scholarly journals A comparative study of glycopyrrolate and dexamethasone in the control of postoperative nausea and vomiting after intrathecal fentanyl and bupivacaine for caesarean section

2021 ◽  
Vol 9 (5) ◽  
pp. 1236
Author(s):  
Ikemefuna P. Okonkwo ◽  
Fidelis A. Onyekwulu
Keyword(s):  
Side Effects ◽  
Caesarean Section ◽  
Postoperative Nausea ◽  
Elective Caesarean Section ◽  
Postoperative Nausea And Vomiting ◽  
Likert Scale ◽  
Nausea And Vomiting ◽  
Controlled Study ◽  
Biophysical Profile ◽  
Group D

Background: Postoperative nausea and vomiting (PONV) is an undesirable outcome that parturient who undergo caesarean section experience. We compare the efficacies of IV glycopyrrolate and IV dexamethasone as prophyaxis against PONV in these paturient.Methods: This was a prospective, randomized, double blind placebo-controlled study of seventy six (76) ASA II patients aged 18-40 years who underwent elective caesarean section under spinal anaesthesia. Patients were randomly allocated to three groups, group G (glycopyrrolate): n=26, group D (dexamethasone): n=25 and group C (control; normal saline): n=25. Data collection was with the aid of a proforma which included the biophysical profile, Belville scoring scale for PONV, Likert scale was used for patient satisfaction and side effects were also documented. The data were analyzed using SPSS version 17 and presented in tables and figures.Results: The demographic characteristics and mallampati scores of patients in all 3 groups were similar. The results showed that the incidence of PONV in group D was 8%, in group G 19.2% and in group C 32% (p= 0.048, OR= 0.185, 95% C.I for OR= 0.035 – 0.983). All patients expressed satisfaction in the care they received as assessed using the Likert scale and only patients who received IV glycopyrrolate experienced side effects in the form of dryness of the mouth. There were no side effects reported in patients who received IV dexamethasone.Conclusions: The study demonstrated that IV dexamethasone 8mg was more effective in controlling PONV after intrathecal fentanyl and bupivacaine for caesarean section when compared to 0.2 mg IV glycopyrrolate.

scholarly journals Is Infusion of Subhypnotic Propofol as Effective as Dexamethasone in Prevention of Postoperative Nausea and Vomiting Related to Laparoscopic Cholecystectomy? A Randomized Controlled Trial

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Mine Celik ◽  
Aysenur Dostbil ◽  
Mehmet Aksoy ◽  
Ilker Ince ◽  
Ali Ahiskalioglu ◽  
...  
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Postoperative Nausea ◽  
Controlled Trial ◽  
Postoperative Nausea And Vomiting ◽  
Nausea And Vomiting ◽  
Controlled Study ◽  
Control Group ◽  
Double Blind ◽  
Significant Difference ◽  
Group D

Background. Postoperative nausea and vomiting (PONV) is one of common complications in patients undergoing laparoscopic cholecystectomy (LC). Aim of this study was to compare the efficacy of subhypnotic (1 mg/kg/h) infusion of propofol with dexamethasone on PONV in patients undergoing LC.Methods. A total of 120 patients were included in this randomized, double-blind, placebo-controlled study. Patients were randomly assigned to 3 groups; patients of group dexamethasone (group D) were administrated 8 mg dexamethasone before induction of anesthesia, patients of group propofol (group P) were infused to subhypnotic (1 mg/kg/h) propofol during operation and patients of group control (group C) were applied infusion of 10% intralipid. The incidence of PONV and needs for rescue analgesic and antiemetic were recorded in the first 24 h postoperatively.Results. In the 0–24 h, the incidence of PONV was significantly lower in the group D and group P compared with the group C (37.5%, 40%, and 72.5%, resp.). There was no significant difference in the incidence of PONV and use of antiemetics and analgesic between group D and group P.Conclusion. We concluded that infusion of propofol 1 mg/kg/h is as effective as dexamethasone for the prevention of PONV during the first 24 hours after anesthesia in patients undergoing LC.

