PLATELET-RICH PLASMA INJECTION IN EARLY OSTEOARTHRITIS KNEE FOLLOW-UP 1 YEAR

2021 ◽  
pp. 6-8
Author(s):  
Abdul Hassan Khan ◽  
Prasanta Kumar Pujari ◽  
Bikramjit Gayen ◽  
Dipak Kumar Jha ◽  
Debarshi Jana
Keyword(s):  
Conservative Treatment ◽  
Platelet Rich Plasma ◽  
Treatment Options ◽  
Repair Process ◽  
Plasma Injection ◽  
Osteoarthritis Knee ◽  
The One ◽  
Tissue Recovery ◽  
Natural Healing ◽  
Better Than

Background: Osteoarthritis (OA) knee is one of the most prevalent musculoskeletal disorders in elderly population. It has got various treatment options but most are unsatisfactory. In recent years Platelet-rich plasma (PRP) is emerged as a promising treatment modality and classied as “Orthobiologics”. PRPenhances tissue recovery, by catalysing the body's natural healing response and tissue repair process. Aim And Objectives:Tocompare the efcacies oftreatmentwithPRPinjectionandconservative treatmentwithNSAIDSandexercise inOAknee. Materials And Methods:This was a observational study in which comparisons of different outcomes were made on the efcacies of the treatments with PRPinjection and compared to conservative treatment with NSAIDS and exercise in OAknee. The study was conducted in the Department of Orthopedics in Ramkrishna Mission SevaPratisthan. Atotal number of 60 patients with power 80% were randomly selected from the patients with OA attended OPD during the period from June 2019 to June 2021. The patients were divided into two groups of 30 patients in each group. The patients of the one group were treated with intra-articular PRPinjection and the patients of another group were treated conservatively with NSAIDS and exercise. After the completion of treatment, the patients were followed-up for 1 year and the outcomes of the treatments were assessed by WOMAC (The Western Ontario and McMaster Universities Osteoarthritis Index) knee assessment scoring system. Results:At 1 year the completion of treatments it was found that both clinical and functional improvements of the patients were signicantly better than the initiation of treatments (p<0.0001). However, the improvements of the patients treated with PRPinjection were signicantly better than the patients treated conservatively with NSAIDS and exercise (p<0.001). Conclusion: From the results of the study it may be concluded that PRP injection is better than conservative treatment with NSAIDS and exercise to treat OAknee

scholarly journals Conservative Treatment of Ankle Osteoarthritis

2021 ◽  
Vol 10 (19) ◽  
pp. 4561
Author(s):  
Sergio Tejero ◽  
Estefanía Prada-Chamorro ◽  
David González-Martín ◽  
Antonio García-Guirao ◽  
Ahmed Galhoum ◽  
...  
Keyword(s):  
Conservative Treatment ◽  
Clinical Studies ◽  
Platelet Rich Plasma ◽  
Scientific Evidence ◽  
Treatment Options ◽  
Pharmacological Treatments ◽  
Ankle Osteoarthritis ◽  
Knee Oa ◽  
Plasma Injection ◽  
Inflammatory Drugs

Despite the disabling nature of ankle osteoarthritis (OA), there is poor scientific evidence for a conservative treatment compared to the hip and knee OA. In this regard, most of the treatment options in use are not based on clinical studies of the ankle, and they are extracted from evidence obtained from clinical studies of other lower limb joints. However, this does not seem to be a good idea, since the aetiology of ankle OA is quite different from that of the hip or knee. Nonpharmacological and pharmacological treatments such as nonsteroidal anti-inflammatory drugs, hyaluronic acid, corticosteroid, platelet-rich plasma injection and mesenchymal stem cells injections have been reported. However, further research is required in this field to obtain a specific clinical practice guideline for the conservative treatment of ankle OA.

scholarly journals To assess the effects of platelet rich plasma application on pain in osteoarthritis knee

