Work-Related Maternal Risk Factors and the Risk of Pregnancy Induced Hypertension and Preeclampsia during Pregnancy. The Generation R Study

Background: Preterm birth is a major cause of mortality and morbidity for newborns. Complications of prematurity are becoming more common as more survivors are spending time in Neonatal intensive care unit.Methods: A retrospective hospital based clinical observational study was conducted in NICU in Sharda hospital, a tertiary care centre in Greater Noida. Data regarding neonates′ age, sex, clinical presentation, maternal risk factors, complications and outcome were recorded.Results: A total of 133 preterm neonates were enrolled in the study. Maternal risk factors like Pregnancy induced hypertension (PIH) was seen in 19.5% cases, Urinary tract infection in 15% and Antepartum haemorrhage in 14.2% cases. Among the complications of prematurity, RDS was noted in 38.3% cases, Hyperbilirubinemia in 16.5% and feed intolerance in 15% cases. Sepsis was present in 3% of the preterm. Mortality rate was 7.5%. Most common cause of death was RDS.Conclusions: Pregnancy induced hypertension and Antepartum haemorrhage were important maternal risk factors for prematurity. Respiratory distress syndrome and perinatal asphyxia were the important causes of mortality in the present study.

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Maternal Risk Factors and Morbidity Pattern of Very Low Birth Weight Infants: A NICU Based Study at Eastern Nepal

Journal of Nepal Paediatric Society ◽

10.3126/jnps.v29i2.2040 ◽

2009 ◽

Vol 29 (2) ◽

pp. 59-66 ◽

Cited By ~ 2

Author(s):

Prakash Poudel ◽

Sunil Budhathoki ◽

Manoj Kumar Shrivastava

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Low Birth Weight ◽

Very Low Birth Weight ◽

Ductus Arteriosus ◽

Pregnancy Induced Hypertension ◽

Maternal Risk Factors ◽

Maternal Risk ◽

Factors Associated ◽

Induced Hypertension

Background: Preterm deliveries of babies weighing less than 1500 grams (VLBW, very low birth weight) are of major concern because of maximum perinatal morbidity and mortality found in this group. VLBW babies overload the neonatal intensive care unit (NICU) and their mortality contributes significantly to neonatal and infant mortality. Objectives: To study the common maternal risk factors associated with VLBW births. To study the morbidity and mortality patterns of VLBW babies. Methods: This was a hospital based retrospective study done in NICU of BP Koirala Institute of Health Sciences. Data were collected from medical records of VLBW babies admitted in NICU over a period of three years (13 April 2005 to 12 April 2008). Data were analyzed with SPSS 10.0 software. Results: Data of 140 VLBW babies were analyzed. Mean birth weight was 1188.9 (±212.78), 10.7% were home deliveries, 24.3% were twins, 31.4% required active resuscitation at birth and 46.4% were exposed to antenatal steroid. Common maternal risk factors associated with premature deliveries were inadequate antenatal check up (ANC) visits (95.7%), twin pregnancy (24.3%), antepartum hemorrhage (APH, 28.6%), premature rupture of membrane (23.6%), pregnancy induced hypertension (12.9%), bad obstetric history (12.9%) and maternal age less than 20 years (8.6%). Common morbidities among VLBW babies were clinical sepsis (77.1%), non physiological hyperbilirubinemia (73.6%), apnea (48.6%), shock (42.9%), hypoglycemia(39.3%), anemia (29.3%), hyaline membrane disease (HMD, 21.4%), patent ductus arteriosus (15.0%), severe hypothermia (12.1%), culture proven sepsis (15.7%), retinopathy of prematurity (5.7%), and bronchopulmonary dysplasia (3.6%). Overall survival was 54.3% and major causes of death were HMD (51.0%) and sepsis (34.7%). Median durations of hospital stay were 17.5 days for survivors and five days for expired cases.Conclusion: Increasing the coverage of ANC visits, early diagnosis and treatment of APH and pregnancy induced hypertension, discouraging the childbirth at too young age, early diagnosis and treatment of acute infections and chronic medical diseases in mothers are important measures to decrease the burden of VLBW births. Common morbidities in VLBW babies are sepsis, HMD, apnea, hyperbilirubinemia, patent ductus arteriosus, shock, anemia, hypoglycemia, hypothermia and hypocalcemia. Common causes death of VLBW babies are HMD and sepsis. Overall survival of VLBW babies in our settings is less. More numbers of well equipped NICUs and services like surfactant therapy are needed to improve survival of VLBW infants in our set up. Key words: Maternal risk factors, Morbidity, Mortality, Very low birth weight. doi: 10.3126/jnps.v29i2.2040 J. Nepal Paediatr. Soc. Vol 29, No. 2, pp.59-66

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Risk factors for necrotizing enterocolitis in neonates:a prospective study

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20192762 ◽

2019 ◽

Vol 6 (4) ◽

pp. 1598

Author(s):

