scholarly journals Immunohistochemistry Expression of Ki-67 in Nodular Hyperplasia, Prostatic Intraepithelial Neoplasia and Adenocarcinoma Prostate

2018 ◽  
Author(s):  
Lidya Imelda Laksmi ◽  
T. Ibnu Alferraly
Keyword(s):  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
Ki 67 ◽  
Nodular Hyperplasia

scholarly journals Spectrum of prostate gland lesions: a clinico-pathologic study in south-western Bihar, India

2019 ◽  
Vol 6 (3) ◽  
pp. 885
Author(s):  
Rajendra Kumar ◽  
Wakeel Ahmad
Keyword(s):  
Chronic Prostatitis ◽  
Operative Procedure ◽  
Prostate Gland ◽  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
Pathological Changes ◽  
Malignant Tumours ◽  
Age Related ◽  
Nodular Hyperplasia ◽  
First Time

Background: Prostate gland is an endocrine dependent organ in males and age-related lesions involve it. Inflammation, benign nodular hyperplasia and tumours are the commonest to involve it worldwide. Occasionally some other pathological changes can also involve it. The study was carried out for the first time to know the spectrum and prevalence of prostate lesions which will be of help to the clinicians in this location.Methods: Retrospective study was carried out for a period of four years and out of surgical cases of males which underwent operative procedure, prostate cases were retrieved and in the department of pathology, haematoxylin and eosin stained slides were evaluated and diagnosed.Results: A total of 138 cases were included and five cases were excluded from this series. Benign nodular hyperplasia (73.9%) was the commonest finding followed by chronic prostatitis associated with hyperplasia (15.2%), atypical glandular hyperplasia (2.9%) and prostatic intraepithelial neoplasia (2.1%). Malignant tumours were 5.8% constituting adenocarcinoma prostate as the most common (62.5%). A case of hemangiopericytoma was also diagnosed.Conclusions: Benign nodular hyperplasia of prostate is the most common affliction among males starting at age 45 years. Early consultation and screening will be of immense value. Adenocarcinoma prostate may involve at age around 58 years.

The utility of Ki-67 expression in the differential diagnosis of prostatic intraepithelial neoplasia and ductal adenocarcinoma

2005 ◽  
Vol 36 (5) ◽  
pp. 531-535 ◽  
Author(s):  
Nathalie Rioux-Leclercq ◽  
Emmanuelle Leray ◽  
Jean-Jacques Patard ◽  
Bernard Lobel ◽  
François Guillé ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
Ductal Adenocarcinoma ◽  
Ki 67

Differential expression of MSX2 in nodular hyperplasia, high-grade prostatic intraepithelial neoplasia and prostate adenocarcinoma

Apmis ◽  
2010 ◽  
Vol 118 (12) ◽  
pp. 918-926 ◽  
Author(s):  
CHEE-WAI CHUA ◽  
YUNG-TUEN CHIU ◽  
HIU-FUNG YUEN ◽  
KWOK-WAH CHAN ◽  
XIANGHONG WANG ◽  
...  
Keyword(s):  
Differential Expression ◽  
Intraepithelial Neoplasia ◽  
Prostate Adenocarcinoma ◽  
Prostatic Intraepithelial Neoplasia ◽  
High Grade ◽  
Nodular Hyperplasia

scholarly journals Conditional Loss of Nkx3.1 in Adult Mice Induces Prostatic Intraepithelial Neoplasia

2002 ◽  
Vol 22 (5) ◽  
pp. 1495-1503 ◽  
Author(s):  
Sarki A. Abdulkadir ◽  
Jeffrey A. Magee ◽  
Thomas J. Peters ◽  
Zahid Kaleem ◽  
Cathy K. Naughton ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Intraepithelial Neoplasia ◽  
Branching Morphogenesis ◽  
Prostatic Intraepithelial Neoplasia ◽  
Prostate Tumor ◽  
Human Prostate ◽  
Ki 67 ◽  
Adult Mice ◽  
Conditional Deletion ◽  
Preinvasive Lesions

ABSTRACT The homeodomain-containing transcription factor NKX3.1 is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3.1 protein expression is common in human prostate carcinomas and prostatic intraepithelial neoplasia (PIN) lesions and correlates with tumor progression. Disruption of the murine Nkx3.1 gene results in defects in prostate branching morphogenesis, secretions, and growth. To more closely mimic the pattern of NKX3.1 loss that occurs in human prostate tumors, we have used Cre- and loxP-mediated recombination to delete the Nkx3.1 gene in the prostates of adult transgenic mice. Conditional deletion of one or both alleles of Nkx3.1 leads to the development of preinvasive lesions that resemble PIN. The pattern of expression of several biomarkers (Ki-67, E-cadherin, and high-molecular-weight cytokeratins) in these PIN lesions resembled that observed in human cases of PIN. Furthermore, PIN foci in mice with conditional deletion of a single Nkx3.1 allele lose expression of the wild-type allele. Our results support the role of NKX3.1 as a prostate tumor suppressor and indicate a role for this gene in tumor initiation.