The Dose-Response Relation and Cost-effectiveness of Granisetron for the Prophylaxis of Pediatric Postoperative Emesis

1996 ◽  
Vol 85 (5) ◽  
pp. 1076-1085 ◽  
Author(s):  
Gary D. Cieslak ◽  
Mehernoor F. Watcha ◽  
Michael B. Phillips ◽  
John H. Pennant
Keyword(s):  
Cost Effectiveness ◽  
Side Effects ◽  
Dose Response ◽  
Postoperative Nausea ◽  
Ambulatory Surgery ◽  
Postoperative Nausea And Vomiting ◽  
Nausea And Vomiting ◽  
Controlled Study ◽  
Discharge Readiness ◽  
Effective Prophylaxis

Background Postoperative nausea and vomiting (PONV) may delay discharge from hospital after ambulatory surgery. The antiserotonin agents, ondansetron and granisetron, provide effective prophylaxis against chemotherapy-induced and postoperative nausea and vomiting in adults, but are expensive. We determined the dose-response relation of granisetron and the financial impact of using this drug in preventing PONV after pediatric outpatient surgery. Methods In a randomized, double-blind, placebo-controlled study, 97 pediatric outpatients received a placebo or 10 or 40 micrograms.kg-1 granisetron intravenously during a standardized anesthetic. Episodes of postoperative retching, vomiting, and times to discharge readiness were recorded. A decision analysis tree was used to divide each study group into nine mutually exclusive subgroups, depending on the incidence of PONV, need for rescue therapy, and the side effects of antiemetics. Costs and probabilities were assigned to each subgroup, and the cost-effectiveness ratio was determined by dividing the sum of these weighted costs by the number of patients free from both PONV and antiemetic side effects. Results Granisetron (40 micrograms.kg-1 intravenously) was more effective than a placebo or 10 micrograms.kg-1 granisetron in decreasing the incidence and frequency of postoperative emesis, both in the ambulatory surgery center and during the first 24 h. Patients receiving 40 micrograms.kg-1 granisetron also had shorter times to discharge readiness compared with those receiving a placebo. Administering this dose of granisetron to all high-risk patients would cost the ambulatory care center an additional $99 (95% CI, range $89-$112) per emesis-free patient if nursing labor costs are excluded and $101 (95% CI, range $91-$113) if nursing costs are included. Conclusions In this study, 40 micrograms.kg-1 intravenous granisetron (but not 10 micrograms.kg-1) provided effective prophylaxis in children against PONV compared with a placebo, but at a high cost. The effective dose of granisetron for PONV prophylaxis is higher than the Food and Drug Administration-recommended dose for chemotherapy-induced emesis.

Effect of Palonosetron, Dexamethasone, or Palonosetron and Dexamethasone in Postoperative Nausea and Vomiting in Highly Susceptible Thyroidectomy Patients: A Randomized Trial

2016 ◽  
Vol 101 (3-4) ◽  
pp. 106-115
Author(s):  
Min Kyoung Kim ◽  
Hyun Kang ◽  
Geun Joo Choi ◽  
Jong In Oh ◽  
So Young Yang ◽  
...  
Keyword(s):  
Side Effects ◽  
Postoperative Nausea ◽  
Postoperative Nausea And Vomiting ◽  
Nausea And Vomiting ◽  
Patient Controlled Analgesia ◽  
Dexamethasone Group ◽  
Kaplan Meier ◽  
Significant Difference ◽  
Group D ◽  
Rescue Antiemetic

Our study aimed to compare the efficacy of dexamethasone added to palonosetron to both palonosetron and dexamethasone monotherapy for preventing postoperative nausea and vomiting in highly susceptible patients receiving opioid-based, intravenous patient-controlled analgesia after thyroidectomy. Nonsmoking women who underwent total thyroidectomy were randomly allocated to either the dexamethasone group (Group D), the palonosetron group (Group P), or to the dexamethasone plus palonosetron group (Group DP). The severity of nausea and pain, the number of episodes of vomiting, the administrations of rescue anti-emetics, and the side effects of the antiemetics were documented in the recovery room at 2, 4, 8, 12, 24, and 48 hours after surgery. The severity of nausea was lowest in Group DP, followed by Group P and Group D. But there was an overall difference only between Group D and Group DP. The overall differences in the time to the first administration of the rescue antiemetic were observed in a Kaplan-Meier analysis (P = 0.017), noting a significant difference between Group D and Group DP (P = 0.003). The combination of dexamethasone and palonosetron decreased the severity of nausea and increased the time to the first antiemetic dose compared with using dexamethasone or palonosetron alone in nausea-susceptible patients undergoing thyroidectomy.

