scholarly journals Spectrum of prostate gland lesions: a clinico-pathologic study in south-western Bihar, India

2019 ◽  
Vol 6 (3) ◽  
pp. 885
Author(s):  
Rajendra Kumar ◽  
Wakeel Ahmad
Keyword(s):  
Chronic Prostatitis ◽  
Operative Procedure ◽  
Prostate Gland ◽  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
Pathological Changes ◽  
Malignant Tumours ◽  
Age Related ◽  
Nodular Hyperplasia ◽  
First Time

Background: Prostate gland is an endocrine dependent organ in males and age-related lesions involve it. Inflammation, benign nodular hyperplasia and tumours are the commonest to involve it worldwide. Occasionally some other pathological changes can also involve it. The study was carried out for the first time to know the spectrum and prevalence of prostate lesions which will be of help to the clinicians in this location.Methods: Retrospective study was carried out for a period of four years and out of surgical cases of males which underwent operative procedure, prostate cases were retrieved and in the department of pathology, haematoxylin and eosin stained slides were evaluated and diagnosed.Results: A total of 138 cases were included and five cases were excluded from this series. Benign nodular hyperplasia (73.9%) was the commonest finding followed by chronic prostatitis associated with hyperplasia (15.2%), atypical glandular hyperplasia (2.9%) and prostatic intraepithelial neoplasia (2.1%). Malignant tumours were 5.8% constituting adenocarcinoma prostate as the most common (62.5%). A case of hemangiopericytoma was also diagnosed.Conclusions: Benign nodular hyperplasia of prostate is the most common affliction among males starting at age 45 years. Early consultation and screening will be of immense value. Adenocarcinoma prostate may involve at age around 58 years.

Intraductal Carcinoma of the Prostate Gland With Transmucosal Spread to the Seminal Vesicle: A Lesion Distinct From High-Grade Prostatic Intraepithelial Neoplasia

2007 ◽  
Vol 131 (7) ◽  
pp. 1122-1125 ◽  
Author(s):  
Ronald J. Cohen ◽  
Beverly A. Shannon ◽  
Sydney L. Weinstein
Keyword(s):  
Seminal Vesicle ◽  
Invasive Carcinoma ◽  
Prostate Gland ◽  
Ejaculatory Duct ◽  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
Intraductal Carcinoma ◽  
High Grade ◽  
Carcinoma Of The Prostate ◽  
High Stage

Abstract Intraductal carcinoma of the prostate (IDC-P) gland represents an intraluminal neoplastic proliferation that is distinct from high-grade prostatic intraepithelial neoplasia (HG-PIN) and almost always coexists with large-volume, high-stage, and high-grade invasive carcinoma. We document an unusual presentation of apparently “early” IDC-P without an aggressive invasive element that, despite being confined to the acinar-ductal system, has gained access to the ejaculatory duct and seminal vesicle by transmucosal spread. This finding confirms that IDC-P, in contrast to HG-PIN, is inherently aggressive and has the ability to spread beyond the prostate gland. In this case, the absence of an aggressive invasive element suggests that IDC-P has most likely evolved within the lumens directly from HG-PIN.

scholarly journals Pathogenetic therapy of benign prostatic hyperplasia and prostatic intraepithelial neoplasia

2020 ◽  
Vol 13 (4) ◽  
pp. 66-74
Author(s):  
S.S. Krasnyak ◽  
◽  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Prostate Gland ◽  
Intraepithelial Neoplasia ◽  
The Elderly ◽  
Prostatic Intraepithelial Neoplasia ◽  
Prostatic Hyperplasia ◽  
Common Disease ◽  
Phosphodiesterase 5 Inhibitors ◽  
Surgical Methods ◽  
Phosphodiesterase 5

Introduction. Benign prostatic hyperplasia (BPH) is a neoplasm and clinically occurred by progressive enlargement of the prostate. However, prostate neoplasm can also be malignant, which is come out from high-grade prostatic intraepithelial neoplasia (PIN). It is a proven precancerous condition. Purpose. Тo evaluate the data published on September and October 2020 on the prevalence, pathogenesis of BPH and PIN and methods of their treatment. Materials and methods. The search results in scientific databases PubMed, MEDLINE, Embase were analyzed for the queries «BPH», «PIN», «epidemiology of BPH», «pathogenesis», «treatment of PIN». Results. BPH is a very common disease in the elderly population. The pathogenesis of BPH includes age, genetics or hormones disorders, growth factors, inflammation, and lifestyle factors. PIN is the only common precursor of prostatic cancer. The main treatment methods are 5α-reductase inhibitors, phosphodiesterase-5 inhibitors, and surgical methods. In addition, plant active molecules are also widely used in the treatment of BPH and PIN. Conclusions. While 5α-reductase and phosphodiesterase-5 inhibitors treatment, as well as surgical methods have a lot of adverse events and complications, a unique herbal complex Gardaprost was developed, which suppresses hyperplasia of prostate. Curcumin, genistein and epigalocatechin-3- gallate, which are part of the preparation, form a safe agent aimed at combating the growth of the prostate gland in BPH, and also has a significant effect in the prevention of exacerbations of chronic prostatitis and malignancy in patients with PIN.

scholarly journals Association of Serum PSA Levels with Histopathological Pattern of Prostate Lesions

2019 ◽  
Vol 8 (2) ◽  
pp. 92-95 ◽  
Author(s):  
Afra Samad ◽  
Nudrat Fayyaz ◽  
Ayesha Siddiqa ◽  
Naseem Akhter ◽  
Rabia Saeed ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Prostate Carcinoma ◽  
Histopathological Examination ◽  
Prostate Gland ◽  
Specific Antigen ◽  
Digital Rectal Examination ◽  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
Prostatic Hyperplasia ◽  
P Value

