scholarly journals Clinico-pathological correlation of linear dermatoses along the lines of Blaschko: An observational study

2021 ◽  
Vol 7 (4) ◽  
pp. 288-295
Author(s):  
Gajanan A Pise ◽  
Shilpa V Dastikop ◽  
Manjunath S ◽  
Naveen Manohar ◽  
Malteshgauda N Patil
Keyword(s):  
Histopathological Examination ◽  
Epidemiological Studies ◽  
Epidermal Nevus ◽  
Hypomelanosis Of Ito ◽  
Histopathological Features ◽  
Linear Lesions ◽  
Lichen Striatus ◽  
Pathological Correlation ◽  
Lines Of Blaschko ◽  
Blaschko’S Lines

Several epidemiological studies have described linear dermatoses; however, only few studies have correlated linear dermatoses along Blaschko’s lines with the histopathological findings. The aims of this study were to investigate the clinical patterns of various linear dermatological lesions along Blaschko’s lines and investigate the correlations between these dermatological lesions and their histopathological features. Patients who attended our dermatology out-patient department with linear dermatoses along the Blaschko’s lines were included in the study. Detailed history was obtained, clinical examination was performed, and a final provisional clinical diagnosis was noted. Subsequently, biopsy of the lesions was performed for histopathological examination. Of 62 patients who presented with linear lesions along the Blaschko’s lines, 45 patients underwent biopsy and histopathological examination. Of 45 patients who underwent biopsy, clinico-pathological correlation was observed in 100% of those diagnosed with lichen striatus and linear morphea, 89% of those diagnosed with hypomelanosis of Ito, 80% of those diagnosed with linear epidermal nevus, 75% of those diagnosed with lichen planus, and 67% of those diagnosed with nevus depigmentosus. The importance of correlation of linear lesions with their histopathological features in dermatology cannot be over emphasized. However, 100% correlation may be wishful thinking, and a correlation can help choose the appropriate line of management. Our results highlight this discrepancy and add to the knowledge on linear dermatosis.

scholarly journals A clinical study on linear dermatoses at a teriary care teaching hospital in Davangere

2021 ◽  
Vol 7 (2) ◽  
pp. 201
Author(s):  
Sowmya Manangi ◽  
Anirudh M. ◽  
Aishwarya Sivuni ◽  
Hosalli Smrutha ◽  
Suga Reddy
Keyword(s):  
Lichen Planus ◽  
Skin Lesions ◽  
Epidermal Nevus ◽  
Linear Lesions ◽  
Cosmetic Reason ◽  
Histopathological Correlation ◽  
Lichen Striatus ◽  
History Of Disease ◽  
History Of ◽  
Blaschko’S Lines

<p class="abstract"><strong>Background:</strong> Skin lesions present with innumerable patterns like discoid, petaloid, arcuate, annular, polycyclic, livedo, reticulate, target, stellate, digitate, linear, serpiginous and whorled. Most of the linear lesions follow the Blaschko’s lines. Aim was to study the incidence of linear dermatoses, the age and sex incidence, various types of clinical presentation, various sites of distribution and their clinical correlation.  </p><p class="abstract"><strong>Methods:</strong> Detailed history including family history, History of disease documented with clinical examination. After counselling and after recording their consent for the test, skin biopsy along with routine investigations was done wherever needed and the results were evaluated. <strong></strong></p><p class="abstract"><strong>Results:</strong> Lichen striatus was seen in 29.91% followed by linear herpes zoster in 24.7%, linear lichen planus in 18.22%, linear verrucous epidermal nevus in 14.01%, segmental vitiligo in 3.73%, nevus depigmentation in 2.33% and others. Maximal cases were asymptomatic and reported for cosmetic reason. Intense itching was the main reason to bring the lichen planus patients and few cases of the lichen striatus patients for treatment.  </p><p class="abstract"><strong>Conclusions:</strong> Lichen striatus was found to be more common, female preponderance. Majority of patients showed unilateral distribution more on the extremities. Histopathological correlation shows the importance of histopathology which ultimately changes the management in any given condition.</p><p> </p>

scholarly journals Vulvar and Perianal Condyloma Superimposed Inflammatory Linear Verrucous Epidermal Nevus: A Case Report and Review of the Literature

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Sümeyra Nergız Avcioğlu ◽  
Sündüz Özlem Altinkaya ◽  
Mert Küçük ◽  
Hasan Yüksel ◽  
Selda Demircan-Sezer ◽  
...  
Keyword(s):  
Case Report ◽  
Lichen Planus ◽  
Review Of The Literature ◽  
Epidermal Nevus ◽  
Lichen Striatus ◽  
Genetic Mosaicism ◽  
Lines Of Blaschko ◽  
Linear Psoriasis

