Could Serum Levels of Telomerase be Considered as an Oxidative Stress Marker in COPD?

2016 ◽  
Keyword(s):  
Oxidative Stress ◽  
Serum Levels ◽  
Oxidative Stress Marker ◽  
Stress Marker

scholarly journals Oxidative stress and outcome of antioxidant supplementation in patients with polycystic ovarian syndrome (PCOS)

2018 ◽  
Vol 7 (5) ◽  
pp. 1667 ◽  
Author(s):  
Abubakar A. Panti ◽  
Constance E. Shehu ◽  
Yusuf Saidu ◽  
Karima A. Tunau ◽  
Emmanuel I. Nwobodo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Enzymes ◽  
Serum Levels ◽  
Clinical Pregnancy ◽  
Oxidative Stress Marker ◽  
Randomised Control Trial ◽  
Antioxidant Supplementation ◽  
Control Groups ◽  
Stress Marker ◽  
And Control

Background: PCOS is a condition with significant decrease in antioxidant with an increased risk of oxidative stress. Antioxidant supplementation has been shown to improve insulin sensitivity in PCOS and may improve outcome of management of PCOS. Objectives of this study were to determine the oxidative stress level of PCOS patients, to assess the effect of antioxidant supplementation on the outcome of management of PCOS and to compare with a control group.Methods: The study was a single blind randomised control trial involving 200 patients with PCOS. The study was conducted at Usmanu Danfodiyo University Teaching Hospital Sokoto. They were randomly divided into intervention and control groups and base line serum levels of oxidative stress marker, antioxidant enzymes, vitamins and minerals were determined. Antioxidant supplementation and placebo were given to the intervention and control groups respectively. All the patients had ovulation induction with clomiphene citrate and were followed up for 6 months. Outcome measures were clinical pregnancy or menstrual regularisation. Level of significance was <0.05.Results: There was statistical significance in the serum levels of oxidative stress marker, antioxidant enzymes, vitamins and minerals between the two groups (post intervention). Glutathione peroxidase (p = 0.001), superoxide dismutase (p = 0.0001), catalase (p= 0.0369), melondialdehyde (p= 0.007), Vitamin A, Vitamin C, Vitamin E (p = 0.0001), zinc and copper (p = 0.0001). The clinical pregnancy outcomes were 22 (22%) versus 2 (2%); live births 18 (18%) versus 2 (2%) and menstrual regularisation 48 (48%) versus 46 (46%) in the intervention and control groups respectively.Conclusions: Antioxidant supplementation in this study significantly affected pregnancy rate in patients with PCOS. Larger studies are suggested to revisit the conclusion of the Cochrane review that antioxidants supplementation had no significant role in female infertility.

Trace elements as an oxidative stress marker in women with gestational diabetes and their neonates

2017 ◽  
Author(s):  
Georgios Boutzios ◽  
Eleni Koukoulioti ◽  
Ioannis Papoutsis ◽  
Sotirios Athanaselis ◽  
Gerasimos Tsourouflis ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Trace Elements ◽  
Gestational Diabetes ◽  
Oxidative Stress Marker ◽  
Stress Marker

The association of plasma prorenin level with an oxidative stress marker, 8-OHdG, in nondiabetic hemodialysis patients

2011 ◽  
Vol 15 (3) ◽  
pp. 398-404 ◽  
Author(s):  
Yoshiyuki Morishita ◽  
Shiho Hanawa ◽  
Takuya Miki ◽  
Taro Sugase ◽  
Yasuhiro Sugaya ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hemodialysis Patients ◽  
Oxidative Stress Marker ◽  
Stress Marker

scholarly journals Hepatoprotective Property of Phyllanthus amarus Alkaloid-Rich Fraction with Respect to Oxidative Stress Marker Enzymes

2021 ◽  
Vol 68 (2) ◽  
Author(s):  
Doraswamy Gangaraju ◽  
Shanmugam Bhasha ◽  
Ravi Sahukari ◽  
Shanmugam Kondeti Ramudu ◽  
Srinivas Kurakula ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Normal Control ◽  
Male Rats ◽  
Oxidative Stress Marker ◽  
Phyllanthus Amarus ◽  
Marker Enzymes ◽  
Isolation And Identification ◽  
Stress Marker ◽  
Antioxidant Defense Enzymes ◽  
Alkaloid Fraction

A disruption in the equilibrium between the generation of reactive oxygen species and antioxidant defense enzymes is referred to as oxidative stress. In the present study, we planned to identify the hepatoprotective effect of Phyllanthus amarus alkaloid rich fraction in wistar strain albino male rats. The hepatic damage was induced by the D-galactosamine and ameliorative effect was tested with alkaloid rich fraction of P. amarus by measuring oxidative stress markers such as G6PDH, LDH, SDH, MDH and GDH in the liver tissue. Activity levels of G6PDH, SDH, MDH and GDH were significantly decreased in D-galactosamine induced hepatitis rats when compare to normal control rat group, while their activities were significantly increased in hepatitis rat group that supplemented with alkaloid rich fraction of P. amarus. In contrast, LDH enzyme activity of liver was significantly increased in the hepatitis rat group when compare to normal control rats, while its activity was significantly decreased in hepatitis rats treated with alkaloid fraction. In conclusion, it is very clear that alkaloid fraction of P. amarus has hepatoprotective property with respect of decreasing oxidative stress by regulating oxidative stress marker enzymes. The isolation and identification of specific alkaloid compounds with hepatoprotective properties and anti-oxidative stress will require much further research.

Significance of the urinary 8-OHdG level as an oxidative stress marker in lung cancer patients

Lung Cancer ◽  
2009 ◽  
Vol 63 (1) ◽  
pp. 111-114 ◽  
Author(s):  
Tokujiro Yano ◽  
Fumihiro Shoji ◽  
Hiromitsu Baba ◽  
Tadashi Koga ◽  
Takeshi Shiraishi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lung Cancer ◽  
Cancer Patients ◽  
Oxidative Stress Marker ◽  
Lung Cancer Patients ◽  
Stress Marker
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