scholarly journals Role of erythrocyte sedimentation rate and C-reactive protein as a predictor of severity of cellulitis and necrotising fasciitis

2020 ◽  
Vol 7 (7) ◽  
pp. 2176
Author(s):  
Sanjay Jain ◽  
Manish Kumar ◽  
M. C. Songara
Keyword(s):  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Mean Value ◽  
Necrotising Fasciitis ◽  
Industrialized Countries ◽  
C Reactive Protein ◽  
Specific Test ◽  
Acute Phase Reactants ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation

Background: Skin infections are major cause of morbidity and mortality worldwide, affecting more than one person/1000 person/year. Sepsis has a worldwide incidence of more than 20 million cases a year, with mortality due to septic shock reaching up to 50% even in industrialized countries. Acute phase reactants like erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) have been used traditionally as markers for inflammation and are readily available in most centres. Aim was to study the correlation between the values of ESR and CRP with severity of cellulitis and necrotising fasciitis (in term of hospital stay and disease outcome).Methods: This was a prospective observational study conducted at Department of Surgery, GMC and Hamidia Hospital, Bhopal from a period of March 2016 to August 2018.Results: Skin and soft tissue infections are most commonly affects male, diabetes mellitus most common co-morbid condition. Mean value of ESR and CRP in patients who could not survived was 64.44 and 145.92 respectively and value more than 54.95 and 93.41 requires longer hospital stay.Conclusions: ESR and CRP are non-specific test but they are good predictors of severity of cellulitis and necrotising fasciitis not only in planning of management of these cases but also predicting outcome of the disease.

scholarly journals Dynamics of Erythrocyte Sedimentation Rate vs. C – reactive protein: Peas in a Pod or Chalk and Cheese?

2021 ◽  
Vol 04 (02) ◽  
Author(s):  
Arash Eatemadi ◽  
Keyword(s):  
Erythrocyte Sedimentation Rate ◽  
Acute Phase ◽  
Antimicrobial Stewardship ◽  
Sedimentation Rate ◽  
Hospitalized Patients ◽  
C Reactive Protein ◽  
Acute Phase Reactants ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation

Acute phase reactants have a supplementary role in the management of hospitalized patients with fever. While not perfect tools, they have some role in formulating a diagnostic and therapeutic plan and may improve antimicrobial stewardship. The Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), while not specific enough to establish a diagnosis, can be helpful in guiding the intensity and duration of anti-infective therapy. However, they have different dynamics during inflammations and infections.

scholarly journals A New Case of Schnitzler Syndrome in Bulgaria

2018 ◽  
Vol 45 (2) ◽  
pp. 58-62
Author(s):  
M. Kirilova-Doneva ◽  
M. Kamusheva ◽  
S. Donev ◽  
I. Popova
Keyword(s):  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Time Course ◽  
Mean Value ◽  
C Reactive Protein ◽  
Immunoglobulin Kappa ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation ◽  
Schnitzler Syndrome ◽  
The Mean

Abstract We describe the case of a 74-year-old Bulgarian woman with a long history of chronic urticaria with severe burning sensation, arthralgia and fever. Additional symptoms of Schnitzler such as monoclonal immunoglobulin – kappa component, elevated erythrocyte sedimentation rate and enlarged lymph nodes were detected six years after the onset of the symptoms. The first diagnoses hypersensitive vasculitis and dermatitis were established in 2009. Schnitzler syndrome was recognized and the diagnosis was established 2 years later after some examination tests. The time course of the values of IgM, C-reactive protein, erythrocyte sedimentation rate and neutrophils were presented. The mean value of IgM is 13.8 ± 2.19 g/l, the mean value of erythrocyte sedimentation rate is 48.6 ± 14.46 mm/h and the mean value of C-reactive protein – 29.8 ± 7.34 mg/l. The use of nonsteroid anti-inflammatory drugs throughout the period and corticosteroids prescribed parenterally and orally resulted in the relief of arthralgia and fever.

Diagnostic value of procalcitonin, erythrocyte sedimentation rate (ESR), quantitative C-reactive protein (CRP) and clinical findings associated with osteomyelitis in patients with diabetic foot

2021 ◽  
pp. 1-7
Author(s):  
Zahra Soleimani ◽  
Fatemeh Amighi ◽  
Zarichehr Vakili ◽  
Mansooreh Momen-Heravi ◽  
Seyyed Alireza Moravveji
Keyword(s):  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Roc Curve ◽  
Diabetic Foot ◽  
Diagnostic Value ◽  
Clinical Findings ◽  
Diabetic Patients ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation

BACKGROUND: The diagnosis of osteomyelitis is a key step of diabetic foot management. Procalcitonin (PCT) is a novel infection marker. This study aimed to investigate the diagnostic value of procalcitonin and other conventional infection markers and clinical findings in diagnosis of osteomyelitis in diabetic foot patients. METHODS AND MATERIALS: This diagnostic value study was carried out on ninety patients with diabetic infected foot ulcers admitted in Kashan Beheshti Hospital, 2016. After obtaining consent, 10 cc blood sample was taken for measuring serum PCT, CBC, ESR, CRP and FBS. Clinical characteristics of the wounds were noted. Magnetic resonance imaging of the foot was performed in all patients to diagnose osteomyelitis. All statistical analyses were done with the use of SPSS-16. RESULTS: PCT levels were 0.13 ± 0.02 ng/mili patients with osteomyelitis (n= 45) and 0.04 ± 0.02 ng/ml in patients without osteomyelitis (n= 45). PCT, Erythrocyte sedimentation rate and C-reactive protein was found significantly higher in patients with osteomyelitis (p< 0.001). The ROC curve was calculated for PCT. The area under the ROC curve for infection identification was 1 (p< 0.001). The best cut-off value for PCT was 0.085 ng/ml. Sensitivity, specificity, and positive and negative predictive values were 100%, 97.8%,97.8% and 100%, respectively. CONCLUSION: In this group of patients, PCT was useful to discriminate patients with bone infection. Also, Erythrocyte sedimentation rate and C-reactive protein can be used as a marker of osteomyelitis in diabetic patients.

Sign in / Sign up

Export Citation Format

Share Document