scholarly journals Postoperative Nausea and Vomiting in Patients Undergoing Total Abdominal Hysterectomy Under Subarachnoid Block: A Randomized Study of Dexamethasone Prophylaxis

2013 ◽  
Vol 10 (2) ◽  
pp. 41-45 ◽  
Author(s):  
S Khatiwada ◽  
B Bhattarai ◽  
BK Biswas ◽  
K Pokharel ◽  
R Acharya ◽  
...  
Keyword(s):  
Patient Satisfaction ◽  
Postoperative Period ◽  
Postoperative Nausea ◽  
Postoperative Nausea And Vomiting ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Nausea And Vomiting ◽  
Controlled Study ◽  
Subarachnoid Block ◽  
Group D

Background Postoperative nausea and vomiting is a common distressing problem in patients undergoing gynaecological surgery under anaesthesia including central neuraxial blockade, which requires frequent medical interventions. Objectives We aimed to find out the antiemetic effect of prophylactic dexamethasone for prevention of postoperative nausea and vomiting in patients undergoing total abdominal hysterectomy under subarachnoid block. Influences of dexamethasone on patient satisfaction and postoperative analgesia were also observed as secondary objectives. Methods This was a prospective, randomized, double blind, placebo controlled study conducted in BPKIHS, a Tertiary care University based hospital from January 2009 to April 2009, for a period of four months. This study involved 80 American Society of Anaesthesiologist Physical Status I&II patients undergoing total abdominal hysterectomy under subarachnoid block. Patients were divided into two groups of 40 each to receive either 4 mg of dexamethasone (group D) or normal saline (group N) in volume of 2 ml intravenously 1 hourr prior to subarachnoid block. Surgery was allowed to start with block height of at least T8 dermatome. Intraoperative and postoperative nausea and vomiting was observed using nausea and vomiting scale every 4 hour for 24 hours. Results Seven (17.4%) patients in group D and 11 (27.5%) patients in group N had nausea and vomiting in the intraoperative period (P=0.284). Sixteen (40%) patients in group D experienced nausea and vomiting in the postoperative period as compared to 27 (67.5%) in group N (P =0.0136). Accordingly, the mean requirement of rescue antiemetic was less in group D compared to Group N (P=0.042). Further, only 15 (37.5%) patients in group D required postoperative supplemental analgesic as compared to 23 (57.5%) in group N (P=0.058). After 24 hrs of surgery, 26 (65%) patients expressed satisfaction in group D as compared to 16 (40.0%) in group N (P =0.025). Conclusions Use of dexamethasone prior to subarachnoid block in patients undergoing total abdominal hysterectomy significantly reduces the incidence of nausea and vomiting and the requirement of antiemetic in the postoperative period, with better patient satisfaction. Kathmandu University Medical Journal | Vol.10 | No. 2 | Issue 38 | Apr – June 2012 | Page 41-45 DOI: http://dx.doi.org/10.3126/kumj.v10i2.7342

scholarly journals Comparison of Ondansetron And Ondansetron Plus Alprazolum for Prevention of Nausea and Vomiting Following Elective Caesarean Section

2009 ◽  
Vol 21 (1) ◽  
pp. 43-49
Author(s):  
Md Rafiqul Hasan Khan ◽  
SN Samad Choudhury
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Caesarean Section ◽  
Postoperative Period ◽  
Postoperative Nausea ◽  
Elective Caesarean Section ◽  
Postoperative Nausea And Vomiting ◽  
Nausea And Vomiting ◽  
Group A ◽  
Group B

