scholarly journals The association between obesity and hematologic inflammatory markers in the first trimester pregnancies

2021 ◽  
Vol 28 (1) ◽  
pp. 17-22
Author(s):  
Feyza Nur İncesu Çintesun
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Inflammatory Markers ◽  
Demographic Data ◽  
First Trimester ◽  
Normal Weight ◽  
Obese Patients ◽  
Distribution Width ◽  
Lymphocyte Ratio ◽  
Significant Difference

Objective Obesity is the defined as the abnormal or excessive accumulation of the fat which is harmful for the health, and its prevalence has been increasing. Many studies have shown that obesity alone leads to inflammation and causes poor gestational outcomes. In our study, we aimed to investigate the association between basic hematologic markers and obesity in the first trimester pregnancies. Methods A total of 321 pregnant women who admitted to the clinic of gynecology and obstetrics in a tertiary state hospital were included in the study. The patients were separated into three groups, which were normal weight (BMI: 18–24.9 kg/m2), overweight (BMI: 25–29.9 kg/m2), and obese (BMI>30 kg/m2). Of the patients, the demographic data (age, gravida, and parity) and the parameters of hemoglobin, hematocrit, white blood cell, neutrophil, lymphocyte, platelet (PLT), eosinophil, basophil, mean platelet volume (MPV), platelet distribution width (PDW), neutrophil/lymphocyte ratio (NLR), red blood cell distribution width (RDW), plateletcrit (PCT) and platelet/lymphocyte ratio (PLR) measured in the complete blood count which was checked in the first trimester routinely during the pregnancy follow-up were analyzed. The three groups were compared in terms of inflammatory markers. Results The patients were evaluated in three groups: 108 patients with normal weight (Group 1), 109 overweight patients (Group 2) and 104 obese patients (Group 3). No significant difference was found in terms of age, parity and gravida when the demographic data were analyzed among the groups (p>0.05). When the groups were compared in terms of hematologic markers, similar values were found in the markers other than white blood cell, neutrophil, lymphocyte, PLT and PCT values. The difference among white blood cell, neutrophil, lymphocyte, PLT and PCT values were between the patients with normal weight and obese patients, and the values of these markers were found higher in overweight / normal weight patient groups than the normal group (p<0.05). Conclusion The values of white blood cell, neutrophil, lymphocyte, PLT and PCT which were shown to be associated with inflammation were higher in the obese patients.

Evaluation of inflammatory biomarkers in patients with keratoconus

2021 ◽  
pp. 112067212110006
Author(s):  
Refik Oltulu ◽  
Zeynep Katipoğlu ◽  
Ali Osman Gündoğan ◽  
Enver Mirza ◽  
Selman Belviranlı
Keyword(s):  
Regression Analysis ◽  
Odds Ratio ◽  
Inflammatory Markers ◽  
Complete Blood Count ◽  
Density Lipoprotein ◽  
Control Group ◽  
Distribution Width ◽  
Cholesterol Ratio ◽  
Lymphocyte Ratio ◽  
Significant Difference

Objective: To investigate the monocyte-to-HDL-cholesterol ratio (MHR), neutrophil to lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), eosinophil-to-lymphocytes ratio (ELR), platelet distribution width (PDW), red blood cell distribution width (RDW), mean platelet volume (MPV), MPV to platelet count ratio (MPV/PC), and RDW to platelet ratio (RPR) that are accepted as inflammatory markers in patients with keratoconus. Methods: In this study, 43 patients with keratoconus and 43 healthy individuals as the control group were retrospectively evaluated. High density lipoprotein cholesterol (HDL-c), lymphocyte, neutrophil, eosinophil, monocyte, platelet, MPV, PDW, and RDW values were obtained with complete blood count performed on the peripheral blood samples. Results: Absolute monocyte (593 ± 182 vs 492 ± 177; p < 0.05) and neutrophil (4860 ± 1553 vs 3954 ± 1297; p < 0.01) counts were statistically significantly higher in the keratoconus groups compared to the control group. MHR (13.18 ± 5.02 vs 9.88 ± 4.45; p < 0.01) and NLR (2.30 ± 0.87 vs 1.77 ± 0.61; p < 0.01) were statistically significantly higher and LMR (4.07 ± 1.67 vs 5.18 ± 2.06; p < 0.01) was significantly lower in the keratoconus group. As a result of univariate logistic regression analysis, it was observed that MHR and NLR were statistically significant relationship with keratoconus ( p = 0.02 and p = 0.021) (Odds ratio = 5.41 (95% CI: 1.169–6.669) and Odds ratio:5.28 (95% CI: 1.024–6.321); respectively). No statistically significant difference was found between the groups in terms of PLR, ELR, RDW, MPV, PDW, MPV/PC, and RPR. Adjusting for age and gender, multivariate regression analysis revealed that MHR was the most significant parameter to demonstrate relationship with keratoconus ( p = 0.025) (Odds ratio = 4.99 (95% CI: 1.019–6.332)). Conclusion: MHR and NLR values considered as inflammatory markers were statistically significantly higher and LMR value was significantly lower in the keratoconus group. Among these values, MHR was the most reliable parameter.

