scholarly journals To assess the effects of platelet rich plasma application on pain in osteoarthritis knee

2017 ◽  
Vol 3 (3) ◽  
pp. 436 ◽  
Author(s):  
Rahul Kadam ◽  
Ankit Agrawal ◽  
Abhay Chhallani ◽  
Santosh Pandhare ◽  
Abhishek Gupta ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Platelet Rich Plasma ◽  
Autologous Blood ◽  
Biologic Treatment ◽  
Orthopaedic Department ◽  
Medical College ◽  
Injured Tissue ◽  
Osteoarthritis Knee ◽  
Natural Healing

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Platelet rich plasma (PRP) is a concentrate extract of platelets from autologous blood. It is known to increase growth factor of plasma and helps to heal the injured tissue. Platelet-rich plasma (PRP) is an autologous biologic treatment including patients own plasma, containing growth factors released from platelets. The rationale for the use of PRP is to stimulate the natural healing cascade and tissue regeneration by an increase release of platelet-derived factors directly at the site of treatment. This study is done to assess the effects of platelet rich plasma application on pain in osteoarthritis knee.</span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">Total of 40 cases was included in this study (18 male and 22 females) with mean age of 57.3 (Range 35-75). All patients received intra-articular PRP injection. This study was conducted on the patients coming to orthopaedic department at MGM medical college and hospital, Navi Mumbai</span>.<strong></strong></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">In this study it was found that there is decrease in pain on vas pain score, with increasing time. We followed up the patients for period of 3 months. We found that average mean VAS score was decreased from 6.0 to 4.13 after follow up of 3 months after a single dose of intra-articular PRP injection. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">PRP is an effective treatment for pain in OA knee. It is one of the new approaches in the field of orthopaedics to solve the issues of pain management.</span></p>

scholarly journals Platelet rich plasma in dermatology and cosmetology

2020 ◽  
Vol 6 (2) ◽  
pp. 288
Author(s):  
Shobhit Mohan ◽  
Lalit Mohan ◽  
Renu Sangal ◽  
Neelu Singh
Keyword(s):  
Wound Healing ◽  
Tissue Regeneration ◽  
Blood Product ◽  
Platelet Rich Plasma ◽  
Autologous Blood ◽  
Detailed Knowledge ◽  
Skin Rejuvenation ◽  
Scar Revision ◽  
Current Review

<p class="abstract">Platelet rich plasma (PRP) therapies in medicine has become increasing popular during the last decade. The interest in in the application of PRP in dermatology and cosmetology has increased recently in different applications such as alopecia, skin rejuvenation, wound healing, scar revision, and tissue regeneration. PRP is an autologous blood product obtained from the blood of the patients. The detailed knowledge about PRP should help clinicians better understand this therapy. In this view, the current review was done for a better understanding of what pathologies can be corrected with PRP.</p>

scholarly journals Type-III supracondylar humerus fracture: functional outcome of open reduction and internal fixation after failed closed reduction

2020 ◽  
Vol 7 (1) ◽  
pp. 62
Author(s):  
Shobha H. P. ◽  
Vishwas K. ◽  
Lingaraju K. ◽  
Giridhar Kumar
Keyword(s):  
Internal Fixation ◽  
Closed Reduction ◽  
Open Reduction ◽  
Supracondylar Fractures ◽  
Orthopaedic Department ◽  
Type Iii ◽  
Medical College ◽  
K Wires ◽  
Age Range

<p><strong>Background: </strong>To evaluate results of open reduction and internal fixation with Criss cross k-wires after failed closed reduction in Gartland type III Supracondylar fracture of humerus in our institution.<strong></strong></p><p><strong>Methods:</strong> This prospective study was conducted at the Krishna Rajendra hospital affiliated to the orthopaedic department of Mysore medical college and research institute from December 2018 to December 2019. Twenty-five patients of type-III fracture of supracondylar humerus were included within the study. Consent was obtained from all patients. Under anaesthesia, closed reduction was attempted first. When 2-3 attempts of closed reduction failed, an open reduction and internal fixation with cross k-wires was performed. Fortnightly follow up was applied for the first 8 weeks then monthly for the next 4 months. The clinical outcome was evaluated using Flynn criteria.</p><p><strong>Results:</strong> Out of 25 patients, 16 were male and 9 were female. Left side was involved in 17 patients and right side in 8. Mean age was 6.9 years with age range from 3 to 12 years. Excellent or good results were obtained in 23 (92%) patients and fair or poor in 2 (8%). </p><p><strong>Conclusions:</strong> We conclude that these fractures must be managed aggressively, by a specialised surgeon. Open reduction and internal fixation of severely displaced supracondylar fractures of the humerus is a safe and effective method when a satisfactory reduction can't be obtained by 2-3 attempts on closed method.</p>

scholarly journals A prospective study of intra-articular injections of platelet rich plasma in early osteoarthritis knee joint

