count. RESULTS The morbid obesity group had significantly higher platelet counts and PCT values (p<0.001), and PLR values (p=0.033). The value of WBC was also higher in the obese group (p=0.001). MPV was lower in the obesity group but not statistically significant (p=0.815). No significant difference was found between hemoglobin and hematocrit values in these groups; but RDW valuewere higher and statistically significant in the obese group (p=0.001). CONCLUSION PLR or PCT may be more useful as a marker in determining an increased thrombotic state and inflammatory response in morbid obesity.

scholarly journals Association of Peptic Ulcer Disease with Obesity, Serum Insulin Level and Lipid Profile

2020 ◽  
Author(s):  
Foroogh Forghani ◽  
Mahboube Mirhashemi
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Lipid Profile ◽  
Gastrointestinal Disease ◽  
Serum Insulin ◽  
Insulin Level ◽  
Contributing Factors ◽  
Ulcer Disease ◽  
Significant Difference

Abstract Background: PUD is a common and important type of gastrointestinal disease. Determination of contributing factors for PUD is an important issue for the development of preventive approaches. In this study, the association of Peptic Ulcer Disease with Obesity and Serum Insulin and Lipid Profile was studied.Methods: In this case-control study in Modarres Hospital in Tehran in 2019 among 170 consecutive subjects including 90 patients with PUD and 80 cases without it were enrolled and sampling tools were checklists. Serum Insulin and Lipid Profile and BMI were compared across the groupsResults: The results in this study demonstrated that Serum Insulin and Lipid Profile and BMI had no statistically significant difference between those patients with and without presence of PUD (P > 0.05).Conclusion: This study showed no statistically significant difference between those patients with and without the presence of PUD from points of Serum Insulin and Lipid Profile and BMI.

scholarly journals Correlation of Clinical, Endoscopic, and Pathological Findings among Suspected Peptic Ulcer Disease Patients in Abuja, Nigeria

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Onyedika Godfrey Okoye ◽  
Oluwole Olayemi Olaomi ◽  
Alexander M.E. Nwofor ◽  
Paul Jibrin ◽  
Cephas Shallangwa Batta ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Gastrointestinal Endoscopy ◽  
Upper Gastrointestinal Endoscopy ◽  
Pathological Findings ◽  
Histological Findings ◽  
National Hospital ◽  
Ulcer Disease ◽  
Endoscopic Findings ◽  
H Pylori ◽  
Upper Gastrointestinal

Background. Peptic ulcer disease (PUD) remains one of the most prevalent gastrointestinal diseases and has been linked to Helicobacter pylori (H. pylori) infection. This condition may be suspected on clinical grounds, but diagnosis is established using upper gastrointestinal endoscopy. Aims. To determine the correlation between the endoscopic and pathological findings among suspected PUD patients who have been referred for diagnostic upper gastrointestinal endoscopy in National Hospital Abuja. Methods. This is a hospital-based prospective study conducted among suspected PUD patients at National Hospital Abuja over a one-year period. Clinical, endoscopic, and histological findings were ascertained and documented. Data obtained were analyzed using SPSS version 21.0. Tests of significance were done using the chi-square test and Student t -test at 95% confidence intervals. Results. One hundred and thirty-two patients were included in the study. The ages ranged from 15 to 87 years, mean age 43.30 ± 11.94 years. Seventy-seven (58.3%) patients had abnormal endoscopic findings, of whom 37 (28.0%) had PUD. Prevalence of H. pylori infection was 42.2% and was found in 81.1% of PUD patients. H. pylori was significantly associated with confirmed PUD ( p < 0.001 ) and abnormal endoscopic findings ( p < 0.001 ). No association was found between normal endoscopic findings and histological findings ( p = 0.924 ). Conclusion. There is a poor correlation between clinical and endoscopic diagnoses of PUD. H. pylori was found to be significantly associated with PUD and abnormal endoscopic findings. Endoscopic facilities should therefore be made available and accessible for proper PUD diagnosis. Empirical treatment of H. pylori in patients with diagnosed PUD is strongly recommended.