Manas Ranjan Sahoo ◽

Pydi Nagasree ◽

Lanka Swetha ◽

Arigela Vasundhara

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Prospective Study ◽

Necrotizing Enterocolitis ◽

Neonatal Intensive Care ◽

Ductus Arteriosus ◽

Pregnancy Induced Hypertension ◽

Mortality And Morbidity ◽

Maternal Risk ◽

Induced Hypertension

Background: Necrotizing enterocolitis (NEC) is mostly limited to preterm babies due to immaturity of gut. NEC is one of important cause of neonatal mortality and morbidity in the neonatal intensive care units all over the world.Aim of study is to find the antenatal and post-natal risk factors associated with necrotizing enterocolitis in neonates admitted to NICU.Methods: A prospective study was conducted on 45 neonates with necrotizing enterocolitis fulfilling the predetermined inclusion criteria. A detailed antenatal history including all maternal risk factors, birth history including the need for resuscitation and type of resuscitation was recorded. The gestational assessment was done by the New Ballard Score.Results: Pregnancy induced hypertension accounts as a risk factor to most of the cases of NEC 18 (40%), followed by setting for sepsis 12 (26.6%), least being gestational diabetes mellitus 1 (2.2%).Conclusions: Prematurity is found to be the most common risk factor followed by patent ductus arteriosus and sepsis. Most common antenatal risk factor was PIH (Pregnancy induced hypertension).

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The effects of work-related maternal risk factors on time to pregnancy, preterm birth and birth weight: the Generation R Study

Occupational and Environmental Medicine ◽

10.1136/oem.2009.046516 ◽

2010 ◽

Vol 68 (3) ◽

pp. 197-204 ◽

Cited By ~ 60

Author(s):

A. Burdorf ◽

T. Brand ◽

V. W. Jaddoe ◽

A. Hofman ◽

J. P. Mackenbach ◽

...

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Preterm Birth ◽

Maternal Risk Factors ◽

Time To Pregnancy ◽

Maternal Risk ◽

Work Related

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Risk Factors of Pregnancy Induced Hypertension in Falluja City

Al-Anbar Medical Journal ◽

10.33091/amj.0701412017 ◽

2017 ◽

Vol 14 (1) ◽

Keyword(s):

Risk Factors ◽

Pregnancy Induced Hypertension ◽

Induced Hypertension

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Faculty Opinions recommendation of Cardiovascular disease risk factors after early-onset preeclampsia, late-onset preeclampsia, and pregnancy-induced hypertension.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725298358.793542862 ◽

2018 ◽

Author(s):

Andrew Shennan ◽

Kate Duhig

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Early Onset ◽

Disease Risk ◽

Late Onset ◽

Cardiovascular Disease Risk ◽

Cardiovascular Disease Risk Factors ◽

Pregnancy Induced Hypertension ◽

Induced Hypertension ◽

Early Onset Preeclampsia

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Maternal Risk Factors Associated with Cleft Lip with or without Cleft Palate: A Review

International journal of odontostomatology ◽

10.4067/s0718-381x2016000200025 ◽

2016 ◽

Vol 10 (2) ◽

pp. 359-368 ◽

Cited By ~ 2

Author(s):

Catalina Barrera ◽

Naiara Mezarobba

Keyword(s):

Risk Factors ◽

Cleft Palate ◽

Cleft Lip ◽

Maternal Risk Factors ◽

Maternal Risk ◽

Factors Associated

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Prevention of Hypertensive Disorders of Pregnancy—Is There a Place for Metformin?

Journal of Clinical Medicine ◽

10.3390/jcm10132805 ◽

2021 ◽

Vol 10 (13) ◽

pp. 2805

Author(s):

Elżbieta Poniedziałek-Czajkowska ◽

Radzisław Mierzyński ◽

Dominik Dłuski ◽

Bożena Leszczyńska-Gorzelak

Keyword(s):

Risk Factors ◽

Risk Groups ◽

Trophoblast Invasion ◽

Pregnancy Induced Hypertension ◽

Hypertensive Disorders Of Pregnancy ◽

Hypertensive Disorders ◽

Induced Hypertension ◽

Endothelium Function ◽

Hypoglycemic Drug ◽

The Ideal

The possibility of prophylaxis of hypertensive disorders of pregnancy (HDPs) such as preeclampsia (PE) and pregnancy-induced hypertension is of interest due to the unpredictable course of these diseases and the risks they carry for both mother and fetus. It has been proven that their development is associated with the presence of the placenta, and the processes that initiate it begin at the time of the abnormal invasion of the trophoblast in early pregnancy. The ideal HDP prophylaxis should alleviate the influence of risk factors and, at the same time, promote physiological trophoblast invasion and maintain the physiologic endothelium function without any harm to both mother and fetus. So far, aspirin is the only effective and recommended pharmacological agent for the prevention of HDPs in high-risk groups. Metformin is a hypoglycemic drug with a proven protective effect on the cardiovascular system. Respecting the anti-inflammatory properties of metformin and its favorable impact on the endothelium, it seems to be an interesting option for HDP prophylaxis. The results of previous studies on such use of metformin are ambiguous, although they indicate that in a certain group of pregnant women, it might be effective in preventing hypertensive complications. The aim of this study is to present the possibility of metformin in the prevention of hypertensive disorders of pregnancy with respect to its impact on the pathogenic elements of development

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