2017 ◽  
Vol 4 (1) ◽  
pp. 133
Author(s):  
Rentala Vamshi ◽  
Vivekananda Bheemisetty ◽  
Raju Bollabathini ◽  
Vishwanath Mahadevuni
Keyword(s):  
Knee Joint ◽  
Prospective Study ◽  
Platelet Rich Plasma ◽  
Autologous Blood ◽  
Womac Score ◽  
Knee Joints ◽  
Osteoarthritis Knee ◽  
Grade Ii ◽  
Autologous Platelet Rich Plasma ◽  
A Prospective Study

<p class="abstract"><strong>Background:</strong> Platelet-rich plasma (PRP) is a natural concentrate of autologous blood growth factors experimented in different fields of medicine in order to test its potential to enhance tissue regeneration. The aim of our study is to study the effects of intra articular injections of autologous “Platelet Rich Plasma“ in the osteoarthritis of knee joint and to assess the functional outcome after injecting platelet rich plasma in osteoarthritic knee joints and compare the results with standard studies and draw conclusions.</p><p class="abstract"><strong>Methods:</strong> This is a prospective study done on 161 Kellgren-Lawrence radiological grade I and grade II knee joints, between August 2013 and March 2016 which, were treated with PRP intra-articular injections. The procedure consisted of injection of 8 ml platelet concentrate into the knee joint with an 18- gauge needle without local anaesthetic. Patients were assessed with WOMAC (Western Ontario McMaster Universities Arthritis Index) scoring pre injection of PRP and post injection period of 1 month and 6 months. A reduction in WOMAC score is suggestive of improvement in the patient’s condition.<strong></strong></p><p class="abstract"><strong>Results:</strong> There is a significant improvement in WOMAC score of all the patients and the results sustained for more than 6 months. Though there is clinically better results are seen in grade I knee joints than grade II knee joints, these results are statistically not significant.</p><p><strong>Conclusions:</strong> Osteoarthritis (Grade I and Grade II) of Kellgren Lawrence radiological grading does give relief from pain, stiffness and improves functionality without any major side effects and can be recommended as a viable modality of treatment. </p>

scholarly journals Intralesional triamcinolone acetonide versus platelet rich plasma: a comparative study in the treatment of alopecia areata of scalp

2019 ◽  
Vol 5 (3) ◽  
pp. 521
Author(s):  
Rahul H. Ranpariya ◽  
Sanjeev B. Gupta ◽  
Mahendra S. Deora ◽  
Prachi V. Agrawal ◽  
Rachita Mathur ◽  
...  
Keyword(s):  
Triamcinolone Acetonide ◽  
Alopecia Areata ◽  
Platelet Rich Plasma ◽  
Autologous Blood ◽  
Chronic Inflammatory Disease ◽  
The Body ◽  
Current Therapy ◽  
Group I ◽  
Group Ii

<p class="abstract"><strong>Background:</strong> Alopecia areata (AA) is a chronic inflammatory disease characterized by nonscarring hair loss involving any hair-bearing surface of the body. The current therapy for AA is not curative but rather aimed at controlling or limiting the pathogenic process. Corticosteroids are the most popular drugs used, however localized atrophy is a common complication, particularly with triamcinolone. Promoting hair growth by application of autologous blood extracted platelet rich plasma (PRP) is a simple, yet effective procedure. The aim of the study was to evaluate and compare the efficacy of intralesional triamcinolone acetonide (5 mg/ml) with intralesional PRP in the treatment of two different scalp AA patches of same individual.</p><p class="abstract"><strong>Methods:</strong> A total of 30 patients having ≥2 patches of AA were randomized and given two separate modalities of treatment in two different patches and divided in Group I, treated with intralesional triamcinolone acetonide (5 mg/ml) and Group II, treated with PRP. Interval time between every follow-up was 3 weeks and four such follow-ups were done. Hair regrowth was calculated according to Mac Donald Hull and Norris grading system at every follow-up and was compared with the initial grading.<strong></strong></p><p class="abstract"><strong>Results:</strong> Group I patches, treated with triamcinolone acetonide have the significantly higher mean grading score than the group II patches, treated with PRP at each follow up.</p><p class="abstract"><strong>Conclusions:</strong> Intralesional triamcinolone acetonide is more efficacious than intralesional PRP in the treatment of scalp alopecia areata with no recurrences and very few adverse effects like atrophy and hypopigmentation.</p>

scholarly journals Effect of platelet rich plasma in osteoarthritis knee-A short term follow up

