Study of ER PR receptors in breast carcinoma: a study of 30 cases

Background: Estrogen and Progesterone receptors are found in breast cancer cells that depend on estrogen and related hormones to grow. These are steroidal nuclear type of receptors. The most common method currently used to test a tumor for estrogen and progesterone receptors is immunohistochemistry or IHC. Patients with positive hormone receptor cancer have better survival. They are candidates of anti-hormonal therapy.Methods: This is a retrospective study was carried out in the Department of Surgery of a tertiary care hospital, affiliated to Government Medical College. This is a retrospective study in which 30 randomly selected case records of breast cancer patients, who presented in the period between 2011 to 2016, and who had undergone surgery, were taken and studied in terms of history, examination, investigations, treatment given, histopathology report and development of recurrence, metastasis and survival.Results: In this study out of 30 patients, 25 patients received adjuvant chemotherapy. 2 patients developed recurrence at local site.1 patient was ER/PR both negative and 1 patient was ER +/PR-. 3 patients developed metastasis. Among these, 2 patients were ER/PR both negative and 1 patient was having ER/PR both positive.Conclusions: Hormone receptors play a significant role in breast carcinoma. Breast cancer is more common in postmenopausal group as compared to premenopausal group. Mean age at diagnosis of breast cancer in western countries is 61 years and in India it is 50 years.

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DRUG PRESCRIPTION PATTERN OF BREAST CANCER PATIENTS IN A TERTIARY CARE HOSPITAL IN WEST BENGAL: A CROSS-SECTIONAL AND QUESTIONNAIRE-BASED STUDY

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i3.23180 ◽

2018 ◽

Vol 11 (3) ◽

pp. 398

Author(s):

Anjan Adhikari ◽

Dipesh Chakraborty ◽

Rania Indu ◽

Sangita Bhattacharya ◽

Moumita Ray ◽

...

Keyword(s):

Breast Cancer ◽

Breast Carcinoma ◽

Cancer Patients ◽

West Bengal ◽

Tertiary Care Hospital ◽

Drug Prescription ◽

Tertiary Care ◽

Care Hospital ◽

Breast Cancer Patients ◽

Cross Sectional

Objective: Cancer is a disease of uncontrolled division of cells in any part of the body. Breast cancer most common in women accounts for 13% of the death worldwide. The objective of the present study was to evaluate the drug prescription pattern of breast carcinoma patients in a tertiary care hospital of West Bengal.Methods: This was a cross-sectional observational questionnaire-based study done for a period of 6 months at the Department of Pharmacology in Collaboration with the Department of Surgery and Department of Radiotherapy of a Tertiary Care Hospital at Kolkata, West Bengal, India. Female patients with breast cancer (originated from epithelial tissues) of different types and grade attending surgery outdoor patient department were taken as subjects for the study, after signing informed consent.Results: The present study evaluated 28 patients (n=28) diagnosed as breast cancer by the physicians of the department of surgery and radiotherapy. It was observed that breast cancer was mostly found in the middle age group. Breast carcinoma in postmenopausal women accounted to 75%. The most prevalent breast cancer was invasive ductal carcinoma, accounting to 75% of the study population. 5-Fluorouracil, epirubicin, doxorubicin, cyclophosphamide, docetaxel/paclitaxel, and carboplatin were mostly used as chemotherapeutic agent.Conclusion: Breast carcinoma being a prevalent type of cancer in females, the present study tried to evaluate the pattern of prescribing chemotherapeutic agents for breast cancer patients in a tertiary care hospital. Such study is essential to evaluate and refine the therapeutic regimen of the cancer patients to reduce their sufferings.

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PROFILE OF BREAST CANCER PATIENTS ATTENDING A TERTIARY CARE CENTRE: A CROSS-SECTIONAL STUDY

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v3i4.214 ◽

2019 ◽

Vol 3 (4) ◽

Author(s):

Ganpat Singh Choudhary ◽

Man Singh Bairwa

Keyword(s):