scholarly journals Histopathologic Pattern of Prostatic Lesions Observed in Autopsy Series

2017 ◽  
Vol 25 (1) ◽  
pp. 39-45
Author(s):  
Jesmin Naz Ferdous ◽  
Sabrina Razzaque ◽  
Rezaul Karim Dewan ◽  
Md Nazmul Haque ◽  
Saiyeda Sinthia Karim ◽  
...  
Keyword(s):  
Precancerous Lesions ◽  
Squamous Metaplasia ◽  
Transitional Cell ◽  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
Low Grade ◽  
Screening Programs ◽  
Medical College ◽  
Autopsy Series ◽  
Nodular Hyperplasia

Incidental autopsy findings may be important to study about the prevalence of prostatic lesions among the male population which remains undiagnosed. Histology is the unique method for diagnosis of silent prostatic disease. The present cross sectional study was carried out with an aim to evaluate the histopathological pattern of prostatic lesions such as nodular hyperplasia of prostate (NHP), the precancerous lesions and the latent cancer in autopsy series over the age of 40 years of male. A total number of 120 specimens of prostates were collected from the dead bodies on whom postmortem examination was done by the Department of Forensic Medicine, Dhaka Medical College and Hospital, Dhaka. All these autopsies were done for medicolegal purposes. This study confirms previous observations and concluded that nodular hyperplasia of prostate was the commonest lesion. Of the total 54 cases of NH, 27 were accompanied with transitional cell metaplasia (TCM), Squamous metaplasia, basal cell hyperplasia (BCH), low grade prostatic intraepithelial neoplasia (LGPIN), inflammation, atypical adenomatous hyperplasia (AAH), high grade prostatic intraepithelial neoplasia (HGPIN) and prostatic carcinoma (PCa). Only 27 cases were NH. Most common pattern of inflammation associated with NHP was chronic inflammation. LGPIN was present in 8 (6.6%) cases and majority were with NH. But none of the LGPIN and metaplasias were associated with carcinoma or HGPIN. The commonest age group of presentation for NH was in fifth decade and increased with advancing age. It can be concluded that many prostatic lesions can remain silent and are diagnosed only at autopsy. Considering the HGPIN and prostate cancer to be silent, the development of screening programs to detect the latent cases of the disease is recommended.J Dhaka Medical College, Vol. 25, No.1, April, 2016, Page 39-45

The role of immunohistochemistry in the diagnosis of cervical intraepithelial neoplasia of different severity

2016 ◽  
pp. 138-140
Author(s):  
S.I. Zhuk ◽  
◽  
O.A. Taran ◽  
A.N. Koshmienskaya ◽  
T.V. Lobastova ◽  
...  
Keyword(s):  
Protein Expression ◽  
Cervical Intraepithelial Neoplasia ◽  
Precancerous Lesions ◽  
Molecular Genetic ◽  
Intraepithelial Neoplasia ◽  
Reproductive Age ◽  
Moderate Degree ◽  
Ki 67 ◽  
The Third ◽  
Diagnosis And Prognosis

The objective: the finding of protein expression of apoptosis regulator BCL-2, Smooth Muscule Actin and the antigen Ki-67 in cervical intraepithelial neoplasia of different severity to optimize the diagnosis and prognosis of the disease. Patients and methods. The study involved 42 women of reproductive age with cervical intraepithelial the neoplasia of the cervix varying degrees applied to the doctor of cervical pathology Zhitomir regional oncologic dispensary. All women (n=42) were divided into groups. The first group included 15 patients (35.7%) with cervical intraepithelial neoplasia with mild. The second group included 13 women (31%) with cervical intraepithelial neoplasia a moderate degree. The third group was represented by patients with cervical intraepithelial neoplasia with severe – 14 respondents (33.3 per cent). Results. Marker BCL-2 in patients of the first group was positive in 7 patients (46.7%), Smooth Muscule Actin was positive in 9 patients (60%) and Ki-67 was diagnosed in 8 of the surveyed women (53.3%). In the second group of BCL-2 was positive in 8 patients (61.5%), Clone 124, Smooth Muscule Actin, Clone 1A4 was positive in 9 patients (69.2%), and Ki-67 was diagnosed in 12 of the surveyed women (92.3%). Marker BCL-2 in patients of the third group was positive in 12 patients (85.7%), Smooth Muscule Actin was positive in 10 patients (71.4%) and Ki-67 was diagnosed in 13 of the surveyed women (92.9% ). Conclusion. Carcinogenesis is associated with molecular genetic damage to the cervix. Some of the products of this process can be used as prognostic and diagnostic markers of tumor progression. Determination of protein expression of apoptosis regulator BCL-2, Smooth Muscule Actin and the antigen Ki-67 in cervical intraepithelial neoplasia makes it possible to accurately verify the diagnosis and to predict the course of pathological changes in the flat epithelium of the cervix. Key words: cervical intraepithelial neoplasia, cervical cancer, morphological diagnostics of precancerous lesions, BCL-2, Smooth Muscule Actin, Ki-67.

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