Liver biopsy in gall stone disease: a prospective study in patients undergoing cholecystectomy

Background: Cholelithiasis has affected mankind since many centuries. It not only affects the biliary tree but also has adverse effects on the hepatic parenchyma, which can get further complicated due to infected bile. Early intervention in these cases not only retards the unwanted effects but also prevents irreversible damage to liver. Aim of study was to see the effect of gallstone disease on liver in patients of GSD (Cholelithiasis, Chronic cholecystitis, CBD Stones).Methods: All patients being subjected for planned cholecystectomy were taken as subjects irrespective of age, sex and co-morbid conditions.Results: 90 patients were included in study and they were evaluated for secondary histopathological changes in liver. Abnormal liver histology was seen in 40% of the cases, with portal tract inflammation being the commonest abnormality seen in 24.4% of patients followed by fatty change (17.8%), cholestasis (10%), lobular parenchymal infiltration (8.9%) and one (1.1%) patient had fibrosis. Choledocholithiasis was associated with a greater incidence of positive bile culture (60%) and greater incidence of abnormal liver histology (80%).Conclusions: Gall stone disease cause significant changes in liver histology and these changes are more common in those patients having long duration of symptoms. In patients of choledocholithiasis incidence of infected bile and liver histology changes are more as compared to cholelithiasis with chronic cholecystitis.

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Prevalence of Sub-Clinical Hypothyroidism in Diagnosed Cases of Gallstone Disease

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i41a32319 ◽

2021 ◽

pp. 207-212

Author(s):

C. Kamalakkhannan

Keyword(s):

Gallstone Disease ◽

Gall Stone ◽

Clinical History ◽

Gallstone Formation ◽

Stone Disease ◽

Thyroid Function Tests ◽

Age Group ◽

Medical College ◽

Gall Stone Disease ◽

A Prospective Study

Thyroid issues have long been debated as a possible cause of gall stone disease. The link between hypothyroidism and gallstone disease could be explained in a variety of ways. The main objective of this study is to determine the prevalence of hypothyroidism in gallstone patients and to rule out hypothyroidism as a probable cause of gallstone formation. A prospective study was conducted in surgical wards of Department of surgery sree balaji medical college from 2016 to 2017. All patients were evaluated using a comprehensive clinical history and examination, as well as suitable investigations such as abdominal USG, thyroid function tests, and lipid profiles. Out of 22 patients 19 patients (86.4%) had normal TSH, 2 patients (9.1%) had increased TSH, 1 patient (4.5%) had decreased TSH. Raised TSH was more in the AGE Group of 61- 75 years, which is comparable to other studies. Out of 22 patients, (100%) had normal T3 levels. 19 patients (86.4%) had normal T4 levels and Ultrasound examination of neck, 2 patients (9.1%) had decreased T4 level and 1 patient (4.5%) had increased T4 levels and 3 patients (13.6%) had abnormal Ultrasound Neck findings. Hence In this Study Cholelithiasis is most commonly seen in Females of age group of 41-60 years and prevalence of raised TSH level in cholelithiasis patient was 9% and most were found in the age group of 61-80 years.

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Laparoscopic Cholecystectomy, A single Surgeon experience at Teaching Hospital Biratnagar, Nepal

Journal of Nobel Medical College ◽

10.3126/jonmc.v6i1.18079 ◽

2017 ◽

Vol 6 (1) ◽

pp. 1-5

Author(s):

Ashok Koirala ◽

Dipendra Thakur ◽

Sunit Agrawal ◽

Kamal Raj Pathak ◽

Manoj Bhattarai ◽

...

