Clinical study and management of non-thyroidal neck swellings

Background: Swellings in the neck are common and are encountered frequently in General Surgery. A diagnosis may be possible based on clinical examination alone but, investigations are required to clarify the diagnosis and, to exclude a diagnosis of malignancy. With this background, the present study is conducted in an effort to find out the causes for non-thyroidal neck swellings, and to assess the various investigations and management available for treating these neck swellings.Methods: The study was conducted on newly diagnosed non thyroidal neck swelling cases coming to the Dept. of General Surgery, ENT, Oro- Maxillofacial and Pulmonary Medicine (OPD and IPD), Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune. The study was conducted from July 2017 to July 2019. Data collection included history taking, clinical examination, and radiological investigation and histopathological examination by specific pathologist throughout the study. After confirmation of diagnosis, patients were subjected to further management.Results: Among 100 patients, male to female ratio was 1:1. The Mean age of the participants is 40.41±12.85 years. There was statistically significant association between tobacco addiction and malignant neck swelling. Considering HPE as gold standard, the sensitivity and specificity of fine needle aspiration cytology (FNAC) diagnosis is 81.8% and 100% respectively.Conclusions: The overwhelming amount of possible diseases linked to a swelling in the neck, makes it of utmost importance to follow a strict protocol for appropriate diagnosis making and prompt treatment so as to prevent diagnostic delay.

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Correlation of Clinico-Histopathological Findings in Leprosy Patients at Tertiary Care Hospital, Bhilai, CG

International Journal of Research and Review ◽

10.52403/ijrr.20210307 ◽

2021 ◽

Vol 8 (3) ◽

pp. 28-31

Author(s):

Bhuvaneshwari Dewangan

Keyword(s):

Clinical Examination ◽

Histopathological Examination ◽

Tertiary Care ◽

Clinical Signs ◽

Public Health Problem ◽

Research Centre ◽

Care Hospital ◽

Female Ratio ◽

Histopathological Findings ◽

Leprosy Patients

Background: Leprosy continues to be public health problem in India. In India, Chhattisgarh state is having the highest prevalence rate of 2.33 per 10000 populations presently. Leprosy expresses itself in different clinics - histopathological forms depending on the immune system the host. Objective: To find the strength of the relationship between clinically diagnosed leprosy patients with histopathological findings. Materials & Methods: This was a prospective study was carried out on 42 new cases of leprosy attending the outpatient department of dermatology and venereology of J. L. N. Hospital and Research Centre Bhilai Steel Plant Bhilai from March 2009 to December 2010 & all the patients were included after taking informed consent. All the cases were subjected detailed history and through clinical examination & histopathological examination of skin tissue as per the structured pro forma. Results: The Male female ratio was 1:1. Majority of the patients were belonged to the age group between 41 to 60 years. Overall positive correlation found between Clinico - histopathological was 0.69. Majority of the patients were found in the borderline tuberculoid leprosy in Clinically & Histopathological findings. The overall agreement was good between clinical spectrum and histopathological findings. Conclusion: In some early cases, clinical signs and symptoms may precede the presently known characteristic tissue changes or vice versa. If a biopsy is taken at an early stage, there is likely to be discordance between the clinical and histopathological observations. Keywords: Leprosy, Clinical Examination, Histopathological Examination, Strength of relationship.

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Evaluation of neck swelling by cytological and histopathological examination

Bangladesh Journal of Otorhinolaryngology ◽

10.3329/bjo.v18i1.10410 ◽

2012 ◽

Vol 18 (1) ◽

pp. 23-29

Author(s):

Md Mahmudul Huq ◽

Mohammad Idrish Ali ◽

SM Nazmul Huque ◽

KM Nurul Alam ◽

Md Abdus Sattar ◽

...

