Assessment of serum levels of ascorbic acid and malondialdehyde as oxidative stress marker in patients with oral lichen planus

Background: PCOS is a condition with significant decrease in antioxidant with an increased risk of oxidative stress. Antioxidant supplementation has been shown to improve insulin sensitivity in PCOS and may improve outcome of management of PCOS. Objectives of this study were to determine the oxidative stress level of PCOS patients, to assess the effect of antioxidant supplementation on the outcome of management of PCOS and to compare with a control group.Methods: The study was a single blind randomised control trial involving 200 patients with PCOS. The study was conducted at Usmanu Danfodiyo University Teaching Hospital Sokoto. They were randomly divided into intervention and control groups and base line serum levels of oxidative stress marker, antioxidant enzymes, vitamins and minerals were determined. Antioxidant supplementation and placebo were given to the intervention and control groups respectively. All the patients had ovulation induction with clomiphene citrate and were followed up for 6 months. Outcome measures were clinical pregnancy or menstrual regularisation. Level of significance was <0.05.Results: There was statistical significance in the serum levels of oxidative stress marker, antioxidant enzymes, vitamins and minerals between the two groups (post intervention). Glutathione peroxidase (p = 0.001), superoxide dismutase (p = 0.0001), catalase (p= 0.0369), melondialdehyde (p= 0.007), Vitamin A, Vitamin C, Vitamin E (p = 0.0001), zinc and copper (p = 0.0001). The clinical pregnancy outcomes were 22 (22%) versus 2 (2%); live births 18 (18%) versus 2 (2%) and menstrual regularisation 48 (48%) versus 46 (46%) in the intervention and control groups respectively.Conclusions: Antioxidant supplementation in this study significantly affected pregnancy rate in patients with PCOS. Larger studies are suggested to revisit the conclusion of the Cochrane review that antioxidants supplementation had no significant role in female infertility.

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Oral Vitamin C Supplementation in Hemodialysis Patients and Its Effect on the Plasma Level of Oxidized Ascorbic Acid and Cu/Zn Superoxide Dismutase, an Oxidative Stress Marker

Nephron Clinical Practice ◽

10.1159/000137628 ◽

2008 ◽

Vol 109 (2) ◽

pp. c49-c54 ◽

Cited By ~ 15

Author(s):

Kazunori Washio ◽

Masahiro Inagaki ◽

Mayumi Tsuji ◽

Yuri Morio ◽

Shinichiro Akiyama ◽

...

Keyword(s):

Oxidative Stress ◽

Ascorbic Acid ◽

Superoxide Dismutase ◽

Plasma Level ◽

Vitamin C ◽

Hemodialysis Patients ◽

Oxidative Stress Marker ◽

Oral Vitamin ◽

Stress Marker ◽

Vitamin C Supplementation

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Evaluation of oxidative stress markers in oral lichen planus

Journal of Oral and Maxillofacial Pathology ◽

10.4103/jomfp.jomfp_19_17 ◽

2017 ◽

Vol 21 (3) ◽

pp. 387 ◽

Cited By ~ 6

Author(s):

VR Rekha ◽

S Sunil ◽

R Rathy

Keyword(s):

Oxidative Stress ◽

Lichen Planus ◽

Oral Lichen Planus ◽

Oxidative Stress Markers ◽

Stress Markers ◽

Oral Lichen

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Serum and Salivary IgA, IgG, and IgM Levels in Oral Lichen Planus: A Systematic Review and Meta-Analysis of Case-Control Studies

10.20944/preprints201809.0477.v1 ◽

2018 ◽

Author(s):

Hamid Reza Mozaffari ◽

Elisa Zavattaro ◽

Abas Abdolahnejad ◽

Pia Lopez Jornet ◽

Neda Omidpanah ◽

...

