scholarly journals Clinicomycological study of tinea infections in and around Pune

2019 ◽  
Vol 5 (3) ◽  
pp. 598
Author(s):  
Snehal Dhayagude ◽  
Vidya Arjunwadkar ◽  
Ravindranath Chavan ◽  
Renu Bharadwaj ◽  
Anju Kagal
Keyword(s):  
Clinical Presentation ◽  
Correct Diagnosis ◽  
Conventional Technique ◽  
Tinea Cruris ◽  
Medical College ◽  
Drug Eruptions ◽  
Appropriate Treatment ◽  
Hair Samples ◽  
One Year ◽  
Super Infection

<p class="abstract"><strong>Background:</strong> Tinea is a common fungal infection seen in the tropical and subtropical countries affecting the skin and its appendages. The presentation may vary from mild scaling to severe inflammation with bacterial super infection. It may be confused with other manifestation such as psoriasis, seborrhea, drug eruptions, eczema, and contact dermatitis. Hence correct diagnosis is necessary for appropriate treatment, which will reduce morbidity, discomfort and lessens possibility of transmissions. The aims and objectives were to determine clinicomycological profile of Tinea infections in patients attending dermatology OPD of B. J. Govt. Medical College and Sassoon General Hospital, Pune.</p><p class="abstract"><strong>Methods:</strong> Skin scrapings, nail clippings; hair samples from clinically suspected cases of tinea<em> </em>were collected. Identification of dermatophytes from these samples was done by conventional technique.<strong></strong></p><p class="abstract"><strong>Results:</strong> 119 clinically suspected cases of Tinea infections were processed over a period of one year. Out of these cases mixed infection of Tinea cruris with corporis was the predominant (27.73%) clinical presentation. Among all the samples, fungal filaments were seen by KOH mount in 48 (40.33%) whereas 35 (29.41%) samples were confirmed as dermatophytes by culture. Among these 35 isolates of dermatophytes 20 were <em>T. rubrum</em>, 7 isolates were <em>T. tonsurans</em>. 8 isolates were of <em>T. mentagrophytes</em>.</p><p class="abstract"><strong>Conclusions:</strong> In present study mixed infections of tinea cruris with corporis was the predominant clinical presentation and <em>T. rubrum</em> was the most common dermatophyte isolated.</p>

scholarly journals A Study of Drugs Causing Fixed Drug Eruptions

2018 ◽  
Vol 27 (1) ◽  
pp. 29-33
Author(s):  
Md Moksedur Rahman ◽  
Md Abdullah ◽  
Moriom Nessa ◽  
Muhammad Afsar Siddique ◽  
Md Moazzem Hossain ◽  
...  
Keyword(s):  
Self Administration ◽  
Fixed Drug Eruption ◽  
College Hospital ◽  
Medical College ◽  
Provocation Tests ◽  
Drug Eruptions ◽  
Fixed Drug ◽  
Distinctive Type ◽  
One Year ◽  
Cutaneous Drug Reaction

Fixed drug eruption (FDE) is a distinctive type of cutaneous drug reaction that characteristically recurs in the same site or sites each time a particular drug is taken. FDEs are among the most frequent problems encountered by the dermatologists. The present study was carried out to recognize offending drugs, to educate the patients and to avoid self-administration of drugs and re-administration of the offending drugs. The study was conducted in Skin & VD outpatient department of Rajshahi Medical College Hospital, Rajshahi over a period of one year. One hundred ten cases with established FDE were evaluated clinically. The causative drugs were identified and confirmed by provocation tests. Cotrimoxazole (25%) was the most common cause of FDE. Other drugs incriminated were NSAID (21.8%), Tetracycline (15.4%), Ciprofloxacin (10%), Amoxicillin (7.2%), Metronidazole (5.4%), Griseofulvin (2.7%) and Fluconazole (1.8%). The lesions were found to be distributed on the oro-genital mucosa, trunk and the acral regions.The main presentation of FDE was circularhyperpigmented lesion.TAJ 2014; 27(1): 29-33

scholarly journals Study of prevalence and clinical spectrum of seizures in children in a teaching hospital in rural Telangana, India