Keyword(s):

Histopathological Examination ◽

Follicular Adenoma ◽

Nodular Goiter ◽

Metastatic Carcinoma ◽

Medical College Hospital ◽

Histopathological Diagnosis ◽

Neck Swelling ◽

College Hospital ◽

Female Ratio ◽

Medical College

Objective: In this study 50 patients of neck swelling were studied to compare the findings with clinical diagnosis and histopathological report for its diagnostic reliability.Methods: This cross sectional study was done in ENT Department of Sher-E-Bangla Medical College Hospital, Barisal, Bangabandhu Sheikh Mujib Medical University and Dhaka Medical College Hospital, Dhaka from July 2006 to December 2006. Fine needle aspiration cytology, MRI, CT scan, and histopathological examination of postoperative specimen of neck swelling, analyzed data presented by various tables, graphs and figures.Results: In the present series 50 cases of neck swelling were studied. Out of these 50 cases 19 were male and 31 were female. The male, female ratio was 1:1.63. Age range was 4 60 years with maximum frequency in the 4th decade with the 3rd and 2nd in the following suit. Most of the patient was poor. Clinical, cytological and histopathological diagnosis was available in all the cases. The three sorts of diagnoses were compared with each other. Histopathologically 12 cases were tubercular lymphadenopathy, 12 cases were nodular goiter, 5 cases were Metastatic carcinoma, 5 were thyroid carcinoma and another 5 cases were lymphoma, Rest were benign, congenital and nonspecific inflammatory conditions. Correct diagnosis was made by FNAC in 45 cases. In the rest 5 cases smear were unsatisfactory in 2 cases and gives inconclusive result, remaining 3 were follicular neoplasmand no definitive result were made which were subsequently diagnosed by histopathological examination as a follicular adenoma in 1 and follicular carcinoma in 2. Sensitivity of FNAC in the diagnosis of neck masses were found 91% for tuberculosis, 100% for metastatic carcinoma and also for salivary gland tumour. In case of nodular goiter sensitivity was 92%. But it is only 60% sensitive in case of thyroid malignancy, as FNAC can not demarcate clearly between follicular adenoma and follicular cell carcinoma. But its accuracy in diagnosing papillary carcinoma of thyroid was 100%.Conclusion: FNAC can reduce substantially the need of open biopsy for histopathological examination. Accuracy of FNAC will be improved with relevant information provided by clinicians.DOI: http://dx.doi.org/10.3329/bjo.v18i1.10410 Bangladesh J Otorhinolaryngol 2012; 18(1): 23-29

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Utility of Tolonium Chloride Rinse in the Diagnosis of Oral Cancer

Bangladesh Journal of Otorhinolaryngology ◽

10.3329/bjo.v26i1.47947 ◽

2020 ◽

Vol 26 (1) ◽

pp. 11-17

Author(s):

Md Kamruzzaman ◽

Kazi Nurjahan ◽

AS Gazi Sharifuddin ◽

SK Ballav

Keyword(s):

Developing Countries ◽

Oral Cancer ◽

Prospective Study ◽

Diagnostic Delay ◽

College Hospital ◽

Female Ratio ◽

Medical College ◽

Biopsy Report ◽

Patient Side ◽

Tolonium Chloride

Background: Oral cancer burden in developing countries is huge. In Bangladesh and India incidence were 10.6% and 10.4% respectively on 2018. At the same time worldwide incident was only 2%. Majority patients present at advanced stage and their survival rate is poor. Diagnostic delay from patient side and health delivery system side is significantly longer and it is more in developing countries. Like other malignancy early diagnosis can save a lot of these patient. Methods: This prospective study was carried out in Khulna Medical College Hospital from July 2017 to July 2019. Patients who will meet the criteria for this prospective study and capable and willing to give informed consent were enrolled. 20 second rinse/gargle with 10ml of 1% Tolonium chloride solution was done. Biopsy were taken from stained lesion, biopsy report were compared with TC stained lesions. Results: Out of 1650 patients in our outdoor department for various problem and only 30 cases were selected for this study according to selection criteria. Of 30 patients, 18 (60%) were male and 12 (40%) were female. The male-to-female ratio was 3:2. It was found that the sensitivity of 1% Tolonium Chloride rinse for oral precancer and cancer detection was 83.33%, whereas the specificity was 84.21%. Conclusion: Tolonium chloride rinse is a good screening test for oral cancer diagnosis with sensitivity 83.33% and specificity 84.21%. Bangladesh J Otorhinolaryngol; April 2020; 26(1): 11-17

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Incidence of filariasis in clinically diagnosed primary vaginal hydrocele

International Surgery Journal ◽

10.18203/2349-2902.isj20200562 ◽

2020 ◽

Vol 7 (3) ◽

pp. 640

Author(s):

Mahendra Bendre ◽

Shrreya Akhil ◽

Srujan Kondreddy

Keyword(s):