2017 ◽  
Vol 3 (3) ◽  
pp. 436 ◽  
Author(s):  
Rahul Kadam ◽  
Ankit Agrawal ◽  
Abhay Chhallani ◽  
Santosh Pandhare ◽  
Abhishek Gupta ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Platelet Rich Plasma ◽  
Autologous Blood ◽  
Biologic Treatment ◽  
Orthopaedic Department ◽  
Medical College ◽  
Injured Tissue ◽  
Osteoarthritis Knee ◽  
Natural Healing

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Platelet rich plasma (PRP) is a concentrate extract of platelets from autologous blood. It is known to increase growth factor of plasma and helps to heal the injured tissue. Platelet-rich plasma (PRP) is an autologous biologic treatment including patients own plasma, containing growth factors released from platelets. The rationale for the use of PRP is to stimulate the natural healing cascade and tissue regeneration by an increase release of platelet-derived factors directly at the site of treatment. This study is done to assess the effects of platelet rich plasma application on pain in osteoarthritis knee.</span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">Total of 40 cases was included in this study (18 male and 22 females) with mean age of 57.3 (Range 35-75). All patients received intra-articular PRP injection. This study was conducted on the patients coming to orthopaedic department at MGM medical college and hospital, Navi Mumbai</span>.<strong></strong></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">In this study it was found that there is decrease in pain on vas pain score, with increasing time. We followed up the patients for period of 3 months. We found that average mean VAS score was decreased from 6.0 to 4.13 after follow up of 3 months after a single dose of intra-articular PRP injection. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">PRP is an effective treatment for pain in OA knee. It is one of the new approaches in the field of orthopaedics to solve the issues of pain management.</span></p>

scholarly journals Outcome of platelet rich plasma injection in osteoarthritis knee

2020 ◽  
Vol 6 (4) ◽  
pp. 810-814
Author(s):  
Bikramjit Gayen ◽  
Dipak Kumar Jha ◽  
Prasanta Kumar Pujari Atanu Chartterjee ◽  
Syamsundar Mondal
Keyword(s):  
Platelet Rich Plasma ◽  
Plasma Injection ◽  
Osteoarthritis Knee

scholarly journals Platelet-rich plasma injection vs corticosteroid injection for conservative treatment of rotator cuff lesions

Medicine ◽  
2021 ◽  
Vol 100 (7) ◽  
pp. e24680 ◽  
Author(s):  
Chenglong Wang ◽  
Zhuo Zhang ◽  
Yihang Ma ◽  
Xiangji Liu ◽  
Qingsan Zhu
Keyword(s):  
Rotator Cuff ◽  
Conservative Treatment ◽  
Platelet Rich Plasma ◽  
Corticosteroid Injection ◽  
Plasma Injection ◽  
Rotator Cuff Lesions

scholarly journals Plantar Fasciitis—A Comparison of Treatment with Intralesional Steroids versus Platelet-Rich Plasma

2017 ◽  
Vol 107 (6) ◽  
pp. 490-496 ◽  
Author(s):  
Carlos Acosta-Olivo ◽  
Jorge Elizondo-Rodriguez ◽  
Ricardo Lopez-Cavazos ◽  
Felix Vilchez-Cavazos ◽  
Mario Simental-Mendia ◽  
...  
Keyword(s):  
Treatment Group ◽  
Conservative Treatment ◽  
Plantar Fasciitis ◽  
Platelet Rich Plasma ◽  
Treatment Options ◽  
Treatment Method ◽  
Great Success ◽  
Functional Evaluation ◽  
Foot And Ankle ◽  
Intralesional Steroids