2018 ◽  
Vol 5 (3) ◽  
pp. 862
Author(s):  
C. P. V. Ramana Sastry ◽  
R. Manohar Reddy
Keyword(s):  
Clinical Spectrum ◽  
Response To Treatment ◽  
Age Group ◽  
Unprovoked Seizure ◽  
Patient Response ◽  
Female Ratio ◽  
Medical College ◽  
Appropriate Treatment ◽  
Long Term Follow Up ◽  
One Year

Background: To study the prevalence and clinical spectrum of seizures and treatment outcome in children.Methods: A hospital based prospective study was done at Maheshwara Medical College and Hospital, Patancheru, Telangana in the department of Paediatrics over one-year period. A total of 75 cases presenting with seizures were studied for demographics, clinical features, imaging studies where possible and patient response to treatment.  Results: T Patient age ranged from one week to 14 years with male to female ratio of 1:4. Majority were in the age group of 1-3 years 25/75 (33.3%). Fever was present on admission in 66.6% of cases in 1 month to 6 years. Unprovoked seizure was common 20/75 (26.6%) in age group 6 to14 years. Neonatal seizures were seen in 6.6% cases. Generalized tonic clonic seizures were common and were seen in 63.3% cases. Only 5 (6.6 %) cases presented with status epilepticus. CT scan was done in 20 cases in unprovoked seizures and showed various etiologies. Conclusions: Seizures in children are a common indication for hospital admission. They can be febrile or unprovoked. CNS infections and space occupying lesions are common causes for paediatric seizures. Early detection of the cause of seizures helps in instituting appropriate treatment. Children with unprovoked seizures should be on regular long term follow up and treatment.

scholarly journals Clinical profile of patients with pancytopenia in a tertiary care centre

2018 ◽  
Vol 6 (4) ◽  
pp. 1187
Author(s):  
Jyotsana . ◽  
Khan Afreen ◽  
Vishakha Sharma ◽  
Prem Kapur ◽  
Smita Manjavkar ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Early Diagnosis ◽  
Clinical Presentation ◽  
Tertiary Care ◽  
Megaloblastic Anaemia ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Common Cause ◽  
Appropriate Treatment ◽  
One Year

Background: Pancytopenia is a condition in which all three cell lines i.e. erythroid, myeloid and megakaryocytic are affected resulting in anaemia, leukopenia and thrombocytopenia. It can be a manifestation of a wide variety of disorders which primarily or secondarily affect the bone marrow. Early diagnosis of these conditions will help in implementing the appropriate treatment. The objective of the study was to know the clinical presentation and etiology of patients presenting with pancytopenia.Methods: A one year study from April 2016 to March 2017 was conducted in the department of medicine at a tertiary care centre. Total 32 patients with pancytopenia were studied to determine their clinical features and etiology through relevant investigations.Results: Our study revealed megaloblastic anaemia (46.87%) as the most common cause of pancytopenia, followed by malaria (12.5%). Other causes included hypothyroidism (6.2%), hypersplenism (6.2%), drugs (12.5%) and miscellaneous (9.43%).Conclusions: Megaloblastic anaemia was found to be the major cause of pancytopenia in patients. Other causes of pancytopenia were malaria, drugs, hypersplenism and hypothyroidism. These should be kept in mind while evaluating patients with pancytopenia.