Inflammatory linear verrucous epidermal nevus (ILVEN) is a benign cutaneous hamartoma characterized by intensely erythematous, pruritic, and inflammatory papules that occur as linear bands along the lines of Blaschko. There is a considerable clinical and histological resemblance between ILVEN and linear psoriasis, lichen striatus, linear lichen planus, and invasion of epidermal nevus by psoriasis. The pathogenesis of ILVEN is unknown. It is regarded as a genetic dyskeratotic disease reflecting genetic mosaicism. Here, a case of vulvar and perianal condyloma superimposed ILVEN is presented.

scholarly journals Study on linear dermatoses

2018 ◽  
Vol 4 (2) ◽  
pp. 190 ◽  
Author(s):  
Saraswathy P. ◽  
Nithya Gayathri Devi D. ◽  
Sivaranjani J.
Keyword(s):  
Tertiary Care ◽  
Outpatient Department ◽  
Incontinentia Pigmenti ◽  
Care Hospital ◽  
Epidermal Nevus ◽  
Koebner Phenomenon ◽  
Linear Lesions ◽  
Histopathological Correlation ◽  
Lichen Striatus ◽  
Linear Psoriasis

<p class="abstract"><strong>Background:</strong> The objective of the study was to study the incidence, age and sex distribution, association, distribution, clinical presentation, histopathological correlation of linear dermatoses at the skin Outpatient Department.</p><p class="abstract"><strong>Methods:</strong> A prospective study was conducted over a period of 1 year in 90 patients, attending the Department of Dermatology, at a tertiary care hospital, Chennai. Data collection, clinical examination and skin biopsy were recorded and analyzed statistically. Inclusion criteria were all patient with linear dermatoses. Exclusion criteria were Koebner phenomenon.<strong></strong></p><p class="abstract"><strong>Results:</strong> The incidence of linear dermatoses in our outpatient department- 0.2% per year. Among the linear dermatoses, lichen striatus was found to be the most common. The other dermatoses following Blaschko’s lines, in the descending order of frequency seen in this study were linear epidermal nevus, linear lichen planus, linear morphoea, inflammatory linear verrucous epidermal nevus, segmental vitiligo, hypomelanosis of ito, linear lichenoid dermatitis, linear psoriasis, segmental neurofibromatosis, linear whorled nevoid hypermelanosis, incontinentia pigmenti, nevus depigmentosus, linear porokeratosis. Female preponderance was noted. Majority of patients showed unilateral distribution mostly on the extremities.</p><p class="abstract"><strong>Conclusions:</strong> Most of the linear lesions are arranged along Blaschko’s line. The importance of histopathological correlation is obvious. Cases which were clinically diagnosed as lichen striatus, showed histopathological features of psoriasis and linear epidermal verrucous nevus. One case diagnosed clinically as epidermal nevus was found to be super imposed by psoriasis histologically. Another case clinically diagnosed as linear psoriasis clinically, was found to be linear porokeratosis on histopathology. Very few associations were noted.</p>

scholarly journals Asymmetric Bilateral Lichen Striatus: A Rare Presentation following Multiple Blaschko’s Lines

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
Jeffrey S. Dickman ◽  
McKay D. Frandsen ◽  
Andrew J. Racette
Keyword(s):  
The United States ◽  
Diagnostic Process ◽  
Unknown Etiology ◽  
Rare Presentation ◽  
Skin Cell ◽  
Lichen Striatus ◽  
Cell Clones ◽  
Lines Of Blaschko ◽  
The Right ◽  
Blaschko’S Lines

Lichen striatus (LS) is an uncommon, acquired, self-limited, and benign linear dermatosis of unknown etiology that most often occurs unilaterally and is confined to the lines of Blaschko. A healthy 7-year-old girl presented to our clinic with bilateral asymmetric LS occurring on the right arm and left leg of 1-year duration. Very few cases of bilateral LS have been previously reported in the literature, with none from clinics within the United States. The etiology of LS is currently unknown; however its confinement to Blaschko’s lines, which represent embryologic migration of skin cell clones, does provide insight into a possible pathogenesis. It seems most likely that an individual’s development of LS is linked to their genetic predisposition and a subsequent triggering event. Our case serves as a strong example of a rare presentation of LS and facilitates discussion of the clinical diagnostic process and possible pathogenesis of this dermatosis.

