scholarly journals Evaluation of serum uric acid in acute ischaemic stroke

2017 ◽  
Vol 4 (1) ◽  
pp. 60
Author(s):  
Inderjeet Kaur ◽  
Ashok Khurana ◽  
Jasmine Kaur Sachdev ◽  
Gurinder Mohan
Keyword(s):  
Uric Acid ◽  
Risk Factor ◽  
Ischaemic Stroke ◽  
Serum Uric Acid ◽  
Acute Ischaemic Stroke ◽  
Serum Uric Acid Level ◽  
Increased Risk ◽  
The Difference ◽  
Stroke Evolution ◽  
Gcs Score

Background: The role of serum uric acid as a risk factor for acute ischaemic stroke is controversial and there is little information about it. Present study was done to estimate serum uric acid levels in patients of acute ischaemic stroke and to assess its risk factor potential.Methods: It was a prospective case control study carried out in the department of Medicine at Sri Guru Ramdas Institute of Medical Sciences and Research, Vallah, Sri Amritsar, Punjab, India from January 2015 to July 2016. 50 cases of acute ischaemic stroke were enrolled and were compared with same number of age and sex matched healthy controls. Serum uric acid levels were measured in cases (within 24 hours of stroke evolution). Glasgow coma scale (GCS) score was calculated for cases at time of admission. The results were statistically analysed.Results: Mean serum uric acid level in cases was 6.15±1.91mg/dl whereas it was 5.1±1.4 mg/dl in controls. The difference of serum uric acid levels between cases and controls was statistically significant (p = 0.0054). Patients with poor GCS had higher mean serum uric acid levels as compared to patients with mild or moderate GCS score which was statistically significant(p = 0.0426).Conclusions: Serum uric acid can be used as a marker for increased risk of stroke. Furthermore, serum uric acid can also be used for risk stratification after stroke.

scholarly journals SERUM URIC ACID LEVEL IN ACUTE ISCHAEMIC STROKE

2013 ◽  
Vol 2 (36) ◽  
pp. 6915-6926
Author(s):  
Arvind Charan Mangal ◽  
Rishi T Guria ◽  
Manish Kumar Singh
Keyword(s):  
Uric Acid ◽  
Ischaemic Stroke ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acute Ischaemic Stroke ◽  
Acid Level ◽  
Serum Uric Acid Level

scholarly journals TO STUDY SERUM URIC ACID AS A RISK FACTOR IN ACUTE ISCHAEMIC STROKE

2017 ◽  
Vol 6 (08) ◽  
pp. 647-652
Author(s):  
Krishan Oberoi ◽  
Ashwani Kumar Sharma ◽  
Sushant Garg ◽  
Rajiv Sharma ◽  
Bhupinder Singh ◽  
...  
Keyword(s):  
Uric Acid ◽  
Risk Factor ◽  
Ischaemic Stroke ◽  
Serum Uric Acid ◽  
Acute Ischaemic Stroke

scholarly journals A study to find out relationship in between serum uric acid level and stroke

2017 ◽  
Vol 4 (5) ◽  
pp. 1255
Author(s):  
Vishwa Deepak Tripathi ◽  
Zakir Hussain
Keyword(s):  
Uric Acid ◽  
Ischaemic Stroke ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acute Ischaemic Stroke ◽  
Acid Level ◽  
Significant Positive Correlation ◽  
Serum Uric Acid Level ◽  
Normal Serum ◽  
Stroke Patients

Background: The role of uric acid as a risk factor in cases of acute ischaemic stroke is controversial. The present study was conducted with the aim to study the clinical profile and the incidence of stroke in patients with normal and elevated uric acid and its correlation with other risk factors.Methods: This study was conducted in 100 patients with acute ischaemic stroke who were admitted in NSCB Hospital Jabalpur from August 2009 to July 2010.Clinical records of patients and their serum uric acid level was investigated. The severity of neurological deficit was recorded according to the scandinavian stroke scale (SSS). Patients were followed up during hospital stay and outcome was graded by using modified Rankin’s scale (mRS). Finally, collected data were analyzed using Chi square and student t test wherever appropriate. P value <0.05 was considered significant.Results: A total of 100 patients were included in the study. Majority of the patients (57%) were in the age group of 50 to 70 years. Males (54%) were more affected than females (46%). Out of 100, 71 had normal serum uric acid levels in which 35 (49%) patients were above 60 years of age. 29 of them had hyperuricemia in which 20 (69%) were above the age of 60 years. Of 54 males and 46 females hyperuricemia was observed in 16 (55%) and 13 (45%) patients respectively. A significant correlation was observed between hyperuricemia and hypertension (p<0.05). Non-significant correlation was seen between hyperuricemia, diabetes and hyperlipidemia (p>0.05). Significant, positive correlation p<0.05 was present amongst male alcoholics. Association of uric acid with smoking in acute ischaemic stroke patients was found to be statistically insignificant (p>0.05). Majority (83%) of patients were having infarct in MCA artery territory. Majority of patients 20 (69%) with elevated serum uric acid were having SSS score >30. Statistically insignificant (p>0.05) association was observed between mean mRS score in patients with normal serum uric acid Vs patients with hyperuricemia.Conclusions: The prevalence of hyperuricemia in acute ischaemic stroke patients was lower than in normal population. Age, hypertension and alcoholism amongst males showed statistically significant positive correlation with hyperuricemia in patient with acute ischaemic stroke and hence they are considered to be the significant risk factors.