2020 ◽  
Vol 6 (1) ◽  
pp. 1069-1072
Author(s):  
Dr. Rammanohar Surepally ◽  
Dr. Nagakumar JS ◽  
Dr. Arun HS
Keyword(s):  
Platelet Rich Plasma ◽  
Short Term ◽  
Osteoarthritis Knee

PLATELET-RICH PLASMA INJECTION IN EARLY OSTEOARTHRITIS KNEE FOLLOW-UP 1 YEAR

2021 ◽  
pp. 6-8
Author(s):  
Abdul Hassan Khan ◽  
Prasanta Kumar Pujari ◽  
Bikramjit Gayen ◽  
Dipak Kumar Jha ◽  
Debarshi Jana
Keyword(s):  
Conservative Treatment ◽  
Platelet Rich Plasma ◽  
Treatment Options ◽  
Repair Process ◽  
Plasma Injection ◽  
Osteoarthritis Knee ◽  
The One ◽  
Tissue Recovery ◽  
Natural Healing ◽  
Better Than

Background: Osteoarthritis (OA) knee is one of the most prevalent musculoskeletal disorders in elderly population. It has got various treatment options but most are unsatisfactory. In recent years Platelet-rich plasma (PRP) is emerged as a promising treatment modality and classied as “Orthobiologics”. PRPenhances tissue recovery, by catalysing the body's natural healing response and tissue repair process. Aim And Objectives:Tocompare the efcacies oftreatmentwithPRPinjectionandconservative treatmentwithNSAIDSandexercise inOAknee. Materials And Methods:This was a observational study in which comparisons of different outcomes were made on the efcacies of the treatments with PRPinjection and compared to conservative treatment with NSAIDS and exercise in OAknee. The study was conducted in the Department of Orthopedics in Ramkrishna Mission SevaPratisthan. Atotal number of 60 patients with power 80% were randomly selected from the patients with OA attended OPD during the period from June 2019 to June 2021. The patients were divided into two groups of 30 patients in each group. The patients of the one group were treated with intra-articular PRPinjection and the patients of another group were treated conservatively with NSAIDS and exercise. After the completion of treatment, the patients were followed-up for 1 year and the outcomes of the treatments were assessed by WOMAC (The Western Ontario and McMaster Universities Osteoarthritis Index) knee assessment scoring system. Results:At 1 year the completion of treatments it was found that both clinical and functional improvements of the patients were signicantly better than the initiation of treatments (p<0.0001). However, the improvements of the patients treated with PRPinjection were signicantly better than the patients treated conservatively with NSAIDS and exercise (p<0.001). Conclusion: From the results of the study it may be concluded that PRP injection is better than conservative treatment with NSAIDS and exercise to treat OAknee

scholarly journals THE TLINICAL EFFICACY OF AUTOLOGOUS CONCENTRATED PLATELETS IN TREATMENT OF TMJ DISORDERS - A PILOT STUDY

2014 ◽  
Vol 04 (03) ◽  
pp. 070-074
Author(s):  
S.M. Sharma ◽  
Dhruvit Thakar
Keyword(s):  
Growth Factors ◽  
Temporomandibular Joint ◽  
Platelet Rich Plasma ◽  
Autologous Blood ◽  
Venous Blood ◽  
Mouth Opening ◽  
Adhesive Properties ◽  
Novel Approach ◽  
Plasma Cytokines

