Serum vitamin D and immunoglobulin E levels in children of allergic rhinitis: a case-control study from Central India

Background: Allergic rhinitis (AR) is the commonest type of non-infective rhinitis. Genetic and environmental factors play an important role in the development of the disease. Researchers are having interest in knowing the role of vitamin D in the pathogenesis of allergy. Immunoglobulin E (IgE) is integral to the pathogenesis of allergic disorders. However, the relationship between serum IgE levels and AR is still a matter of debate. Thus, this study aimed to know serum IgE and serum 25 (OH) vitamin D levels in patients with clinically diagnosed AR and control group.Methods: A case-control study was performed from May 2019 to October 2019 in LNMC and JK hospital. All 54 children with physician diagnosed AR aged 12 to 18 years of both genders who have come in the OPD (total enumeration sampling) during the above mentioned period were enrolled into the study and their 54 healthy counterparts are taken as controls. Other parameters such as age, gender, occupation and region of residence were also compared between the groups.Results: This study found highly significant difference in the mean serum IgE levels while there is a significant difference in the mean serum vitamin D levels between two groups.Conclusions: The study group with AR had significantly higher mean level of serum IgE and lower mean serum vitamin D levels as compared to control groups. However, upon stratification of vitamin D levels, the differences were insignificant. Further studies should be conducted to know the value of IgE as a prognostic factor of AR severity and to throw more light on association of vitamin D with AR.

Download Full-text

Assessment of Serum Vitamin D Levels in Patients with Vitiligo in Jordan: A Case-Control Study

Dermatology Research and Practice ◽

10.1155/2019/2048409 ◽

2019 ◽

Vol 2019 ◽

pp. 1-4 ◽

Cited By ~ 3

Author(s):

Diala M. Alshiyab ◽

Firas A. Al-qarqaz ◽

Leen H. Heis ◽

Jihan M. Muhaidat ◽

Wlla S. Eddin ◽

...

Keyword(s):

Vitamin D ◽

Case Control Study ◽

Skin Diseases ◽

Serum Vitamin ◽

Case Control ◽

Vitamin D Receptors ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Significant Difference ◽

Control Study

Background. Low vitamin D serum levels have been associated with many autoimmune disorders and several other skin diseases. Vitiligo is an autoimmune disease characterized by destruction of melanocytes by immune mechanisms. Melanocytes express vitamin D receptors, and their function can be affected by vitamin D status. Objectives. The main objective of this study is to compare vitamin D levels in patients with vitiligo vs normal population and whether vitamin D deficiency is associated with vitiligo. Methods. A case-control study was conducted. 100 vitiligo patients and 100 as controls were included in this study. Serum vitamin D level was measured for both vitiligo patients and controls, results were compared, and statistical analysis was done to compare the results. Results. The median age of vitiligo cases was 23 years (ranges, 2–80). 58% of vitiligo patients were females. The median vitamin D level was not significantly different between the two groups (vitiligo = 14.1 (IQR 9.9–20.4) vs control = 16.5 (IQR 10.3–25.3) (P=0.28)). Most vitiligo cases and controls were found to have low levels of vitamin D (either insufficient 20–30 ng/mL or low <20 ng/mL). Conclusions. There was no significant difference in vitamin D levels in vitiligo patients compared to controls. However, vitamin D levels were generally low in both groups.

Download Full-text

Relationship between vitamin D levels and brucellosis: a case-control study from Sanandaj, Iran

Iranian Journal of Microbiology ◽

10.18502/ijm.v13i2.5987 ◽

2021 ◽

Author(s):

Behzad Mohsenpour ◽

Amjad Ahmadi ◽

Anvar Mohammadi Baneh ◽

Ebrahim Ghaderi ◽

Shahla Afrasiabian ◽

...

Keyword(s):

Vitamin D ◽

Case Control Study ◽

Serum Vitamin ◽

Case Control ◽

Control Group ◽

Case Group ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Significant Difference ◽

Control Study

Background and Objectives: Brucellosis is a zoonotic disease that is caused by the Brucella species. This disease is common in Iran and its incidence is increasing .This study measures serum vitamin D levels in patients with brucellosis and healthy people. Materials and Methods: This research was conducted as a case-control study at Tohid Hospital, Sanandaj, Iran. The calculated sample size included 90 patients in the case group and 90 patients in the control group. The measurement of vitamin D levels in the case and control groups were performed by ELISA. Results: The mean serum vitamin D level was 19.91 ng/ml in the case group and 22.87 ng/ml in the control group. (Serum vitamin D level <10 ng/mL is accepted as deficiency, 10-30 ng/mL as insufficiency, 30-100 ng/mL as sufficiency, and >100 ng/mL as toxicity). Conclusion: There was no significant difference between the two groups in terms of vitamin D deficiency (p-value=0.097).

