scholarly journals A prospective study to assess the social stigma, perceived stress and psychological distress among security guards during COVID-19 pandemic in All India Institute of Medical Sciences, New Delhi

2021 ◽  
Vol 8 (10) ◽  
pp. 5029
Author(s):  
Sheenu Ahlawat ◽  
Poonam Joshi ◽  
Cecilia Mary Susaimuthu ◽  
Prabudh Goel ◽  
Rakesh Lodha ◽  
...  
Keyword(s):  
Psychological Distress ◽  
Prospective Study ◽  
Perceived Stress ◽  
Social Stigma ◽  
Tertiary Care ◽  
Health Sector ◽  
New Delhi ◽  
Security Guards ◽  
The Mean ◽  
A Prospective Study

Background: People working in the health sector were being labelled, stereotyped, discriminated against, stigmatized, and treated indifferently in the early phase of coronavirus disease 2019 (COVID-19) pandemic. To assess social stigma, perceived stress, and psychological distress among hospital security guards during the COVID-19 pandemic.Methods: A prospective study was conducted among security guards, working in a tertiary care health facility, during the early part of the COVID-19 pandemic. The data were collected using an online Google form. The stigma, perceived stress, and psychological distress were assessed using standardized tools.Results: The mean age of 280 (males: 219, 78.2%) guards enrolled in the study was 37.13±9.1 years. The mean stigma, stress, and psychological distress scores among security guards were 28.76±11.9, 17.64±6.4, and 4.35±2.8, respectively. A significant correlation was found between perceived stigma and psychological distress (r=0.197, p=0.009) and perceived stress and psychological distress (r=0.302, p=0.001). The predictor of perceived stress among the security guards were gender, [β=1.88; (1.13, 2.63), p=0.001] and loss of job by the family member during pandemic [β=2.8 (4.56, 1.03), p=0.001], similarly the predictors of psychological distress were gender and COVID positive status [β=0.06 (0.10, 0.33), p=0.001].Conclusions: The majority of the security guards had moderate to high perceived social stigma, and moderate level stress during the COVID-19 Pandemic and a few being psychologically distressed requiring referral to experts. 

scholarly journals Role of Immunohistochemical Markers p53 and Ki-67 in Grading of Glial Tumours: A Prospective Study

2021 ◽  
Author(s):  
Aparna Singh ◽  
Aparna Bhardwaj ◽  
Sanjay Kaushik ◽  
Sanjeev Kishore ◽  
Seema Acharya
Keyword(s):  
Prospective Study ◽  
Tertiary Care ◽  
Histologic Grade ◽  
World Health ◽  
Cell Of Origin ◽  
Ki 67 ◽  
Fixed Tissue ◽  
Grade Ii ◽  
The Mean ◽  
A Prospective Study

Introduction: Gliomas are the tumours of neuroepithelial tissues and are named according to their cell of origin. Squash cytology and sterotactic biopsies with Haematoxylin and Eosin (H&E) staining form the backbone of diagnosis, nevertheless recent advances in Immunohistochemistry (IHC) have revolutionised the way gliomas are diagnosed and graded. Aim: To evaluate expression and correlation of p53 and Ki-67/MIB 1 amongst a series of gliomas diagnosed morphologically according to World Health Organisation (WHO) classification of Central Nervous System (CNS) tumours 2007. Materials and Methods: The present study was a prospective study conducted over a period of 18 months from December 2016 to May 2018 at a tertiary care centre in Uttarakhand, India. The study group comprised all consecutive cases of glial tumours that were clinically diagnosed and histopathologically confirmed as Gliomas during this period. Histopathological sections were made from formalin fixed tissue and stained with H&E and grading was done according to the WHO grading system 2007 for CNS neoplasms. Subsequently, IHC sections were taken on poly L-lysine coated slides and IHC staining of p53 and MIB1 (Ki-67) was performed. The IHC scores were calculated and correlated with histopathological grade. Statistical analysis was done using Statistical Package for the Social Sciences (SPSS) software version 17.0. Results: A total of 40 cases of glial tumours diagnosed on histopatholgy were included in the study. They showed M:F ratio of 1.22:1 with peak age incidence of 21-30 years. Astrocytoma, grade IV was the most frequent diagnosis followed by grade II on H&E. On IHC, grade II diffuse astrocytomas, grade III Anaplastic Astrocytomas (AA), and Glioblastoma Multiforme (GBM) demonstrated a mean p53 positivity of 29.5, 50.83 and 47.66, respectively and a Ki-67 positivity of 32.5, 48.33 and 58.08, respectively. For ependymomas grade I, II and III the mean p53 positivity was 9, 5.26 and 12, respectively and the mean Ki-67 positivity was 2, 7.93 and 40, respectively. Amongst oligodendrogliomas grade II and III showed a p53 positivity of 6 and 8.25 and Ki-67 positivity of 12 and 30.5, respectively. A stronger correlation was found between an increase in histologic grade and proliferation markers. Conclusion: Histologic grade was the most important prognostic factor with respect to patient survival in glial neoplasms. The immunopositivity for p53 and Ki-67 correlated well with histological malignancy grade in all glioma subtypes, but a considerable overlap of proliferative index was observed between different subtypes.