scholarly journals Association between systemic immune inflammation index and newly diagnosed adult celiac disease

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Isil Cakir ◽  
Serkan Dogan
Keyword(s):  
Celiac Disease ◽  
Inflammatory Markers ◽  
Volume Distribution ◽  
Platelet Volume ◽  
Distribution Width ◽  
Cholesterol Ratio ◽  
Lymphocyte Ratio ◽  
Adult Celiac Disease ◽  
Significant Difference ◽  
Immune Inflammation

Abstract Objectives The systemic immune inflammation index (SII) is a novel biomarker based on platelet, neutrophil and lymphocyte counts. SII serum levels have diagnostic, prognostic degrees and correlations with various immune, inflammatory diseases. Celiac disease (CD) is an immune-mediated chronic enteropathy with inflammatory situations. Here we aimed to evaluate clinical significance of SII and to compare SII with other inflammatory markers in CD. Methods 161 pathologically confirmed CD and 75 dyspeptic patients were enrolled. Hemogram, biochemical markers, SII, platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), mean platelet volume-to-platelet ratio (MPR) and monocyte-to-high density lipoprotein cholesterol ratio (MHR) were evaluated. Results There was a statistically significant difference between groups for SII (p<0.001). SII was statistically correlated with and superior to inflammatory markers in relation with CD. There were also statistically significant differences between groups for hsCRP, PLR, NLR, MPR, haemoglobin, platelet count, platelet volume distribution width, plateletcrit, ferritin, total cholesterol and HDL cholesterol (p=0.034; 0.015; 0.032; <0.001; <0.001; <0.001; 0.030; 0.001; <0.001; <0.001; 0.048, respectively). Correlations between SII and NLR, PLR, MHR, hsCRP were statistically significant (p≤0.001; <0.001; 0.033; 0.030, respectively). ROC analysis was used to determine the optimal cut-off value for CD by SII. A baseline SII level >560.0 was associated with CD with 64% specificity, 78% sensitivity (p<0.001). Conclusions To the best of our knowledge, this is the first study analyzed the diagnostic value of SII in CD. SII may serve as a beneficial marker for the diagnosis of inflammatory state superior to that of hsCRP, PLR, NLR, MHR, MPR and WBC.

Blood Cell Parameters and Predicting Coronary In-Stent Restenosis

Angiology ◽  
2019 ◽  
Vol 70 (8) ◽  
pp. 711-718 ◽  
Author(s):  
Zhichao Wang ◽  
Chi Liu ◽  
Hong Fang
Keyword(s):  
Blood Cell ◽  
Platelet Activation ◽  
Blood Cells ◽  
Inflammatory Marker ◽  
Distribution Width ◽  
Cell Parameters ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Stent Restenosis ◽  
In Stent Restenosis

Major advances in coronary interventional techniques and pharmacotherapy as well as the use of drug-eluting stents (DESs) have considerably reduced the risk of in-stent restenosis (ISR). However, ISR remains a major clinical challenge. Inflammation and platelet activation are important processes that underlie the pathophysiology of ISR. Parameters related to blood cells, entailing both cell count and morphology, are useful markers of the inflammatory response and platelet activation in clinical practice. Recent studies have highlighted several new combined or derived parameters related to blood cells that independently predict ISR after DES implantation. The neutrophil/lymphocyte ratio, an inflammatory marker, is regarded as a predictor of the risk of ISR and the stability of atherosclerotic plaques. The mean platelet volume, a widely used platelet activation parameter, has been shown to be a predictor of the risk of ISR and the efficacy of antiplatelet therapy. Other markers considered include the platelet/lymphocyte ratio, red blood cell distribution width, and platelet distribution width. This review provides an overview of these parameters that may help stratify the risk of coronary angiographic and clinical outcomes related to ISR.