Download Full-text

Association between vitamin D deficiency and prostate cancer: Prospective case-control study

Journal of Clinical Urology ◽

10.1177/2051415821993606 ◽

2021 ◽

pp. 205141582199360

Author(s):

Ghanshyam Kumawat ◽

Vijay Chaudhary ◽

Anurag Garg ◽

Nishkarsh Mehta ◽

Gagan Talwar ◽

...

Keyword(s):

Prostate Cancer ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Case Control Study ◽

Serum Vitamin ◽

P Value ◽

Serum Vitamin D ◽

Severe Vitamin ◽

Vitamin D Levels ◽

Control Study

Objective: We aimed to find out the association of low serum vitamin D levels with the incidence of prostate cancer through a prospective case-control study. Material and methods: This study was carried out in the tertiary care hospital (India). All newly diagnosed patients of prostate cancer and age-matched controls were included. Serum vitamin D levels were measured in all of them. Vitamin D status (ng/mL) was classified as severe deficiency <10, moderate deficiency 10–<30, normal 30–100, and toxicity >100. Normality of the data was tested by the Kolmogorov–Smirnov test, statistical analysis was done with Statistical Package for the Social Sciences version 26.0, p-value of <0.05 was considered significant. Results: In our study, 320 cases and 320 controls were included. The mean vitamin D levels in cases and controls were 15.71 ± 6.5 (ng/mL) and 17.63 ± 4.54 (ng/mL), respectively, ( p-Value <0.01). Patients with severe vitamin D deficiency (73.58%) had a Gleason score ⩾8 on biopsy and 79.24% of them had a serum prostate specific antigen (PSA) level >20 ng/mL. Conclusion: We had concluded that there was no significant association between vitamin D deficiency and increased risk of prostate cancer, although patients with higher-grade prostate cancer and with higher PSA level had severe vitamin D deficiency. Level of evidence: Not applicable for this multicentre audit.

Download Full-text

To study the association of serum vitamin D levels with migraine in Indian rural female population: Case-control study

International Journal of Advanced Research in Medicine ◽

10.22271/27069567.2020.v2.i2b.56 ◽

2020 ◽

Vol 2 (2) ◽

pp. 110-113

Author(s):

Dr. Arshdeep S Mann ◽

Dr. Harmanjot Singh ◽

Dr. Beant Singh Maan

Keyword(s):

Vitamin D ◽

Case Control Study ◽

Serum Vitamin ◽

Case Control ◽

Female Population ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Control Study

Download Full-text

A case control study of serum vitamin D levels in alopecia areata

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20204227 ◽

2020 ◽

Vol 8 (10) ◽

pp. 3550

Author(s):

Bobbili Tarun Kesava Naidu ◽

Kavya Baddireddy

Keyword(s):

Vitamin D ◽

Alopecia Areata ◽

Case Control Study ◽

Serum Vitamin ◽

Autoimmune Disorder ◽

Case Control ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Severity Of The Disease ◽

Control Study

Background: Alopecia areata is an autoimmune disorder of anagen hair follicle leading to distressing and relapsing non-scarring hair loss. Vitamin D is an immunomodulator and plays a role in regulating normal hair cycle. Recent evidence suggests inconsistent association between vitamin D deficiency and alopecia areata.Methods: This case control study included 70 newly diagnosed cases of alopecia areata and 70 healthy controls. Competitive chemiluminescence immunoassay was used to determine and compare the serum vitamin D (25‑hydroxyvitamin D) levels between these groups. Also, the serum vitamin D levels correlation with severity of the disease was studied. ANOVA test and student t test were used for the statistical analysis.Results: Serum Vitamin D levels were significantly decreased in alopecia areata patients than in controls (p<0.05). There was no stastically significant relationship between serum 25-OH Vitamin D levels and severity of the disease (p=0.06).Conclusions: Prevalence of serum 25 (OH) deficiency was significantly higher in alopecia areata group. However no significant relation was found with disease severity.

Download Full-text