Histopathological Examination ◽

Peripheral Blood Smear ◽

Cross Sectional Study ◽

Research Centre ◽

Bancroftian Filariasis ◽

College Hospital ◽

Cross Sectional ◽

Medical College ◽

Filarial Antigen ◽

Circulating Filarial Antigen

Background: Lymphatic filariasis is caused by a mosquito-borne parasite affecting roughly 100 million people round the world. There is consensus that hydrocele is the most frequent clinical manifestation of bancroftian filariasis. In endemic areas, about 40% of men are suffering from testicular hydrocele. With this background, the present study was aimed to find the incidence of filariasis in clinically diagnosed primary vaginal hydrocele.Methods: A hospital based prospective, cross-sectional study was conducted with 60 patients diagnosed clinically as primary vaginal hydrocele coming to the department of surgery, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune, to assess the incidence of filariasis.Results: Anti-filarial antibody and circulating filarial antigen in serum were detected in 5 (8.3%). Out of 60 patients and anti-filarial antibody was detected in hydrocele fluid of 2 (3.3%) patients. 2 patients out of these 5 showed microfilaria in peripheral blood smear and eosinophilic infiltrates in histopathological examination of sac.Conclusions: In 5 out of 60 cases both anti-filarial antibody and circulating filarial antigen in serum are positive thus proving that incidence of filarial hydrocele is 8% in clinically diagnosed primary vaginal hydrocele which is supposed to be idiopathic. Even though these cases have presented as clinically primary vaginal hydrocele, they are found to be filarial hydrocele after analysis of serum and hydrocele fluid. So, it is advised that all cases of clinically diagnosed primary vaginal hydroceles should be investigated for filariasis and if not, may lead to recurrence in these cases.

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Clinico-pathological and radiological correlation of sino-nasal masses in a tertiary care center

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20202790 ◽

2020 ◽

Vol 6 (7) ◽

pp. 1342

Author(s):

Dimple Sahni ◽

Gagandeep Kaur ◽

Peeyush Verma ◽

Rajwant Kaur ◽

Harpal Singh

Keyword(s):

Histopathological Examination ◽

Care Center ◽

Tertiary Care ◽

Inflammatory Lesion ◽

P Value ◽

Radiological Investigation ◽

Female Ratio ◽

Histopathological Correlation ◽

Neoplastic Lesion ◽

Neoplastic Lesions

Background: The nasal masses are most commonly encountered condition in outpatient department of otorhinolaryngology. The purpose of this study was to show the clinical, radiological and histopathological correlation of sino nasal masses.Methods: This study was conducted on 100 cases with sino nasal masses over a period of 2 years. A provisional diagnosis was made after clinical and radiological investigation which was confirmed with histopathological examination and the findings were correlated. Results: The number of non-neoplastic lesions were more than neoplastic lesions (75% vs 25%). Incidence was highest in the age group of 31-40 year (21%) with male to female ratio of 1.5:1. In our study among non-neoplastic lesion, inflammatory lesion had highest frequency (75%). We found clinical and histopathological correlation in 94.6% cases (p value 0.04). 93.33% cases correlated radiologically and histopathologically (p value 0.04). Conclusions: We concluded that for proper evaluation of sino nasal masses, clinical, radiological, histopathological evaluation should be carried out conjointly. Histopathologic evaluation remains the gold standard.

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Clinico-etiological study of erythroderma cases from tertiary care hospital, Chitradurga, Karnataka, India

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20202655 ◽

2020 ◽

Vol 6 (4) ◽

pp. 502

Author(s):

Harish Gangaraju ◽

Raghu M. T. ◽

Yogendra M. ◽

Virupakshappa H. E. ◽

Ashwini S. ◽

...

