scholarly journals Radiation-induced angiosarcoma masquerading as recurrent carcinoma cervix - A diagnostic challenge

2020 ◽  
Vol 7 (3) ◽  
pp. 491-494
Author(s):  
Varsha P ◽  
Keyword(s):  
Carcinoma Cervix ◽  
Diagnostic Challenge ◽  
Recurrent Carcinoma ◽  
Radiation Induced

scholarly journals Radiation-induced vertebral compression fracture following spine stereotactic radiosurgery: clinicopathological correlation

2013 ◽  
Vol 18 (5) ◽  
pp. 430-435 ◽  
Author(s):  
Ameen Al-Omair ◽  
Roger Smith ◽  
Tim-Rasmus Kiehl ◽  
Louis Lao ◽  
Eugene Yu ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Stereotactic Radiosurgery ◽  
Vertebral Compression Fracture ◽  
Compression Fracture ◽  
Spinal Tumors ◽  
High Dose ◽  
Diagnostic Challenge ◽  
New Era ◽  
Radiation Induced ◽  
Dose Radiation

Spine stereotactic radiosurgery (SRS) is increasingly being used to treat metastatic spinal tumors. As the experience matures, high rates of vertebral compression fracture (VCF) are being observed. What is unknown is the mechanism of action; it has been postulated but not confirmed that radiation itself is a contributing factor. This case report describes 2 patients who were treated with spine SRS who subsequently developed signal changes on MRI consistent with tumor progression and VCF; however, biopsy confirmed a diagnosis of radiation-induced necrosis in 1 patient and fibrosis in the other. Radionecrosis is a rare and serious side effect of high-dose radiation therapy and represents a diagnostic challenge, as the authors have learned from years of experience with brain SRS. These cases highlight the issues in the new era of spine SRS with respect to relying on imaging alone as a means of determining true tumor progression. In those scenarios in which it is unclear based on imaging if true tumor progression has occurred, the authors recommend biopsy to rule out radiation-induced effects within the bone prior to initiating salvage therapies.

scholarly journals Eccrine Angiomatous Hamartoma: A Rare Presentation in Late Adulthood

2021 ◽  
Vol 5 (11) ◽  
Author(s):  
Zeany Cheran Momin ◽  
Veena Gupta ◽  
Gauri Munjal ◽  
Rahul Jakhar ◽  
Chandershekhar Yadav ◽  
...  
Keyword(s):  
The Elderly ◽  
Interesting Case ◽  
Concurrent Chemotherapy ◽  
Early Infancy ◽  
Carcinoma Cervix ◽  
Diagnostic Challenge ◽  
Rare Presentation ◽  
Late Adulthood ◽  
Vascular Elements ◽  
Infancy And Childhood

Eccrine angiomatous hamartoma is a tumor characterized by benign malformation of eccrine and vascular elements, occurring generally at birth or during early infancy and childhood. The rarity with which it is encountered in adults and the elderly makes it a diagnostic challenge in such age brackets. We report an interesting case of eccrine angiomatous hamartoma presenting in late adulthood confirmed by histopathology. Keywords: Cisplatin, concurrent chemotherapy, daily, weekly, three weekly, carcinoma cervix

scholarly journals A Case of Radiation-Induced Multifocal Laryngeal Angiosarcoma Presenting as a Diagnostic Dilemma

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Jayme R. Dowdall ◽  
Krisha J. Opfermann ◽  
Harold Kim ◽  
Ho-Sheng Lin
Keyword(s):  
Head And Neck ◽  
Interesting Case ◽  
Unknown Primary ◽  
Small Subset ◽  
Diagnostic Challenge ◽  
Diagnostic Dilemma ◽  
Multiple Biopsies ◽  
Endothelial Proliferation ◽  
Radiation Induced ◽  
Previously Treated

Head and neck sarcomas are relatively rare tumors, with angiosarcomas representing a small subset. Angiosarcoma is a malignant endothelial neoplasm characterized by atypical, multilayered, or solid endothelial proliferation with vasoformative architecture. The global incidence of irradiation-associated sarcoma is estimated as between 0.03% and 0.08%. Here we reported the case of an elderly woman previously treated with radiation more than 20 years ago for an unknown primary of head and neck. This interesting case presented as a diagnostic challenge, and multiple biopsies were required to eventually establish the diagnosis of laryngeal angiosarcoma. We additionally have confirmation from our prior radiation records that the patient did, in fact, receive a substantial dose of radiation to the site previously. To our knowledge, this case represents the first report of a documented radiation-induced multifocal laryngeal angiosarcoma.

Radiation-induced sarcoma presenting as a gluteal abscess: a diagnostic and therapeutic challenge

2020 ◽  
Vol 13 (12) ◽  
pp. e236601
Author(s):  
Sudharshan Mahalingam ◽  
Sudharsanan Sundaramurthi ◽  
Balamourougan Krishnaraj ◽  
Sarath Chandra Sistla
Keyword(s):  
Radiation Treatment ◽  
Diagnostic Challenge ◽  
Incision And Drainage ◽  
Aggressive Management ◽  
Aged Woman ◽  
Increased Risk ◽  
Middle Aged Woman ◽  
Treatment Complication ◽  
Radiation Induced ◽  
Gluteal Abscess

Sarcomas are a rare and fatal treatment complication following radiotherapy. Radiation-induced sarcomas (RISs) presenting as a gluteal abscess is a rarity, accounting for its varied presentation. We present a case of a middle-aged woman, post-chemo-radiation for carcinoma cervix 5 years ago, who presented with gluteal abscess. Achieving haemostasis post incision and drainage under anaesthesia was a challenge. On further evaluation, she was diagnosed with radiation-induced gluteal soft tissue sarcoma. Haemostasis was achieved after radiation following failed attempts of surgical and radiological interventions. She is currently planned for chemotherapy. Cancer survivors have an increased risk of developing a second malignancy following radiation treatment. RISs are highly aggressive, exhibit a varied clinical presentation and pose a challenge in early diagnosis; thus, have a poor outcome. RISs pose a diagnostic challenge; any dubious lesion in the previously irradiated field should raise suspicion and prompt aggressive management.

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