Detection of Abnormal Spontaneous Brain Activity Patterns in Patients with Orbital Fractures using Fractional Amplitude of Low Frequency Fluctuation
Abstract To date, no in-depth study has been conducted on the intrinsic pathological relationship between altered brain activity and related behavioral changes in patients with orbital fracture (OF).The present research aimed to explore the potential functional network cerebrum activities in patients with OF using resting state functional magnetic resonance imaging–fractional amplitude of low-frequency fluctuation (rsfMRI-fALFF). 20 patients with OF and 20 healthy controls (HCs) were included, closely matched in terms of gender, age, weight and education level. To record spontaneous cerebral activity changes, the rsfMRI-fALFF tool was applied. Receiver operating characteristic (ROC) curves and Pearson’s correlation analysis were used to analyze mean fALFF values. The Hospital Depression and Anxiety scale was applied to reveal the relationship between emotional states and fALFF values of the right superior temporal gyrus in OF patients.Compared with HCs, significantly lower fALFF values were detected in the left anterior cingulate gyrus (LACG) and right superior temporal gyrus (RSTG) in patients with OF. The mean fALFF values of the RSTG negatively correlated with the depression score as well as anxiety score.The finding of abnormal spontaneous activities in cerebral regions may contribute to more comprehensive understanding of the potential neural network changes in patients with OF.