scholarly journals The clinical profile of dengue infection cases presenting in a tertiary care institute: an observational study

2018 ◽  
Vol 5 (6) ◽  
pp. 2294
Author(s):  
Kiran Shrivastava ◽  
Sakshi Ojha ◽  
Jayashree Nadkarni
Keyword(s):  
Observational Study ◽  
Early Recognition ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Central India ◽  
Febrile Illness ◽  
Viral Disease ◽  
Clinical Profile ◽  
Tertiary Referral Centre ◽  
Atypical Symptoms

Background: Dengue is a mosquito-borne viral disease that has rapidly spread in all regions of WHO in recent years. It is an acute febrile illness, caused by infection with any of 4 related positive-sense, single-stranded RNA viruses of the genus Flavivirus, dengue viruses 1, 2, 3, or 4. Objective of study was to study the clinical profile of dengue viral infection in the paediatric age group.Methods: This observational study was conducted in a tertiary referral centre in Central India. Cases were classified based on the WHO 2009 Dengue guidelines for diagnosis, treatment, prevention and control and the clinical and laboratory parameters were analyzed for demographic and other correlates.Results: 75 patients met all the inclusion criteria and were analyzed. Most children were in age group 6-10 years. Fever, bleeding, rash, abdominal pain and vomiting were the common symptoms. We noted some atypical symptoms also.Conclusions: When infected, early recognition and prompt supportive treatment in dengue infection can substantially lower the risk of medical complications and death.

scholarly journals THE PREVALENCE AND CLINICAL PROFILE OF PATIENTS PRESENTED WITH POSTERIOR FOSSA EXTRA DURAL HEMATOMA IN TERTIARY CARE HOSPITAL: A RETROSPECTIVE OBSERVATIONAL STUDY.

2020 ◽  
Vol 4 (5) ◽  
Author(s):  
Deepak Karn
Keyword(s):  
Observational Study ◽  
Posterior Fossa ◽  
Early Recognition ◽  
Tertiary Care ◽  
Postoperative Outcome ◽  
Clinical Profile ◽  
Retrospective Observational Study ◽  
Care Hospital ◽  
The Mean ◽  
Admission Glasgow Coma Scale

Aim: to determine the prevalence and clinical profile of patients presented with posterior fossa extra dural hematoma. Materials and Methods: The present retrospective observational study was conducted in the Department of Neurosurgery, SKMCH, Muzaffarpur, Bihar, India.  The records were retrospectively analyzed for clinical presentation, admission Glasgow Coma Scale (GCS), mode of injury, type of intervention and postoperative outcome. Outcomes were assessed on the basis of Glasgow Outcome Score (GOS) at the time of discharge and at 3 months Results: Of these 39 patients, 28 were males and 11 females. The mean age of patients was 29.21 years. 24 patients had GCS 13-15 at admission followed by 9 with GCS 9-12 and only 5 of them had GCS <9 at admission. Mean EDH volume was 28.7 ml. 36 patients were operated, 5 patients managed conservatively. Conclusion: The posterior fossa is an uncommon site for epidural haematomas. Due to the small volume of the posterior fossa and contained important structures mortality can be high if the haematoma is missed. Clinical progress is silent and slow, but the deterioration is sudden and quick to become fatal if not promptly treated. Early recognition is extremely important. Keywords: Extradural hematoma, Posteriors fossa, GCS, Trauma

scholarly journals Neurological and Cardiac Manifestations of Children with Dengue Presenting to a Tertiary Care Institute: An Observational Study

2020 ◽  
Vol 40 (3) ◽  
pp. 224-231
Author(s):  
Jayashree Nadkarni ◽  
Amit Agrawal ◽  
Kiran Shrivastava
Keyword(s):  
Observational Study ◽  
Tertiary Care ◽  
Clinical Manifestations ◽  
Central India ◽  
Neurological Dysfunction ◽  
Tertiary Referral Centre ◽  
Echocardiographic Evaluation ◽  
Atypical Manifestations ◽  
Cardiac Manifestations ◽  
And Control

Introduction: Dengue is a common arboviral infection in tropical areas of world with increased incidence in the past few years. Spread of disease has led to increased recognition of various atypical manifestations apart from the classical features. This study was conducted to find out the neurological and cardiac manifestations of dengue in children. Methods: This observational study was conducted in a tertiary referral centre in Central India. Cases were classified based on the WHO 2009 Dengue guidelines for the diagnosis, treatment, prevention and control. The neurological and cardiac manifestations of dengue were studied and compared with those cases without manifestations. Results: In this study, a total of 75 dengue cases were included and out of them, five (6.75%) cases presented with CNS abnormalities. The most common neurological manifestations were fever with seizures, altered sensorium, vomiting and headache. Hepatomegaly, hypotension, coagulopathy, and leucocytosis (> 11,000 cells/mm3) were significantly associated with neurological dysfunction (p < 0.05). Ten children out of 75 (13.33%) had cardiac manifestations. They included bradycardia in five cases, tachycardia and signs of CCF in three cases and shock in two cases. Echocardiographic evaluation showed mild pericardial effusion in one patient. Conclusions: Dengue poses a huge burden to healthcare system with its various atypical manifestations. A better understanding of neurological and cardiac clinical manifestations of dengue will reduce morbidity and mortality in such cases.

scholarly journals Dengue infection in central India: a 5 years study at a tertiary care hospital