Clinical, MRI, and Histopathological Features of Hypothalamic Neuronal Hamartoma in a Young Vizsla

2021 ◽  
Author(s):  
Leonardo Bibbiani ◽  
Sara Canal ◽  
Daiana Marabese ◽  
Maria T. Mandara ◽  
Greta Foiani ◽  
...  
Keyword(s):  
Congenital Malformations ◽  
Histopathological Examination ◽  
Middle Cranial Fossa ◽  
Clinical Imaging ◽  
First Report ◽  
Histopathological Features ◽  
Neurological Signs ◽  
Cranial Fossa ◽  
The Brain ◽  
Clinical Mri

ABSTRACT Human hypothalamic neuronal hamartomas are rare, nonprogressive, congenital malformations of the hypothalamus that do not expand or metastasize to other locations. A 1 yr old female vizsla was presented for progressive intracranial multifocal neurological signs already present since adoption at 3 mo of age. MRI of the brain showed an ill-defined, intra-axial, space-occupying, nonenhancing lesion located in the ventral middle cranial fossa. Histopathological examination was consistent with hypothalamic neuronal hamartoma. This is the first report describing clinical, imaging, and histopathological features of a hypothalamic neuronal hamartoma in a dog. These findings are compared with the human counterparts.

scholarly journals Cryotherapy for Lichen Striatus in an Adult – a Case Report

2015 ◽  
Vol 7 (4) ◽  
pp. 163-171
Author(s):  
Slobodan Stojanović ◽  
Marina Jovanović ◽  
Nada Vučković
Keyword(s):  
Inflammatory Infiltrate ◽  
Unknown Origin ◽  
Skin Condition ◽  
First Year ◽  
Linear Distribution ◽  
Lichen Striatus ◽  
Full Resolution ◽  
Lines Of Blaschko ◽  
History Of ◽  
First Year Of Life

Abstract Lichen striatus (linear lichenoid dermatosis) is an uncommon, self-limited, inflammatory, linear skin condition of unknown origin. The causes of linear distribution are unknown, though the pattern of lichen striatus (LS) mostly follows the lines of Blaschko (BL). The condition most commonly occurs in children between 5 and 15 years of age, usually after the first year of life. We report a 27-year-old, otherwise healthy flight attendant with LS whose diagnosis was based on: the history of sudden appearance and rapid linear spread of lesions; clinical presentation of small pink, coalescing scaly papules without umbilication or Wickham’s striae, linear distribution following one BL down a lower limb to the ankle, with a band broadening into plaque on the left buttock; histology showed some hyperkeratosis, lichenoid dermatitis similar to lichen planus, but with the presence of inflammatory infiltrate in the papillary dermis and also deeper in the perifollicular region. The inflammatory infiltrate consisted mainly of limphocytes, with some melanophages and histiocytes. There is no standard treatment for LS, and it is given for cosmetic or psychological reasons only, as we have done in our patient due to slight pruritus and occupational reasons. With regard to her occupational demands, in order to achieve satisfying results, she was successfully treated with cryotherapy, which she tolerated well, without any side effects. Cryotherapy was performed twice, with a two-week interval. Full resolution was achieved twelve weeks after cryotherapy. In conclusion, we present an adult female who developed lichen striatus suddenly three months after delivery and was successfully treated with cryotherapy.

Hypomelanosis of Ito

2018 ◽  
Vol 16 (05) ◽  
pp. 265-275 ◽  
Author(s):  
Federica Sullo ◽  
Agata Polizzi ◽  
Chiara Battaglini ◽  
Carmelo Schepis ◽  
Concetta Pirrone ◽  
...  
Keyword(s):  
Fungal Infections ◽  
Somatic Growth ◽  
Incontinentia Pigmenti ◽  
First Year ◽  
Hypomelanosis Of Ito ◽  
Genetic Mosaicism ◽  
Lines Of Blaschko ◽  
Endocrine Status ◽  
Neurocutaneous Syndrome ◽  
First Year Of Life