Comparison of hematological parameters and perinatal outcomes between COVID-19 pregnancies and healthy pregnancy cohort

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Esin Merve Erol Koç ◽  
Rahime Bedir Fındık ◽  
Hatice Akkaya ◽  
Işılay Karadağ ◽  
Eda Özden Tokalıoğlu ◽  
...  
Keyword(s):  
Complete Blood Count ◽  
Perinatal Outcomes ◽  
Control Group ◽  
Strong Positive Correlation ◽  
Monocyte Count ◽  
Distribution Width ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Significant Difference ◽  
Adverse Perinatal Outcomes

AbstractObjectivesTo evaluate the relationship between Coronavirus Disease 2019 (COVID-19) in pregnancy and adverse perinatal outcomes. The secondary aim is to analyze the diagnostic value of hematologic parameters in COVID-19 complicated pregnancies.MethodsThe current study is conducted in a high volume tertiary obstetrics center burdened by COVID-19 pandemics, in Turkey. In this cohort study, perinatal outcomes and complete blood count indices performed at the time of admission of 39 pregnancies (Study group) complicated by COVID-19 were compared with 69 uncomplicated pregnancies (Control group).ResultsThere was no significant difference between the obstetric and neonatal outcomes of pregnancies with COVID-19 compared to data of healthy pregnancies, except the increased C-section rate (p=0.026). Monocyte count, red cell distribution width (RDW), neutrophil/lymphocyte ratio (NLR), and monocyte/lymphocyte ratio (MLR) were significantly increased (p<0.0001, p=0.009, p=0.043, p<0.0001, respectively) whereas the MPV and plateletcrit were significantly decreased (p=0.001, p=0.008) in pregnants with COVID-19. ROC analysis revealed that the optimal cut-off value for MLR was 0.354 which indicated 96.7% specificity and 59.5% sensitivity in diagnosis of pregnant women with COVID-19. A strong positive correlation was found between the MLR and the presence of cough symptom (r=41.4, p=<0.0001).ConclusionsThe study revealed that, pregnancies complicated by COVID-19 is not related with adverse perinatal outcomes. MLR may serve as a supportive diagnostic parameter together with the Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) in assessment of COVID-19 in pregnant cohort.

scholarly journals Can Hematological Parameters Play a Role in the Differential Diagnosis of Adrenal Tumors?

Uro ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 39-44
Author(s):  
Mehmet Gürkan Arıkan ◽  
Göktan Altuğ Öz ◽  
Nur Gülce İşkan ◽  
Necdet Süt ◽  
İlkan Yüksel ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Inflammatory Markers ◽  
Blood Count ◽  
Complete Blood Count ◽  
Low Cost ◽  
Easy Access ◽  
Adrenal Tumors ◽  
Tumor Diameter ◽  
Lymphocyte Ratio ◽  
Significant Difference

There have been few studies reported with conflicting results in the use of neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), redcell-distribution-width (RDW), etc. for predicting prognosis and differential diagnosis of adrenal tumors. The aim of this study is to investigate the role of inflammatory markers through a complete blood count, which is an easy access low-cost method, for the differential diagnosis of adrenocortical adenoma (ACA), adrenocortical carcinoma (ACC), and pheochromocytoma. The data of patients who underwent adrenalectomy between the years of 2010–2020 were retrospectively analyzed. Systemic hematologic inflammatory markers based on a complete blood count such as neutrophil ratio (NR), lymphocyte ratio (LR), NLR, PLR, RDW, mean platelet volume (MPV), and maximum tumor diameter (MTD) were compared between the groups. A statistically significant difference was found between the three groups in terms of PLR, RDW, and MTD. With post-hoc tests, a statistically significant difference was found in PLR and MTD between the ACA and ACC groups. A statistically significant difference was found between the ACA and pheochromocytoma groups in PLR and RDW values. In conclusion, it could be possible to plan a more accurate medical and surgical approach using PLR and RDW, which are easily calculated through an easy access low-cost method such as a complete blood count, together with MTD in the differential diagnosis of ACC, ACA, and pheochromocytoma.