Breast Cancer ◽

Breast Carcinoma ◽

Rural Areas ◽

Tertiary Care ◽

Nipple Discharge ◽

Cross Sectional Study ◽

Breast Cancer Patients ◽

Tertiary Care Centre ◽

Cross Sectional ◽

Medical College

Background: World-wide breast cancer is the most frequent type of cancer among females with increasing incidence. Methods: This study was retrospective and prospective both. Total 40 Female patients of Breast cancer, from all age group admitted in Department of Surgery, Dr. S.N. Medical College, Jodhpur were included. Results: Lump was presenting feature in all cases 100%. The next most common presenting feature was pain, which was present in 62.5% cases. 10%, 17.5% and 2.5% cases had nipple discharge, nipple retraction and skin ulceration. Conclusion: The highest incidence of breast carcinoma was in 4th, 5th and 6the decades.Majority of the patients was Hindus and of rural areas and all the patients were married female. Keywords: Breast Carcinoma, Histopathologically Positive, Metastasis

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To Determine the Prevalence of Obesity in Breast Cancer Patients

Liaquat National Journal of Cancer Care ◽

10.37184/lnjcc.2789-0112.2.1 ◽

2021 ◽

Keyword(s):

Breast Cancer ◽

Body Mass Index ◽

Cancer Patients ◽

Body Mass ◽

Tertiary Care ◽

Overweight And Obesity ◽

World Health ◽

Care Hospital ◽

Breast Cancer Patients ◽

Prevalence Of Obesity

Background: Breast Cancer is one of the leading causes of death worldwide. Pakistan alone has the highest rate of Breast Cancer than any other Asian country as approximately 90000 new cases are diagnosed every year out of which 40000 dies. Obesity is also a critical public health problem growing with every passing year in Pakistan and worldwide. Research studies are being conducted worldwide regarding the relation between the two problems. Objective: The objective of this study is to determine the prevalence of obesity in breast cancer patients in a tertiary care hospital in Karachi, Pakistan. Methods: BMI is used as a screening tool for overweight and obesity. According to World Health Organization, a body mass index (BMI) over 25 is considered overweight, and over 30 is obese. A retrospective analysis of 262 patients diagnosed with Breast Cancer during 2019 and 2020 was performed. Patients’ hospital records in Oncology were reviewed. The weight in kilograms and height in centimeters of patients were reviewed. Their BMI was calculated and recorded using the SPSS system. Results: The median BMI was 28.25 kg/m2 with an interquartile range of 25.15 - 31.99 kg/m2. Nearly 80% of the study participants had body mass index higher than normal levels (n=203, 77.5%) and out of them approximately half were overweight (n=104, 51.2%) and the remaining were obese (n=99, 48.7%). Conclusion: We conclude from our study that body mass index is positively correlated with breast cancer occurrence and thus the proportion of females having BMI >= 25 was significantly higher among patients.

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Comparison of free radicals in blood in pre-operative and post-operative phases of breast malignancies: a clinicopathological study

International Surgery Journal ◽

10.18203/2349-2902.isj20195972 ◽

2019 ◽

Vol 7 (1) ◽

pp. 210

Author(s):

Abhishek Jina ◽

U. C. Singh

Keyword(s):

Breast Cancer ◽

Free Radicals ◽

Breast Carcinoma ◽

Ductal Carcinoma ◽

Lipid Peroxide ◽

P Value ◽

Breast Cancer Patients ◽

Medical College ◽

Surgery Department

Background: Various factors have been identified as influencing factors of breast cancer. The free radicals can cause increased oxidative stress by negatively affecting the body’s nucleic acids, lipids and proteins leading to various illnesses including cancer. Therefore, this study was aimed at discovering the progress of treatment of breast carcinoma by exploring the connections of the disease with free radical injury.Methods: The present study was conducted among 30 breast carcinoma patients received in the surgery department of BRD Medical College Gorakhpur. Determination of the levels superoxide dismutase (SOD) (the procedure of photoluminescence), catalase (method of Cavarochi) and the lipid peroxidise was done. The results were presented as mean and standard error (SE). P value of <0.05 was considered as statistically significant.Results: Among the total participants, 73% patients had infiltrating ductal carcinoma and 27% patients had intraductal carcinoma. The dismutase levels showed an increase in the post-operative patients for both the groups. The catalase levels and the lipid peroxide levels showed a reduction in the postoperative patients (p<0.05).Conclusions: The present study result showed that the low amounts of SOD and catalase may not be sufficient to detoxify high amounts of free radicals. The administration of catalase could help in reducing the symptoms. Though, low amounts of SOD and catalase may not be sufficient to detoxify high amounts of free radicals. The administration of enzymes could help in the treatment of breast cancer patients.

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