Pregnancy & operation both causes anxiety. Excessive anxiety & noncompliance with fasting can increase gastric volume & predispose patients to postoperative nausea & vomiting. Prevention rather than treatment of postoperative nausea and vomiting should be the anesthetist's aim. It was a prospective double blind comparative study of 60 parturient scheduled for elective caesarean section under subarachnoid block to see the effect of anxiolytic drug on per & PONV in LUCS. We have carried out comparative study with alprazolum as anxiolytic agent & compared the action of Ondansetron with Ondansetron +alprazolum. Parturient at term or elective caesarean section included in the study were ASA grade I & II. A total of 60 cards, 30 in each group were prepared by another person who was blind for the study. Every parturient was allowed to draw one card and grouped accordingly. Group A: Inj. Ondansetron (8mg), Group B: Oral alprazolum (0.25mg) +inj. ondansetron (8mg). After 20 minutes of prehydration under all aseptic precaution lumber puncture was performed with 25 gauge Quincke's needle in the L3-L4 or L4-L5 space in sitting position and 0.5% Hyperbaric Bupivacaine 2.5 ml (12.5 mg.) was injected within 10-12 sec. Immediately after administration of spinal anaesthesia fetal heart rate was noted for any changes in pulse rate, blood pressure, rate of respiration, discomfort and occurrence of side effects: shivering, nausea, vomiting was recorded every 2 minute for first 10 minutes, then at 10 minutes interval for remainder of the operation. Per operative monitoring such as ECG, continuous SpO2, non invasive arterial blood pressure was recorded each two minutes interval from time of intrathecal injection up to 10 minutes and then at 10 minutes interval until the end of operation. In the recovery room postoperative analgesia was provided with injection ketorolac tromethamine 30 mg IM on complaining pain and repeated in all patients if necessary. Presence of nausea and vomiting patients were interviewed at one hourly over the first 3 hours then at 3 hourly up to 24 hours postoperative period. Rescue antiemetic of prochlorparazine 10 mg I/M was given if vomiting occurs once, nausea for 10 minutes or at the patient request. Rest other parameters as for example; heart rate, BP, respiration and SpO2 were also recorded at same interval. Patients were carefully observed for any adverse effects like headache, flushing, drowsiness or any other symptoms. In the present study incidence of nausea and vomiting in group-A was one and in group-B was zero. Regarding hemodynamic changes (Pulse, Blood pressure) SpO2, respiratory changes, during operation and 24 hours post operative period in some occasions significant changes were observed (P<0.05) but in other occasions no significant changes occur. No other adverse effect like headache, constipation and flushing during operation and 24 hours postoperative period were observed in this study. In this study we have found that Ondansetron reduces peroperative and postoperative nausea and vomiting. But addition of Alprazolum (an anxiolytic) to Ondansetron, the chance of nausea and vomiting was less.   Journal of BSA, Vol. 21, No. 1, January 2008 43-49

scholarly journals Evaluating the Effect of Intraoperative Dextrose 10% Administration on Reducing Postoperative Nausea and Vomiting after Laparoscopic Surgery

2019 ◽  
Vol 13 (1) ◽  
pp. 78-85
Author(s):  
Ashraf Nabil Saleh ◽  
Dalia Fahmy Emam ◽  
Mohamed Mohamed Kamal
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Postoperative Nausea ◽  
Postoperative Nausea And Vomiting ◽  
Study Groups ◽  
Primary Objective ◽  
Nausea And Vomiting ◽  
Controlled Study ◽  
Double Blind ◽  
Female Patients ◽  
Medication Consumption

Background: Although PONV is usually self-limiting or is treated without sequelae, the incidence of PONV could be as high as 70% to 80% in high-risk populations such as female sex, obese patients, age younger than 40 years, nonsmoker patients, history of PONV or motion sickness. Objectives: The study aimed to investigate whether dextrose 10% decreases the incidence of postoperative nausea and vomiting in female patients undergoing laparoscopic cholecystectomy Materials and Methods: This prospective, double-blind randomized placebo-controlled study comprised 130 ASA physical status I and II nonsmoker female patients, 20-40 years of age, scheduled for laparoscopic cholecystectomy at Ain Sham University – Assembled operating theater from August 2018 to October 2018. Patients were arbitrarily divided into two study groups of 65 patients each. Group LR received lactated Ringer’s solution and group D received 10% dextrose. The primary objective of this study was to compare the incidence of PONV in the study treatment groups. The secondary outcomes included measurement of antiemetic medication consumption as well as blood glucose changes between groups. Results: 50 from a total of 65 participants (76.9%) in Lactated Ringer (LR) group experienced nausea. On the other hand, 30 participants only (46.2%) in dextrose (D) group were nauseated. This dissimilarity was statistically highly significant (P= 0.0003). Conclusion: In this study, dextrose 10% administration resulted in improved postoperative emesis management as explained by the lower incidence of nausea and rescue antiemetic consumption.

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