The role of the platelet profile in the prediction of gestational diabetes

2021 ◽  
pp. 50-54
Keyword(s):  
Body Mass Index ◽  
Blood Glucose ◽  
Gestational Diabetes ◽  
Pregnant Women ◽  
Body Mass ◽  
First Trimester ◽  
Oral Glucose ◽  
Mean Corpuscular Hemoglobin ◽  
Lymphocyte Ratio ◽  
Significant Difference

Objective: In our study, the results of oral glucose tolerance test (OGTT) and other hemogram parameters of pregnant women with and without gestational diabetes mellitus (GDM) were compared. The aim of our study is to investigate the benefit of these parameters in predicting GDM risk. Material and Method: The study was planned as a descriptive, retrospective and cross-sectional study. It was included 218 pregnant women who applied to the Gynecology and Obstetrics Clinic of Amasya Sabuncuoğlu Şerefeddin Training and Research Hospital between January 01, 2019 and January 31, 2020. It was examined complete blood count parameters, ultrasound findings, complete urinalysis, first trimester blood glucose, body mass index, age, and gravide parameters the patients we included in the study. The results were analyzed retrospectively and was evaluated the statistical significance relationship with gestational diabetes. Results: There was no statistically significant difference in age, body mass index (BMI), obesity status and number of gravida between the pregnant women who were examined and those without GDM (p> 0.05). The hemoglobin, platelet count, mean platelet volume (MPV), mean corpuscular volume (MCV), mean corpuscular hemoglobine (MCH), and mean corpuscular hemoglobin concentration (MCHC) values, and neutrophil, lymphocyte, monocyte and basophil counts, urine density and femur length were statistically significant. There was no difference (p> 0.05). No statistically significant difference was found in terms of neutrophile lymphocyte ratio (NLR), neutrophile monocyte ratio (NMR), platelet lymphocyte ratio (PLR), monocyte eosinophil ratio (MER), platelet MPV ratio (PMPVR), and platelet neutrophile ratio (PNR) values (p> 0.05) Conclusion: HbA1c, hematocrit and blood glucose in the first trimester may be predictors of GDM. In addition, we think that further studies are needed in a prospective design in more patients in terms of others parameters.

scholarly journals Platelet-to-lymphocyte ratio (PLR) and Plateletcrit (PCT) in young patients with morbid obesity

2019 ◽  
Vol 65 (9) ◽  
pp. 1182-1187 ◽  
Author(s):  
Emrah Erdal ◽  
Mehmet İnanir
Keyword(s):  
Morbid Obesity ◽  
Healthy Subjects ◽  
Complete Blood Count ◽  
Young Patients ◽  
Obese Group ◽  
Platelet To Lymphocyte Ratio ◽  
Distribution Width ◽  
Lymphocyte Ratio ◽  
Platelet Counts ◽  
Significant Difference

SUMMARY OBJECTIVE To compare the complete blood counts, namely the plateletcrit (PCT) and Platelet-To-Lymphocyte Ratio (PLR) of healthy subjects and those with morbid obesity in the young population. METHODS We included 45 patients with morbid obesity (body mass index -BMI - greater than or equal to 45 kg/m2) and 45 healthy subjects (BMI less than or equal to 25 kg/m2) in our study. Blood samples were obtained from the participants following a 12-hour fasting period. Then we evaluated the levels of hemoglobin (Hb), hematocrit (HCT), red cell distribution width (RDW), mean platelet volume (MPV), white blood cell (WBC), PLR, platelet counts, and PCT in the complete blood count. RESULTS The morbid obesity group had significantly higher platelet counts and PCT values (p<0.001), and PLR values (p=0.033). The value of WBC was also higher in the obese group (p=0.001). MPV was lower in the obesity group but not statistically significant (p=0.815). No significant difference was found between hemoglobin and hematocrit values in these groups; but RDW valuewere higher and statistically significant in the obese group (p=0.001). CONCLUSION PLR or PCT may be more useful as a marker in determining an increased thrombotic state and inflammatory response in morbid obesity.

scholarly journals The Association between Peripheral Blood Cells and the Frailty Syndrome in Patients with Cardiovascular Diseases

2020 ◽  
Vol 20 (9) ◽  
pp. 1419-1433
Author(s):  
Constantin Bodolea ◽  
Elisabeta I. Hiriscau ◽  
Elena-Cristina Buzdugan ◽  
Alin I. Grosu ◽  
Laurențiu Stoicescu ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Blood Cell ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Peripheral Blood Cell ◽  
Neutrophil To Lymphocyte Ratio ◽  
Frailty Syndrome ◽  
Distribution Width ◽  
Lymphocyte Ratio ◽  
Frail Patients