Keyword(s):

Lichen Planus ◽

Oral Lichen Planus ◽

Meta Analysis ◽

Serum Levels ◽

Inflammatory Factors ◽

Cochrane Library ◽

Healthy Controls ◽

Case Control Studies ◽

Salivary Iga ◽

Oral Lichen

Background and Aim: Immunoglobulins (IgA, IgG, and IgM) are significant anti-inflammatory factors. The meta-analysis aimed to assess the serum and salivary levels of Igs as more important immunoglobulins in patients affected by oral lichen planus (OLP) compared to the healthy controls. Materials and Methods: Four databases, including PubMed/Medline, Scopus, Web of Science, and Cochrane Library as well as Iranian databases were checked up to January 2018 without language restriction. The quality of each involved study was done using the NOS questionnaire. A random-effects model analysis was done by RevMan 5.3 software applying the mean difference (MD) plus 95% confidence intervals (CIs). The CMA 2.0 software was applied to calculate the publication bias among the studies. Results: Out of 70 studies found in the databases, eight studies were involved and analyzed in the meta-analysis. The meta-analysis included 282 OLP patients and 221 healthy controls. The pooled MDs of serum levels of  IgA, IgG, and IgM were -0.13 g/L [95%CI: -0.24, -0.02; P = 0.02], 1.01 g/L [95%CI: -0.91, 2.93; P = 0.30], and -0.06 g/L [95%CI: -0.25, 0.14; P = 0.56], respectively; whereas, the salivary IgA and IgG levels were 71.54 mg/L [95%CI: 12.01, 131.07; P = 0.02] and 0.59 mg/L [95%CI: -0.20, 1.38; P = 0.14], respectively. Conclusions: Considering the few studies performed on saliva, the results suggested that the salivary levels, especially IgA level had a higher diagnostic value than the serum levels. Therefore, the salivary immunoglobulins can play a significant function in the OLP pathogenesis.

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Serum and Salivary IgA, IgG, and IgM Levels in Oral Lichen Planus: A Systematic Review and Meta-Analysis of Case-Control Studies

Medicina ◽

10.3390/medicina54060099 ◽

2018 ◽

Vol 54 (6) ◽

pp. 99 ◽

Cited By ~ 3

Author(s):

Hamid Mozaffari ◽

Elisa Zavattaro ◽

Abas Abdolahnejad ◽

Pia Lopez-Jornet ◽

Neda Omidpanah ◽

...

Keyword(s):

Lichen Planus ◽

Oral Lichen Planus ◽

Meta Analysis ◽

Serum Levels ◽

Inflammatory Factors ◽

Cochrane Library ◽

Healthy Controls ◽

Case Control Studies ◽

Salivary Iga ◽

Oral Lichen

Immunoglobulins (IgA, IgG, and IgM) are significant anti-inflammatory factors. The meta-analysis aimed to assess the serum and salivary levels of Igs as more important immunoglobulins in patients affected by oral lichen planus (OLP) compared to the healthy controls. Four databases, including PubMed/Medline, Scopus, Web of Science, and Cochrane Library as well as Iranian databases were checked up to January 2018 without language restriction. The quality of each involved study was done using the Newcastle–Ottawa Quality Assessment Scale (NOS) questionnaire. A random-effects model analysis was done by RevMan 5.3 software applying the mean difference (MD) plus 95% confidence intervals (CIs). The CMA 2.0 software was applied to calculate the publication bias among the studies. Out of 70 studies found in the databases, 8 studies were involved and analyzed in the meta-analysis. The meta-analysis included 282 OLP patients and 221 healthy controls. The pooled MDs of serum levels of IgA, IgG, and IgM were −0.13 g/L [95% CI: −0.24, −0.02; P = 0.02], 1.01 g/L [95% CI: −0.91, 2.93; P = 0.30], and −0.06 g/L [95% CI: −0.25, 0.14; P = 0.56], respectively; whereas, the salivary IgA and IgG levels were 71.54 mg/L [95% CI: 12.01, 131.07; P = 0.02] and 0.59 mg/L [95% CI: −0.20, 1.38; P = 0.14], respectively. Considering the few studies performed on saliva, the results suggested that the salivary levels, especially IgA level had higher values than the serum levels. Therefore, the salivary immunoglobulins can play a significant function in the OLP pathogenesis.

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