Artery of Percheron Infarction: A Characteristic Pattern of Ischemia and Variable Clinical Presentation: a literature review

2020 ◽  
Vol 16 ◽  
Author(s):  
Osama Kheiralla ◽  
Salem Alghamdi ◽  
Rowa Aljondi ◽  
Abdulrahman Tajaldeen ◽  
Adel Othman Bakheet
Keyword(s):  
Clinical Presentation ◽  
Correct Diagnosis ◽  
Small Diameter ◽  
Characteristic Pattern ◽  
Arterial Trunk ◽  
Appropriate Treatment ◽  
Clinical Presentations ◽  
Artery Of Percheron ◽  
Diagnostic Difficulties ◽  
Thalamic Infarct

: The Artery of Percheron (AOP) is an uncommon anatomic variant that provides arterial supply to the paramedian region of the thalami and bilaterally to the rostral part of the midbrain; it is a solitary arterial trunk that branches from a proximal segment of the posterior cerebral artery (PCA). Although AOP infarction results in a characteristic pattern of ischemia—namely bilateral paramedian thalamic infarct with or without midbrain involvement— it may cause diagnostic difficulties due to the variety of its clinical presentations and wide differentials, as well as its small diameter and the difficulty of obtaining visualization through diagnostic imaging. Early neuroimaging of AOP infarction and correct diagnosis are mandatory for early initiation of the appropriate treatment and better patient outcomes. In this study, we discuss imaging the patterns of AOP infarction, as well as its differentials and clinical presentation.

scholarly journals Experience of Persistent Gestation Trophoblastic Disease in a Tertiary Medical College Hospital, Bangladesh

2016 ◽  
Vol 27 (2) ◽  
pp. 50-56
Author(s):  
Kamrun Nahar ◽  
Halima Yesmin ◽  
Kanika Roy ◽  
Safiul Alam ◽  
Kashefa Khatun
Keyword(s):  
Clinical Presentation ◽  
Single Agent ◽  
Low Risk ◽  
Molar Pregnancy ◽  
College Hospital ◽  
Medical College ◽  
Trophoblastic Disease ◽  
Multi Agent ◽  
One Year ◽  
Methotrexate Chemotherapy

Objectives: To study the clinical presentation and risk factors of persistent trophoblastic disease and its outcome of treatment with chemotherapy.Materials and methods: This observational study was carried out on fifty patients of persistent trophoblastic disease who were admitted in the Department of Obstetrics & Gynaecology, Mymensingh Medical Hospital (MMCH) during one year period. Evaluation of disease was done by thorough clinical examination and a set of investigations including chest radiography, ultrasound scan of abdomen and pelvis and estimation of serum â hCG. The four factors under analysis of PTD were age of the patient, clinical presentation, gestational age at diagnosis of molar pregnancy and nature of antecedent pregnancy. Patients with non-metastatic trophoblastic disease and low risk metastatic trophoblastic disease were offered single agent chemotherapy with methotrexate and folinic acid rescue in consultation with the oncologist. When â hCG response was inadequate, multi-agent chemotherapy was given. Complications of chemotherapy were also observed and supportive treatment was given.Results: Out of 50 patients, 49 (98%) patients had antecedent molar pregnancy and 1(2%) had missed abortion. In cases of post molar trophoblastic disease, 28 (57.58%) were in 20-30 yrs. Mean ± SD was 31.35 ± 7.25. In these cases gestational size of molar pregnancy was between 16-20 weeks in 24 (48.98%), <16 wks in 19 (38.78%) and >20 wks in 6 (12.24%) cases. Mean ± SD was 16.78 ± 4.45 wks (p<0.001). Associated theca lutein cysts were present among higher number of cases (57.14%) but not statistically significant. Regarding clinical presentation, 40 (80%) patients presented with irregular pervaginal bleeding, 3(6%) patients with features of metastasis. Most of the of the study subjects 43 (86%) were treated with chemotherapy and 7 (14%) had undergone both hysterectomy and chemotherapy. Single agent methotrexate was given in 47 (94%) cases and multiple agent (EMA-CO) in 3 (6%). After giving 4 cycles of chemotherapy 11 (22%) patients were cured, 38 (76%) had declining â hCG level and one had static â hCG level. Overall remission was 98 %. Complication of chemotherapy was observed in 5 (10%) patients.Conclusion: Theca lutein cyst are important in the prediction of persistent disease after molar pregnancy. Methotrexate chemotherapy is effective and well tolerated in treating patients with nonmetastatic and low risk metastatic gestational trophoblastic neoplasia.Bangladesh J Obstet Gynaecol, 2012; Vol. 27(2) : 50-56