Keyword(s):

Laparoscopic Cholecystectomy ◽

Hepatic Duct ◽

Gall Stone ◽

Age Groups ◽

Biliary Tree ◽

Anatomical Variations ◽

Stone Disease ◽

Symptomatic Cholelithiasis ◽

Surgeon Experience ◽

Gall Stone Disease

Background :Laparoscopic cholecystectomy (LC) is a treatment of choice for symptomatic gall stone disease and is commonly done all over the country in general surgical practice. The aim of this study is to show the results of LC in our medical college.Material and Methods: A retrospective analysis of the patients underwent laparoscopic cholecystectomy from July 2015 to September 2016 was carried out in NMCTH, Biratnagar. A total of 391 patients admitted through OPD of our Hospital underwent laparoscopic cholecystectomy were studied. All age groups and both sex were included.Results: Out of 391 patients with symptomatic cholelithiasis, 385(98.46%) patients underwent successful laparoscopic cholecystectomy. Age range of patients in the study varied between 12-84 years and maximum patients (30.69%) were found in the age group of 31-40 years. There were 333(82.58%) female and 58(17.41%)male patients. Mean age of the patients was 39.61 years. Indication for surgery was symptomatic cholelithiasis. Conversion was done in 6(1.53%) cases due to unclear anatomy. A rare congenital anomaly, Accessory right hepatic duct with cystic duct continuous with it was encountered in 12-yearboy; LC was done safely without injuring biliary tree. As postoperative complications, one patient developed biliary peritonitis which was managed by drainage tube.Conclusion: Laparoscopic cholecystectomy is successfully being done for last 5 years in our institute. The results are comparable with those of published series. Anatomical variations and complications may present, for which care must be taken. Journal of Nobel Medical CollegeVolume 6, Number 1, Issue 10 (January-June, 2017), page: 1-5

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ROLE OF TRANSDERMAL AND ENDOSCOPIC TECHNIQUES IN THE TREATMENT OF PATIENTS WITH GALLSTONE DISEASE AND ITS COMPLICATIONS

Kharkiv Surgical School ◽

10.37699/2308-7005.1.2020.17 ◽

2020 ◽

pp. 109-114

Author(s):

B. S. Zaporozhchenko ◽

K. V. Kravets ◽

O. B. Zubkov ◽

I. V. Gomonyuk

Keyword(s):

Surgical Treatment ◽

Bile Ducts ◽

Gallstone Disease ◽

Gall Stone ◽

Stone Disease ◽

Endoscopic Techniques ◽

Surgical Department ◽

Steady Growth ◽

Gall Stone Disease ◽

Extrahepatic Bile Ducts

Summary. In recent years, along with the steady growth of patients with gall-stone disease (cholelithiasis), the growth of its complicated forms is also noted. Most of these patients are elderly and senile people with various concomitant diseases. They constitute the so-called risk group. Materials and methods. The present work is based on an analysis of the results of surgical treatment of 320 patients with complicated forms of cholelithiasis for the period from 2015 to 2020, who were treated at the surgical department of the Department of Surgery KNP «OOKMT» OOR Department of Surgery No. 2 of ONMedU. Results. LCE was performed in 133 (67.2 %) patients, MLCE was performed in 39 (19.7 %) patients, and TCE was performed in 26 (13.1 %) patients. A phased method of surgical treatment was used in 70 (35.4 %) patients with acute cholecystitis with concomitant cardiopulmonary pathology. In 52 patients with choledocholithiasis and obstructive jaundice, in whom it was not possible to eliminate choledocholithiasis using endoscopic transpapillary interventions after external drainage of the bile ducts and resolution of jaundice, the second stage was performed cholecystectomy with correction of the pathology of extrahepatic bile ducts. Conclusions. Realized tactics of stage treatment in patients with concomitant pathology of cardiovascular pathology, as well as the widespread use of minimally invasive technologies, have reduced mortality and the incidence of postoperative complications in patients with concomitant cardiopulmonary pathology.

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Comparative study of single versus multiple gallstone disease in KGH, Visakhapatnam

International Surgery Journal ◽

10.18203/2349-2902.isj20204139 ◽

2020 ◽

Vol 7 (10) ◽

pp. 3370

Author(s):

C. Dharma Kishore Raja ◽

Dondapati Keerthi ◽

Adikari Sai Kiran ◽

Gunto Aravind ◽

Sreerama Raja ◽

...