AbstractHypomelanosis of Ito (HI) is a congenital neurocutaneous syndrome presenting in the first year of life. It was first described by Ito in 1952 as a purely cutaneous disease presenting with skin hypopigmentation. Several extracutaneous manifestations were later described, and it is now known that several organs can be involved (including brain, muscle, bone, heart, eye, kidney, and teeth) and that the prognosis is strictly related to the number of involved organs. The incidence and prevalence of this syndrome have been estimated to range between 1 in 7,540 births and 1 in 82,000; the disorder affects both the sexes, occurs in all races, and is characterized by depigmentation of the skin along the lines of Blaschko on the trunk and extremities in whorled and linear streaks and patterns. The pathogenesis is unknown, but it is likely to be multifactorial. Several models of inheritance have been proposed but not proved; genetic mosaicism is nowadays the most likely explanation for its inheritance. The differential diagnosis comprises other disorders with hypopigmentation following the lines of Blaschko and thus includes the atrophic/hypopigmented (fourth) stage manifestations of incontinentia pigmenti of the Bloch–Sulzberger type, tuberous sclerosis complex, vitiligo, and skin fungal infections. Consensus recommendations for the screening of associated extracutaneous conditions do not exist and management is symptomatic, but a regular evaluation of somatic growth, neurodevelopment, endocrine status, eyes, and teeth should be performed, and the screening of renal function is also advisable. HI still represents a challenging disorder for the child neurologist and a controversial issue in the medical literature. Awareness of this disorder could allow an early diagnosis and appropriate genetic counseling and screening.

scholarly journals Schimmelpenning Syndrome with Large Nevus Sebaceous and Multiple Epidermal Nevi

2020 ◽  
Vol 12 (3) ◽  
pp. 186-191
Author(s):  
Reiva Farah Dwiyana ◽  
Maryam Nissa Hazari ◽  
Inne Arline Diana ◽  
Srie Prihianti Gondokaryono ◽  
Raden Mohamad Rendy Ariezal Effendi ◽  
...  
Keyword(s):  
Sebaceous Gland ◽  
Histopathological Examination ◽  
The Body ◽  
Epidermal Nevus ◽  
Clinical Variant ◽  
Central Nervous Systems ◽  
Brownish Black ◽  
Almost All ◽  
Nevus Sebaceous ◽  
Congenital Syndrome

Epidermal nevus syndromes are a group of rare multiorgan disorders. Schimmelpenning syndrome is a clinical variant of epidermal nevus syndromes. This congenital syndrome is characterized by the existence of nevus sebaceous and usually accompanied by abnormalities of the eyes, skeletal, cardiovascular, and central nervous systems. A 2-year-old girl presented with large, hairless, yellowish-brown plaques on the scalp and face along with multiple brownish-black verrucose plaques and brownish-black macules on almost all parts of the body. The skin-colored verrucose tumors were also found on the lips and around the mouth. Histopathological examination of the lesion on the forehead revealed hyperkeratosis, acanthosis, and sebaceous gland hyperplasia supporting the diagnosis of nevus sebaceous, while histopathological examination of the lesions on the lips and abdomen demonstrated hyperkeratosis, acanthosis, and papillomatosis consistent with verrucous epidermal nevus. The pediatrician suspected that the patient had mental retardation; however, there were no neurological, cardiac, skeletal, nor ophthalmologic abnormalities. The lesions on the lips and around the mouth were excised, and it demonstrated a good result. To conclude, epidermal nevus syndrome (e.g., Schimmelpenning syndrome) should be considered in children born with nevus sebaceous.

scholarly journals A Case of Disseminated Hypopigmented Keratoses Improved with Oral Acitretin

2017 ◽  
Vol 2017 ◽  
pp. 1-3
Author(s):  
Ali Haydar Eskiocak ◽  
Cumhur İbrahim Bassorgun ◽  
Sarp Uzun ◽  
Soner Uzun
Keyword(s):  
Salicylic Acid ◽  
Laboratory Tests ◽  
Histopathological Examination ◽  
Clinical Entity ◽  
Radiological Examination ◽  
Normal Amount ◽  
Present Patient ◽  
Histopathological Features ◽  
History Of ◽  
Significant Regression

Disseminated hypopigmented keratosis is a distinct clinical entity and only few cases have been reported so far. Here, we present a 21-year-old man with almost 10-year history of hypopigmented, nonfollicular, keratotic lichenoid papules occurring on the extensor surfaces of the extremities, back and lumber region. Histopathological examination showed orthohyperkeratosis, irregular acanthosis, and sporadic papillomatosis with a normal amount of melanin and number of melanocytes. In addition, no marked inflammation or melanophages were seen. In order to exclude other possible causes, we performed laboratory tests and radiological examination which were all found to be normal. As the clinical and histopathological features of our patient were taken into account, it was considered to be compatible with the diagnosis of disseminated hypopigmented keratoses. So far, only topical therapies have been used with failure in the previously reported cases except one patient. Considering the extensive lesions, we treated the present patient with 5% salicylic acid in addition to oral acitretin and significant regression in all lesions was achieved, particularly on the keratosis.

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