scholarly journals A prospective study of adverse drug reactions in a tertiary care teaching hospital

2018 ◽  
Vol 7 (10) ◽  
pp. 1965
Author(s):  
More Pankaj Daulat ◽  
Ambika Abhishake V. J. ◽  
Prabhakar Singh ◽  
Bhupendra Raj
Keyword(s):  
Prospective Study ◽  
Adverse Drug Reactions ◽  
Tertiary Care ◽  
New Delhi ◽  
Drug Reactions ◽  
Study Results ◽  
Systems Identification ◽  
A Prospective Study ◽  
Clinical Departments ◽  
Reporting Pattern

Background: Adverse drug reactions (ADRs) have become frequent cause for hospitalization and are coming up as an economic burden on health systems. Identification of ADRs and their reporting pattern can provide useful information for their management.Methods: This was an observational and prospective study. ADR reports of 130 patients were collected of the inpatient department of various clinical departments of Sanjay Gandhi Memorial Hospital, Rewa, Madhya Pradesh (M.P.) The ADRs were collected during October 2014-September 2015, with ADR reporting form of Central Drugs Standard Control Organization (CDSCO), New Delhi. ADRs were assessed for their causality, severity, and preventability as per the standard scales. Data was analysed using descriptive statistics and expresses in percentages.Results: Overall occurrence of ADRs was slightly more in males (55%). Maximum (26%) suspected ADR reported during study period was skin rash. Skin (44%) was the most commonly affected organ system. Antimicrobials (68%) were the drug group most commonly involved in ADRs. Most of the suspected ADRs were probable in causality assessment, moderate in severity and probably preventable.Conclusions: The study results revealed opportunities for interventions in ADR management to ensure safer drug use.

scholarly journals Serum Concentration of Myelin Basic Protein as a Prognostic Marker in Mild-to-moderate Head Injury Patients: A Prospective Study in a Tertiary Care Center

2021 ◽  
Author(s):  
Ashvamedh Singh ◽  
Kulwant Singh ◽  
Anurag Sahu ◽  
R. S. Prasad ◽  
N. Pandey ◽  
...  
Keyword(s):  
Head Injury ◽  
Prospective Study ◽  
Myelin Basic Protein ◽  
Prognostic Marker ◽  
Outcome Prediction ◽  
Basic Protein ◽  
Care Center ◽  
Tertiary Care ◽  
Gcs Score ◽  
A Prospective Study

Abstract Objective To estimate the level of myelin basic protein (MBP) and look for its validity in outcome prediction among mild-to-moderate head injury patients. Materials and Methods It was a prospective study done at the Department of Neurosurgery, Institute of Medical Sciences, Banaras Hindu University from Jan 2018 to July 2019. All patients who presented to us within 48 hours of injury with mild-to-moderate head injury with apparently normal CT brain were include in the study. The serum sample were collected on the day of admission and 48 hours later, and patients were treated with standard protocols and observed 6 months postdischarge. Results Of the 32 patients enrolled, we observed mean MBP level was higher for severity of brain damage, but not associated with age, mode of injury, and radiological diagnosis. Mean MBP levels were not statistically associated with Glasgow coma scale (GCS) score at admission but was correlated to outcome with p < 0.05, with sensitivity of 50% and specificity 72%, that is, patients with good outcome have lower mean MBP levels. Conclusion MBP as per our analysis can be used as a prognostic marker in patients with head injury. It is not the absolute value rather a trend showing rise in serum MBP levels, which carries a significant value in outcome prediction.

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