Keyword(s):

Incidental Finding ◽

Gallstone Disease ◽

Gall Stone ◽

Stone Disease ◽

Disease Group ◽

Gall Stone Disease ◽

Group 2 ◽

A Prospective Study ◽

Single Versus ◽

Group 1

Objective: To evaluate the differences in the presentation, their operative implications and difficulties of single stone versus multiple gall stone disease.Methods: This is a prospective study of a minimum of 60 patients with gall stone disease (Group 1-single, Group 2-multiple) from January 2019 to December 2019 in KGH, Visakhapatnam.Results: More common in females, 40-50 years symptoms and complications, TC count difficult cholecystectomies were more in multiple gall stone pts.Conclusion: Multiple gall stones have led to more severe symptoms and complications and difficult surgery. should be motivated for early surgery even in incidental finding and should not opt for conservative management.

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Incidence of Choledocholithiasis in Gallstone Disease in Eastern Zone of India: A Single Centre Study

International Journal of Medical and Dental Sciences ◽

10.18311/ijmds/2017/18800 ◽

2017 ◽

Vol 6 (1) ◽

pp. 1417

Author(s):

Mrigendra Kumar Rai ◽

Vinod Kumar

Keyword(s):

Bile Duct ◽

Common Bile Duct ◽

Gallstone Disease ◽

Tertiary Care ◽

Gall Stone ◽

Common Bile Duct Stones ◽

Stone Disease ◽

Care Hospital ◽

Bile Duct Stones ◽

Gall Stone Disease

Background: Common bile duct stones are found in 10-15% of patients having gall stone disease and the incidence increases with the age, both in India and in western countries and the majority of common bile duct stones are secondary to gall bladder stones, their incidence is more in Northern India.Objective: To study the incidence of common bile duct stone in patients having gall stone disease in tertiary care hospital.Methods: This was a cross sectional study of 125 patients admitted in different wards of the department of surgery on the basis of symptoms and signs of gall stone disease and latter on trans-abdominal ultrasound and MRCP confirmed that 18.4% of total patients having also choledocholithiasis.Result: Incidence of choledocholithiasis was 18.4% in patients having gall stone disease. It was 3 times more common in females. Maximum incidence 35% in between 40-49 years, obese (52%) and middle socio-economic group (74%).Conclusion: Incidence of choledocholithiasis is in increasing trend and is more common in females in between 40-49 years age group. Obesity is the commonest risk factor.

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Investigation of the Lith1 candidate genes ABCB11 and LXRA in human gall stone disease

Zeitschrift für Gastroenterologie ◽

10.1055/s-2006-950845 ◽

2006 ◽

Vol 44 (08) ◽

Author(s):

C Schafmayer ◽

J Tepel ◽

JH Egberts ◽

A Franke ◽

S Buch ◽

...

Keyword(s):

Candidate Genes ◽

Gall Stone ◽

Stone Disease ◽

Gall Stone Disease

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Early experience of laparoscopic cholecystectomy in acutely inflamed gallbladder

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v9ispl1.1283 ◽

2018 ◽

Vol 9 (SPL1) ◽

Author(s):

Ali Abdul Hussein Handoz ◽

Ahmed Kh Alsagban

Keyword(s):

Laparoscopic Cholecystectomy ◽

Acute Cholecystitis ◽

Gall Stone ◽

The Elderly ◽

Stone Disease ◽

Definitive Treatment ◽

Adjacent Structures ◽

Common Causes ◽

Gall Stone Disease ◽

Male To Female

Gallstones are now among the most important disease in the era of surgery. Definitive treatment of gall stone disease remains cholecystectomy. One of the common causes of emergency surgical referral is acute cholecystitis of which 50-70% cases are seen in the elderly patients.50 patients were treated with laparoscopic cholecystectomy from October 2013 to October 2015. The patient’s age was from 20 to 65 years old with a mean age of 34 ±3 years old. The patients received in the emergency unit and their attack not more than 72 hrs of acute gall stone inflammation were included in this study.From the 50 patients,15 were males (34%) and females were 35 (74%) so the ratio of 1:2of male to female. Problems and complications that facing in this study at time of laparoscopy were mainly adhesions to the adjacent structures like stomach, colon, and omentum. Adhesion into CBD also considered.Early intervention for acute cholecystitis of calculus type by laparoscopy now regarding safe and gold standard approach that should be kept in mind when dealing with such cases.

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