scholarly journals Uric acid levels are critical for non-alcoholic fatty liver disease

2020 ◽  
Author(s):  
Guanqun Chao ◽  
Yue Zhu ◽  
Lizheng Fang
Keyword(s):  
Risk Factors ◽  
Uric Acid ◽  
Risk Factor ◽  
Fatty Liver ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Density Lipoprotein ◽  
Diagnostic Threshold

Abstract Background: To clarify the risk factors associated with NAFLD and further clarify the correlation between uric acid level and NAFLD by analyzing the correlation between NAFLD and different metabolic factors.Methods: Datas were obtained from subjects who underwent health examination in the Health promotion centre of Sir Run Run Shaw hospital of Zhejiang University from January 2016 to December 2017.The diagnosis of NAFLD was according to the clinical diagnosis of the Guidelines.Statistical analyses were performed using R software.Results: 79492 subjects were analyzed. 56680(71.3%) participants did not have NAFLD, 22812(28.7%) participants had NAFLD. Male, age, BMI, high blood pressure, central obesity, high glycosylated hemoglobin, high serum uric acid, high triglyceride, high total cholesterol, high low density lipoprotein cholesterol (LDL-C), abnormal liver function were risk factors of NAFLD, however, low high-density lipoprotein cholesterol (HDL-C) level was another risk factor of NAFLD.OR value suggested serum uric acid was a robust risk factor for NAFLD in all subgroups.In male group, AUC was 0.656 (95%CI: 0.651-0.661), the optimal diagnostic threshold was 395.5 mol/L, the sensitivity was 61.9%, the specificity was 61.1%, and the yoden index was 0.23. In female group, AUC was 0.716 (95%CI: 0.708-0.724), the optimal diagnostic threshold was 294.5 mol/L, sensitivity was 67.7%, specificity was 64.5%, and the Jordan index was 0.32.Conclusions: Our study suggested that there was a close correlation between serum uric acid level and NAFLD.Uric acid levels was a key risk factor for NAFLD.The diagnosis of fatty liver in patients can be preliminarily determined by detecting uric acid level.Contributions to the literature：1. The purpose of this study was to clarify the risk factors associated with NAFLD and further clarify the correlation between uric acid level and NAFLD by analyzing the correlation between NAFLD and different metabolic factors in the physical examination population.2. There was a close correlation between serum uric acid level and NAFLD.Uric acid levels was a key risk factor for NAFLD.3. The diagnosis of fatty liver in patients can be preliminarily determined by detecting uric acid level.

Serum uric acid levels and outcome during admission in acute ischaemic stroke, depending on renal function

2018 ◽  
Vol 128 (10) ◽  
pp. 906-912 ◽  
Author(s):  
José Carlos Arévalo-Lorido ◽  
Juana Carretero-Gómez ◽  
Nicolás Roberto Robles
Keyword(s):  
Renal Function ◽  
Uric Acid ◽  
Ischaemic Stroke ◽  
Serum Uric Acid ◽  
Acute Ischaemic Stroke

scholarly journals Serum Uric Acid is Associated with Renal Prognosis of Lupus Nephritis in Women but not in Men

2020 ◽  
Vol 9 (3) ◽  
pp. 773 ◽  
Author(s):  
Tae Ryom Oh ◽  
Hong Sang Choi ◽  
Chang Seong Kim ◽  
Dong-Ryeol Ryu ◽  
Sun-Hee Park ◽  
...  
Keyword(s):  
Uric Acid ◽  
Risk Factor ◽  
Lupus Nephritis ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Lupus Erythematosus ◽  
Acid Level ◽  
Independent Risk Factor ◽  
Serum Uric Acid Level ◽  
Cox Proportional Hazards

Lupus nephritis (LN) is a major complication of systemic lupus erythematosus. Early intervention in lupus nephritis improves prognosis. There is an association between hyperuricemia and lupus nephritis; nevertheless, the sex-specific role of uric acid in lupus nephritis remains unclear. We retrospectively analyzed 578 patients diagnosed with LN by renal biopsy. We determine the relationship of serum uric acid to progression of LN using Kaplan–Meier survival analyses and Cox proportional hazards models. The primary end point was LN progression defined as the initiation of dialysis or kidney transplantation. Men had higher mean serum uric acid levels than did women. Every 1 mg/dL increase in baseline uric acid level increased the risk of LN progression by 15.1%. The serum uric acid level was an independent risk factor for LN progression in women (hazard ratio [HR], 1.158; confidence interval [CI], 1.018–1.317; p = 0.028) but not in men (HR, 1.499; CI, 0.964–2.331; p = 0.072). Sensitivity analysis involving serum uric acid terciles generated consistent and robust results. Serum uric acid level was an independent risk factor for LN progression in women but not in men.

scholarly journals Study of Serum Uric Acid Level as an Independent Risk Factor in Acute Ischemic Stroke

2020 ◽  
Vol 7 (9) ◽  
pp. 442-445
Author(s):  
Chandrashekhar K ◽  
Mohammed Anwar Hussain ◽  
Ishwar S. Hasabi ◽  
Suryakanth Suryakanth ◽  
Chethan K. Ganteppanavar
Keyword(s):  
Uric Acid ◽  
Risk Factor ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Independent Risk Factor ◽  
Serum Uric Acid Level
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