Abnormalities of CSF Neurotransmitters/Folates

2016 ◽  
Author(s):  
Simon Heales ◽  
Simon Pope ◽  
Viruna Neergheen ◽  
Manju Kurian
Keyword(s):  
Pyridoxal Phosphate ◽  
Clinical Presentation ◽  
Correct Diagnosis ◽  
Paediatric Population ◽  
Acid Decarboxylase ◽  
Primary Defect ◽  
Inborn Errors ◽  
Amino Acid Decarboxylase ◽  
Aromatic Amino Acid Decarboxylase ◽  
Appropriate Treatment

The term Neurotansmitter disorder, in the area of metabolic disease, focuses particularly on inborn errors affecting monoamine (dopamine & serotonin), pyridoxal phosphate (B6) and folate metabolism. Whilst there has been considerable focus on these disorders with regards to the paediatric population, it is clear that an increasing number of adult patients are being identified. Adult neurologists need to be aware of the clinical presentation of such patients and the appropriate tests that need to be requested to ensure a correct diagnosis is achieved. CSF profiling, by a specialist laboratory, is often required. This has the ability to very often identify the nature of a primary defect with regards to implementation of appropriate treatment. For some of these disorders, treatment can be effective. This may be in the form of monoamine/vitamin replacement. However there are exceptions, e.g. aromatic amino acid decarboxylase and dopamine transporter deficiencies. There also needs also to be an awareness of the growing list of secondary factors that can cause impaired dopamine and serotonin metabolism.

Major Surgery in a Subject with Factor V Deficiency

1971 ◽  
Vol 25 (03) ◽  
pp. 438-446 ◽  
Author(s):  
E. J Melliger ◽  
F Duckert
Keyword(s):  
Intercellular Space ◽  
Correct Diagnosis ◽  
Postoperative Bleeding ◽  
Major Surgery ◽  
Factor V ◽  
Factor V Deficiency ◽  
Disappearance Time ◽  
Fresh Plasma ◽  
One Year

SummaryA further case of parahaemophilia is reported. One year after the correct diagnosis had been made the patient had to undergo cholecystectomy which was performed under prophylactic substitutive treatment with fresh plasma at a factor V level of 31 %. A minimal factor V level of 11 to 12% was maintained throughout the first week after operation. There was no abnormal postoperative bleeding. The half disappearance time of factor V was found to be about 12 h. Infusion of equivalent amounts of fresh plasma supplied a higher yield of factor V in the patient’s plasma before operation than postoperatively what may be explained by an increased diffusion of factor V into the intercellular space resulting from a postoperatively increased capillar permeability. The results are compared with those of other authors.

Characteristics of Polycystic Ovarian Syndrome in Sub-fertile Woman Attending to GOPD in ShSMCH

2019 ◽  
Vol 11 (1) ◽  
pp. 17-23
Author(s):  
Jinnat Ara Islam ◽  
Fatema Ashraf ◽  
Eva Rani Nandi
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovaries ◽  
Cross Sectional ◽  
Medical College ◽  
Appropriate Treatment ◽  
Pcos Group ◽  
Symptom Complex ◽  
Ovarian Syndrome ◽  
Selection Of ◽  
Fertile Women