Background: Pathological changes that mainly affect prostate gland are prostatitis, benign prostatic hyperplasia (BPH) and cancerous lesions. Digital rectal examination (DRE), Transrectal Ultrasonography (TUS), and prostate specific antigen (PSA) followed by histopathological examination, are routinely used tests for diagnosis of prostate lesions. The aim of the present study is to determine the role of serum PSA levels in differentially diagnosing the different types of prostate lesions.Material and Methods: This retrospective (observational) study was conducted in Ibn-e-Sina Hospital Multan. Data of 2189 patients who were operated from 2007 to 2017 due to prostatic lesions were included in this analysis. Patients with BPH, prostatitis, prostate carcinoma and Prostatic Intraepithelial Neoplasia (PIN) were grouped according to serum PSA levels (ranging from 0 to >100 ng/ml) into five groups. Frequencies and percentages were calculated for different histopathological findings. Association of PSA levels with different histological patterns was determined with chi-square test with P-value < 0.05 taken as significant difference.Results: Mean age of patients was 62.45+10.64 years. On histopathology, BPH was diagnosed in 1676 (76.56%) patients, prostatitis in 133 (6.07%), carcinoma in 378 (17.26%) and PIN in 02 (0.09%) patients, respectively. Serum PSA levels of 4.01-10 ng/ml were found in 1050 (62.64%) BPH patients and in 59 (44.36%) prostatitis patients. Serum PSA levels of 10.01-20 ng/ml were found in only 40 (2.4%) BPH patients, 47 (35.33%) prostatitis patients, 22 (5.82%) carcinoma patients and in 1 (50.0%) PIN patient. Serum PSA levels of 20.01-100 ng/ml were found in 32 (1.9%) BPH patients, 11 (8.27%) prostatitis patients, 302 (79.89%) carcinoma patients, and in 1 (50.0%) PIN patient. Serum PSA levels of >100 ng/ml were absent in patients with BPH and PIN, and present in 1 (0.75%) prostatitis and 54 (14.28%) carcinoma patients.Conclusion: Benign prostatic hyperplasia was the commonest lesion in our patients (76.56%) with serum PSA levels >10 ng/ml reported in all patients with prostate carcinoma and prostatic intraepithelial neoplasia (PIN) patients.

Pathological changes of high-grade prostatic intraepithelial neoplasia and prostate cancer after monotherapy with bicalutamide 150 mg

2006 ◽  
Vol 98 (1) ◽  
pp. 54-58 ◽  
Author(s):  
VINCENZO SCATTONI ◽  
RODOLFO MONTIRONI ◽  
ROBERTA MAZZUCCHELLI ◽  
MASSIMO FRESCHI ◽  
LUCIANO NAVA ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
High Grade ◽  
Pathological Changes

A STUDY TO CORRELATE HISTOPATHOLOGY, SERUM PSA LEVEL AND IMMUNOHISTOCHEMICAL EXPRESSION OF ER & PR IN PROSTATIC GROWTH

2021 ◽  
pp. 66-69
Author(s):  
Prashant Bhardwaj ◽  
Sumit Nandy ◽  
Keya Basu ◽  
Manjari Kumari ◽  
Dilip Karmakar
Keyword(s):  
Epithelial Cells ◽  
Stromal Cells ◽  
Chronic Prostatitis ◽  
Histopathological Examination ◽  
Immunohistochemical Analysis ◽  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
Immunohistochemical Expression ◽  
Altered Expression ◽  
Prostatic Growth

Objectives- Prostate is a bromusculoglandular structure situated at the neck of urinary bladder. It enlarges due to benign hyperplasia of prostate (BHP), prostatic intraepithelial neoplasia (PIN) or adenocarcinoma. Enlargement of prostate is associated with raised serum level of prostate-specic antigen (PSA) and altered expression of estrogen receptor (ER) and progesterone receptor (PR). The aim of our study is to correlate the histopathology, PSA levels and altered expression of ER and PR by immunohistochemistry in different prostatic growth lesions. Methodology- Patients diagnosed as having prostatic growth were enrolled and their serum PSA levels were noted. Histopathological examination and immunohistochemical analysis of prostatic tissues for ER and PR were carried out to nd out correlation of different type of growth with serum PSA level and expression of ER and PR. Results- A total 96 cases studied of them 61(63.54%) patients presented with BHP, 20(20.83%) patients with BHP with chronic prostatitis, 3 patients presented with metaplastic changes, 5 cases with of PIN and 6 patients presented with adenocarcinoma with different Gleason score. PR expression positivity in epithelial cells and stromal cells of BHP cases were 51(83.6%) and 53(86.88%) respectively. Patients presented with adenocarcinoma showed only 33.33 %( 2cases) positivity in epithelial cells and 50% (3cases) positivity in stromal cells. Serum PSA level were signicantly higher in adenocarcinoma patients as compare to BHP patients. Conclusion- By observing these ndings it can be suggested that and antiprogesterone therapy may be helpful in the treatment of prostatic adenocarcinoma.

Differential expression of MSX2 in nodular hyperplasia, high-grade prostatic intraepithelial neoplasia and prostate adenocarcinoma

Apmis ◽  
2010 ◽  
Vol 118 (12) ◽  
pp. 918-926 ◽  
Author(s):  
CHEE-WAI CHUA ◽  
YUNG-TUEN CHIU ◽  
HIU-FUNG YUEN ◽  
KWOK-WAH CHAN ◽  
XIANGHONG WANG ◽  
...  
Keyword(s):  
Differential Expression ◽  
Intraepithelial Neoplasia ◽  
Prostate Adenocarcinoma ◽  
Prostatic Intraepithelial Neoplasia ◽  
High Grade ◽  
Nodular Hyperplasia
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