scholarly journals The association between obesity and hematologic inflammatory markers in the first trimester pregnancies

2021 ◽  
Vol 28 (1) ◽  
pp. 17-22
Author(s):  
Feyza Nur İncesu Çintesun
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Inflammatory Markers ◽  
Demographic Data ◽  
First Trimester ◽  
Normal Weight ◽  
Obese Patients ◽  
Distribution Width ◽  
Lymphocyte Ratio ◽  
Significant Difference

Objective Obesity is the defined as the abnormal or excessive accumulation of the fat which is harmful for the health, and its prevalence has been increasing. Many studies have shown that obesity alone leads to inflammation and causes poor gestational outcomes. In our study, we aimed to investigate the association between basic hematologic markers and obesity in the first trimester pregnancies. Methods A total of 321 pregnant women who admitted to the clinic of gynecology and obstetrics in a tertiary state hospital were included in the study. The patients were separated into three groups, which were normal weight (BMI: 18–24.9 kg/m2), overweight (BMI: 25–29.9 kg/m2), and obese (BMI>30 kg/m2). Of the patients, the demographic data (age, gravida, and parity) and the parameters of hemoglobin, hematocrit, white blood cell, neutrophil, lymphocyte, platelet (PLT), eosinophil, basophil, mean platelet volume (MPV), platelet distribution width (PDW), neutrophil/lymphocyte ratio (NLR), red blood cell distribution width (RDW), plateletcrit (PCT) and platelet/lymphocyte ratio (PLR) measured in the complete blood count which was checked in the first trimester routinely during the pregnancy follow-up were analyzed. The three groups were compared in terms of inflammatory markers. Results The patients were evaluated in three groups: 108 patients with normal weight (Group 1), 109 overweight patients (Group 2) and 104 obese patients (Group 3). No significant difference was found in terms of age, parity and gravida when the demographic data were analyzed among the groups (p>0.05). When the groups were compared in terms of hematologic markers, similar values were found in the markers other than white blood cell, neutrophil, lymphocyte, PLT and PCT values. The difference among white blood cell, neutrophil, lymphocyte, PLT and PCT values were between the patients with normal weight and obese patients, and the values of these markers were found higher in overweight / normal weight patient groups than the normal group (p<0.05). Conclusion The values of white blood cell, neutrophil, lymphocyte, PLT and PCT which were shown to be associated with inflammation were higher in the obese patients.

Predictive value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio for primary patency of percutaneous transluminal angioplasty in hemodialysis arteriovenous fistula stenosis

Vascular ◽  
2021 ◽  
pp. 170853812110396
Author(s):  
Feng Zhu ◽  
Yao Yao ◽  
Hongbo Ci ◽  
Alimujiang Shawuti
Keyword(s):  
Arteriovenous Fistula ◽  
Percutaneous Transluminal Angioplasty ◽  
Transluminal Angioplasty ◽  
Primary Patency ◽  
Neutrophil To Lymphocyte Ratio ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Significant Difference ◽  
Percutaneous Transluminal ◽  
Hemodialysis Arteriovenous Fistula