2017 ◽  
Vol 5 (6) ◽  
pp. 2483 ◽  
Author(s):  
Smita T. Deshkar ◽  
Sharmila S. Raut ◽  
Ravindra K. Khadse
Keyword(s):  
Wide Spectrum ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Central India ◽  
Dengue Shock Syndrome ◽  
Viral Disease ◽  
Antibody Detection ◽  
Care Hospital ◽  
Significant Drop ◽  
Clinical Illness

Background: Dengue is one of the most important mosquito borne viral disease with wide spectrum of clinical presentation and often with unpredictable clinical evolution and outcome. Approximately 50 million infections occur annually world-wide, but what’s the real size of the problem in India?  Nobody truly knows...!!  Present study was carried out to determine seropositivity, clinical profile and seasonal variation of dengue infection in central India.Methods: Study was carried out from January 2012 to December 2016. Blood samples were collected from 15,606 patients with dengue like clinical illness and serum was separated. All the samples were subjected to IgM antibody detection by dengue MAC ELISA.Results: Prevalence of dengue in dengue suspected cases was found to be 24.49% (3,822/15,606). Maximum number of positive cases, 1,548 (40.50%) were in the age group of 0-10 years. Males (60.83%) were affected more than females (39.17%). Peak was observed in the months of August, September, October and November. Common presenting features were fever followed by myalgia, arthralgia, headache and bleeding manifestations. Significant drop in platelet count was observed in patients with dengue shock syndrome and dengue haemorrhagic fever.Conclusions: Number of dengue cases in central India are on increase and continued surveillance is essential to determine epidemiological and seasonal trend.

scholarly journals Can serum ferritin levels predict the severity of dengue early?: an observational study

2019 ◽  
Vol 7 (3) ◽  
pp. 876
Author(s):  
Velammal Petchiappan ◽  
Thaha Mohammed Hussain ◽  
Saravanan Thangavelu
Keyword(s):  
Platelet Count ◽  
Clinical Practice ◽  
Observational Study ◽  
Hospital Stay ◽  
Serum Ferritin ◽  
Early Recognition ◽  
Dengue Infection ◽  
Elevated Serum ◽  
Severe Dengue ◽  
Elderly Subjects

Background: Dengue infection is a major public health threat; early recognition is crucial to improve the survival in severe dengue. Although there are various biomarkers to predict the severity of dengue, they are not routinely used in clinical practice for prognostication. We analyzed whether serum ferritin can be used to predict the severity at an earlier stage.Methods: A hospital based prospective observational study was done involving 119 dengue cases diagnosed by positive NS1 antigen or dengue specific serology (capture ELISA). Serum ferritin was measured in all at the time of diagnosis. Clinical and platelet count monitoring was done daily; classified as severe and non-severe according to 2009 WHO criteria.Results: Out of 119, 5 developed severe dengue; patients with severe dengue had significantly lower median platelet count (p<0.0001); higher ferritin levels (p=0.03) and hospital stay (p<0.0001) than non-severe group. Age had a significant negative co-relation with platelet count (r= -0.427; p<0.0001); positive correlation with ferritin levels (r=0.16; p=0.08) and hospital stay (r= 0.26; p=0.004) indicating that elderly subjects are at risk of severe disease. Serum ferritin levels negatively correlated with the platelet count (r= -0.51 p<0.001). High ferritin levels in severe cases are noted from day 4 of clinical illness.Conclusions: Elevated serum ferritin levels can be used as a potential early prognostic marker to predict the severity of dengue infection in clinical practice.

scholarly journals Clinical profile of dengue fever in children: analysis of 2017 outbreak from Central Kerala, India

2018 ◽  
Vol 5 (6) ◽  
pp. 2265 ◽  
Author(s):  
Senthil Kumar K. ◽  
Rajendran N. K. ◽  
Ajith Brabhukumar C.
Keyword(s):  
Dengue Fever ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Hemorrhagic Fever ◽  
Warning Signs ◽  
Clinical Profile ◽  
Severe Dengue ◽  
High Morbidity ◽  
Care Hospital ◽  
High Grade Fever

Background: In India, dengue epidemics are becoming more frequent (WHO, 2008). The majority of dengue viral infections are self-limiting, but complications may cause high morbidity and mortality. The objective of this study is to assess the clinical profile of the dengue infection in children less than 15 years of age and to evaluate the outcomes of dengue fever from March 2017 to July 2017 at the Pediatric Department of Karuna Medical College, the tertiary care hospital in Palakkad.Methods: In this retrospective study, medical records were reviewed and analyzed. Patients with suspected dengue infection were classified further into 2 groups, Dengue fever (probable dengue, dengue with warning signs) and ‘Severe Dengue’ (dengue hemorrhagic fever and/or dengue shock syndrome (DHF/DSS) according to WHO.Results: A total of 77 cases were classified into 67 (87%) non-severe and 10 (13%) severe dengue cases. The most common age of presentation was above 10 yrs. The mean age of admission was 8.9 yrs. The most common presenting symptom was fever seen in 93% followed by vomiting in 68%. Elevation in Aspartate transaminase (SGOT) and thrombocytopenia were found in 32.4 %.Conclusions: High grade fever, vomiting, abdominal pain and skin rash with normal or low platelet count were the presenting features. Early diagnosis, monitoring and prompt supportive management can reduce mortality.

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