Background: Many treatment options for plantar fasciitis currently exist, some with great success in pain relief. The objective of our study was to compare the use of intralesional steroids with platelet-rich plasma (PRP), using pain scales and functional evaluation, in patients with plantar fasciitis who did not respond to conservative treatment. Methods: A controlled, randomized, blinded clinical assay was performed. Patients were assigned to one of the two groups by selecting a sealed envelope. The steroid treatment group received 8 mg of dexamethasone plus 2 mL of lidocaine as a local anesthetic. The PRP treatment group received 3 mL of PRP activated with 0.45 mL of 10% calcium gluconate. All of the patients were evaluated at the beginning of the study, and at 2, 4, 8, 12, and 16 weeks post-treatment with the Visual Analog Scale (VAS), Foot and Ankle Disability Index (FADI), and American Orthopedic Foot and Ankle Society (AOFAS) scale. Results: The right foot was the most frequently affected foot (63%). The average age of the patients was 44.8 years (range, 24–61 years). All scales used (VAS, FADI and AOFAS) showed that the difference was not statistically significant between the two groups. Conclusions: We can conclude that the use of PRP is an effective treatment method for patients with plantar fasciitis who do not respond to conservative treatment because PRP demonstrates an efficacy equal to that of steroids. However, the cost and the time for preparation the PRP are two of the disadvantages of this treatment.

scholarly journals Platelet-rich plasma injection for tennis elbow: did it ever work?

2022 ◽  
Vol 8 (1) ◽  
pp. e001258
Author(s):  
Teemu Karjalainen ◽  
Bethan Richards ◽  
Rachelle Buchbinder
Keyword(s):  
Clinical Trials ◽  
Preparation Method ◽  
Tennis Elbow ◽  
Platelet Rich Plasma ◽  
Cochrane Review ◽  
Clinical Use ◽  
Approval Process ◽  
Plasma Injection ◽  
Phases Of Development ◽  
Better Than

Platelet-rich plasma (PRP) is a commonly used treatment for tendinopathies such as tennis elbow despite the questionable evidence of its efficacy. A recent Cochrane review suggests that it likely does not provide clinically meaningful benefits in people with tennis elbow. In this viewpoint, we discuss how lack of regulation allowed aggressive marketing and clinical use without normal phases of drug development and approval process or rigorous evidence of benefits. Since several phases of development were bypassed, we still do not know the optimal preparation method and dosing of PRP for tendinopathies. Furthermore, several clinical trials compared PRP with other interventions although it was unclear if PRP was better than placebo and these comparisons created distraction rather than improved understanding of its effects.

scholarly journals Adverse event following platelet rich plasma injection for the management of early Osteoarthritis of knee – A report of 4 cases

2021 ◽  
Vol 7 (1) ◽  
pp. 42-45
Author(s):  
Buddhadeb Nayak ◽  
Harshal S Sakale ◽  
Alok Chandra Agrawal ◽  
Bikram Kar ◽  
Rudra Narayan Dash ◽  
...  
Keyword(s):  
Acute Inflammation ◽  
Platelet Rich Plasma ◽  
Treatment Options ◽  
Outpatient Basis ◽  
Early Osteoarthritis ◽  
Cell Growth And Migration ◽  
Chronic Disability ◽  
Plasma Injection ◽  
And Migration ◽  
Protein Transcription

Osteoarthritis is the leading cause of chronic disability affecting more than 80% of people over the age of 55. Several treatment options are there for early Osteoarthritis (OA) knee, like- rest, ice, brace, NSAIDs, intra-articular corticosteroid, Intra-Articular Hyaluronic Acid (IAHA), and intra-articular platelet-rich plasma (PRP) injection. Growth factors in PRP (PDGF, IGF, VEGF) promote matrix synthesis, cell growth, and migration, thus facilitating protein transcription. Several studies regarding PRP injection in the management of OA knee support this line of management without any documented complications of PRP at the knee joint.We report 4 cases of acute inflammation related to PRP injection for the treatment of OA knee. Two patients developed mild inflammation which was treated with oral medication on an outpatient basis. Another two patients developed moderate to severe inflammation which warranted surgical intervention.Intraarticular PRP injection has been reported in the literature as a successful modality of treatment in OA knee without any significant adverse effect. We are reporting four cases of adverse events following intraarticular PRP injection. Two cases were mild inflammations while the other two were moderate to severe. All four patients recovered and the outcome was satisfactory compared to the pre-injection status. The exact cause for the reaction after PRP injection in the knee is not known. Further study is needed for the cause of the inflammatory reaction.

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