Background: Polycystic ovarian syndrome (PCOS) is a condition characterized by menstrual abnormalities (oligo/amenorrhea) and clinical or biochemical features of hyperandrogenism and may manifest at any age. It is a common cause of female subfertility. All the dimensions of PCOS have not been yet completely explored. Methods: It was a cross sectional comparative study carried out at-GOPD of Shaheed Suhrawardy Medical College & Hospital from January, 2016 to December 2016 on 162 subfertile women. Among them 54 were PCOS group and 108 were non PCOS group. PCOS was diagnosed by (Rotterdam criteria 2003) (i) Oligo or anovulation (ii) hyperandrogenism (iii) Polycystic ovaries. Study was done to evaluate and compare the demographic characteristics, clinical, biochemical and ultrasoundgraphic features of sub-fertile women with and without PCOS. Results: A total of 162 sub-fertile women aged 16-36 years. Mean age was 29.5±5.4. There were significant differences between the two groups in terms of (oligo/amenorrhea), hirsutism, WHR and ovarian ultrasound features. There were no significant differences between two groups in correlations between the level of obesity with the incidence of anovulation, hyperandrogenism or with hormonal features. Conclusion: PCOS is one of the important factors causing Infertility. It is an ill-defined symptom complex needed due attention. There is a need to increase awareness regarding. The clinical features of PCOS are heterogenous thus can be investigated accordingly of selection of appropriate treatment modality. J Shaheed Suhrawardy Med Coll, June 2019, Vol.11(1); 17-23

scholarly journals Clinical presentation of strokes confined to the insula: a systematic review of literature

2021 ◽  
Author(s):  
Vincenzo Di Stefano ◽  
Maria Vittoria De Angelis ◽  
Chiara Montemitro ◽  
Mirella Russo ◽  
Claudia Carrarini ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Presentation ◽  
Insular Cortex ◽  
Affective Processing ◽  
Appropriate Treatment ◽  
Insula Cortex ◽  
Atypical Presentations ◽  
High Level ◽  
To Receive ◽  
Insular Region

Abstract Background and purpose The insular cortex serves a wide variety of functions in humans, ranging from sensory and affective processing to high-level cognition. Hence, insular dysfunction may result in several different presentations. Ischemic strokes limited to the insular territory are rare and deserve a better characterization, to be quickly recognized and to receive the appropriate treatment (e.g. thrombolysis). Methods We reviewed studies on patients with a first-ever acute stroke restricted to the insula. We searched in the Medline database the keywords “insular stroke” and “insular infarction”, to identify previously published cases. Afterwards, the results were divided depending on the specific insular region affected by the stroke: anterior insular cortex (AIC), posterior insular cortex (PIC) or total insula cortex (TIC). Finally, a review of the clinical correlates associated with each region was performed. Results We identified 25 reports including a total of 49 patients (59.7 ± 15.5 years, 48% male) from systematic review of the literature. The most common clinical phenotypes were motor and somatosensory deficits, dysarthria, aphasia and a vestibular-like syndrome. Atypical presentations were also common and included dysphagia, awareness deficits, gustatory disturbances, dysautonomia, neuropsychiatric or auditory disturbances and headache. Conclusions The clinical presentation of insular strokes is heterogeneous; however, an insular stroke should be suspected when vestibular-like, somatosensory, speech or language disturbances are combined in the same patient. Further studies are needed to improve our understanding of more atypical presentations.

scholarly journals An intrasellar germinoma with normal tumor marker concentrations mimicking primary lymphocytic hypophysitis

2013 ◽  
Vol 57 (7) ◽  
pp. 566-570 ◽  
Author(s):  
Mariana F. Guzzo ◽  
Cristina B. Formiga Bueno ◽  
Thiago T. Amancio ◽  
Sergio Rosemberg ◽  
Cleonice Bueno ◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
Correct Diagnosis ◽  
Careful Analysis ◽  
Malignant Neoplasms ◽  
Pituitary Hormone ◽  
Appropriate Treatment ◽  
Suprasellar Region ◽  
Neoplastic Lesions ◽  
Posterior Pituitary Hormone ◽  
Pituitary Stalk Thickening

Intracranial germinomas (GE) are malignant neoplasms most commonly found in the suprasellar region, which may cause anterior and particularly posterior pituitary hormone deficits with central diabetes insipidus (DI). Differential diagnosis of pituitary stalk thickening includes granulomatous, inflammatory, infectious, and neoplastic lesions. Although careful analysis of clinical, laboratory, and imaging findings may facilitate the diagnosis, transsphenoidal biopsy is indicated to confirm the disease, as the correct diagnosis directs the appropriate treatment.

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