Endoscopic sinus surgery and its effects on pulmonary function test in patients of chronic rhinosinusitis with nasal polyposis

Background: The human upper and lower respiratory tract share a close relationship in respect to existence of diseases. The objectives of this study were to evaluate the outcome of endoscopic sinus surgery with the Lund- Mackay staging system and to find any objective changes between the pre and post-operative pulmonary function test values in patients with chronic rhinosinusitis undergoing endoscopic sinus surgery.Methods: A total of 50 patients of CRSwNP refractory to maximal medical treatment (for 1 month) planned for endoscopic sinus surgery were included in the study. Results were assessed on the basis of pre and post-operative endoscopic and CT scores and PFT (FEV1, FVC and FEV1/FVC) values. Results: Postoperatively, Lund Mackay endoscopic and CT scores improved from the preoperative values, which were statistically significant with p values<0.05. Comparing FEV1/FVC, FVC and FEV1 values in three situations- preoperative versus postoperative 1 month, preoperative versus postoperative 3rd month and post-operative 1st month versus postoperative 3rd month, the difference between the means were found to be statistically significant (p=0.000), except for FVC between postoperative 3rd month and 1st month.Conclusions: This study provides objective evidence that patients with CRSwNP may have non clinical lower airway disease detected by PFT and ESS is effective in improvement of both nasal and lower airway disease as evident from the improvements in PFT values.

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Effect of Endoscopic Sinus Surgery on Bronchiectasis Patients With Chronic Rhinosinusitis

American Journal of Rhinology and Allergy ◽

10.1177/1945892418793539 ◽

2018 ◽

Vol 32 (5) ◽

pp. 432-439 ◽

Cited By ~ 4

Author(s):

Jesada Kanjanaumporn ◽

Peter H. Hwang

Keyword(s):

Pulmonary Function ◽

Chronic Rhinosinusitis ◽

Endoscopic Sinus Surgery ◽

Pulmonary Function Tests ◽

Pearson Correlation ◽

Airway Disease ◽

Forced Expiratory Volume ◽

Sinus Surgery ◽

Post Operation ◽

Snot 22

Background The concept of unified airway disease has linked bronchiectasis with chronic rhinosinusitis (CRS), much in the same way as in asthma and CRS. Although the outcomes of endoscopic sinus surgery (ESS) on comorbid asthma have been relatively well studied, the outcomes of ESS on comorbid bronchiectasis have rarely been examined. Objective We sought to determine sinonasal and pulmonary clinical outcomes of ESS in bronchiectasis patients with CRS. Method We reviewed all bronchiectasis patients who had ESS for CRS at our institution from 2006 to present. The sinonasal outcome test 22 (SNOT-22) was administered preoperatively and at 3 months, 1 year, and 3 years postoperatively. Pulmonary function tests (PFTs) were measured preoperatively and at 6 months and 1 year post operation to assess the forced expiratory volume in 1 s (FEV1), forced viral capacity (FVC), and FEV1/FVC values. Paired t test and Pearson correlation were used to compare pre- and postsurgical results. Results A total of 141 bronchiectasis patients who had ESS for CRS were studied. The most common cause of bronchiectasis was cystic fibrosis (CF) (42.55%). SNOT-22 scores improved at 3 months post operation and were maintained at 1 year and 3 years post operation ( P < .001). All SNOT sub-domains showed a significant improvement after surgery ( P < .01). However, PFTs did not change at 6 months post operation and 1 year post operation ( P > .05). There were significant differences in the outcomes in CF versus non-CF patients ( P < .05) but not by sex or age. Conclusion ESS is effective in improving long-term sinonasal outcomes in bronchiectasis patients with CRS. However, ESS does not appear to improve the pulmonary function.

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Functional Endoscopic Sinus Surgery in Patients with Chronic Rhinosinusitis and Polyposis and Asthma

Clinical Rhinology An International Journal ◽

10.5005/jp-journals-10013-1194 ◽

2014 ◽

Vol 7 (2) ◽

pp. 52-57

Author(s):

Nishi Sonkhya ◽

Kalpana Sharma

Keyword(s):

Chronic Rhinosinusitis ◽

Endoscopic Sinus Surgery ◽

Inflammatory Responses ◽

Airway Disease ◽

Functional Endoscopic Sinus Surgery ◽

Sinus Surgery ◽

Controlled Study ◽

Physiological Data ◽

Lower Airway ◽

Middle Ear Mucosa

ABSTRACT There has been an increasing awareness of the inter-relationship between inflammatory disease of the upper and lower airway. Both epidemiological and physiological data suggest that the respiratory tract, from the middle ear mucosa, through the nose and sinuses, and into the pulmonary tree behave as an integerated unit. Recent progress in understanding the biology of airway disease has identified that systemic inflammatory responses play a critical and integerating role in these diseases. The role of sinus surgery in the management of asthma patients has been a matter of debate for many years. We are presenting a well-designed prospective, controlled study in 50 patients with asthma and chronic rhinosinusitis (CRS) with nasal polyposis who were submitted to either functional endoscopic sinus surgery (FESS) or medical therapy. How to cite this article Sonkhya N, Sharma K. Functional Endoscopic Sinus Surgery in Patients with Chronic Rhinosinusitis and Polyposis and Asthma. Clin Rhinol An Int J 2014;7(2):52-57.