Keyword(s):

Age Of Onset ◽

Histopathological Examination ◽

Tertiary Care ◽

Cross Sectional Study ◽

Care Hospital ◽

Drug Induced ◽

College Hospital ◽

Cross Sectional ◽

Female Ratio ◽

Histopathological Correlation

Background: Erythroderma is a cutaneous morphological reaction pattern of skin having many underlying causes and finding the etiology helps in the proper management of erythroderma cases.Methods: A cross sectional study was performed at the department of dermatology, Basaveshwara Medical College, Hospital and Research center, Chitradurga. Authors studied 30 consecutive cases of erythroderma from July 2017 to June 2019 with respect to the epidemiological, clinical and histological data. Clinico-histological correlation was analyzed for etiology of erythroderma.Results: The mean age of onset was 35.03 years with a male to female ratio of 3:2. In addition to erythrema and scaling that were present in all patinets, other co-existent features included were pruritus (43.3%), fever (23.3%), and edema (16.7%). Of the pre-existing dermatoses, psoriasis was the most common (36.6%) disease followed by eczema (26.7%), drug-induced erythroderma (16.7%), colloidan baby (3.3%), pityriasisrubrapilaris (3.3%) and in 13.3% of cases, etiology could not be ascertained. Clinico-histopathological correlation could be established in 73.3% of cases.Conclusions: In all erythroderma cases cutaneous features were identical irrespective of etiology. Detailed history, clinico-histopathological examination and other necessary haematological investigations helps to establish the etiology of erythroderma which helps in further management.

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Clinicopathological Study of Carcinoma Larynx

Bangladesh Journal of Otorhinolaryngology ◽

10.3329/bjo.v26i1.47951 ◽

2020 ◽

Vol 26 (1) ◽

pp. 37-40

Author(s):

Mohammad Nazim Uddin ◽

Abu Hena Mohammad Parvez Humayun ◽

Muhammad Bipul Islam ◽

Md Masudur Rahaman

Keyword(s):

Laryngeal Carcinoma ◽

Histopathological Examination ◽

Neck Surgery ◽

Undifferentiated Carcinoma ◽

Glottic Carcinoma ◽

College Hospital ◽

Female Ratio ◽

Medical College ◽

Carcinoma Larynx ◽

Education Group

Setting: Department of otolaryngology and Head-Neck surgery, Rajshahi Medical College Hospital, Rajshahi. Methods: 80 patients were included in this study during a period of July 2006 to June 2007. Study based on history, clinical, radiological, laboratory and histopathological examination. The larynx is divided for purpose of tumour classification into three regions- Supraglottic, Glottic and Subglottic. Results: The age ranges from 25 to 85 years. The overall male to female ratio 93.75:6.25. Laryngeal carcinoma shows significant association with low socioeconomic and education group. The commonest symptoms of laryngeal carcinoma was change of voice 100%(20) in case of glottic carcinoma and 90%(54)in cases of supraglottic carcinoma.Other common symptoms were difficulty of swallowing, respiratory distress, cough, neck swelling, haemoptysis, neck pain. Palpable cervical lymph node was present in 50% (40) cases Conclusion: Predominant histological type was squamous cell carcinoma 97.5%(78), undifferentiated carcinoma 1.25%(1), adenocarcinoma 1.25%(1). Symptoms of presentation has a significant association with site of involvement. The symptoms of presentation of supraglottic carcinoma occurred more frequently at the advanced stage. Bangladesh J Otorhinolaryngol; April 2020; 26(1): 37-40

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Frequency & pattern of malignancy in solitary thyroid nodule

Bangladesh Journal of Otorhinolaryngology ◽

10.3329/bjo.v15i1.4303 ◽

1970 ◽

Vol 15 (1) ◽

pp. 1-5

Author(s):

Md Rafiqul Islam ◽

AFM Ekramuddaula ◽

MS Alam ◽

MS Kabir ◽

Md Delwar Hossain ◽

...

Keyword(s):