Background: Frailty syndrome is characterized by multisystem dysregulation frequently found in older individuals or even in younger patients with chronic disabling diseases such as cardiovascular diseases. Objective: To determine whether peripheral blood cell count, and its subpopulations, red blood cell and platelets, morphology and different ratios (neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and red blood distribution width-to-platelet ratio) are associated with cardiac frail patients, and through this to improve the prediction of frailty status in patients with cardiovascular diseases. Methods: An observational, retrospective, cohort study enrolling 179 patients with cardiovascular disease divided into two groups: non-frail group (100 pts) and frail group (79 pts), a cohort detached from the Frail.RO study. The frailty was evaluated based on the Fried criteria; haematological markers, sociodemographic data, and variables related to cardiovascular diseases and comorbidities were also recorded. Results: Lower lymphocytes, platelet count, and neutrophil-to-lymphocyte ratio were significantly associated with a more severe frailty syndrome. Regarding red blood cells, haemoglobin concentration and red cell distribution width significantly correlated with the severity of the frailty syndrome. Receiver operating characteristic curve analysis for these markers associated with the frailty syndrome revealed an acceptable sensitivity of 66 % and specificity of 65% to identify frail individuals. Malnutrition and hypercholesterolemia are relevant predictors for identifying frailty in hospitalized cardiovascular patients. Conclusion: The evaluation of peripheral blood cell composition routinely measured in clinical practice can represent a valuable, but limited indicator, to diagnose frailty syndrome and eventually, the effects of interventions in frail patients with cardiovascular diseases.

scholarly journals Evaluation of the relationship of disease activity with neutrophile to lymphocyte ratio and platelet to lymphocyte ratio in patients with peptic ulcer and gastritis

2020 ◽  
Vol 8 (11) ◽  
pp. 3850
Author(s):  
Burcu Gulbagci ◽  
Fettah Sametoglu ◽  
Hasret Cengiz ◽  
Ceyhun Varim
Keyword(s):  
Peptic Ulcer ◽  
Evaluation Method ◽  
Demographic Data ◽  
Normal Subjects ◽  
Upper Gastrointestinal Endoscopy ◽  
Platelet To Lymphocyte Ratio ◽  
Ulcer Disease ◽  
Lymphocyte Ratio ◽  
Significant Difference ◽  
Internal Medicine Clinic

Background: Dyspepsia is a confusing complaint in terms of patient approach and management. Since the most important clinical diagnoses that occur with dyspeptic complaints are gastroduodenitis, peptic ulcer disease and gastric-esophageal cancers, endoscopic evaluation method is often preferred in the diagnosis. It has been shown that NLR (neutrophil to lymphocyte ratio) can be an important marker in many chronic systemic diseases, especially malignancies. Since upper gastrointestinal endoscopy is an invasive and costly procedure, NLR and PLR (Platelet to lymphocyte ratio) may be useful as a new marker to help in the diagnosis of gastritis and peptic ulcer. In our study, we aimed to investigate how NLR and PLR changes seen in patients with gastritis and peptic ulcer diseases.Methods: A total of 906 patients who applied to the internal medicine clinic of our hospital between January 2016 and September 2017 were included in the study. The demographic data, drugs, endoscopy and biopsy results and hemogram parameters of the patients were obtained from the outpatient clinic records. NLR and PLR values were calculated and statistically interpreted.Results: According to the endoscopy results, a total of 906 patients with 311 (34.3%) gastritis, 288 (31.8%) peptic ulcer and 307 (33.9%) normal findings were included in to the study. Male to female ratios were 55% to 45% in gastritis patients, 55,6% to 44,4% in peptic ulcer patients and 53,4% to 46,6% in normal subjects. The median age of the patients was 50 years (18-82 years). The median NLR and PLR ratios were 1.82 (0.54-8.35) and 107.8 (46.27-446.43) in the gastritis group, 1.9 (0.61-9.86) in the peptic ulcer group and 110.95 (44.03-340.65) and 1.71 (0.56-12.89) and 106.02 (40.41-397.62) in the normal group. While a significant difference was obtained between the groups in terms of NLR ((p=0.048), no significant difference was found for PLR (p=0.422).Conclusions: In our study, a statistical significant difference was found between patients with gastritis and peptic ulcer and normal subjects in terms of NLR, but this difference was not at a level that could be used in clinical practice.

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