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A clinical study of hyperreactive airway disease with wheeze in children aged five to twelve years with special reference to pulmonary function test

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20191499 ◽

2019 ◽

Vol 6 (3) ◽

pp. 1027

Author(s):

Arjun Reddy ◽

Abhishek Patel ◽

Sanjeev Chetty

Keyword(s):

Pulmonary Function ◽

Pulmonary Function Test ◽

Cost Effective ◽

Airway Disease ◽

Age Group ◽

Medical College ◽

Function Test ◽

Before And After ◽

Group 5 ◽

Marginal Improvement

Background: Pulmonary function test is the easiest and most cost-effective method to evaluate respiratory functions. PFT can be measured by a simple instrument spirometer. Measuring PFT has been suggested as an important tool in understanding HRAD and its complications and management by all international guidelines. The objectives of this study were to clinically diagnose the hyperreactive airway disease in children coming to Navodaya Medical College, Raichur, of age group 5 to 12 years. And to perform pulmonary function test before and after the use of a bronchodilator.Methods: PFT was measured in 100 children who came with HRAD with wheeze using Spiro lab III spirometer. The child was given then nebulization with salbutamol and PFT was performed again after 30 min.Results: A total of 100 clinically diagnosed cases of HRAD of age group 5 to 12 years of both the gender was taken into the study, of which more than 44% of the children showed more than 20% improvement in parameters FEV1, PEF, FVC and marginal improvement in EV1/FVC post bronchodilator compared to their prebronchodilator parameters. The young children of both the gender showed better improvement than elder children.Conclusions: Spirometry is the best tool to assess HRAD even in younger children, early diagnosis and regular follow up with PFT helps to understand and prevent the progression of the disease with prompt treatment.

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Feasibility of balloon sinuplasty in patients with chronic rhinosinusitis: the Graz experience

Rhinology Journal ◽

10.4193/rhino12.194 ◽

2013 ◽

Vol 51 (2) ◽

pp. 120-127

Author(s):

P.V. Tomazic ◽

H. Stammberger ◽

H. Braun ◽

W. Habermann ◽

C. Schmid ◽

...

Keyword(s):

Chronic Rhinosinusitis ◽

Failure Rate ◽

Endoscopic Sinus Surgery ◽

Hybrid Procedure ◽

Sinus Surgery ◽

Study Group ◽

Hybrid Procedures ◽

Routine Treatment ◽

Balloon Sinuplasty ◽

Study Results

Background: Balloon sinuplasty (BSP) is a catheter-based technique to dilate sinus ostia and drainage pathways to create ventilation and drainage. The aim of this study was to evaluate the feasibility of BSP in routine treatment of patients suffering from chronic rhinosinusitis (CRS). Methodology: Patients with CRS refractory to medical therapy who had been scheduled for endoscopic sinus surgery between 2009 and 2011 were included in this study. Results: Forty-five consecutive patients were included in this study, in whom 112 sinuses were approached by BSP. Of the 112 sinuses, 68 (60%) were planned as a "Balloon-Only" procedure and 44 (40%) were planned as a "Hybrid" procedure. Of the 68 sinuses in the "Balloon-Only" group, in 44 sinuses BSP failed, equating to a failure rate of 65%. Forty-four sinuses were planned for "Hybrid" procedures. In 29 of these sinuses BSP failed, giving a failure rate of 66%. Conclusion: According to literature, BSP can be a useful adjunct technique to standard FESS. In our experience, however, a failure rate of 65% for "Balloon-Only" and of 66% for "Hybrid" procedures occurred, which was regarded as unacceptable by the study group. Therefore, the study initially scheduled for 200 consecutive patients, was abandoned.

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Effect of Endoscopic Sinus Surgery on Pulmonary Function of Chronic Rhinosinusitis with Asthma

Otolaryngology ◽

10.1177/0194599812451426a383 ◽

2012 ◽

Vol 147 (2_suppl) ◽

pp. P245-P245

Author(s):

Mikiya Asako ◽

Koichi Tomoda

Keyword(s):

Pulmonary Function ◽

Chronic Rhinosinusitis ◽

Endoscopic Sinus Surgery ◽

Sinus Surgery

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A Study of Pulmonary Function Tests in Patients with Chronic Rhinosinusitis Following Endoscopic Sinus Surgery

Indian Journal of Otolaryngology and Head & Neck Surgery ◽

10.1007/s12070-021-02759-7 ◽

2021 ◽

Author(s):

Ankita Chaudhary ◽

Rekha Harshvardhan ◽

Ramlakhan Meena ◽

Shraddha Sharma ◽

Bharat Bhushan Sharma ◽

...