Thyroid Nodule ◽

Papillary Carcinoma ◽

Histopathological Examination ◽

Malignant Lesion ◽

Medullary Carcinoma ◽

College Hospital ◽

Frequency Pattern ◽

Cross Sectional ◽

Female Ratio ◽

Solitary Thyroid Nodule

This cross sectional study done in the department of Banghabandhu Sheikh Mujib Medical University and Dhaka Medical College Hospital during the period of July 2005 to October 2007 to determine frequency & pattern of malignancy in solitary thyroid nodule. For this study, 118 patients who were diagnosed as a case of malignancy in solitary thyroid nodule by detailed history, clinical examination, thyroid hormone assay, ultrasonogram, thyroid scan, FNAC and histopathological examination, were collected. In this study majority of the patients were within 21-40 years of age. Frequency of solitary thyroid nodule is more in female with male female ratio 1: 2.11 Majority of the nodules were firm (72.03%), others were hard (16.95%) and cystic (11.02%). Malignant lesion was more common in hard nodule (70%). Most of the nodules were cold (66.10%) among them 25.6% cases were malignant, followed by warm (30.5%) and hot (3.3%). No malignancy was found in hot nodule. FNAC showed colloid nodule (44%), cellular follicular lesion (29.66%), papillary carcinoma (12.7%), colloid degeneration (4.2%) and medullary carcinoma (1.6%) Out of 118 patients, histopathologically non malignant were 96 (81.35%) and malignant were 22(18.65%). Among malignant cases, 16 (72.72%) cases were papillary carcinoma, 4 (18.18%) cases were follicular carcinoma and 2(9.1%) cases were medullary carcinoma. Key words: Solitary thyroid nodule, FNAC, Papillary carcinoma, Follicular carcinomaDOI: 10.3329/bjo.v15i1.4303 Bangladesh J of Otorhinolaryngology 2009; 15(1): 1-5

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Performance of CT Scan in diagnosis of Sinonasal mass

Bangladesh Journal of Otorhinolaryngology ◽

10.3329/bjo.v24i2.44176 ◽

2019 ◽

Vol 24 (2) ◽

pp. 149-155

Author(s):

Lodh Dipankar ◽

Islam Nazmul ◽

Talukder Debesh ◽

Majumder Rita ◽

Arafat Shahriar ◽

...

Keyword(s):

Ct Scan ◽

Histopathological Examination ◽

Malignant Tumour ◽

Cross Sectional Study ◽

College Hospital ◽

Cross Sectional ◽

Female Ratio ◽

Medical College ◽

Sinonasal Mass ◽

Histopathological Results

Objective: To establish CT scan as a sensitive modality in the diagnosis of sinonasal mass by correlating with the findings of histopathological examination Methods: This cross sectional study was conducted in Dhaka Medical College Hospital (DMCH) from 01/07/2013 to 30/06/2014. A total of 32 cases were studied. Results: In this study male and female ratio was 1.4:1. So, the incidence of sinonasal mass slightly higher in male (59.3%) compared to the female (40.6%). Incidence of malignant tumour was found more in age group above 60 years. Out of 32 patients, 6 patients (18.7%) were diagnosed histopathologically as infective, 7 patients (21.8%) were benign and 19 patients (59%) had malignant sinonasal mass. Conclusion: Computed tomography (CT) scan examination of the sinonasal mass correlate well in most of the cases with histopathological results. It is therefore can be concluded that CT examination of nose and paranasal sinuses is a useful modality in the evaluation of sinonasal mass. Bangladesh J of Otorhinolaryngology; October 2018; 24(2): 149-155

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Diagnostic Performance of CT Scan in Sinonasal Mass

Bangladesh Journal of Otorhinolaryngology ◽

10.3329/bjo.v23i2.45163 ◽

2020 ◽

Vol 23 (2) ◽

pp. 164-170

Author(s):

Dipankar Lodh ◽

Islam Nazmul ◽

Talukder Debesh ◽

Majumder Rita ◽

Arafat Shahriar ◽

...

Keyword(s):

Ct Scan ◽

Histopathological Examination ◽

Anatomical Variations ◽

Malignant Tumour ◽

Cross Sectional Study ◽

College Hospital ◽

Cross Sectional ◽

Female Ratio ◽

Medical College ◽

Sinonasal Mass

Background: CT imaging of nose and paranasal sinuses is to confirm the diagnosis, localize the disease, characterize the extent of pathology and describe any anatomical variations. A careful histopathological examination (HPE) is nesessary to decide the nature of a specific lesion. Objective: To observe performance of CT scan as a sensitive modality in the diagnosis of sinonasal mass by comparing with the findings of histopathological examination. Methods: This cross sectional study in Dhaka Medical College Hospital (DMCH). From 01/ 07/2013 to 30/06/2014 (One year), 42 patients were selected. Resuls: Here male and female ratio was found 1.4:1 So, the incidence of sinonasal growth slightly higher in male (59.3%) compared to the female (40.6%).Incidence of malignant tumour was found more in age group above 60 years. Out of 32 patients, 6 patients (18.7%) were diagnosed histopathologically as infective, 7 patients (21.8%) were benign and 19 patients (59%) had malignant sinonasal mass. Bangladesh J Otorhinolaryngol; October 2017; 23(2): 164-170

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