Objective The aim of this study is to investigate the potential association of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with the primary patency of percutaneous transluminal angioplasty (PTA) in hemodialysis arteriovenous fistula (AVF) stenosis. Methods This study conducted a retrospective review of patients with end-stage renal disease referred for hemodialysis AVF stenosis in one center. The study consisted of 114 patients with significant (significant stenosis was defined as a reduction in the caliber of the fistula vein of > 50% with respect to the non-aneurysmal venous segment). AVF stenosis patients were treated with PTA, with conventional balloon angioplasty. The NLR and PLR were calculated from the pre-interventional blood samples. The patients were classified into two groups: group A, primary patency < 12 months ( n = 35) and group B, and primary patency ≥ 12 months ( n = 79). Comparisons between the groups were performed using the Mann–Whitney U test. Kaplan–Meier analysis was performed to compare the factors, NLR and PLR, for association with primary patency AVFs. A receiver-operating characteristic curve analysis was performed to identify the sensitivity and specificity of the NLR and PLR cut-off values in the prediction of primary patency time. Results There was no difference in gender; age; side of AVF; AVF type; comorbid diseases such as diabetes mellitus and hypertension; or blood parameters such as white cell count, erythrocytes, hemoglobin, neutrophils, lymphocytes, monocytes, eosinophils, basophils, C-reactive protein, NLR, or PLR between the two groups ( p > 0.05). There was also no significant difference in the patency rate between the NLR < 4.13 and NLR ≥ 4.13 groups at 12 months (NLR cut-off point = 4.13, p = 0.273). There were statistically significant differences between the primary patency rates of the PLR < 187.86 and PLR ≥ 187.86 groups at 12 months (PLR cut-off point = 187.86, p = 0.023). The cut-off value for PLR for the determination of primary patency was 187.86, with a sensitivity of 57.0% and specificity of 34.4%. Conclusion An increased level of PLR may be a risk factor for the development of early AVF restenosis after successful PTA. However, more studies are needed to validate this finding.

Effects of Ramadan fasting on peptic ulcer disease as diagnosed by upper gastrointestinal endoscopy

2012 ◽  
Vol 13 (4) ◽  
pp. 180-183
Author(s):  
Ali Kagan Gokakin ◽  
Atilla Kurt ◽  
Gunduz Akgol ◽  
Boran Cihat Karakus ◽  
Mustafa Atabey ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Gastrointestinal Endoscopy ◽  
Upper Gastrointestinal Endoscopy ◽  
Ramadan Fasting ◽  
Ulcer Disease ◽  
Upper Gastrointestinal

scholarly journals Predictive value of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients with Vaginitis

2020 ◽  
Vol 37 (1) ◽  
Author(s):  
Eren Pek ◽  
Fatma Beyazit ◽  
Nilay Sen Korkmaz
Keyword(s):  
Bacterial Vaginosis ◽  
Predictive Value ◽  
Inflammatory Marker ◽  
Diagnostic Value ◽  
Neutrophil To Lymphocyte Ratio ◽  
Platelet To Lymphocyte Ratio ◽  
Cross Sectional ◽  
Distribution Width ◽  
Lymphocyte Ratio ◽  
Significant Difference

Objectives: This study was conducted to evaluate the diagnostic value of platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) in vaginitis patients. Methods: This cross-sectional retrospective study was performed in Afyon Dinar State Hospital between July 2016 to August 2017. A total of 64 bacterial vaginosis (BV) patients, 66 vulvovaginal candidiasis (VVC) patients and 65 age-matched control subjects were enrolled. NLR, PLR, mean platelet volume (MPV), red cell distribution width (RDW) and other conventional inflammatory marker values were recorded for all patients before and after treatment. Results: In the BV group, NLR values were found to be elevated compared to VVC and healthy controls [2.9 (1.2-14.7), 2.1 (1.1-11.7) and 2.1 (0.8-7.0), respectively] (p=0.008). Although not found to be statistically significant, the median NLR levels of BV patients decreased from 2.9 (1.2-14.7) to 2.4 (1.2-7.0) after treatment. PLR levels did not show a statistically significant difference between the three groups (p=0.970). The cut-off value of the NLR for BV was 2.19, with 67.2% sensitivity and 63.8% specificity. Conclusions: The present study demonstrated that NLR levels are elevated in bacterial vaginosis and NLR levels can be used as a reflection of systemic inflammatory response in vaginosis patients. doi: https://doi.org/10.12669/pjms.37.1.2774 How to cite this:Pek E, Beyazit F, Korkmaz NS. Predictive value of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients with Vaginitis. Pak J Med Sci. 2021;37(1):250-255. doi: https://doi.org/10.12669/pjms.37.1.2774 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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