Keyword(s):

Pulmonary Function ◽

Chronic Rhinosinusitis ◽

Endoscopic Sinus Surgery ◽

Pulmonary Function Tests ◽

Sinus Surgery ◽

Function Tests

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Effects of Endoscopic Sinus Surgery for Eosinophilic Chronic Rhinosinusitis on Respiratory Functions and FeNO Production in the Lower Respiratory Tract

Ear Nose & Throat Journal ◽

10.1177/01455613211032006 ◽

2021 ◽

pp. 014556132110320

Author(s):

Tetsuya Terada ◽

Takaki Inui ◽

Kou Moriyama ◽

Keiki Noro ◽

Yusuke Kikuoka ◽

...

Keyword(s):

Chronic Rhinosinusitis ◽

Endoscopic Sinus Surgery ◽

Sinus Surgery ◽

Lower Airway ◽

Act Scores ◽

Asthma Control Test ◽

Eosinophilic Chronic Rhinosinusitis ◽

Before And After ◽

The Mean ◽

Asthma Group

Objective: To confirm the relevance of upper and lower airway inflammation in eosinophilic chronic rhinosinusitis (ECRS), the effects of endoscopic sinus surgery (ESS) on lower airway functions and inflammation need to be examined in ECRS patients. Methods: Chronic rhinosinusitis patients with nasal polyps (25 non-ECRS, 28 ECRS) were enrolled. The 12 patients in the ECRS group had comorbid asthma, in contrast to none in the non-ECRS group. We divided ECRS patients into 2 groups of ECRS with and without asthma. Clinical markers, including fraction of exhaled nitric oxide (FeNO), respiratory functions, and the Asthma Control Test (ACT) questionnaire, were investigated before and after ESS. Results: The FeNO levels in the ECRS with asthma group decreased after ESS. The mean FeNO levels in this group were 56.3 ppb before ESS and 24.9, 25.1, 25.0, and 15.5 ppb 1, 2, 3, and 4 months, respectively, after ESS. The mean forced expiratory rates in 1 second before and after ESS were 67.6% and 73.0%, respectively. The mean maximal expiratory flow rates at 50% of the vital capacity before and after ESS were 45.8% and 58.0%, respectively. Significant differences were observed in respiratory functions before and after ESS. The mean ACT scores in the ECRS with asthma group before and after ESS were 17.5 and 23.5, respectively. The ACT scores were significantly higher after than before ESS. Conclusions: The present results indicate that ECRS and bronchial asthma are common eosinophilic airway inflammatory diseases, and ESS for eosinophilic sinusitis may improve lower airway function.

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Pulmonary function of patients with chronic rhinosinusitis and the impact of endoscopic sinus surgery

The Egyptian Journal of Otolaryngology ◽

10.4103/ejo.ejo_99_16 ◽

2018 ◽

Vol 34 (3) ◽

pp. 167

Author(s):

OsamaG Abdel-Naby Awad ◽

AhmedM Youssef ◽

Mohamed Taha

Keyword(s):

Pulmonary Function ◽

Chronic Rhinosinusitis ◽

Endoscopic Sinus Surgery ◽

Sinus Surgery ◽

The Impact

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GAP Score and CA-153 Associated with One-Year Mortality in Anti-MDA-5 Antibody-Positive Patients: A Real-World Experience

Journal of Clinical Medicine ◽

10.3390/jcm10225241 ◽

2021 ◽

Vol 10 (22) ◽

pp. 5241

Author(s):

Chih-Wei Tseng ◽

Kao-Lun Wang ◽

Pin-Kuei Fu ◽

Cheng-Yi Huang ◽

Tsu-Yi Hsieh ◽

...

Keyword(s):

Pulmonary Function ◽

Pulmonary Function Test ◽

Laboratory Data ◽

Pneumocystis Pneumonia ◽

Forced Expiratory Volume ◽

Inflammatory Myositis ◽

Idiopathic Inflammatory Myositis ◽

Study Results ◽

Function Test ◽

One Year

Background. Anti-melanoma differentiation-associated gene 5 (MDA-5) antibody is associated with respiratory failure and death in patients with idiopathic inflammatory myositis (IIM) and interstitial lung disease (ILD). This study aimed to investigate clinical parameters associated with mortality in anti-MDA-5 antibody-positive patients. Methods. We retrospectively reviewed the clinical and laboratory data, and pulmonary function test results in 55 anti-MDA-5 antibody-positive patients. A comparison was made between the survivors and non-survivors at the 12-month follow-up. Results. A total of 13 patients (23.6%) died within 12 months. Non-survivors had higher GAP scores (gender, age, and physiology score for idiopathic pulmonary fibrosis) (1 vs. 6, p < 0.01) and CA-153 (16.4 vs. 72.9, p < 0.01). In addition, rapid progressive ILD, fever, peak ferritin, leukocyte count, lactate dehydrogenase, CT score, intravenous immunoglobulin, mycophenolic acid, CMV infections, pneumocystis pneumonia, and pneumothorax were significantly associated with increased risks of 1-year mortality, while forced vital capacity, forced expiratory volume in one second, and diffusion capacity for carbon monoxide were correlated with decreased risk of 1-year mortality. Conclusions. Our study results suggest that GAP scores and CA-153 could be prognostic factors for 1-year mortality in anti-MDA-5 antibody-positive patients. A prompt pulmonary function test and CA-153 are essential for these patients to guide further management.

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