AbstractPlatelet rich plasma is a natural concentrate of autologous blood growth factor which is obtained by sequestering and concentrating platelets by gradient density centrifugation experimented in different fields of medicine in order to test its potential to enhance tissue regeneration. These platelets when activated undergo degranulation to release growth factors with healing properties. It also contains plasma, cytokines, thrombin, and other growth factors that are implicated in wound healing and have inherent biological and adhesive properties. The aim of the study is to explore a novel approach to treat degenerative lesion of the articular cartilage of temporomandibular joint. Patients with chronic degenerative conditions of the joint, were treated with intra articular PRP injections. The procedure involved collection of 10 ml of venous blood and twice centrifuged to obtain 2 ml of PRP which was used for injection after activation by calcium chloride. The patients were clinically prospectively evaluated before and at the end of the treatment, and at 2, 4, and 6 months of follow up. Inter incisical mouth opening, clicking of temporomandibular joint and VAS for pain were used for clinical evaluation. The results showed significant improvement of all clinical scores from basal evaluation to the end of the therapy and on follow up at 2-6 months. The preliminary results indicate that the treatment with PRP injections are safe and has the potential to reduce pain and improvement joint function with low degree of articular degeneration.

scholarly journals Clinical outcome of platelet rich plasma versus steroid in treatment of frozen shoulder

2021 ◽  
Vol 7 (6) ◽  
pp. 1085
Author(s):  
Johney Juneja ◽  
Mahendra Prakash Jain ◽  
Raghvendra Choubisa ◽  
A. K. Mehra ◽  
Ramesh Sen
Keyword(s):  
Platelet Rich Plasma ◽  
Adhesive Capsulitis ◽  
Frozen Shoulder ◽  
Sudden Onset ◽  
Trauma Centre ◽  
Onset Of Action ◽  
Medical College ◽  
A Prospective Study

<p class="abstract"><strong>Background: </strong>Evaluate functional outcome of use of platelet rich plasma versus steroid in frozen shoulder.</p><p class="abstract"><strong>Methods: </strong>The study was conducted in Department of Orthopaedics in RNT Medical College, Udaipur. Adult patients with periarthritis shoulder (frozen shoulder or adhesive capsulitis) admitted to Trauma centre in Maharana Bhupal Government hospital attached with R.N.T. Medical College, Udaipur were included in this study after obtaining their informed, valid written consent. This is a prospective study from October 2018 to February 2020.</p><p class="abstract"><strong>Results:</strong> Our study demonstrated that PRP is not inferior to CS in any of the measured parameters. Both of the groups experienced similar benefits from the injection therapies with no statistical differences detected in ROM or VAS scores at 1 week, 1 month and 3 months. No adverse effects were detected in either of the two groups.</p><p class="abstract"><strong>Conclusions: </strong>We can conclude that both PRP and MPS showed efficacy on treating frozen shoulder. The current study provides strong evidence in support of a statistically significant effect of platelet concentrates in the treatment of frozen shoulder in vivo where steroid contraindicated or refused by patient. However, inj. Methylprednisolone has sudden onset of action because of anti-inflammatory action with respect to inj. PRP, so has better result at 1 week follow up post injection. But in long term (at 3 months follow up) inj. PRP has better effect in compared to Inj. MPS.</p>

Classification systems for platelet-rich plasma

2019 ◽  
Vol 101-B (8) ◽  
pp. 891-896 ◽  
Author(s):  
L. A. Rossi ◽  
I. R. Murray ◽  
C. R. Chu ◽  
G. F. Muschler ◽  
S. A. Rodeo ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Tissue Regeneration ◽  
Platelet Rich Plasma ◽  
Autologous Blood ◽  
Clinical Effectiveness ◽  
Classification Systems ◽  
Sufficient Information ◽  
Biological Therapies ◽  
Musculoskeletal Tissue ◽  
Scientific Rationale

There is good scientific rationale to support the use of growth factors to promote musculoskeletal tissue regeneration. However, the clinical effectiveness of platelet-rich plasma (PRP) and other blood-derived products has yet to be proven. Characterization and reporting of PRP preparation protocols utilized in clinical trials for the treatment of musculoskeletal disease is highly inconsistent, and the majority of studies do not provide sufficient information to allow the protocols to be reproduced. Furthermore, the reporting of blood-derived products in orthopaedics is limited by the multiple PRP classification systems available, which makes comparison of results between studies challenging. Several attempts have been made to characterize and classify PRP; however, no consensus has been reached, and there is lack of a comprehensive and validated classification. In this annotation, we outline existing systems used to classify preparations of PRP, highlighting their advantages and limitations. There remains a need for standardized universal nomenclature to describe biological therapies, as well as a comprehensive and reproducible classification system for autologous blood-derived products.Cite this article: Bone Joint J 2019;101-B:891–896.

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