scholarly journals Altered spontaneous brain activity patterns in patients with hyperthyroidism exophthalmos using amplitude of low-frequency fluctuation: a resting-state fMRI study

2021 ◽  
Vol 14 (12) ◽  
pp. 1957-1962
Author(s):  
Ling Ling ◽  
◽  
Yu Guo ◽  
Rong-Bin Liang ◽  
Hui-Ye Shu ◽  
...  
Keyword(s):  
Resting State ◽  
Brain Activity ◽  
Activity Patterns ◽  
Clinical Manifestations ◽  
Area Under The Curve ◽  
Low Frequency ◽  
Roc Curves ◽  
Frequency Fluctuation ◽  
Roc Curve Analysis ◽  
Spontaneous Brain Activity

AIM: To assess changed spontaneous brain activity in hyperthyroid exophthalmos (HE) patients by the amplitude of the low-frequency fluctuation (ALFF) method, and to analyze the correlation between brain activity and ALFF values in these patients. METHODS: Totally 18 HE and 18 hyperthyroid non-exophthalmos (HNE) patients were enrolled. The participants were tested by resting-state functional magnetic resonance imaging, and receiver operating characteristic (ROC) curves were generated to classify the ALFF values of the study population. Pearson’s correlation analysis was utilized to evaluate the relationship between the ALFF values obtained from different brain areas and clinical manifestations. RESULTS: Contrary to HNE patients, we observed lower ALFF values in the left calcarine fissure and surrounding cortex (LCFSC) in HE patients. In the ROC curve analysis of the LCFSC, the area under the curve reflected a high degree of accuracy. In addition, there was positive correlation between mean ALFF values of the LCFSC and the best-corrected visual acuity of the affected eyes. CONCLUSION: The study displays abnormal brain activity in LCFSC in patients with HE, which might suggest pathological mechanism of visual impairment of HE patients.

scholarly journals Detection of Abnormal Spontaneous Brain Activity Patterns in Patients with Orbital Fractures using Fractional Amplitude of Low Frequency Fluctuation

2021 ◽  
Author(s):  
Min-Jie Chen ◽  
Rong Huang ◽  
Qian-Min Ge ◽  
Li-Juan Zhang ◽  
Hui-Ye Shu ◽  
...  
Keyword(s):  
Brain Activity ◽  
Activity Patterns ◽  
Low Frequency ◽  
Superior Temporal Gyrus ◽  
Roc Curves ◽  
Depression Score ◽  
Anterior Cingulate ◽  
Frequency Fluctuation ◽  
Orbital Fracture ◽  
Emotional States

Abstract To date, no in-depth study has been conducted on the intrinsic pathological relationship between altered brain activity and related behavioral changes in patients with orbital fracture (OF).The present research aimed to explore the potential functional network cerebrum activities in patients with OF using resting state functional magnetic resonance imaging–fractional amplitude of low-frequency fluctuation (rsfMRI-fALFF). 20 patients with OF and 20 healthy controls (HCs) were included, closely matched in terms of gender, age, weight and education level. To record spontaneous cerebral activity changes, the rsfMRI-fALFF tool was applied. Receiver operating characteristic (ROC) curves and Pearson’s correlation analysis were used to analyze mean fALFF values. The Hospital Depression and Anxiety scale was applied to reveal the relationship between emotional states and fALFF values of the right superior temporal gyrus in OF patients.Compared with HCs, significantly lower fALFF values were detected in the left anterior cingulate gyrus (LACG) and right superior temporal gyrus (RSTG) in patients with OF. The mean fALFF values of the RSTG negatively correlated with the depression score as well as anxiety score.The finding of abnormal spontaneous activities in cerebral regions may contribute to more comprehensive understanding of the potential neural network changes in patients with OF.

Altered Brain Network Centrality in Patients With Orbital Fracture: A Resting-State fMRI Study. Running Head: DC Alterations in OF Patients

2021 ◽  
Author(s):  
Yi-Nuo Liu ◽  
Yu-Xuan Gao ◽  
Hui-Ye Shu ◽  
Qiu-Yu Li ◽  
Qian-Min Ge ◽  
...  
Keyword(s):  
Resting State ◽  
Brain Activity ◽  
Area Under The Curve ◽  
Roc Curves ◽  
Resting State Fmri ◽  
Brain Regions ◽  
Brain Network ◽  
Orbital Fracture ◽  
Orbital Fractures ◽  
Roc Curve Analysis

Abstract Objective: We aimed to identify potential functional network brain-activity abnormalities in patients with orbital fractures (OFs) by using the voxel-wise degree centrality (DC) method.Methods:We selected 20 patients with OFs (12 men and 8 women) and 20 healthy controls (HCs; 12 men and 8 women) matched by gender, age, and education level for this study. Resting-state functional magnetic resonance imaging (fMRI) has been widely used in various disciplines. We calculated receiver operating characteristic (ROC) curves to differentiate characteristics between patients with orbital fractures and HCs; in addition, we applied correlation analyses between behavioral performance and average DC values in different areas. The DC method served to evaluate spontaneous brain activity.Results:The DC values of patients with OFs were higher in the right cerebellum 9 area (Cerebelum_9_R) and left cerebellar peduncle 2 area (Cerebelum_Crus2_L) than those in HCs. The area under the curve (AUC) values for Cerebelum_9_R and Cerebelum_Crus2_L were 0.983 and 1, respectively. The accuracy of our ROC curve analysis result was reliable. Conclusion:Many brain regions seem to show abnormal brain network characteristics in patients with orbital fractures, suggesting potential neuropathic mechanisms.

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